Diansong Zhou

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Rapid Classification of CYP3A4 Inhibition Potential Using Support Vector Machine Approach

R. Zauhar, I. Zamora, Diansong Zhou, 2007 .

Clinical Pharmacokinetics and Pharmacodynamics of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist

Diansong Zhou, K. Bui, Hongmei Xu, 2017, Clinical Pharmacokinetics.

Physiologically Based Pharmacokinetic Modeling for Selumetinib to Evaluate Drug‐Drug Interactions and Pediatric Dose Regimens

Diansong Zhou, L. Jain, H. Tomkinson, 2021, Journal of clinical pharmacology.

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

Diansong Zhou, Trevor N Johnson, Diansong Zhou, 2014, Biopharmaceutics & drug disposition.

Population pharmacokinetics of the MEK inhibitor selumetinib and its active N‐desmethyl metabolite: data from 10 phase I trials

Paul D. Martin, L. Aarons, Diansong Zhou, 2018, British journal of clinical pharmacology.

Physiologically Based Pharmacokinetic Modelling of Glycopyrronium in Patients with Renal Impairment.

Diansong Zhou, M. Gillen, M. Higashimori, 2020, Journal of pharmaceutical sciences.

Population Exposure‐Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid‐Induced Constipation

Diansong Zhou, K. Bui, Hongmei Xu, 2017, CPT: pharmacometrics & systems pharmacology.

Effects of CYP3A Modulators on the Pharmacokinetics of Naloxegol

Diansong Zhou, K. Bui, N. Al-Huniti, 2016, Journal of clinical pharmacology.

A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.

Diansong Zhou, S. Grimm, Mark A. Smith, 2012, British journal of clinical pharmacology.

In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics

T. Andersson, Diansong Zhou, S. Grimm, 2011, Drug Metabolism and Disposition.

In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P450 enzyme identification, inhibition, and induction studies

Diansong Zhou, S. Grimm, S. Ferguson, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Evaluation of Aztreonam Dosing Regimens in Patients With Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis

Diansong Zhou, Hongmei Xu, N. Al-Huniti, 2017, Journal of clinical pharmacology.

Evaluation of the Effect of Selumetinib on Cardiac Repolarization: A Randomized, Placebo- and Positive-controlled Crossover QT/QTc Study in Healthy Subjects.

Paul D. Martin, Karen So, Diansong Zhou, 2016, Clinical therapeutics.

Population pharmacokinetic analysis of esomeprazole in Japanese subjects with various CYP2C19 phenotypes

Diansong Zhou, N. Al-Huniti, J. Dunyak, 2020, Journal of clinical pharmacy and therapeutics.

Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects

Diansong Zhou, Diansong Zhou, K. Bui, 2015, Journal of clinical pharmacology.

Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

Diansong Zhou, S. Grimm, K. Bui, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Assessing pharmacokinetic differences in Caucasian and East Asian (Japanese, Chinese and Korean) populations driven by CYP2C19 polymorphism using physiologically-based pharmacokinetic modelling.

Diansong Zhou, Hongmei Xu, N. Al-Huniti, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Preclinical Pharmacology and Pharmacokinetics of AZD3783, a Selective 5-Hydroxytryptamine 1B Receptor Antagonist

Diansong Zhou, P. Bernstein, M. E. Pierson, 2011, Journal of Pharmacology and Experimental Therapeutics.

Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation

Diansong Zhou, Hongmei Xu, N. Al-Huniti, 2018, Antimicrobial Agents and Chemotherapy.

Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

J. Ware, Diansong Zhou, V. Pilla Reddy, 2021, Cancer Chemotherapy and Pharmacology.

A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2− Primary Breast Cancer

P. Fasching, J. Robertson, N. Harbeck, 2020, Clinical Cancer Research.

Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

Andreas M. Abend, B. Griffin, Diansong Zhou, 2022, Pharmaceutics.

Population Pharmacokinetic and Exposure‐Response Analysis of Selumetinib and Its N‐desmethyl Metabolite in Patients With Non‐Small Cell Lung Cancer

Diansong Zhou, H. Tomkinson, Hongmei Xu, 2018, Journal of clinical pharmacology.

In vitro and in vivo metabolism of a selective δ-opioid receptor agonist

Diansong Zhou, S. Grimm, K. Bui, 2011 .

