A. Mildvan

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Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy.

G. T. Marks, T. Harris, M. Massiah, 2001, Biochemistry.

Interactions of the products, 8-oxo-dGMP, dGMP, and pyrophosphate with the MutT nucleoside triphosphate pyrophosphohydrolase.

M. Massiah, A. Mildvan, L. Amzel, 2002, Biochemistry.

Magnetic resonance studies of the anomeric distribution and manganese binding properties of fructose phosphates.

S. Benkovic, A. Mildvan, J. L. Engle, 1972, Biochemical and biophysical research communications.

Kinetic and magnetic resonance studies of the interaction of the Cr-ATP complex with phosphoribosylpyrophosphate synthetase from Salmonella typhimurium.

A. Mildvan, R. Switzer, T. Li, 1979, Archives of biochemistry and biophysics.

Nuclear relaxation measurements of the geometry of enzyme-bound substrates and analogs.

A. Mildvan, R. Gupta, A S Mildvan, 1978, Methods in enzymology.

Magnetic resonance studies of the proximity and spatial arrangement of propionyl coenzyme A and pyruvate on a biotin-metalloenzyme, transcarboxylase.

A. Mildvan, R. Gupta, C. Fung, 1976, Biochemistry.

Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR.

T. Flatmark, A. Mildvan, J. Haavik, 1993, Biochemistry.

Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase.

T. Harris, M. Massiah, A. Mildvan, 1999, Biochemistry.

4-Oxalocrotonate tautomerase: pH dependence of catalysis and pKa values of active site residues.

A. Mildvan, J. Stivers, G. Hajipour, 1996, Biochemistry.

Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies.

L. H. Chen, A. Mildvan, J. Stivers, 1996, Biochemistry.

NMR evidence for a short, strong hydrogen bond at the active site of a cholinesterase.

T. Harris, M. Massiah, A. Mildvan, 2000, Biochemistry.

Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies.

M. Massiah, A. Mildvan, T. Rosenberry, 2001, Biochemistry.

Ultraviolet resonance Raman spectroscopy of delta 5-3-ketosteroid isomerase revisited: substrate polarization by active-site residues.

A. Mildvan, T. Spiro, P. Talalay, 1995, Biochemistry.

Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the pKa values of active site residues and on the pH dependence of catalysis.

T. Harris, A. Mildvan, J. Stivers, 1999, Biochemistry.

The mechanism of aconitase action. 3. Detection and properties of enzyme-metal-substrate and enzyme-metal-inhibitor bridge complexes with manganese(II) and iron(II).

A. Mildvan, J. Villafranca, 1972, The Journal of biological chemistry.

PROTON RELAXATION RATE ENHANCEMENT WITH FREE AND PROTEIN-BOUND FLAVIN RADICALS†

A. Mildvan, G. Palmer, 1972 .

Magnetic resonance and kinetic studies of the manganese(II) ion and substrate complexes of the catalytic subunit of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart.

A. Mildvan, E. Kaiser, R. Armstrong, 1979, Biochemistry.

Kinetic and magnetic resonance studies of pyruvate kinase. 3. The enzyme-metal-phosphoryl bridge complex in the fluorokinase reaction.

A. Mildvan, M. Cohn, J. Leigh, 1967, Biochemistry.

NMR studies of the MgATP binding site of adenylate kinase and of a 45-residue peptide fragment of the enzyme.

A. Mildvan, D. Fry, S. Kuby, 1985, Biochemistry.

Temperature dependence of the longitudinal relaxation rates and exchange rates of the amide protons in peptide substrates of protein kinase

P. Rosevear, A. Mildvan, D. Fry, 1985 .

Studies of the mechanism of the delta 5-3-ketosteroid isomerase reaction by substrate, solvent, and combined kinetic deuterium isotope effects on wild-type and mutant enzymes.

A. Mildvan, L. Xue, P. Talalay, 1990, Biochemistry.

Combined effects of two mutations of catalytic residues on the ketosteroid isomerase reaction.

A. Mildvan, P. Talalay, A. Kuliopulos, 1990, Biochemistry.

Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase.

D. Shortle, A. Mildvan, P. Talalay, 1989, Biochemistry.

NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase.

A. Mildvan, P. Talalay, Q. Zhao, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of malic enzyme from pigeon liver. Magnetic resonance and kinetic studies of the role of Mn2+.

A. Mildvan, G. Chang, R. Y. Hsu, 1976, The Journal of biological chemistry.

NMR and computer modeling studies of the conformations of glutathione derivatives at the active site of glyoxalase I.

I. Kuntz, P. Rosevear, A. Mildvan, 1984, The Journal of biological chemistry.

NUCLEAR RELAXATION STUDIES OF THE ROLE OF THE DIVALENT CATION IN THE MECHANISM OF PYRUVATE KINASE AND ENOLASE: INNER SPHERE AND SECOND SPHERE COMPLEXES *

A. Mildvan, T. Nowak, C. Fung, 1973, Annals of the New York Academy of Sciences.

Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of delta 5-3-ketosteroid isomerase by steroid binding.

A. Mildvan, P. Talalay, Q. Zhao, 1995, Biochemistry.

Stereoselective interactions of phosphoenolpyruvate analogues with phosphoenolpyruvate-utilizing enzymes.

A. Mildvan, T. Nowak, 1970, The Journal of biological chemistry.

Magnetic resonance and kinetic studies of initiator-substrate distances on RNA polymerase from Escherichia coli.

A. Mildvan, P. Stein, 1978, Biochemistry.

Mechanism of action of methoxatin-dependent alcohol dehydrogenase.

