I. Cleynen

K. Van Steen, P. Rutgeerts, S. Vermeire, 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

University of Birmingham Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus

C. Wijmenga, E. Kuipers, P. Moayyedi, 2022 .

Prognostic factors for long‐term infliximab treatment in Crohn's disease patients: a 20‐year single centre experience

S. Vermeire, I. Cleynen, A. Gils, 2016, Alimentary pharmacology & therapeutics.

Risk Stratification for Surgery in Stricturing Ileal Crohn’s Disease: The BACARDI Risk Model

S. Vermeire, I. Cleynen, M. Ferrante, 2018, Journal of Crohn's & colitis.

RISK stratification in paediatric Crohn's disease

I. Cleynen, I. Arijs, 2017, The Lancet.

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Noor B. Dawany, Judy H. Cho, David T. Okou, 2022, Nature Genetics.

Validation of the ‘United Registries for Clinical Assessment and Research’ [UR-CARE], a European Online Registry for Clinical Care and Research in Inflammatory Bowel Disease

J. Gisbert, I. Cleynen, F. Baert, 2018, Journal of Crohn's & colitis.

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

Andre Franke, Isabelle Cleynen, Kristel Van Steen, 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults

P. Dupont, R. Vandenberghe, K. Van Laere, 2022, Alzheimer's Research & Therapy.

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

Isabelle Cleynen, Frans Schuit, Emiel F M Wouters, 2015, Inflammatory bowel diseases.

Review Article. Absent in melanoma 2 (AIM2) in the intestine: diverging actions with converging consequences

S. Vermeire, I. Cleynen, M. Ferrante, 2017 .

Genetic Evidence Supporting the Association of Protease and Protease Inhibitor Genes with Inflammatory Bowel Disease: A Systematic Review

Stefan Wyder, Peter Jüni, Isabelle Cleynen, 2011, PloS one.

Gene and Mirna Regulatory Networks During Different Stages of Crohn's Disease.

P. Rutgeerts, S. Vermeire, I. Cleynen, 2019, Journal of Crohn's & colitis.

Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC

P. Rutgeerts, S. Vermeire, I. Cleynen, 2016, Gut.

Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn's disease.

K. Van Steen, P. Rutgeerts, S. Vermeire, 2015, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Long term evolution and impact of immunomodulator cotreatment and withdrawal on infliximab on trough levels in 223 patients with Crohn's disease

P. Rutgeerts, S. Vermeire, I. Cleynen, 2011 .

Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

R. Dobson, K. Blennow, J. Molinuevo, 2019, bioRxiv.

Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses

J. Raes, G. Falony, S. Vermeire, 2019, Nature Microbiology.

Inflammatory bowel disease and Parkinson’s disease: common pathophysiological links

S. Vermeire, I. Cleynen, J. Sabino, 2020, Gut.

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis

P. Rutgeerts, S. Vermeire, I. Cleynen, 2011, Gut.

Oncostatin M Is a Biomarker of Diagnosis, Worse Disease Prognosis, and Therapeutic Nonresponse in Inflammatory Bowel Disease

S. Vermeire, I. Cleynen, M. Ferrante, 2021, Inflammatory bowel diseases.

Fine-mapping inflammatory bowel disease loci to single variant resolution

Hailiang Huang, Kyle Kai-How Farh, Andre Franke, 2017, Nature.

High density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Hailiang Huang, Stephan Ripke, Andre Franke, 2014, Nature Genetics.

Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility

Noor B. Dawany, Judy H. Cho, H. Ostrer, 2021, medRxiv.

Genetics of inflammatory bowel disease: beyond NOD2.

Masa Umicevic Mirkov, I. Cleynen, B. Verstockt, 2017, The lancet. Gastroenterology & hepatology.

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

Isabelle Cleynen, Kristel Van Steen, Frans Schuit, 2009, PloS one.

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress

S. Vermeire, P. Agostinis, I. Cleynen, 2013, Autophagy.

Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients.

P. Rutgeerts, S. Vermeire, I. Cleynen, 2012, Journal of Crohn's & colitis.

Materials for : Host-microbe interactions shape genetic risk for inflammatory bowel disease

Judy H. Cho, C. Gieger, M. Daly, 2012 .

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Judy H. Cho, John P. Ferguson, G. Wainrib, 2019, Scientific Reports.

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

J. González, D. Jewell, S. Vermeire, 2012, Gut.

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

Isabelle Cleynen, Michel Georges, Paul Rutgeerts, 2011, Nature Genetics.

The HMGA proteins: a myriad of functions (Review).

Isabelle Cleynen, W. V. D. Van de Ven, I. Cleynen, 2008, International journal of oncology.

The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease

S. Vermeire, I. Cleynen, T. Vanuytsel, 2013, Tissue barriers.

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Judy H. Cho, Nadezhda T. Doncheva, O. Andreassen, 2013, Nature Genetics.

Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation

I. Cleynen, S. Ryoo, H. Kim, 2021, Gut.

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease

Y. Moreau, J. Vermeesch, C. Robberecht, 2016, Inflammatory bowel diseases.

An efficient algorithm to perform multiple testing in epistasis screening

Louis Wehenkel, Kristel Van Steen, François Van Lishout, 2013, BMC Bioinformatics.

Genetic Influences on the Development of Fibrosis in Inflammatory Bowel Disease

I. Cleynen, B. Verstockt, S. Verstockt, 2018 .

Paradoxical inflammation induced by anti-TNF agents in patients with IBD

S. Vermeire, I. Cleynen, 2012, Nature Reviews Gastroenterology &Hepatology.

Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

Alex V. Kotlar, Sunny X. Tang, E. Zackai, 2020, Molecular Psychiatry.

HMGA2 Regulates Transcription of the Imp2 Gene via an Intronic Regulatory Element in Cooperation with Nuclear Factor-κB

R. Sciot, W. V. D. Van de Ven, I. Cleynen, 2007, Molecular Cancer Research.

HMGA 2 Regulates Transcription of the Imp 2 Gene via an Intronic Regulatory Element in Cooperation with Nuclear Factor-K B

R. Sciot, I. Cleynen, M. Debiec‐Rychter, 2007 .

ABO histo-blood group might modulate predisposition to Crohn's disease and affect disease behavior.

S. Vermeire, M. Clerici, I. Cleynen, 2014, Journal of Crohn's & colitis.

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease

P. Rutgeerts, S. Vermeire, I. Cleynen, 2017, Inflammatory bowel diseases.

Polymorphisms Near TBX 5 and GDF 7 Are Associated With Increased Risk for Barrett ’ s

C. Wijmenga, E. Kuipers, P. Moayyedi, 2017 .

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

P. Whorwell, R. Spiller, D. Lambrechts, 2013, Gut.

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.

C. Gieger, C. Wijmenga, M. Manns, 2012, Journal of hepatology.

A Genetic Variation in the Neonatal Fc-Receptor Affects Anti-TNF Drug Concentrations in Inflammatory Bowel Disease

S. Vermeire, I. Cleynen, A. Gils, 2016, The American Journal of Gastroenterology.

Genetic Influences on the Development of Fibrosis in Crohn’s Disease

I. Cleynen, B. Verstockt, 2016, Front. Med..

Genetic susceptibility and genotype-phenotype association in 588 Danish children with inflammatory bowel disease.

S. Vermeire, P. Andersen, I. Cleynen, 2014, Journal of Crohn's & colitis.

How to approach understanding complex trait genetics – inflammatory bowel disease as a model complex trait

I. Cleynen, J. Halfvarsson, 2019, United European gastroenterology journal.

TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn’s disease patients?

S. Vermeire, I. Cleynen, M. Ferrante, 2018, Gut.

Assessing aCCess to Investigations in Inflammatory Bowel Disease (ACCID): results from an international survey

J. Gisbert, I. Cleynen, M. Ferrante, 2021, European journal of gastroenterology & hepatology.

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

C. Wijmenga, T. Ahmad, P. Rutgeerts, 2013, Gut.

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

M. Nöthen, D. Lambrechts, S. Vermeire, 2013, Gut.

Molecular Profiling of IBD Subtypes and Therapy Responses

I. Cleynen, Ho-Su Lee, 2019, Molecular Genetics of Inflammatory Bowel Disease.

Inflammatory Bowel Disease (IBD)—A Textbook Case for Multi-Centric Banking of Human Biological Materials

S. Vermeire, I. Cleynen, M. Ferrante, 2019, Front. Med..

Molecular Changes in the Non-Inflamed Terminal Ileum of Patients with Ulcerative Colitis

S. Vermeire, I. Cleynen, M. Ferrante, 2020, Cells.

A Matrix-based Model Predicts Primary Response to Infliximab in Crohn's Disease.

S. Vermeire, I. Cleynen, M. Ferrante, 2015, Journal of Crohn's & colitis.

Molecular Profiling of IBD Subtypes/Response to Therapy

S. Vermeire, I. Cleynen, 2013 .

Characteristics of Skin Lesions Associated With AntiTumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease

P. Rutgeerts, I. Cleynen, J. J. van den Oord, 2015, Annals of Internal Medicine.

Association mapping of inflammatory bowel disease loci to single variant resolution

Masa Umicevic Mirkov, Judy H. Cho, M. Daly, 2015, bioRxiv.

Polymorphisms Near TBX 5 and GDF 7 Are Associated With Increased Risk for Barrett ’ s Esophagus

C. Wijmenga, E. Kuipers, P. Moayyedi, 2022 .

Extracellular vesicles in inflammatory bowel disease: small particles, big players.

