C. Van Waes

S. Rosenberg, C. Van Waes, R. Morgan, 2011, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL‐1α, EGF and TGF‐β1 through NF‐κB dependent and independent mechanisms

C. Van Waes, G. Dong, Zhong Chen, 2001 .

The Biology of Tobacco and Nicotine: Bench to Bedside

M. Spitz, G. C. Yeh, C. Van Waes, 2005, Cancer Epidemiology Biomarkers & Prevention.

Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy.

J. Schlom, C. Van Waes, J. Friedman, 2019, JCI insight.

Endolymphatic sac tumors in von Hippel-Lindau disease.

W. Linehan, E. Oldfield, C. Van Waes, 2004, Journal of neurosurgery.

Early Tumor Progression Associated with Enhanced EGFR Signaling with Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer

N. Simone, Minyoung Jang, Seungwon Kim, 2011, Clinical Cancer Research.

Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma.

C. Van Waes, G. Dong, C. Waes, 2001, Cancer research.

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF‐κB and AP‐1 activation and IL‐8 and VEGF expression in human head and neck squamous cell carcinoma lines

C. Van Waes, Zhong Chen, J. Yeh, 2002, International journal of cancer.

Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.

James B. Mitchell, C. Van Waes, M. Grompe, 2008, Cancer research.

Head and Neck Cancers Promote an Inflammatory Transcriptome through Coactivation of Classic and Alternative NF-κB Pathways

R. Nussinov, O. Keskin, A. Gursoy, 2019, Cancer Immunology Research.

Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers.

Scott E. Martin, Ramya Viswanathan, C. Van Waes, 2022, Molecular cancer research : MCR.

Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers

W. Xiao, R. Ferris, C. Van Waes, 2018, Cell reports.

YAP Dysregulation by Phosphorylation or ΔNp63-mediated Gene Repression Promotes Proliferation, Survival and Migration in Head and Neck Cancer Subsets

M. Brown, S. Feller, C. Van Waes, 2010, Oncogene.

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.

James B. Mitchell, C. Van Waes, Zhong Chen, 2016, Cancer research.

Deficient TP53 Expression, Function, and Cisplatin Sensitivity Are Restored by Quinacrine in Head and Neck Cancer

C. Van Waes, Zhong Chen, B. Yan, 2007, Clinical Cancer Research.

Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV− and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy

C. Van Waes, Zhong Chen, Xinping Yang, 2019, Clinical Cancer Research.

Burkitt's/Burkitt's-like lymphoma presenting as bacterial sinusitis in two HIV-infected children.

C. Van Waes, I. Magrath, S. Zeichner, 2001, AIDS patient care and STDs.

Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

J. Schlom, C. Van Waes, J. Friedman, 2020, bioRxiv.

Nuclear Factor-κB in Development, Prevention, and Therapy of Cancer

C. Van Waes, 2007, Clinical Cancer Research.

Nuclear factor-kappaB in development, prevention, and therapy of cancer.

C. Van Waes, 2007, Clinical cancer research : an official journal of the American Association for Cancer Research.

Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.

C. Van Waes, J. Yeh, Ming Yu, 2006, Cancer research.

Targeting NF-κB in mouse models of lung adenocarcinoma.

C. Van Waes, 2011, Cancer discovery.

Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

James B. Mitchell, C. Van Waes, Zhong Chen, 2004, Cancer research.

Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

C. Van Waes, G. Dong, F. Ondrey, 1999, Cancer research.

Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus

C. Van Waes, Zhong Chen, Jialing Zhang, 2017, Cancer.

Putting T cells to work-outsourcing neoantigen detection in head and neck cancers?

C. Van Waes, N. Schmitt, R. Xiao, 2017, Oral diseases.

Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib.

J. Xie, B. Wood, King Li, 2008, Radiology.

Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzae.

C. Van Waes, J. Battey, Jianping Li, 2003, Vaccine.

NIH symposium summary: organ preservation therapies for squamous cancers of the head and neck.