A. Mildvan, R. Abeles, J. A. Bell, 1981, Biochemistry.

Kinetic and magnetic resonance studies of the glutamate-43 to serine mutant of staphylococcal nuclease.

J. Gerlt, A. Mildvan, E. Serpersu, 1989, Biochemistry.

Electron spin echo modulation and nuclear relaxation studies of staphylococcal nuclease and its metal-coordinating mutants.

A. Mildvan, E. Serpersu, J. Peisach, 1988, Biochemistry.

Nuclear relaxation studies of the interaction of substrates with a metalloaldolase from yeast.

G. M. Smith, A. Mildvan, E. T. Harper, 1980, Biochemistry.

Magnetic resonance studies of the interaction of Co2+ and phosphoenolpyruvate with pyruvate kinase.

A. Mildvan, E. Melamud, 1975, The Journal of biological chemistry.

Electron paramagnetic resonance, 1-H, and 13C nuclear magnetic resonance studies of the interaction of manganese and bicarbonate with ribulose 1, 5-diphosphate carboxylase.

A. Mildvan, H. Miziorko, 1974, The Journal of biological chemistry.

Nuclear Overhauser effect studies of the conformations of MgATP bound to the active and secondary sites of muscle pyruvate kinase.

P. Rosevear, A. Mildvan, T. Fox, 1987, Biochemistry.

Nuclear magnetic resonance studies of selectively hindered internal motion of substrate analogs at the active site of pyruvate kinase.

A. Mildvan, T. Nowak, 1972, Biochemistry.

KINETIC AND MAGNETIC RESONANCE STUDIES OF THE PYRUVATE KINASE REACTION. I. DIVALENT METAL COMPLEXES OF PYRUVATE KINASE.

A. Mildvan, M. Cohn, 1965, The Journal of biological chemistry.

Stereospecificity of the metal--adenosine 5'-triphosphate complex in reactions of muscle pyruvate kinase.

A. Mildvan, W. Cleland, D. Dunaway-Mariano, 1979, Biochemistry.

NMR studies of the nucleotide conformation and the arrangement of substrates and activators on phosphoribosylpyrophosphate synthetase.

A. Mildvan, R. Switzer, J. Granot, 1980, The Journal of biological chemistry.

Nuclear relaxation studies on human methemoglobin. Observation of cooperativity and alkaline Bohr effect with inositol hexaphosphate.

A. Mildvan, R. Gupta, 1975, The Journal of biological chemistry.

Studies of the mechanism of action and regulation of cAMP-dependent protein kinase.

A. Mildvan, E. Kaiser, J. Granot, 1980, Archives of biochemistry and biophysics.

Kinetic and magnetic resonance studies of the pyruvate kinase reaction. II. Complexes of enzyme, metal, and substrates.

A. Mildvan, M. Cohn, 1966, The Journal of biological chemistry.

Electron spin resonance studies with dioldehydrase. Evidence for radical intermediates in reactions catalyzed by coenzyme B 12.

A. Mildvan, R. Abeles, J. Valinsky, 1973, The Journal of biological chemistry.

Chromium(III)-adenosine triphosphate as a paramagnetic probe to determine intersubstrate distances on pyruvate kinase. Detection of an active enzyme-metal-ATP-metal complex.

A. Mildvan, R. Gupta, C. Fung, 1976, The Journal of biological chemistry.

Probes of Structure and Function of Macromolecules and Membranes

B. Chance, A. Mildvan, G. Vanderkooi, 1972 .

Mechanism of Inhibition of Vaccinia DNA Topoisomerase by Novobiocin and Coumermycin (*)

A. Mildvan, S. Shuman, J. Stivers, 1996, The Journal of Biological Chemistry.

Escherichia coli deoxyribonucleic acid polymerase I, a zinc metalloenzyme. Nuclear quadrupolar relaxation studies of the role of bound zinc.

L. Loeb, A. Mildvan, R. Abramson, 1973, The Journal of biological chemistry.

Studies on adenosine triphosphate transphosphorylases. XVIII. Synthesis and preparation of peptides and peptide fragments of rabbit muscle ATP-AMP transphosphorylase (adenylate kinase) and their nucleotide-binding properties

D. Bredt, A. Mildvan, Mark S. Johnson, 1989 .

Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation.

P. Pedersen, M. Massiah, A. Mildvan, 1999, Biochemistry.

Nuclear Overhauser effect studies of the conformations and binding site environments of deoxynucleoside triphosphate substrates bound to DNA polymerase I and its large fragment.

A. Mildvan, L. Ferrin, 1985, Biochemistry.

Nuclear Overhauser effect studies of the conformations of tetraamminecobalt(III)-adenosine 5'-triphosphate free and bound to bovine heart protein kinase.

P. Rosevear, A. Mildvan, E. Kaiser, 1983, Biochemistry.

[12] Use of NMR and EPR to study cAMP-dependent protein kinase

P. Rosevear, A. Mildvan, E. Kaiser, 1983 .

Phosphorus nuclear magnetic resonance studies of phosphoglucomutase and its metal ion complexes.

J. Grutzner, A. Mildvan, W. Ray, 1977, Archives of biochemistry and biophysics.

Magnetic resonance and kinetic studies of the mechanism of membrane-bound sodium and potassium ion- activated adenosine triphosphatase.

A. Mildvan, C. Grisham, 1975, Journal of supramolecular structure.

Electron and nuclear magnetic resonance studies of the interaction of pyruvate with transcarboxylase.

