M. Hedl

发表

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

David C. Wilson, Judy H. Cho, C. Gieger, 2012, Nature.

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

David C. Wilson, Judy H. Cho, C. Gieger, 2018, Nature Communications.

Enterococcus faecalis mevalonate kinase

M. Hedl, V. Rodwell, 2004, Protein science : a publication of the Protein Society.

Inhibition of the Class II HMG–CoA reductase of Pseudomonas mevalonii

M. Hedl, V. Rodwell, 2004, Protein science : a publication of the Protein Society.

Enterococcus faecalis Acetoacetyl-Coenzyme A Thiolase/3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, a Dual-Function Protein of Isopentenyl Diphosphate Biosynthesis

Autumn L. Sutherlin, M. Hedl, M. Mazzulla, 2002, Journal of bacteriology.

Enterococcus faecalis 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase, an Enzyme of Isopentenyl Diphosphate Biosynthesis

Autumn L. Sutherlin, M. Hedl, J. Burgner, 2002, Journal of bacteriology.

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Francis J. Huber, Judy H. Cho, Wei Zhang, 2012, Nature.

Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines.

C. Abraham, M. Hedl, 2012, Gastroenterology.

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 polarization By Regulating Proximal Signaling and Akt2 Activation

C. Abraham, M. Hedl, Jie Yan, 2016 .

TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages

C. Abraham, M. Hedl, Shasha Zheng, 2015, The Journal of Immunology.

This information is current as Human Macrophages following Chronic NOD 2 Stimulation of Proinflammatory Cytokine Downregulation SOCS 3 and MAPKs Contributes to Dependent Regulation of − TAM Receptor

C. Abraham, M. Hedl, Shasha Zheng, 2015 .

IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.

C. Abraham, M. Hedl, Jie Yan, 2016, Cell reports.

The IL18RAP Region Disease Polymorphism Decreases IL-18RAP/IL-18R1/IL-1R1 Expression and Signaling through Innate Receptor–Initiated Pathways

C. Abraham, M. Hedl, Shasha Zheng, 2014, The Journal of Immunology.

Secretory mediators regulate Nod2-induced tolerance in human macrophages.

C. Abraham, M. Hedl, 2011, Gastroenterology.

ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation

C. Abraham, M. Hedl, P. Dempsey, 2017, Cell Death and Disease.

Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators

C. Abraham, M. Hedl, Shasha Zheng, 2015, The Journal of Immunology.

Downregulation following Chronic NOD2 Twist1 and Twist2 Contribute to Cytokine

C. Abraham, M. Hedl, Shasha Zheng, 2015 .

IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome

C. Abraham, M. Hedl, Jie Yan, 2018, The Journal of Immunology.

3-Hydroxy-3-methylglutaryl-CoA reductase.

M. Hedl, P. Kennelly, K. Bischoff, 2000, Methods in enzymology.

The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes

C. Abraham, M. Hedl, K. Ranjan, 2021, Proceedings of the National Academy of Sciences.

Negative regulation of human mononuclear phagocyte function

C. Abraham, M. Hedl, 2013, Mucosal Immunology.

Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

C. Abraham, M. Hedl, Jie Yan, 2017, Nature Communications.

High density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Hailiang Huang, Stephan Ripke, Andre Franke, 2014, Nature Genetics.

MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation

C. Abraham, M. Hedl, A. Lahiri, 2015, Proceedings of the National Academy of Sciences.

Materials for : Host-microbe interactions shape genetic risk for inflammatory bowel disease

Judy H. Cho, C. Gieger, M. Daly, 2012 .

Chronic stimulation of Nod2 mediates tolerance to bacterial products

Judy H. Cho, C. Abraham, M. Hedl, 2007, Proceedings of the National Academy of Sciences.

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8–induced IL-1

C. Abraham, M. Hedl, 2014, Proceedings of the National Academy of Sciences.

Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters

C. Abraham, M. Hedl, Rui Sun, 2019, The Journal of Immunology.

Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.

Judy H. Cho, C. Abraham, Kaida Ning, 2014, Immunity.

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

C. Abraham, M. Hedl, Jie Yan, 2018, eLife.

Distinct Roles for Nod2 Protein and Autocrine Interleukin-1β in Muramyl Dipeptide-induced Mitogen-activated Protein Kinase Activation and Cytokine Secretion in Human Macrophages*

C. Abraham, M. Hedl, 2011, The Journal of Biological Chemistry.

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations.

Judy H. Cho, D. Nicolae, C. Abraham, 2004, Human molecular genetics.

IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes

C. Abraham, M. Hedl, Rui Sun, 2019, Gut.

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.

C. Abraham, M. Hedl, Xuchen Zhang, 2021, Journal of Clinical Investigation.

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

R. Xavier, C. Abraham, Aylwin Ng, 2017, Nature Communications.

A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion

C. Abraham, M. Hedl, 2015, Gut.

TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants

C. Abraham, M. Hedl, Rui Sun, 2020, Cellular and molecular gastroenterology and hepatology.

An inflammatory bowel disease–risk variant in INAVA decreases pattern recognition receptor–induced outcomes

C. Abraham, M. Hedl, Jie Yan, 2017, The Journal of clinical investigation.

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.

C. Abraham, M. Hedl, K. Ranjan, 2019, Cell reports.

Disease Risk–Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor–Induced Outcomes in Human Macrophages

C. Abraham, M. Hedl, Rui Sun, 2020, The Journal of Immunology.

JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages

C. Abraham, M. Hedl, D. Proctor, 2016, The Journal of Immunology.

IRF5 Risk Polymorphisms Contribute to Interindividual Variance in Pattern Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells

C. Abraham, M. Hedl, 2012, The Journal of Immunology.

Coenzyme a Reductases Class Ii 3-hydroxy-3-methylglutaryl

Lydia Tabernero, L. Tabernero, M. Hedl, 2022 .

Secretion in Human Monocyte-Derived Cells Recognition Receptor-Mediated Cytokine Interindividual Variance in Pattern Risk Polymorphisms Contribute to IRF5

M. Hedl, 2012 .

NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.

C. Abraham, M. Hedl, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Running Head : Dual Outcomes of Chronic Nod 2 Stimulation 1 2 The NLRP 1 and NLRP 3 Inflammasome is Essential for Distinct Outcomes of Decreased 3 Cytokines but Enhanced Bacterial Killing Upon Chronic Nod 2 Stimulation 4

C. Abraham, M. Hedl, 2012 .

STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor–Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes

C. Abraham, M. Hedl, Rui Sun, 2019, The Journal of Immunology.

Myeloid Cell–Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions

C. Abraham, M. Hedl, Jie Yan, 2020, The Journal of Immunology.

Supplemental Information IRF 5 and IRF 5 Disease-Risk Variants Increase Glycolysis and Human M 1 Macrophage Polarization by Regulating Proximal Signaling and Akt 2 Activation

C. Abraham, M. Hedl, Jie Yan, 2016 .

Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP

R. Xavier, C. Abraham, Aylwin Ng, 2017, Nature Communications.

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Judy H. Cho, C. Gieger, H. Hakonarson, 2015 .

Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductases

L. Tabernero, M. Hedl, V. Rodwell, 2004, Journal of bacteriology.

Isopentenyl pyrophosphate synthesis in bacteria: Genes and enzymes of the mevalonate pathway

M. Hedl, 2003 .