C. Van Waes, B. Conley, C. Waes, 1901, Clinical cancer research : an official journal of the American Association for Cancer Research.

The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth.

C. Van Waes, Zhong Chen, Hai Lu, 2008, Cancer research.

Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous‐cell carcinoma

C. Van Waes, Zhong Chen, Z. Chen, 1999, International journal of cancer.

Immunodominance deters the response to other tumor antigens thereby favoring escape: prevention by vaccination with tumor variants selected with cloned cytolytic T cells in vitro.

C. Van Waes, P. Monach, H. Schreiber, 1996, Tissue antigens.

Dyskeratosis congenita: The first NIH clinical research workshop

M. Greene, J. Tolar, S. Savage, 2009, Pediatric blood & cancer.

The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC

C. Van Waes, G. Dong, Zhong Chen, 1998, Clinical & Experimental Metastasis.

Sino-orbital-cerebral aspergillosis in immunocompromised pediatric patients.

R. Hertle, C. Van Waes, S. Whitcup, 2000, The Pediatric infectious disease journal.

A human vascular endothelial cell model to study angiogenesis and tumorigenesis.

J. Lautenberger, J. Rhim, C. Van Waes, 1998, Carcinogenesis.

Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy.

R. Seethala, R. Ferris, C. Van Waes, 2008, Journal of the National Cancer Institute.

Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma

C. Van Waes, G. Dong, Zhong Chen, 1997, Journal of cellular biochemistry. Supplement.

Identification of a unique tumor antigen as rejection antigen by molecular cloning and gene transfer

C. Van Waes, C. Waes, H. Schreiber, 1986, The Journal of experimental medicine.

Phase III randomized trial of patient-specific vaccination for previously untreated patients with follicular lymphoma in first complete remission: protocol summary and interim report.

J. Winter, E. Jaffe, K. Takeshita, 2005, Clinical lymphoma.

IL‐12‐ and IL‐2‐induced tumor regression in a new murine model of oral squamous‐cell carcinoma is promoted by expression of the CD80 co‐stimulatory molecule and interferon‐γ

C. Van Waes, Zhong Chen, I. Enamorado, 2000, International journal of cancer.

Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer.

Sharon Smith, P. Albert, D. Citrin, 2009, International journal of radiation oncology, biology, physics.

The monoclonal antibody BQ16 identifies the alpha 6 beta 4 integrin on bladder cancer.

C. Van Waes, T. Carey, G. Wedemeyer, 1993, Hybridoma.

Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer

D. Citrin, C. Van Waes, Tom Shokri, 2016, Case reports in otolaryngology.

Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck

L. Rinaldi, C. Van Waes, M. Lingen, 2022, bioRxiv.

Metastastic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction

C. Van Waes, Zhong Chen, Conrad W. Smith, 1997, Clinical & Experimental Metastasis.

PD-1 blockade reverses adaptive immune resistance induced by high-dose hypofractionated but not low-dose daily fractionated radiation

James B. Mitchell, C. Van Waes, J. Friedman, 2018, Oncoimmunology.

Lipoblastoma of the Back; A Case of a 7-month-old Boy

C. Van Waes, M. Bronckaers, 2009, Acta chirurgica Belgica.

Nuclear Factor-κB is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma

James B. Mitchell, C. Van Waes, Zhong Chen, 2004, Cancer Research.

HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.

James B. Mitchell, C. Van Waes, Zhong Chen, 2013, Translational oncology.

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

S. Feller, C. Van Waes, R. Ehsanian, 2011, Cell Communication and Signaling.

Upper airway obstruction in the rheumatic diseases.

C. Van Waes, C. Waes, C. Langford, 1997, Rheumatic diseases clinics of North America.

Overexpression of the A9 antigen/alpha 6 beta 4 integrin in head and neck cancer.