A. Mildvan, C. Fung, J. Leigh, 1974, Biochemistry.

Magnetic resonance and catalytic studies of pyruvate kinase with essential sulfhydryl or lysyl epsilon-amino groups chemically modified.

M. J. Coon, A. Mildvan, M. Flashner, 1973, The Journal of biological chemistry.

Application of physical methods to the study of enzymes containing bound manganese: problems and prospects.

G. H. Reed, A. Mildvan, M. Scrutton, 1973, Advances in experimental medicine and biology.

Pyruvate carboxylase: nuclear magnetic resonance studies of the enzyme-manganese-oxalacetate and enzyme-manganese-pyruvate bridge complexes.

A. Mildvan, M. Scrutton, 1970, Archives of biochemistry and biophysics.

Interaction of a spin-labeled analog of nicotinamide-adenine dinucleotide with alcohol dehydrogenase. II. Proton relaxation rate and electron paramagnetic resonance studies of binary and ternary complexes.

A. Mildvan, H. Weiner, 1969, Biochemistry.

Positioning of a spin-labeled substrate analogue into the structure of delta 5-3-ketosteroid isomerase by combined kinetic, magnetic resonance, and X-ray diffraction methods.

A. Mildvan, E. Westbrook, P. Talalay, 1987, Biochemistry.

Spinach leaf phosphoenolpyruvate carboxylase: purification, properties, and kinetic studies.

A. Mildvan, H. Miziorko, T. Nowak, 1974, Archives of biochemistry and biophysics.

Heme-environment of horseradish peroxidase as observed by oxygen-17 superhyperfine interaction in EPR.

A. Mildvan, R. Gupta, G. R. Schonbaum, 1979, Biochemical and biophysical research communications.

The role of Glu 57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR.

A. Mildvan, D. Frick, M. Bessman, 1996, Biochemistry.

Kinetic analysis of Escherichia coli deoxyribonucleic acid polymerase I.

L. Loeb, A. Mildvan, E. Travaglini, 1975, The Journal of biological chemistry.

Nuclear magnetic relaxation studies of the conformation of adenosine 5'-triphosphate on pyruvate kinase from rabbit muscle.

A. Mildvan, D. Sloan, 1976, The Journal of biological chemistry.

Mandelate racemase from Pseudomonas putida. Magnetic resonance and kinetic studies of the mechanism of catalysis.

G. L. Kenyon, A. Mildvan, G. Hegeman, 1975, Biochemistry.

The properties of isolated human cardiac age pigment. I. Preparation and physical properties.

B. Strehler, A. Mildvan, D. Hendley, 1963, Journal of gerontology.

Chapter 15 - KINETIC AND MAGNETIC RESONANCE STUDIES OF THE INTERACTION OF Mn 2+ , SUBSTRATES AND TEMPLATES WITH DNA POLYMERASES

L. Loeb, A. Mildvan, R. Beckman, 1986 .

THE PROPERTIES OF ISOLATED HUMAN CARDIAC AGE PIGMENT. II. CHEMICAL AND ENZYMATIC PROPERTIES.

B. Strehler, A. Mildvan, D. Hendley, 1963, Journal of gerontology.

NMR studies of the interactions of substrates with enzymes and their peptide fragments 1

A. Mildvan, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Thallium-205 nuclear relaxation and kinetic studies of sodium and potassium ion-activated adenosine triphosphatase.

A. Mildvan, R. Gupta, C. Grisham, 1974, The Journal of biological chemistry.

Solution structure of the 45-residue MgATP-binding peptide of adenylate kinase as examined by 2-D NMR, FTIR, and CD spectroscopy.

A. Mildvan, D. Fry, H. Susi, 1986, Biochemistry.

Solution structure of Delta 5-3-ketosteroid isomerase complexed with the steroid 19-nortestosterone hemisuccinate.

M. Massiah, A. Mildvan, A. Gittis, 1999, Biochemistry.

Zinc in DNA polymerases.

L. Loeb, A. Mildvan, J. P. Slater, 1971, Biochemical and biophysical research communications.

ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

A. Mildvan, D. Fry, D C Fry, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis.

D. Shortle, A. Mildvan, E. Serpersu, 1987, Biochemistry.

X-ray absorption studies of the Zn2+ site of glyoxalase I.

B Chance, B. Chance, A. Mildvan, 1984, Biochemistry.

Role of divalent cations in the 3',5'-exonuclease reaction of DNA polymerase I.

A. Mildvan, J. Rifkind, H. Han, 1991, Biochemistry.

Role of magnesium and other divalent cations in ATP-utilizing enzymes.

A. Mildvan, 1987, Magnesium.

The role of divalent cations in the mechanism of enzyme catalyzed phosphoryl and nucleotidyl transfer reactions

A. Mildvan, C. Grisham, 1974 .

9 Metals in Enzyme Catalsis

A. Mildvan, 1970 .

Studies of the catalytic mechanism of an active-site mutant (Y14F) of delta 5-3-ketosteroid isomerase by kinetic deuterium isotope effects.

A. Mildvan, L. Xue, P. Talalay, 1991, Biochemistry.

Interaction of pyruvate with pyruvate carboxylase and pyruvate kinase as studied by paramagnetic effects on 13 C relaxation rates.

A. Mildvan, R. Komoroski, A. Allerhand, 1973, Biochemistry.

The presence of tightly bound copper in ribulose diphosphate carboxylase from spinach.

