K. Du

发表

Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating*

T. Ma, A. Shelat, Hong Yang, 2003, Journal of Biological Chemistry.

The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis*

H. Senderowitz, K. Du, G. Lukács, 2010, The Journal of Biological Chemistry.

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

K. Du, G. Lukács, W. Rabeh, 2012, Cell.

Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects

K. Du, G. Lukács, M. Caplan, 2004, Science.

The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR

Kai Du, K. Du, G. Lukács, 2005, Nature Structural &Molecular Biology.

K. Du, H. Yeger, C. Bear, 2014, Chemistry & biology.

Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery.

K. Du, G. Lukács, H. Barrière, 2007, Molecular biology of the cell.

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

T. Ma, A. Shelat, Hong Yang, 2003, The Journal of biological chemistry.

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

Jason C. Young, K. Du, G. Lukács, 2010, Science.

Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue

K. Du, R. Pomès, P. Ray, 2017, EMBO molecular medicine.

Transducing Airway Basal Cells with a Helper-Dependent Adenoviral Vector for Lung Gene Therapy.

A. Coates, K. Du, H. Yeger, 2018, Human gene therapy.

Dominant and Recessive Distal Renal Tubular Acidosis Mutations of Kidney Anion Exchanger 1 Induce Distinct Trafficking Defects in MDCK Cells

K. Du, G. Lukács, R. Reithmeier, 2006, Traffic.

Inhibitory effect of artesunate on the growth of breast cancer cells and its mechanism

K. Du, Liang Liu, Geng Zhang, 2020 .

Inflammatory epithelial cytokines after in vitro respiratory syncytial viral infection are associated with reduced lung function

K. Du, Y. Cen, W. Duan, 2021, ERJ Open Research.

Long-Term Expression of the Human CFTR Gene in Mouse Airway via Helper-Dependent Adenoviral Vector Delivery and Transient Immunosuppression.

Jing Wu, K. Du, H. Yeger, 2016, Human gene therapy.

Testing gene therapy vectors in human primary nasal epithelial cultures

Jing Wu, K. Du, H. Yeger, 2015, Molecular therapy. Methods & clinical development.

A fluorescent channel-type Eu(III)-organic framework for selective detection of Fe3+ ion and protective effect against Parkinson disease by increasing mitochondrial complex activity

K. Du, Na Xu, Wei Zhang, 2020 .

SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

J. Rommens, K. Du, C. Bear, 2018, eLife.

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF.

S. Stanojevic, J. Rossant, S. Pereira, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations.

C. Ackerley, K. Du, H. Yeger, 2015, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Destabilization of the Transmembrane Domain Induces Misfolding in a Phenotypic Mutant of Cystic Fibrosis Transmembrane Conductance Regulator*

K. Du, G. Lukács, C. Deber, 2005, Journal of Biological Chemistry.

Cooperative assembly and misfolding of CFTR domains in vivo.

Kai Du, K. Du, G. Lukács, 2009, Molecular biology of the cell.

Altered Connection and Diagnosis Utility of White Matter in Alzheimer’s Disease: A Multi-site Automated Fiber Quantification Study

Yong Liu, Bing Liu, K. Du, 2021, 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).

Misfolding diverts CFTR from recycling to degradation

B. Papsin, K. Du, G. Lukács, 2004, The Journal of cell biology.

SLC 6 A 14 , an amino acid transporter , modifies the primary 1 CF defect in fluid secretion . 2

J. Rommens, K. Du, C. Bear, 2022 .

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Kai Du, Nicoletta Pedemonte, A S Verkman, 2005, The Journal of clinical investigation.

Activity of lumacaftor is not conserved in zebrafish Cftr bearing the major cystic fibrosis‐causing mutation

K. Du, C. Bear, S. Erwood, 2019, FASEB bioAdvances.

Efficient Gene Delivery to Pig Airway Epithelia and Submucosal Glands Using Helper-Dependent Adenoviral Vectors

A. Coates, Jing Wu, K. Du, 2013, Molecular therapy. Nucleic acids.

Synergy of cAMP and calcium signaling pathways in CFTR regulation

K. Du, J. Forman-Kay, C. Bear, 2017, Proceedings of the National Academy of Sciences.

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation

M. Moran, K. Du, H. Yeger, 2015, Proteomics.

Augmentation of CFTR function in human bronchial epithelial cells via SLC6A14-dependent amino acid uptake: Implications for treatment of Cystic Fibrosis.

K. Du, J. Forman-Kay, C. Bear, 2019, American journal of respiratory cell and molecular biology.

The Role of the C Terminus and Na+/H+ Exchanger Regulatory Factor in the Functional Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Nonpolarized Cells and Epithelia*

S. Grinstein, K. Du, G. Lukács, 2003, Journal of Biological Chemistry.

Phosphodiesterase-2 Inhibitor Bay 60-7550 Ameliorates Aβ-Induced Cognitive and Memory Impairment via Regulation of the HPA Axis

K. Du, Jianchun Pan, Jinpeng Lv, 2019, Front. Cell. Neurosci..

Misfolding diverts CFTR from recycling to degradation

B. Papsin, K. Du, G. Lukács, 2004, The Journal of cell biology.