C. Van Waes, T. Carey, 1992, Otolaryngologic clinics of North America.

Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches

C. Van Waes, Zhong Chen, C. Allen, 2015, Cancers.

Epidermal overexpression of transgenic ΔNp63 promotes type 2 immune and myeloid inflammatory responses and hyperplasia via NF‐κB activation

C. Van Waes, S. Sinha, A. Mattox, 2014, The Journal of pathology.

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.

C. Van Waes, S. Sinha, Zhong Chen, 2011, Cancer research.

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

James B. Mitchell, G. Illei, Shuying Liu, 2012, Proceedings of the National Academy of Sciences.

Blood group antigens and integrins as biomarkers in head and neck cancer: is aberrant tyrosine phosphorylation the cause of altered alpha 6 beta 4 integrin expression?

C. Van Waes, T. Carey, G. Wolf, 1993, Journal of cellular biochemistry. Supplement.

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer.

C. Smith, C. Van Waes, C. Waes, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

Z Chen, E. Sausville, P. Elliott, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Inhibition of transcription factor nuclear factor-κB by a mutant inhibitor-κBα attenuates resistance of human head and neck squamous cell carcinoma to TNF-α caspase-mediated cell death

C. Van Waes, G. Dong, C. Waes, 2000, British Journal of Cancer.

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

C. Van Waes, Zhong Chen, Hai Lu, 2014, Neoplasia.

TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.

C. Van Waes, S. Sinha, Zhong Chen, 2011, Cancer research.

Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway.

E. Liu, C. Van Waes, G. Dong, 2001, Cancer research.

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

C. Van Waes, Zhong Chen, Anthony D. Saleh, 2018, Oncoimmunology.

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition

James B. Mitchell, C. Van Waes, J. Friedman, 2019, Oncoimmunology.

Genetic Landscape of Human Papillomavirus-Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors.

D. Hayes, C. Van Waes, T. Seiwert, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kδ/γ.

C. Van Waes, Zhong Chen, J. Friedman, 2017, Cancer research.

Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways

C. Van Waes, Zhong Chen, A. Derakhshan, 2016, Clinical Cancer Research.

Genomics and advances towards precision medicine for head and neck squamous cell carcinoma

C. Van Waes, Carter Van Waes, O. Musbahi, 2017, Laryngoscope investigative otolaryngology.

Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma

C. Van Waes, Zhong Chen, Chengyu Liu, 2015, Scientific Reports.

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.

C. Van Waes, C. Allen, R. Davis, 2016, Oral oncology.

Current and potential inflammation targeted therapies in head and neck cancer.

Jay Friedman, Frederick Wang, C. Van Waes, 2009, Current opinion in pharmacology.

Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

C. Van Waes, Zhong Chen, C. Allen, 2007, Head & neck.

A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma

C. Van Waes, Zhong Chen, N. Yeh, 2005, Head & neck.

Lymphotoxin‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer

C. Van Waes, Zhong Chen, Anthony D. Saleh, 2018, Molecular carcinogenesis.

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

James B. Mitchell, A. Kulkarni, C. Van Waes, 2013, Clinical Cancer Research.

Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma

C. Van Waes, Zhong Chen, X. Yang, 2007, Genome Biology.

Nuclear factor-κB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101

C. Van Waes, Zhong Chen, J. Friedman, 2007, Molecular Cancer Therapeutics.

Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

Christian J Stoeckert, Shane T. Jensen, Shane T Jensen, 2008, Genome Biology.

The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

C. Van Waes, C. Waes, Zhong Chen, 2015, Oral diseases.

EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy

C. Van Waes, Zhong Chen, J. Friedman, 2011, Expert opinion on therapeutic targets.

Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancer.

Hai Lu, Oumou Diallo, Jonah Cohen, 2009, Cancer research.

Nuclear Factor-κB–Related Serum Factors as Longitudinal Biomarkers of Response and Survival in Advanced Oropharyngeal Carcinoma

P. Albert, C. Van Waes, Zhong Chen, 2007, Clinical Cancer Research.

Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression.