A. Mildvan, M. Lane, M. Scrutton, 1969, The Journal of biological chemistry.

Magnetic resonance studies of the conformations of enzyme-bound substrates

A. Mildvan, 1977 .

Nuclear relaxation measurements of water protons and other ligands.

A. Mildvan, J. L. Engle, 1972, Methods in enzymology.

Metal requirements of a diadenosine pyrophosphatase from Bartonella bacilliformis: magnetic resonance and kinetic studies of the role of Mn2+.

A. Mildvan, M. Bessman, G. Wu, 2000, Biochemistry.

Effect of urea on the divalent cation binding site of pyruvate kinase.

A. Mildvan, G. Cottam, 1971, The Journal of biological chemistry.

Stuies on the interaction of substrate and monovalent and divalent cations with pyruvate kinase.

A. Mildvan, F. Kayne, J. Glass, 1966, Biochemistry.

High‐Precision Measurement of Hydrogen Bond Lengths in Proteins by Nuclear Magnetic Resonance Methods

T. Harris, A. Mildvan, Thomas K. Harris, 1999, Proteins.

Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(beta, gamma-methylenetriphosphate).

A. Mildvan, E. Kaiser, H. N. Bramson, 1980, Biochemistry.

Nuclear magnetic resonance studies of the conformation of tetraamminecobalt (III)--ATP bound at the active site of bovine heart protein kinase.

A. Mildvan, E. Kaiser, R. Armstrong, 1979, Biochemistry.

The role of metals in enzyme-catalyzed substitutions at each of the phosphorus atoms of ATP.

A. Mildvan, 1979, Advances in enzymology and related areas of molecular biology.

Role of peripheral side chains of vitamin B12 coenzymes in the reaction catalyzed by dioldehydrase.

A. Mildvan, T. Toraya, R. Abeles, 1979, Biochemistry.

NMR docking of a substrate into the X‐ray structure of staphylococcal nuclease

David J Weber, E. Lattman, A. Mildvan, 1992, Proteins.

Interactions of the acid and base catalysts on staphylococcal nuclease as studied in a double mutant.

David J Weber, A. Mildvan, A. Meeker, 1991, Biochemistry.

Pyruvate carboxylase. VII. A possible role for tightly bound manganese.

A. Mildvan, M. Utter, M. Scrutton, 1966, The Journal of biological chemistry.

Nuclear relaxation and kinetic studies of the role of Mn 2+ in the mechanism of enolase.

G. L. Kenyon, A. Mildvan, T. Nowak, 1973, Biochemistry.

Mechanism of Carboxylation by Biotin Enzymes

A. Mildvan, E. Serpersu, D. Fry, 1990 .

NMR studies of the mechanism of enzyme action.

A. Mildvan, D. Fry, 1987, Advances in Enzymology and Related Subjects.

NMR Studies of the Exchange of the Amide Protons of d‐Biotin and Its Derivatives a

A. Mildvan, M. Lane, D. Fry, 1985, Annals of the New York Academy of Sciences.

DETERNATION OF CO-FACTOR DISSOCIATION CONSTANTS FROM THE KINETICS OF INHIBITION OF ENZYMES.

A. Mildvan, R. Leigh, 1964, Biochimica et biophysica acta.

Probes of enzymes and hemoproteins

B. Chance, A. Mildvan, T. Yonetani, 1971 .

13C NMR studies of the product complex of glyoxalase I.

P. Rosevear, A. Mildvan, B. Mannervik, 1983, The Journal of biological chemistry.

Nuclear relaxation studies of the role of the essential metal in glyoxalase I.

P. Rosevear, A. Mildvan, B. Mannervik, 1982, The Journal of biological chemistry.

ENZYME-LIGAND INTERACTIONS AS DETECTED BY NUCLEAR RELAXATION RATES OF SUBSTRATES AND INHIBITORS*

A. Mildvan, 1971 .

Structures of enzyme-bound metal-nucleotide complexes in the phosphoryl transfer reaction of muscle pyruvate kinase. 31P NMR studies with magnesium and kinetic studies with chromium nucleotides.

A. Mildvan, R. Gupta, 1977, The Journal of biological chemistry.

Environments and mechanistic roles of the tyrosine residues of delta 5-3-ketosteroid isomerase.

A. Mildvan, P. Talalay, A. Kuliopulos, 1993, Biochemistry.

Mechanism of enzyme action.

A. Mildvan, 1974, Annual review of biochemistry.

Magnetic resonance studies of the geometry of bound nicotinamide adenine dinucleotide and isobutyramide on spin-labeled alcohol dehydrogenase.

A. Mildvan, D. Sloan, 1974, Biochemistry.

Proton relaxation and kinetic studies of ternary complexes of an allosteric pyruvate kinase from yeast.

A. Mildvan, G. Cottam, C. Suelter, 1972, The Journal of biological chemistry.

Magnetic resonance studies of the role of the divalent cation in the mechanism of yeast aldolase.

W. Rutter, A. Mildvan, R. D. Kobes, 1971, Biochemistry.

Pyruvate carboxylase. VI. The presence of tightly bound manganese.

A. Mildvan, M. Utter, M. Scrutton, 1966, The Journal of biological chemistry.

Exchange characteristics of the amide protons of d-biotin and derivatives: implications for the mechanism of biotin enzymes and the role of sulfur in biotin

A. Mildvan, M. Lane, D. Fry, 1985 .

Pyruvate carboxylase. XI. Nuclear magnetic resonance studies of the properties of the bound manganese after interaction of the biotin residues with avidin.