I. Cleynen, S. Verstockt, M. Valter, 2020, Journal of Crohn's & colitis.

The genetic architecture of inflammatory bowel disease: past, present and future

S. Vermeire, I. Cleynen, 2015, Current opinion in gastroenterology.

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

S. Vermeire, I. Cleynen, M. Ferrante, 2018, Journal of Crohn's & colitis.

Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis

S. Vermeire, I. Cleynen, M. Ferrante, 2019, Journal of Crohn's & colitis.

OP10 Importance of trough levels and antibodies on the long-term efficacy of infliximab therapy in ulcerative colitis

P. Rutgeerts, S. Vermeire, I. Cleynen, 2012 .

405 High Infliximab Trough Levels are Associated With Mucosal Healing in Crohn's Disease

P. Rutgeerts, S. Vermeire, I. Cleynen, 2010 .

Evolution of cytokines and inflammatory biomarkers during infliximab induction therapy and the impact of inflammatory burden on primary response in patients with Crohn’s disease

S. Vermeire, I. Cleynen, A. Gils, 2017, Scandinavian journal of gastroenterology.

Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis

S. Vermeire, J. L. Costa, I. Cleynen, 2020, Clinical and translational gastroenterology.

Crohn's Disease: Infliximab Trough Levels and CRP During Infliximab-Immunomodulator Combination Treatment Are Associated With Clinical Outcome After Immunomodulator Withdrawal

P. Rutgeerts, S. Vermeire, I. Cleynen, 2011 .

Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort

C. Wijmenga, P. Rutgeerts, S. Vermeire, 2009, The American Journal of Gastroenterology.

539 Anti-TNF-Induced Skin Manifestations in IBD Patients: Role for Increased Drug Exposure?

P. Rutgeerts, S. Vermeire, I. Cleynen, 2015 .

The genetics of non-monogenic IBD

I. Cleynen, D. Jans, 2023, Human Genetics.

W1223 Genetic Factors Conferring an Increased Susceptibility to Develop Crohn's Disease Also Influence Disease Phenotype, but Do Not Predict it. Results From the IBDChip European Project

J. González, D. Jewell, S. Vermeire, 2010 .

E prostanoid receptor 4 expressing macrophages promote the regeneration of the intestinal epithelial barrier upon inflammation

I. Cleynen, S. Ryoo, H. Kim, 2020, bioRxiv.

Lack of association between bridging integrator 1 (BIN1) rs744373 polymorphism and tau‐PET load in cognitively intact older adults

P. Dupont, K. Sleegers, C. van Broeckhoven, 2022, Alzheimer's & dementia.

Anti-TNF induced skin manifestations in IBD patients : characterization and search for predisposing factors

P. Rutgeerts, S. Vermeire, I. Cleynen, 2011 .

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Judy H. Cho, C. Gieger, H. Hakonarson, 2015 .

Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults

P. Dupont, R. Vandenberghe, Katarzyna Adamczuk, 2023, Alzheimer's Research & Therapy.

Genomic analyses of hair from Ludwig van Beethoven

Malte C. Boecker, T. Kivisild, D. Behar, 2023, Current Biology.

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Lisa, Husam, John P. Ferguson, 2023 .

M2064 Development of Psoriasiform Skin Lesions Under Anti-TNF Therapy: A Common Link with IL23R Gene Variants?

P. Rutgeerts, S. Vermeire, I. Cleynen, 2008 .

Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

C. Wijmenga, E. Kuipers, P. Moayyedi, 2015, Gastroenterology.

Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease

P. Rutgeerts, S. Vermeire, I. Cleynen, 2011, Inflammatory bowel diseases.

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

M. Nöthen, D. Lambrechts, S. Vermeire, 2013, Gut.

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

P. Whorwell, R. Spiller, D. Lambrechts, 2013, Gut.

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.

C. Gieger, C. Wijmenga, M. Manns, 2012, Journal of hepatology.

The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease

S. Vermeire, I. Cleynen, T. Vanuytsel, 2013, Tissue barriers.

Cellular diversity in the colon: another brick in the wall

D. Laukens, I. Cleynen, 2019, Nature Reviews Gastroenterology & Hepatology.

Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses

J. Raes, G. Falony, S. Vermeire, 2019, Nature Microbiology.

Characteristics of Skin Lesions Associated With AntiTumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease

P. Rutgeerts, I. Cleynen, J. J. van den Oord, 2016, Annals of Internal Medicine.

Prognostic factors for long‐term infliximab treatment in Crohn's disease patients: a 20‐year single centre experience

I. Cleynen, G. Assche, T. Billiet, 2016, Alimentary pharmacology & therapeutics.

The need for surgery in stricturing ileal CD is linked to clinical and imaging factors but independent of NOD2 genotype

S. Vermeire, I. Cleynen, M. Ferrante, 2016 .

S31 Mucosal healing in Crohn's disease is associated with high infliximab trough levels

P. Rutgeerts, S. Vermeire, I. Cleynen, 2010 .