J. Rhim, C. Van Waes, T. Carey, 1995, Cancer research.

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

Christian Freudlsperger, C. Van Waes, Zhong Chen, 2012, Oncogene.

A phase II trial of PS-341 (bortezomib) followed by the addition of doxorubicin at progression in incurable adenoid cystic carcinoma of the head and neck: An Eastern Cooperative Oncology Group study.

C. Van Waes, A. Argiris, M. Goldwasser, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-κB and activator protein-1 related mechanisms

C. Van Waes, Zhong Chen, Tin-Lap Lee, 2008, Molecular Cancer Therapeutics.

A comprehensive, multidisciplinary, precision medicine approach to discover effective therapy for an undiagnosed, progressive, fibroinflammatory disease.

C. Mason, W. Gahl, C. Van Waes, 2020, Translational research : the journal of laboratory and clinical medicine.

Pecking order among tumor‐specific antigens

C. Van Waes, H. Schreiber, J. Urban, 1984, European journal of immunology.

A Novel Nuclear Factor-κB Gene Signature Is Differentially Expressed in Head and Neck Squamous Cell Carcinomas in Association with TP53 Status

A. Elkahloun, C. Van Waes, G. Dong, 2007, Clinical Cancer Research.

ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer

C. Van Waes, C. Allen, N. Schmitt, 2020, Oncoimmunology.

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

C. Van Waes, Zhong Chen, C. Allen, 2018, Oncoimmunology.

Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer.

Anurag K. Singh, J. Dancey, D. Citrin, 2010, International journal of radiation oncology, biology, physics.

Combined Inhibition of IAPs and WEE1 Enhances TNFα- and Radiation-Induced Cell Death in Head and Neck Squamous Carcinoma

James B. Mitchell, Ramya Viswanathan, C. Van Waes, 2023, Cancers.

Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis

S. Holland, C. Van Waes, C. Waes, 2018, Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery.

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

O. Harismendy, S. Lippman, E. Szabo, 2018, Clinical Cancer Research.

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

S. Hughes, J. Kovacs, M. Polis, 2016, Proceedings of the National Academy of Sciences.

Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC

C. Van Waes, Zhong Chen, D. Eytan, 2015, The Laryngoscope.

Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.

C. Van Waes, G. Dong, C. Waes, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Randomized, Double-Blind, Placebo-Controlled Phase IIB Trial of the Cyclooxygenase Inhibitor Ketorolac as an Oral Rinse in Oropharyngeal Leukoplakia

S. Steinberg, S. Lippman, J. Mulshine, 2004, Clinical Cancer Research.

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

L. Dang, C. Van Waes, Zhong Chen, 2013, Oncogene.

Asymptomatic laryngeal malformations are common in patients with Pallister-Hall syndrome.

L. Biesecker, C. Van Waes, A. Griffith, 2000, American journal of medical genetics.

Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

C. Van Waes, Zhong Chen, Tin-Lap Lee, 2006, Molecular Cancer Therapeutics.

Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling.

C. Van Waes, Zhong Chen, R. Vander Broek, 2014, Oral oncology.

Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer

C. Van Waes, Zhong Chen, Matthew S. Brown, 2009, Clinical Cancer Research.

Cisplatin Alters Antitumor Immunity and Synergizes with PD-1/PD-L1 Inhibition in Head and Neck Squamous Cell Carcinoma

C. Van Waes, C. Allen, E. Moore, 2017, Cancer Immunology Research.

Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine.

C. Van Waes, Zhong Chen, X. Jiao, 2006, Immunology letters.

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

C. Van Waes, Zhong Chen, J. Friedman, 2017, Oncotarget.

Regulation of NFκB Signalling by Ubiquitination: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma?

C. Van Waes, Zhong Chen, Ethan L. Morgan, 2020, Cancers.

Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer

H. Qun, C. Van Waes, Zhong Chen, 2015, Cell & Bioscience.

The Role of the NF-kappaB Transcriptome and Proteome as Biomarkers in Human Head and Neck Squamous Cell Carcinomas.