A. Mildvan, M. Scrutton, 1968, Biochemistry.

Pyruvate carboxylase. X. The demonstration of direct coordination of pyruvate and alpha-ketobutyrate by the bound manganese and the formation of enzyme-metal-substrate bridge complexes.

A. Mildvan, M. Scrutton, 1967, Biochemistry.

The enzymatic carboxylation of phosphoenolpyruvate. IV. The binding of manganese and substrates by phosphoenolpyruvate carbosy-kinase and phosphoenolypyruvate carboxylase.

A. Mildvan, M. Lane, H. Maruyama, 1968, The Journal of biological chemistry.

Kinetic and magnetic resonance studies of the pyruvate kinase reaction. II. Complexes of enzyme, metal, and substrates.

A. Mildvan, M. Cohn, 1966, The Journal of biological chemistry.

Stereochemistry of the concerted enolization catalyzed by delta 5-3-ketosteroid isomerase.

A. Mildvan, L. Xue, G. P. Mullen, 1991, Biochemistry.

Aspects of enzyme mechanisms studies by nuclear spin relazation induced by paramagnetic probes.

M Cohn, A. Mildvan, M. Cohn, 2006, Advances in enzymology and related areas of molecular biology.

Kinetic and magnetic resonance studies of the mechanism of D-xylose isomerase. I. Binary and ternary complexes with manganese(II), substrates, and inhibitors.

A. Mildvan, K. Schray, 1972, The Journal of biological chemistry.

Proton magnetic relaxation studies of the interaction of D-xylose and xylitol with D-xylose isomerase. Characterization of metal-enzyme-substrate interactions.

A. Mildvan, K. Schray, J. Young, 1975, The Journal of biological chemistry.

4‐Oxalocrotonate tautomerase, a 41‐kDa homohexamer: Backbone and side‐chain resonance assignments, solution secondary structure, and location of active site residues by heteronuclear NMR spectroscopy

A. Mildvan, J. Stivers, C. P. Whitman, 1996, Protein science : a publication of the Protein Society.

Interaction of substrate and pterin cofactor with the metal of human tyrosine hydroxylase as determined by 1H-NMR.

T. Flatmark, A. Mildvan, J. Haavik, 1993, Advances in experimental medicine and biology.

STUDIES OF DEHYDROGENASE MECHANISMS USING ADP-TETRAMETHYLPIPERIDINE-1-OXYL (ADP-R.), A PARAMAGNETIC ANALOG OF NAD†

A. Mildvan, J. Villafranca, H. Weiner, 1972 .

The mechanism of aconitase action. I. Preparation, physical properties of the enzyme, and activation by iron (II).

A. Mildvan, J. Villafranca, A S Mildvan, 1971, The Journal of biological chemistry.

NMR docking of a substrate into the X-ray structure of the Asp-21-->Glu mutant of staphylococcal nuclease.

David J Weber, A. Libson, A. Mildvan, 1994, Biochemistry.

Interaction of a spin-labeled analog of acetyl coenzyme A with citrate synthase. Paramagnetic resonance and proton relaxation rate studies of binary and ternary complexes.

A. Mildvan, S. Weidman, G. Drysdale, 1973, Biochemistry.

Presence of a flavin semiquinone in methanol oxidase.

A. Mildvan, R. Abeles, G. Tayrien, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase.

A. Mildvan, P. Talalay, Q. Zhao, 1995, Biochemistry.

Substrate polarization by residues in Δ5‐3‐ketosteroid isomerase probed by site‐directed mutagenesis and UV resonance Raman spectroscopy

A. Mildvan, T. Spiro, A. Kuliopulos, 1992, Protein science : a publication of the Protein Society.

Catalytic mechanism of an active-site mutant (D38N) of delta 5-3-ketosteroid isomerase. Direct spectroscopic evidence for dienol intermediates.

A. Mildvan, L. Xue, P. Talalay, 1991, Biochemistry.

GEE MV: Rate and magnitude of age pigment accumulation in the human myocardium.

B. Strehler, A. Mildvan, D. D. Mark, 1959, Journal of gerontology.

Nuclear magnetic resonance studies of the role of histidine residues at the active site of rabbit muscle creatine kinase.

G. L. Kenyon, P. Rosevear, A. Mildvan, 1981, Biochemistry.

Inhibition of reverse transcription in vivo by elevated manganese ion concentration.

J. Boeke, A. Mildvan, Eric C. Bolton, 2002, Molecular cell.

NMR studies of conformations and interactions of substrates and ribonucleotide templates bound to the large fragment of DNA polymerase I.

A. Mildvan, L. Ferrin, 1986, Biochemistry.

Conformation of an enzyme-bound substrate of staphylococcal nuclease as determined by NMR.

David J Weber, A. Mildvan, G. P. Mullen, 1991, Biochemistry.

On the fidelity of DNA replication: manganese mutagenesis in vitro.

L. Loeb, A. Mildvan, R. Beckman, 1985, Biochemistry.

Apparent suicidal inactivation of DNA polymerase by adenosine 2',3'-riboepoxide 5'-triphosphate.

L. Loeb, A. Mildvan, M. Abboud, 1978, The Journal of biological chemistry.

The mechanism of Escherichia coli deoxyribonucleic acid polymerase I. Magnetic resonance and kinetic studies of the role of metals.

L. Loeb, A. Mildvan, I. Tamir, 1972, The Journal of biological chemistry.

NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme.

David J Weber, A. Gittis, A. Mildvan, 1995, Biochemistry.

