Y. Kawashima

发表

Hollow microspheres for use as a floating controlled drug delivery system in the stomach.

Y. Kawashima, T. Niwa, H. Takeuchi, 1992, Journal of pharmaceutical sciences.

Mucoadhesive nanoparticulate systems for peptide drug delivery.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, Advanced drug delivery reviews.

Preparation of a Sustained-Release Matrix Tablet of Acetaminophen with Pulverized Low-Substituted Hydroxypropylcellulose via Dry Granulation

Y. Kawashima, T. Niwa, H. Takeuchi, 1993 .

The role of the kneading paddle and the effects of screw revolution speed and water content on the preparation of solid dispersions using a twin-screw extruder.

Tomio Nakano, Shogo Izumi, Kouichi Nakamichi, 2002, International journal of pharmaceutics.

Determination of optimum processing temperature for transformation of glyceryl monostearate.

Y. Kawashima, H. Takeuchi, T. Yajima, 2002, Chemical & pharmaceutical bulletin.

Optimum heat treatment conditions for masking the bitterness of the clarithromycin wax matrix.

Y. Kawashima, H. Takeuchi, T. Yajima, 2003, Chemical & pharmaceutical bulletin.

Drug delivery applications of supercritical fluid technology

Y. Kawashima, P. York, 2008 .

Nanoparticles Enhance Therapeutic Efficiency by Selectively Increased Local Drug Dose in Experimental Colitis in Rats

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2005, Journal of Pharmacology and Experimental Therapeutics.

Brain targeting with surface-modified poly(D,L-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration.

Y. Kawashima, J. Kreuter, K. Tahara, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Mucoadhesive DL-Lactide/Glycolide Copolymer Nanospheres Coated with Chitosan to Improve Oral Delivery of Elcatonin

Hirofumi Takeuchi, Y. Kawashima, H. Takeuchi, 2000, Pharmaceutical development and technology.

Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, The Journal of pharmacology and experimental therapeutics.

Particle design of poorly water-soluble drug substances using supercritical fluid technologies.

Hirofumi Takeuchi, Y. Kawashima, H. Takeuchi, 2008, Advanced drug delivery reviews.

Redispersible dry emulsion system as novel oral dosage form of oily drugs: in vivo studies in beagle dogs.

Y. Kawashima, T. Niwa, H. Takeuchi, 1991, Chemical & pharmaceutical bulletin.

Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes

Y. Kawashima, T. Niwa, H. Takeuchi, 1996, Pharmaceutical Research.

A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles.

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2005, Journal of controlled release : official journal of the Controlled Release Society.

pH-sensitive microsphere delivery increases oral bioavailability of calcitonin.

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Microsphere design for the colonic delivery of 5-fluorouracil.

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Enhancement of the dissolution rate of a poorly water‐soluble drug (tolbutamide) by a spray‐drying solvent deposition method and disintegrants

Y. Kawashima, H. Takeuchi, T. Handa, 1987, The Journal of pharmacy and pharmacology.

The preparation of enteric solid dispersions with hydroxypropylmethylcellulose acetate succinate using a twin-screw extruder

Y. Kawashima, Shogo Izumi, K. Nakamichi, 2004 .

Multifunctional Composite Microcapsules for Oral Delivery of Insulin

Y. Kawashima, F. Cui, Na Liang, 2016, International journal of molecular sciences.

Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin

Y. Kawashima, F. Cui, Na Liang, 2011, International journal of nanomedicine.

Mucoadhesion of polymer-coated liposomes to rat intestine in vitro.

Y. Kawashima, T. Niwa, H. Takeuchi, 1994, Chemical & pharmaceutical bulletin.

Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Pluronic surfactants affecting diazepam solubility, compatibility, and adsorption from i.v. admixture solutions.

S. Lin, Y. Kawashima, 1987, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

Drug Release from the Water-in-Oil-in-Water Multiple Emulsion in Vitro. II. Effects of the Addition of Hydrophilic Surfactants to the Internal Aqueous Compartment on the Release Rate of Secretin

Y. Kawashima, T. Niwa, H. Takeuchi, 1993 .

Percutaneous Absorption Study of Biodegradable PLGA Nano-spheres via Human Skin Biopsies

Y. Kawashima, H. Takeuchi, N. Miwa, 2004 .

Preparation of a prolonged release tablet of aspirin with chitosan.

S. Lin, Y. Kawashima, T. Handa, 1985, Chemical & pharmaceutical bulletin.

Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery.

Y. Kawashima, H. Takeuchi, K. Tahara, 2008, International journal of pharmaceutics.

Properties of a peptide containing DL-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods.

Y. Kawashima, T. Niwa, H. Takeuchi, 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The physicochemical parameters determining the size of agglomerate prepared by the wet spherical agglomeration technique

Y. Kawashima, H. Takenaka, Keiko Furukawa, 1981 .

Spherical agglomeration of aminophylline crystals during reaction in liquid by the spherical crystallization technique.

Y. Kawashima, H. Takenaka, A. Shigeru, 1982 .

Direct agglomeration of sodium theophylline crystals produced by salting out in liquid.

Y. Kawashima, Shan‐Yang Lin, H. Takenaka, 1982 .

The effects of temperature on the spherical crystallization of salicylic acid

Y. Kawashima, H. Takenaka, M. Okumura, 1984 .

Particle Design of Tolbutamide by the Spherical Crystallization Technique. V. Improvement of Dissolution and Bioavailability of Direct Compressed Tablets Prepared Using Tolbutamide Agglomerated Crystals

Y. Kawashima, T. Niwa, H. Takeuchi, 1992 .

Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects.