C. Van Waes, Zhong Chen, B. Yan, 2008, Biomarkers in medicine.

Chemokine Receptor 7 (CCR7) Gene Expression Is Regulated by NF-κB and Activator Protein 1 (AP1) in Metastatic Squamous Cell Carcinoma of Head and Neck (SCCHN)*

A. Egloff, R. Seethala, Lin Wang, 2011, The Journal of Biological Chemistry.

Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer

Steven J. M. Jones, Thomas M. Harris, Ludmila V. Danilova, 2019, Clinical Cancer Research.

Concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer.

P. Albert, C. Van Waes, C. Waes, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma

C. Van Waes, Zhong Chen, J. Ricker, 2004, Clinical Cancer Research.

Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers

C. Van Waes, R. Uppaluri, C. Allen, 2016, Cancer Immunology Research.

Carcinoembryonic antigen as a target for specific antitumor immunotherapy of head and neck cancer.

F. Guadagni, J. Schlom, C. Van Waes, 2002, Cancer research.

Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer.

C. Van Waes, So-Jin Park, Michelle R. Padget, 2019, Oral oncology.

Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen–Specific T Cells

C. Van Waes, J. Friedman, H. Schreiber, 2019, Clinical Cancer Research.

Highly malignant tumor variants retain tumor-specific antigens recognized by T helper cells

C. Van Waes, H. Schreiber, J. Rothstein, 1986, The Journal of experimental medicine.

Multiple cancers. Tumor burden permits the outgrowth of other cancers

C. Van Waes, C. Waes, H. Schreiber, 1985, The Journal of experimental medicine.

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

C. Van Waes, R. Uppaluri, C. Allen, 2015, Oncotarget.

Established T Cell–Inflamed Tumors Rejected after Adaptive Resistance Was Reversed by Combination STING Activation and PD-1 Pathway Blockade

C. Van Waes, C. Allen, E. Moore, 2016, Cancer Immunology Research.

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

C. Van Waes, Zhong Chen, D. Eytan, 2015, Clinical Cancer Research.

Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384

James B. Mitchell, C. Van Waes, W. Degraff, 2014, Clinical Cancer Research.

Signaling Networks of Activated Oncogenic and Altered Tumor Suppressor Genes in Head and Neck Cancer

C. Van Waes, Zhong Chen, B. Yan, 2013, Journal of carcinogenesis & mutagenesis.

Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF‐κB

James B. Mitchell, C. Van Waes, G. Dong, 2000, Head & neck.

Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL‐6: a general role for inflammation?

Z Chen, J. Mulshine, C. Van Waes, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer

Xiaojiang Xu, Jay Friedman, C. Van Waes, 2009, Clinical Cancer Research.

Intravenous delivery of 5′‐iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancers: Results of a pilot study

C. Van Waes, R. Lebovics, P. Okunieff, 1998, The Laryngoscope.

Bortezomib-Induced Apoptosis with Limited Clinical Response Is Accompanied by Inhibition of Canonical but not Alternative Nuclear Factor-κB Subunits in Head and Neck Cancer

C. Van Waes, K. Saigal, Zhong Chen, 2008, Clinical Cancer Research.

Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing

C. Van Waes, 1995, Head & neck.

NF-kappaB in carcinoma therapy and prevention.

M. Brown, C. Van Waes, Zhong Chen, 2008, Expert opinion on therapeutic targets.

The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers

Z. Chen, C. Van Waes, Zhong Chen, 2021, Cancer Research.

High Incidence of Oral Dysesthesias on a Trial of Gefitinib, Paclitaxel, and Concurrent External Beam Radiation for Locally Advanced Head and Neck Cancers

Anurag K. Singh, C. Van Waes, D. Gius, 2008, American journal of clinical oncology.

cDNA microarray and bioinformatic analysis of nuclear factor-kappaB related genes in squamous cell carcinoma.