NMR docking of the competitive inhibitor thymidine 3′,5′‐diphosphate into the X‐ray structure of staphylococcal nuclease

David J Weber, E. Lattman, A. Mildvan, 1993, Proteins.

Electron spin resonance studies with dioldehydrase. II. The hyperfine structure of proposed radical intermediates derived from isotopic substitution in 2-chloroacetaldehyde.

A. Mildvan, R. Abeles, J. Valinsky, 1974, The Journal of biological chemistry.

General theory of mortality and aging.

B. Strehler, A. Mildvan, B L STREHLER, 1960, Science.

Mechanisms of signaling and related enzymes

A. Mildvan, 1997, Proteins.

Vaccinia DNA topoisomerase I: evidence supporting a free rotation mechanism for DNA supercoil relaxation.

T. Harris, A. Mildvan, J. Stivers, 1997, Biochemistry.

Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step.

A. Mildvan, S. Shuman, J. Stivers, 1994, Biochemistry.

Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions.

A. Mildvan, S. Shuman, J. Stivers, 1994, Biochemistry.

Structures and mechanisms of Nudix hydrolases.

M. Massiah, A. Mildvan, L. Amzel, 2005, Archives of biochemistry and biophysics.

X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.

A. Mildvan, L. Amzel, S. Gabelli, 2006, Biochemistry.

Mutational, kinetic, and NMR studies of the mechanism of E. coli GDP-mannose mannosyl hydrolase, an unusual Nudix enzyme.

M. Massiah, A. Mildvan, P. M. Legler, 2002, Biochemistry.

MAGNETIC RESONANCE STUDIES OF THE INTERACTION OF THE MANGANOUS ION WITH BOVINE SERUM ALBUMIN.

A. Mildvan, M. Cohn, 1963, Biochemistry.

Enzymes Utilizing ATP: Kinases, ATPases and Polymerases

A. Mildvan, 2007 .

NMR and isotopic exchange studies of the site of bond cleavage in the MutT reaction.

D J Weber, David J Weber, A. Mildvan, 1992, The Journal of biological chemistry.

Nuclear magnetic resonance methods for the detection and study of low-barrier hydrogen bonds on enzymes.

T. Harris, A. Mildvan, C. Abeygunawardana, 1999, Methods in enzymology.

Magnetic-Resonance Approaches to Transition-State Structure

A. Mildvan, 1978 .

Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action.

A. Mildvan, Jian Lin, D. Frick, 1997, Biochemistry.

The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50.

T. Harris, M. Massiah, A. Mildvan, 2001, Biochemistry.

Secondary structure of the MutT enzyme as determined by NMR.

David J Weber, A. Mildvan, M. Bessman, 1993, Biochemistry.

Recognition in cell adhesion. A comparative study of the conformations of RGD‐containing peptides by Monte Carlo and NMR methods

A. Mildvan, L. Amzel, J. August, 1989, Journal of molecular recognition : JMR.

Mechanistic studies of cAMP-dependent protein kinase action.

A. Mildvan, E. Kaiser, H. N. Bramson, 1984, CRC critical reviews in biochemistry.

Ligand conformations and ligand-enzyme interactions as studied by the nuclear Overhauser effect.

P. Rosevear, A. Mildvan, 1989, Methods in enzymology.

GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases.

M. Massiah, A. Mildvan, P. M. Legler, 2000, Biochemistry.

The mitochondrion updated.

P. Pedersen, A. Mildvan, M. Lane, 1986, Science.

MAGNETIC RESONANCE STUDIES OF THE INTERACTIONS OF IMIDAZOLE AND OTHER LIGANDS WITH COBALT SUBSTITUTED ALCOHOL DEHYDROGENASE FROM LIVER

A. Mildvan, J. Young, 1977 .

15N NMR relaxation studies of free and inhibitor-bound 4-oxalocrotonate tautomerase: backbone dynamics and entropy changes of an enzyme upon inhibitor binding.

A. Mildvan, J. Stivers, C. P. Whitman, 1996, Biochemistry.

Metal binding to DNA polymerase I, its large fragment, and two 3',5'-exonuclease mutants of the large fragment.

L. Loeb, A. Mildvan, E. Serpersu, 1990, Journal of Biological Chemistry.

Quantitative interpretations of double mutations of enzymes.

David J Weber, A. Mildvan, A. Kuliopulos, 1992, Archives of biochemistry and biophysics.

Magnetic resonance studies of the conformation of enzyme-bound adenylyl(3' leads to 5')uridine and adenosine 5'-triphosphate on RNA polymerase from Esherichia coli.

A. Mildvan, B. Bean, R. Koren, 1977, Biochemistry.

Hydrogen Bonding at the Active Site of Δ5-3-Ketosteroid Isomerase†

A. Mildvan, A. Gittis, Qinjian Zhao, 1997 .

Hydrogen bonding at the active site of delta 5-3-ketosteroid isomerase.

A. Mildvan, A. Gittis, C. Abeygunawardana, 1997, Biochemistry.

Study of vitreous liquifaction by NMR spectroscopy and imaging.

T. Brady, A. Mildvan, H. Cheng, 1985, Investigative ophthalmology & visual science.

Metal content of DNA polymerase I purified from overproducing and wild type Escherichia coli.

L. Loeb, A. Mildvan, L. Ferrin, 1983, Biochemical and biophysical research communications.

Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase.

A. Mildvan, W. Miller, D. Fry, 1987, Biochemistry.

NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase.

P. Rosevear, A. Mildvan, D. Fry, 1984, Biochemistry.

Nuclear magnetic resonance studies of the conformation and kinetics of the peptide-substrate at the active site of bovine heart protein kinase.