Microsoft Word-57727391-file00.docx

T. Andersson, Diansong Zhou, S. Grimm, 2010 .

Development of a physiologically based pharmacokinetic model to predict the effects of flavin‐containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure

Diansong Zhou, S. Neuhoff, N. Al-Huniti, 2017, Biopharmaceutics & drug disposition.

Bridging Olaparib Capsule and Tablet Formulations Using Population Pharmacokinetic Meta-analysis in Oncology Patients

Diansong Zhou, H. Tomkinson, K. Bui, 2018, Clinical Pharmacokinetics.

The effect of quinidine, a strong P‐glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol

Diansong Zhou, K. Bui, N. Al-Huniti, 2016, Journal of clinical pharmacology.

Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients

Diansong Zhou, J. Romero, J. Bradley, 2016, Antimicrobial Agents and Chemotherapy.

Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients

Diansong Zhou, J. Romero, T. Edeki, 2016 .

Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab

N. Shire, Diansong Zhou, H. Kluger, 2022, Frontiers in Immunology.

Evolving drug regulatory landscape in China: A clinical pharmacology perspective

Diansong Zhou, Ying Huang, Xiaoying Zhao, 2021, Clinical and translational science.

Role of Human UGT2B10 in N-Glucuronidation of Tricyclic Antidepressants, Amitriptyline, Imipramine, Clomipramine, and Trimipramine

Diansong Zhou, S. Grimm, A. Linnenbach, 2010, Drug Metabolism and Disposition.

Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition.

Diansong Zhou, S. Grimm, Jian Guo, 2011, Journal of pharmaceutical and biomedical analysis.

Population pharmacokinetic modeling of quetiapine after administration of seroquel and seroquel XR formulations to Western and Chinese patients with schizophrenia, schizoaffective disorder, or bipolar disorder

Diansong Zhou, K. Bui, N. Al-Huniti, 2015, Journal of clinical pharmacology.

Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children

Diansong Zhou, K. Bui, Hongmei Xu, 2018, Clinical pharmacology and therapeutics.

Physiologically based pharmacokinetic modelling to predict exposure differences in healthy volunteers and subjects with renal impairment: Ceftazidime case study

Diansong Zhou, Hongmei Xu, N. Al-Huniti, 2019, Basic & clinical pharmacology & toxicology.

Single‐ and Multiple‐Dose Pharmacokinetic Comparison of a Sustained‐Release Tablet and Conventional Tablets of Naproxen in Healthy Volunteers

Diansong Zhou, Qiang Zhang, Qing Xia, 1998, Journal of clinical pharmacology.

In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite

Diansong Zhou, S. Grimm, Minli Zhang, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Physiologically Based Pharmacokinetic Modeling for Olaparib Dosing Recommendations: Bridging Formulations, Drug Interactions, and Patient Populations

Diansong Zhou, Venkatesh Pilla Reddy, Diansong Zhou, 2018, Clinical pharmacology and therapeutics.

Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy

Diansong Zhou, J. Mullen, Hongmei Xu, 2018, Journal of clinical pharmacology.

Population Pharmacokinetic Modeling and Probability of Target Attainment Analyses in Asian Patients With Community‐Acquired Pneumonia Treated With Ceftaroline Fosamil

Diansong Zhou, N. Al-Huniti, Jianguo Li, 2019, Clinical pharmacology in drug development.

Ceftaroline fosamil doses and breakpoints for Staphylococcus aureus in complicated skin and soft tissue infections

Diansong Zhou, J. Yan, Jianguo Li, 2018, The Journal of antimicrobial chemotherapy.

Physiologically Based Pharmacokinetic Modeling to Evaluate the Systemic Exposure of Gefitinib in CYP2D6 Ultrarapid Metabolizers and Extensive Metabolizers

Diansong Zhou, Weifeng Tang, N. Al-Huniti, 2018, Journal of clinical pharmacology.

Tumor Growth Dynamic Modeling in Oncology Drug Development and Regulatory Approval: Past, Present, and Future Opportunities

Diansong Zhou, N. Al-Huniti, Jingyu Yu, 2020, CPT: pharmacometrics & systems pharmacology.

Ceftazidime‐Avibactam Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Across Adult Indications and Patient Subgroups

James G. Wright, Diansong Zhou, T. Riccobene, 2018, Clinical and translational science.