C. Van Waes, G. Dong, Zhong Chen, 2007, Methods in molecular biology.

Unraveling Regulatory Programs for NF-kappaB, p53 and MicroRNAs in Head and Neck Squamous Cell Carcinoma

Ming Zhan, Huai Li, Sige Zou, 2013, PloS one.

Cytokines IL-1 alpha, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon gamma.

C. Van Waes, Zhong Chen, J. Wen, 2004, Cancer immunology, immunotherapy : CII.

Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma.

C. Van Waes, Zhong Chen, X. Yang, 2005, Cancer research.

Inhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC)

James B. Mitchell, C. Van Waes, Zhong Chen, 2023, Cell Death & Differentiation.

Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers.

C. Van Waes, Zhong Chen, N. Issaeva, 2018, Cancer research.

Dynamic Effect of Bortezomib on Nuclear Factor-κB Activity and Gene Expression in Tumor Cells

J. McNally, C. Van Waes, M. Sung, 2008, Molecular Pharmacology.

Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133+ Skin Cancer Stem Cells

P. Meltzer, C. Van Waes, Zhong Chen, 2018, Molecular Cancer Therapeutics.

Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1alpha, EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms.

C. Van Waes, G. Dong, E. Loukinova, 2001, International journal of cancer.

Inhibitor-κB Kinase in Tumor Promotion and Suppression During Progression of Squamous Cell Carcinoma

M. Karin, C. Van Waes, L. Nottingham, 2007, Clinical Cancer Research.

Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck

C. Van Waes, C. Waes, Zhong Chen, 2007 .

Oncogenic Ras and ΔNp63α cooperate to recruit immunosuppressive polymorphonuclear myeloid-derived suppressor cells in a mouse model of squamous cancer pathogenesis

C. Van Waes, Zhong Chen, A. George, 2023, Frontiers in Immunology.

Abstract 2988: Proteasomal deubiquitinases represent an attractive therapeutic target in head and neck squamous cell carcinomas (HNSCC)

Ramya Viswanathan, C. Van Waes, Zhong Chen, 2022, Cancer Research.

Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma.

M. Karin, C. Van Waes, L. Nottingham, 2007, Clinical cancer research : an official journal of the American Association for Cancer Research.

SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck

J. Licht, Sohyoung Kim, R. Chari, 2023, Cell reports.

Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing

C. Van Waes, C. Waes, 1995, Head & neck.

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Joshua M. Stuart, Joshua D. Campbell, Christopher K. Wong, 2018, Cell reports.

The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck

Yusuke Nakamura, C. Van Waes, G. Hager, 2018, Oral oncology.

Comprehensive multiomic characterization of human papillomavirus-driven recurrent respiratory papillomatosis reveals distinct molecular subtypes

C. Van Waes, X. Yang, J. Friedman, 2021, Communications Biology.

Pharmacological inhibition of HSP90 radiosensitizes HNSCC xenograft by inhibition of DNA damage repair, nucleotide metabolism, and radiation-induced tumor vasculogenesis.

James B. Mitchell, C. Van Waes, S. Naz, 2021, International journal of radiation oncology, biology, physics.

Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy.

R. Seethala, R. Ferris, C. Van Waes, 2008, Journal of the National Cancer Institute.

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.

C. Van Waes, S. Sinha, Zhong Chen, 2011, Cancer research.

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

James B. Mitchell, A. Kulkarni, C. Van Waes, 2013, Clinical Cancer Research.

High Incidence of Oral Dysesthesias on a Trial of Gefitinib, Paclitaxel, and Concurrent External Beam Radiation for Locally Advanced Head and Neck Cancers

Anurag K. Singh, C. Van Waes, D. Gius, 2008, American journal of clinical oncology.

Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas

C. Van Waes, Zhong Chen, X. Yang, 2021, Scientific Reports.

Nuclear factor-KappaB as a common target and activator of oncogenes in head and neck squamous cell carcinoma.

C. Van Waes, Angela A. Chang, 2005, Advances in oto-rhino-laryngology.