A. Mildvan, E. Kaiser, H. N. Bramson, 1981, Biochemistry.

Conformation of deoxynucleoside triphosphate substrates on DNA polymerase I from Escherichia coli as determined by nuclear magnetic relaxation.

L. Loeb, A. Mildvan, D. Sloan, 1975, The Journal of biological chemistry.

Nuclear overhauser effect studies on the conformation of magnesium adenosine 5'-triphosphate bound to rabbit muscle creatine kinase.

G. L. Kenyon, P. Rosevear, A. Mildvan, 1987, Biochemistry.

NMR studies of the AMP-binding site and mechanism of adenylate kinase.

A. Mildvan, D. Fry, S. Kuby, 1986, Biochemistry.

Nuclear magnetic resonance studies of the nucleotide binding sites of porcine adenylate kinase.

A. Mildvan, G. M. Smith, G. M. Smith, 1982, Biochemistry.

Nuclear magnetic resonance studies of the function of potassium in the mechanism of pyruvate kinase.

A. Mildvan, T. Nowak, 1972, Biochemistry.

Solution structure and mechanism of the MutT pyrophosphohydrolase.

David J Weber, A. Mildvan, C. Abeygunawardana, 1999, Advances in enzymology and related areas of molecular biology.

Nuclear magnetic resonance and chemical modification studies of the role of the metal in yeast aldolase.

A. Mildvan, G. M. Smith, G. M. Smith, 1981, Biochemistry.

MAGNETIC RESONANCE STUDIES OF THE MECHANISM OF RNA POLYMERASE FROM E. COLI

A. Mildvan, P. Stein, B. Bean, 1978 .

1H and 31P Fourier transform magnetic resonance studies of the conformation of enzyme-bound propionyl coenzyme A on the transcarboxylase.

A. Mildvan, C. Fung, R. Feldmann, 1976, Biochemistry.

Substrate and DNA binding to a 50-residue peptide fragment of DNA polymerase I. Comparison with the enzyme.

A. Mildvan, G. P. Mullen, P. Shenbagamurthi, 1989, The Journal of biological chemistry.

Short, strong hydrogen bonds on enzymes: NMR and mechanistic studies

G. T. Marks, T. Harris, M. Massiah, 2002 .

Hydrogen bonding in the mechanism of GDP-mannose mannosyl hydrolase

S. Withers, A. Mildvan, L. Amzel, 2006 .

Two-dimensional NMR, circular dichroism, and fluorescence studies of PP-50, a synthetic ATP-binding peptide from the beta-subunit of mitochondrial ATP synthase.

P. Pedersen, A. Mildvan, W. Chuang, 1992, Biochemistry.

NMR studies of the active site of DNA polymerase I and of a 50-residue peptide fragment of the enzyme.

A. Mildvan, G. P. Mullen, J. B. Vaughn, 1990, Biochemical pharmacology.

NMR studies of strong hydrogen bonds in enzymes and in a model compound

T. Harris, A. Mildvan, Q. Zhao, 2000 .

The mechanism of aconitase action. II. Magnetic resonance studies of the complexes of enzyme, manganese(II), iron(II), and substrates.

A. Mildvan, J. Villafranca, 1971, The Journal of biological chemistry.

Magnetic resonance studies of the effect of the regulatory subunit on metal and substrate binding to the catalytic subunit of bovine heart protein kinase.

A. Mildvan, E. Kaiser, H. Kondo, 1980, The Journal of biological chemistry.

NMR studies of the mechanism of action and regulation of protein kinase.

P. Rosevear, A. Mildvan, D. Fry, 1985, Current topics in cellular regulation.

Deoxynucleoside [1-thio]triphosphates prevent proofreading during in vitro DNA synthesis.

T. Kunkel, L. Loeb, A. Mildvan, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Proton and phosphorus-31 Fourier transform magnetic resonance studies of the conformation of enzyme-bound propionyl coenzyme A on transcarboxylase

A. Mildvan, C. Fung, R. Feldmann, 1976 .

The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis.

M. Massiah, A. Mildvan, H. Azurmendi, 2004, Biochemistry.

13C NMR relaxation studies of backbone and side chain motion of the catalytic tyrosine residue in free and steroid-bound delta 5-3-ketosteroid isomerase.

A. Mildvan, C. Abeygunawardana, Q. Zhao, 1996, Biochemistry.

Arrangement of the phosphate-and metal-binding subsites of phosphoglucomutase. Intersubsite relationships by means of inhibition patterns.

A. Mildvan, J. W. Long, W. Ray, 1973, Biochemistry.

Fluorocitrate Inhibition of Aconitase: Relative Configuration of Inhibitory Isomer by X-ray Crystallography

H. L. Carrell, A. Mildvan, J. Villafranca, 1970, Science.

Inverse thinking about double mutants of enzymes.

A. Mildvan, 2004, Biochemistry.

Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus.

A. Mildvan, L. Amzel, S. Gabelli, 2004, Structure.

Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase.

T. Harris, M. Massiah, A. Mildvan, 2000, Biochemistry.

Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase.

David J Weber, A. Mildvan, A. Gittis, 1995, Biochemistry.

Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes.

David J Weber, A. Mildvan, J. R. Gillespie, 1994, The Journal of biological chemistry.

Solution structure, mutagenesis, and NH exchange studies of the MutT enzyme-Mg2+-8-oxo-dGMP complex

M. Massiah, A. Mildvan, H. Azurmendi, 2004 .

Sequence-specific assignments of the backbone 1H, 13C, and 15N resonances of the MutT enzyme by heteronuclear multidimensional NMR.

