X. Bai

发表

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles

S. Scheres, X. Bai, I. S. Fernández, 2013, eLife.

Cryo-EM structure of a 3D DNA-origami object

T. G. Martin, S. Scheres, X. Bai, 2012, Proceedings of the National Academy of Sciences.

How cryo-EM is revolutionizing structural biology.

S. Scheres, X. Bai, G. McMullan, 2015, Trends in biochemical sciences.

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

S. Scheres, X. Bai, I. S. Fernández, 2014, eLife.

Design of a molecular support for cryo-EM structure determination

Tanmay A M Bharat, Hendrik Dietz, Sjors H W Scheres, 2016, Proceedings of the National Academy of Sciences.

CryoEM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

C. Oubridge, K. Nagai, S. Scheres, 2016, Nature.

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

X. Bai, J. García-Nafría, C. Tate, 2018, bioRxiv.

Cellular Internalization of Exosomes Occurs Through Phagocytosis

Qiang Zhou, X. Bai, Qiang Zhou, 2010, Traffic.

Sampling the conformational space of the catalytic subunit of human γ-secretase

Guanghui Yang, Xiao-chen Bai, Sjors H W Scheres, 2015, bioRxiv.

Structures of the human mitochondrial ribosome in native states of assembly

V. Ramakrishnan, D. Kimanius, X. Bai, 2017, Nature Structural &Molecular Biology.

Structures of the Calcium-activated Non-Selective Cation Channel TRPM4

X. Bai, J. She, Youxing Jiang, 2017, Nature.

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

X. Bai, Jianping Wu, N. Yan, 2016, Cell Research.

Structural mechanisms of phospholipid activation of the human TPC 2 1 channel 2

X. Bai, J. She, Youxing Jiang, 2022 .

Sampling the conformational space of the catalytic subunit of human γ-secretase

Yigong Shi, X. Bai, E. Rajendra, 2015, bioRxiv.

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors.

X. Bai, Xuewu Zhang, Kai Cai, 2022, Chemical reviews.

Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

X. Bai, Jie Li, Jiayi Wu, 2022, bioRxiv.

Structure of a D2 dopamine receptor-G protein complex in a lipid membrane

R. Sunahara, D. Rosenbaum, X. Bai, 2020, Nature.

Structural and functional characterization of an otopetrin family 1 proton channel 2

X. Bai, J. She, W. Zeng, 2019 .

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

S. Ralph, T. Triglia, A. Cowman, 2017, Nature Microbiology.

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif

Zhijian J. Chen, X. Bai, Xuping Xie, 2022, Science Immunology.

Structural characterization of full-length NSF and 20S particles

X. Bai, Hongwei Wang, Jiansen Jiang, 2012, Nature Structural &Molecular Biology.

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway.

Zhijian J. Chen, X. Bai, Xuewu Zhang, 2020, Immunity.

Activation of the insulin receptor by an insulin mimetic peptide

D. Accili, X. Bai, J. Mayer, 2022, Nature Communications.

CTCF and R-loops are boundaries of cohesin-mediated DNA looping

Ilya J. Finkelstein, X. Bai, Hongtao Yu, 2022, bioRxiv.

Structural basis for gating mechanism of the human sodium-potassium pump

X. Bai, B. Levine, Michael Fine, 2022, Nature Communications.

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Alan Brown, Fei Long, V. Ramakrishnan, 2014, Science.

Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

Yigong Shi, S. Scheres, Chuangye Yan, 2015, Genes & development.

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

Yigong Shi, S. Scheres, Chuangye Yan, 2014, Nature.

An atomic structure of human γ-secretase

Sjors H. W. Scheres, Guanghui Yang, Xiao-chen Bai, 2015, Nature.

Cryo-EM structure of the human cohesin-NIPBL-DNA complex

X. Bai, Hongtao Yu, Zhubing Shi, 2020, Science.

Activation of STING by targeting a pocket in the transmembrane domain

X. Bai, Xuewu Zhang, D. Lu, 2022, Nature.

Structural basis of STING binding with and phosphorylation by TBK1

Zhijian J. Chen, X. Bai, Xuewu Zhang, 2019, Nature.

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Zhijian J. Chen, X. Bai, Xuewu Zhang, 2019, Nature.

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

X. Bai, J. She, Youxing Jiang, 2019, Cell.

Three-dimensional structure of human γ-secretase

Yanyu Zhao, Sjors H. W. Scheres, Guanghui Yang, 2014, Nature.

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex

X. Bai, Xuewu Zhang, Xiaojing He, 2021, Nature Communications.

Cryo-EM structures of the human cation-chloride cotransporter KCC1

Jingyuan Li, X. Bai, E. Delpire, 2019, Science.

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

X. Bai, Hongtao Yu, E. Uchikawa, 2019, eLife.

Cryo-EM structure of the Hippo signaling integrator human STRIPAK

X. Bai, Xuewu Zhang, Xuelian Luo, 2021, Nature Structural & Molecular Biology.

Structure of the large ribosomal subunit from human mitochondria

Alan Brown, V. Ramakrishnan, Sjors H. W. Scheres, 2014, Science.

Structure of a spliceosome remodelled for exon ligation

Max E. Wilkinson, Chris Oubridge, C. Oubridge, 2017, Nature.

Structural basis of the activation of c-MET receptor

X. Bai, Xuewu Zhang, Zhiming Chen, 2021, Nature Communications.

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Zhijian J. Chen, X. Bai, Xuewu Zhang, 2019, Nature.