Evaluation of the Drug–Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP‐5862, Using a Physiologically‐Based Pharmacokinetic Modeling Approach

J. Ware, Diansong Zhou, J. G. Slatter, 2019, CPT: pharmacometrics & systems pharmacology.

Pharmacokinetics and pharmacodynamics of MEDI0680, a fully human anti-PD-1 monoclonal antibody, in patients with advanced malignancies

Diansong Zhou, M. Gibbs, S. Ren, 2022, Cancer Chemotherapy and Pharmacology.

Efficacy and Safety Exposure‐Response Analyses of Olaparib Capsule and Tablet Formulations in Oncology Patients

Diansong Zhou, H. Tomkinson, K. Bui, 2019, Clinical pharmacology and therapeutics.

Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct

Diansong Zhou, S. Grimm, C. Elmore, 2012, Drug Metabolism and Disposition.

Exposure-Response Analyses of Tremelimumab Monotherapy or in Combination with Durvalumab in Patients with Unresectable Hepatocellular Carcinoma

G. Abou-Alfa, Diansong Zhou, R. Kelley, 2022, Clinical cancer research : an official journal of the American Association for Cancer Research.

Population pharmacokinetics and exposure–response of selumetinib and its N‐desmethyl metabolite in pediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas

Karen So, Diansong Zhou, H. Tomkinson, 2021, Cancer Chemotherapy and Pharmacology.

Pharmacokinetics of Aminolevulinic Acid After Intravesical Administration to Dogs

Diansong Zhou, M. Meyer, J. Dalton, 2004, Pharmaceutical Research.

Population Pharmacokinetic Analysis of Zolmitriptan and Its Metabolite in Adults and Adolescents to Support Dose Selection in Children With Migraine

Diansong Zhou, Hongmei Xu, N. Al-Huniti, 2017, Journal of clinical pharmacology.

Using Molecular Fingerprint as Descriptors in the QSPR Study of Lipophilicity

Ruifeng Liu, Diansong Zhou, Diansong Zhou, 2008, J. Chem. Inf. Model..

Baculovirus Infected Insect Cells

Diansong Zhou, S. Grimm, A. Linnenbach, 2010 .

Cytochrome P-450 2C9 Sensitizes Human Prostate Tumor Cells to Cyclophosphamide via a Bystander Effect

Diansong Zhou, J. Dalton, M. Steiner, 2000, Antimicrobial Agents and Chemotherapy.

Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells

Diansong Zhou, S. Grimm, A. Linnenbach, 2010, Drug Metabolism and Disposition.

Expression and Characterization of Dog Cytochrome P 450 2 A 13 and 2 A 25 in Baculovirus-Infected Insect Cells

Diansong Zhou, S. Grimm, A. Linnenbach, 2010 .

Selecting the dosage of ceftazidime–avibactam in the perfect storm of nosocomial pneumonia

Diansong Zhou, Jianguo Li, Shampa Das, 2019, European Journal of Clinical Pharmacology.

Physiologically based pharmacokinetic modeling to predict complex drug–drug interactions: a case study of AZD2327 and its metabolite, competitive and time‐dependent CYP3A inhibitors

Diansong Zhou, Jian Guo, Yan Li, 2015, Biopharmaceutics & drug disposition.

In Vitro and In Vivo Metabolism of a Selective δ-Opioid Receptor

Diansong Zhou, S. Grimm, K. Bui, 2011, Drug Metabolism and Disposition.

COMPARISON OF METHODS FOR THE PREDICTION OF THE METABOLIC SITES FOR CYP3A4-MEDIATED METABOLIC REACTIONS

Diansong Zhou, Ismael Zamora, Tommy B Andersson, 2006, Drug Metabolism and Disposition.

Evaluation of the Drug–Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP‐5862, Using a Physiologically‐Based Pharmacokinetic Modeling Approach

J. Ware, Diansong Zhou, J. G. Slatter, 2019, CPT: pharmacometrics & systems pharmacology.

Preclinical Pharmacology and Pharmacokinetics of AZD3783, a Selective 5-Hydroxytryptamine 1B Receptor Antagonist

Diansong Zhou, P. Bernstein, M. E. Pierson, 2011, Journal of Pharmacology and Experimental Therapeutics.