David J Weber, A. Mildvan, D. Frick, 1993, Biochemistry.

Pulse Fourier-transform NMR spectroscopy with applications to redox proteins.

A. Mildvan, R. Gupta, 1978, Methods in enzymology.

EPR study of 17O nuclear hyperfine interaction in cobalt-oxyhemoglobin: conformation of bound oxygen.

A. Mildvan, T. Yonetani, R. Gupta, 1975, Biochemical and biophysical research communications.

Kinetic and magnetic resonance studies of effects of genetic substitution of a Ca2+-liganding amino acid in staphylococcal nuclease.

D. Shortle, A. Mildvan, E. Serpersu, 1986, Biochemistry.

Conformations and arrangement of substrates at active sites of ATP-utilizing enzymes.

A. Mildvan, 1981, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Distinguishing among protein kinases by substrate specificities.

P. Greengard, A. Nairn, A. Mildvan, 1987, Biochemistry.

Magnetic resonance and kinetic studies of the mechanism of sodium and potassium ion-activated adenosine triphosphatase.

A. Mildvan, C. Grisham, 1974, The Journal of biological chemistry.

The role of metal ions in the mechanisms of DNA and RNA polymerases.

L. Loeb, A. Mildvan, 1979, CRC critical reviews in biochemistry.

Proton transfer in the mechanism of triosephosphate isomerase.

R. Cole, T. Harris, A. Mildvan, 1998, Biochemistry.

NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase.

T. Harris, A. Mildvan, C. Abeygunawardana, 1997, Biochemistry.

Preparation, physical properties, and effects of a Cr3+-ADP complex on phosphoryl transfer enzyme systems

A. Mildvan, D. Foster, 1972 .

Use of NMR and EPR to study cAMP-dependent protein kinase.

P. Rosevear, A. Mildvan, E. Kaiser, 1983, Methods in enzymology.

Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.

Jun O. Liu, A. Mildvan, K. Han, 2007, Biochemistry.

Water proton relaxation studies of the heme-environment in Mn(III)-substituted and native horseradish peroxidases.

A. Mildvan, R. Gupta, G. R. Schonbaum, 1980, Archives of biochemistry and biophysics.

Kinetic and structural effects of mutations of the catalytic amino-terminal proline in 4-oxalocrotonate tautomerase.

T. Harris, A. Mildvan, C. P. Whitman, 1997, Biochemistry.

Solution structure and function in trifluoroethanol of PP-50, an ATP-binding peptide from F1ATPase.

P. Pedersen, A. Mildvan, A. Gittis, 1995, Archives of biochemistry and biophysics.

Sequential proton NMR resonance assignments, circular dichroism, and structural properties of a 50-residue substrate-binding peptide from DNA polymerase I.

A. Mildvan, G. P. Mullen, J. B. Vaughn, 1993, Archives of biochemistry and biophysics.

Role of bivalent cations in the phosphoglucomutase system. IV. A study of the Mn2+ binding site by means of nuclear relaxation measurements on water protons.

A. Mildvan, W. Ray, 1970, Biochemistry.

Transient state kinetic studies of the MutT-catalyzed nucleoside triphosphate pyrophosphohydrolase reaction.

A. Mildvan, H. Azurmendi, Zuyong Xia, 2005, Biochemistry.

Interaction of a spin-labeled analogue of nicotinamide adenine dinucleotide with alcohol dehydrogenase. 3. Thermodynamic, kinetic, and structural properties of ternary complexes as determined by nuclear magnetic resonance.

A. Mildvan, H. Weiner, 1969, The Journal of biological chemistry.

Kinetic and Magnetic Resonance Studies of the PY ruvate Kinase Reaction COMPLEXES OF ENZYME, METAL, AND SUBSTRATES*

A. Mildvan, M. Cohn, 2003 .

Computer simulation studies of mammalian pyruvate kinase.

D Garfinkel, D. Garfinkel, A. Mildvan, 1967, The Journal of biological chemistry.

Magnetic resonance studies of the binding of oligonucleotide substrates to mutants of staphylococcal nuclease

A. Gittis, A. Mildvan, W. Chuang, 1994, Proteins.

Mutational tests of the NMR‐docked structure of the staphylococcal nuclease–metal–3′,5′‐pdTp complex

David J Weber, A. Mildvan, A. Gittis, 1993, Proteins.

Diverse interactions between the individual mutations in a double mutant at the active site of staphylococcal nuclease.

David J Weber, D. Shortle, A. Mildvan, 1990, Biochemistry.

Involvement of a divalent cation in the binding of fructose 6-phosphate to Trypanosoma cruzi phosphofructokinase: kinetic and magnetic resonance studies.

A. Mildvan, X. Ysern, J. Urbina, 1990, Archives of biochemistry and biophysics.

Dual divalent cation requirement for activation of pyruvate kinase; essential roles of both enzyme- and nucleotide-bound metal ions.

A. Mildvan, R. Gupta, R. M. Oesterling, 1976, Biochemistry.

Specificity of bovine heart protein kinase for the Δ‐stereoisomer of the metal—ATP complex

E. M. Brown, A. Mildvan, E. Kaiser, 1979 .

Arrangement and conformations of substrates at the active site of pyruvate kinase from model building studies based on magnetic resonance data.

A. Mildvan, E. Melamud, R. Gupta, 1976, The Journal of biological chemistry.