A structural model of a Ras–Raf signalosome

P. Jänne, D. Shaw, Y. Shan, 2020, Nature Structural & Molecular Biology.

Cryo-EM structure of a separase-securin complex at near-atomic resolution

T. G. Martin, D. Barford, S. Scheres, 2017, Nature Structural &Molecular Biology.

Molecular Architecture of a Eukaryotic Translational Initiation Complex

V. Ramakrishnan, Sjors H. W. Scheres, Jon R. Lorsch, 2013, Science.

Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the Ribosome

V. Ramakrishnan, Israel S. Fernández, Garib Murshudov, 2014, Cell.

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

Christopher G Tate, X. Bai, J. García-Nafría, 2018, bioRxiv.

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

Yigong Shi, S. Scheres, X. Bai, 2017, Proceedings of the National Academy of Sciences.

Mefloquine targets the Plasmodium falciparum 80 S ribosome to inhibit 3 protein synthesis 4 5

S. Ralph, T. Triglia, A. Cowman, 2017 .

The architecture of the spliceosomal U4/U6.U5 tri-snRNP

Sjors H. W. Scheres, Xiao-chen Bai, K. Nagai, 2015, Nature.

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila

Yigong Shi, S. Scheres, Chuangye Yan, 2015, Genes & development.

Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

V. Mootha, X. Bai, J. She, 2020, bioRxiv.

Figures and figure supplements Structural and functional characterization of an otopetrin family proton channel

X. Bai, J. She, Youxing Jiang, 2019 .

Structural mechanisms of phospholipid activation of the human TPC2 channel

Weizhong Zeng, Youxing Jiang, X. Bai, 2019, eLife.

Structural mechanisms of phospholipid activation of the human TPC2 channel

Weizhong Zeng, Youxing Jiang, X. Bai, 2019, eLife.

Synergistic activation of the insulin receptor via two distinct sites

X. Bai, J. Mayer, M. Stowell, 2022, Nature Structural & Molecular Biology.

Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel

X. Bai, J. She, Youxing Jiang, 2018, Nature.

Structural basis of the activation of type 1 insulin-like growth factor receptor

X. Bai, Hongtao Yu, E. Choi, 2019, Nature Communications.

Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins.

Xiao-jing Wang, X. Bai, Jianlin Lei, 2011, Structure.

Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

X. Bai, Hongwei Wang, Q. Shen, 2009, Proceedings of the National Academy of Sciences.

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1.

Sean P. Brown, D. A. Thayer, X. Bai, 2020, Cell reports.

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

X. Bai, J. She, Youxing Jiang, 2017, Nature.

Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

X. Bai, J. Liou, Xuewu Zhang, 2019, eLife.

Cryo-EM structure of the mitochondrial calcium uniporter

V. Mootha, Yifan Cheng, J. Armache, 2018, Nature.

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

Zhijian J. Chen, X. Bai, Xuewu Zhang, 2019, Nature.

The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region

X. Bai, M. Stewart, S. Aibara, 2016, Journal of structural biology.

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

X. Bai, Xuewu Zhang, Y. Kuo, 2020, Nature Communications.

Characterization of the subunit composition and structure of adult human glycine receptors

X. Bai, Weiwei Wang, Hailong Yu, 2021, Neuron.

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit

Alan Brown, Eric Hanssen, Israel S. Fernández, 2014 .

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold

X. Bai, Xuewu Zhang, Guoming Gao, 2023, Science advances.

Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor

X. Bai, Catherin Hall, E. Choi, 2023, Nature Structural & Molecular Biology.

Seeing Atoms by Single-Particle Cryo-EM.

X. Bai, 2021, Trends in biochemical sciences.

Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

X. Bai, Youxing Jiang, W. Zeng, 2020, eLife.

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex

J. Rizo, X. Bai, Xuewu Zhang, 2022, bioRxiv.

Characterization of the subunit composition and structure of native adult glycine receptors

X. Bai, Weiwei Wang, Hailong Yu, 2021, bioRxiv.

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

X. Bai, Xuewu Zhang, Y. Kuo, 2020, Nature Communications.

The Activation Mechanism of the Insulin Receptor: A Structural Perspective.

X. Bai, E. Choi, 2023, Annual review of biochemistry.

Author response: Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

X. Bai, Hongtao Yu, E. Uchikawa, 2019 .

Cryo-EM structure of human TPC2 channel in the ligand-bound closed state

X. Bai, J. She, Youxing Jiang, 2019 .

Activation mechanism of the insulin receptor revealed by cryo-EM structure of 1 the fully liganded receptor – ligand complex 2

X. Bai, E. Uchikawa, G. Shang, 2019 .

Structural basis of STING binding with and phosphorylation by TBK1

Zhijian J. Chen, X. Bai, Xuewu Zhang, 2019, Nature.

An atomic structure of human γ-secretase

Yigong Shi, S. Scheres, Chuangye Yan, 2015, Nature.

Cryo-EM structure of the adenosine A 2 A receptor coupled to an engineered 3 heterotrimeric G protein 4 5 6

X. Bai, J. García-Nafría, C. Tate, 2018 .

Cryo-EM structure of the mitochondrial calcium uniporter

V. Mootha, Yifan Cheng, J. Armache, 2018, Nature.

Structural insights into the assembly of the agrin/LRP4/MuSK signaling complex

X. Bai, T. Xie, Yun Liu, 2023, Proceedings of the National Academy of Sciences of the United States of America.