Y. Kawashima, N. Miwa, C. C. Huang, 2007, Bioorganic & medicinal chemistry letters.

Effects of Heteroatom Substitution on the Structures, Physicochemical Properties, and Redox Behavior of Nickel(II) Complexes with Pyridine-Containing Macrocyclic Ligands

Y. Kawashima, T. Hirayama, M. Taki, 2008 .

Spray-dried composite particles of lactose and sodium alginate for direct tabletting and controlled releasing

Y. Kawashima, H. Takeuchi, T. Hino, 1998 .

Ultrastructural and Immunohistochemical Studies on Uptake and Distribution of FITC-Conjugated PLGA Nanoparticles Administered Intratracheally in Rats

Y. Kawashima, M. Tsutsumi, C. C. Huang, 2012, Journal of toxicologic pathology.

Histological examination of PLGA nanospheres for intratracheal drug administration.

Y. Kawashima, M. Tsutsumi, C. C. Huang, 2008, International journal of pharmaceutics.

Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel

Y. Kawashima, F. Cui, Na Liang, 2020, Journal of biomaterials applications.

Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2005, International journal of pharmaceutics.

In vitro drug release behavior of D,L-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method.

Y. Kawashima, T. Niwa, H. Takeuchi, 1994, Journal of pharmaceutical sciences.

Low-Substituted Hydroxypropylcellulose as a Sustained-Drug Release Matrix Base or Disintegrant Depending on Its Particle Size and Loading in Formulation

Y. Kawashima, T. Niwa, H. Takeuchi, 1993, Pharmaceutical Research.

Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.

Kohei Tahara, Hirofumi Takeuchi, Y. Kawashima, 2009, International journal of pharmaceutics.

Development of a PLGA-Nanosphere DDS Prepared by Spherical Crystallization with a Polymer

Y. Kawashima, 2019, Spherical Crystallization as a New Platform for Particle Design Engineering.

The suppression of IgE-mediated histamine release from mast cells following exocytic exclusion of biodegradable polymeric nanoparticles.

Y. Kawashima, N. Hirashima, S. Tadokoro, 2012, Biomaterials.

Intracellular drug delivery using polysorbate 80-modified poly(D,L-lactide-co-glycolide) nanospheres to glioblastoma cells

Y. Kawashima, J. Kreuter, K. Tahara, 2011, Journal of microencapsulation.

Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(D,L-lactide-co-glycolide) nanospheres for inflammatory bowel disease.

R. Morishita, Y. Kawashima, K. Tahara, 2011, Biomaterials.

Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery.

Y. Kawashima, H. Takeuchi, N. Hirashima, 2011, Chemical & pharmaceutical bulletin.

Interaction of Biodegradable Polymeric Nanospheres with Cells : the Effect of Surface Properties

Y. Kawashima, K. Tahara, Hiromitsu Yamamoto, 2011 .

Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery.

Y. Kawashima, K. Tahara, Hiromitsu Yamamoto, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Kinetic studies on the stability of indomethacin in alkaline aqueous solution containing poly(oxyethylene)poly(oxypropylene) surface-active block copolymers.

S. Lin, Y. Kawashima, 1985, Pharmaceutica acta Helvetiae.

Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin Into the Vascular Endothelium

K. Sunagawa, Y. Kawashima, Ling Chen, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Observation of antibacterial effect of biodegradable polymeric nanoparticles on Staphylococcus epidermidis biofilm using FE-SEM with an ionic liquid.

Y. Kawashima, C. Takahashi, Hiromitsu Yamamoto, 2015, Microscopy.

Electron microscopy of Staphylococcus epidermidis fibril and biofilm formation using image-enhancing ionic liquid

Y. Kawashima, M. Tanemura, C. Takahashi, 2015, Analytical and Bioanalytical Chemistry.

NOVEL PREPARATION OF FREE FLOWING SPHERICALLY GRANULATED DIBASIC CALCIUM PHOSPHATE ANHYDROUS FOR DIRECT TABLETTING

Y. Kawashima, Kiyoshi Takami, Hitoshi Machmura, 1996 .

Endocytosis-like uptake of surface-modified drug nanocarriers into giant unilamellar vesicles.

Y. Kawashima, N. Hirashima, S. Tadokoro, 2012, Langmuir : the ACS journal of surfaces and colloids.

Design of rolipram-loaded nanoparticles: comparison of two preparation methods.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, Journal of controlled release : official journal of the Controlled Release Society.

[Aerosolization of lactide/glycolide copolymer (PLGA) nanospheres for pulmonary delivery of peptide-drugs].

Y. Kawashima, T. Niwa, H. Takeuchi, 1995, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Use of Spouted Bed Type Binderless Granulation to Design PLGA Nano-composite Granules for Dry Powder Inhalation

Y. Kawashima, Shigenobu Hatano, Hiroyuki Tsujimoto, 2007 .

A new agglomerated KSR-592 beta-form crystal system for dry powder inhalation formulation to improve inhalation performance in vitro and in vivo.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Improvement in the variation of inhalation properties of an FK888 dry powder inhaler using an E-haler, by adding coarse lactose in spherical soft agglomerates of fine drug particles, and its absorption in healthy volunteers

Y. Kawashima, A. Ohike, R. Ibuki, 2005 .

Particulate Design for Inhalation Dosage Forms

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2002 .

Local Delivery of Imatinib Mesylate (STI571)–Incorporated Nanoparticle Ex Vivo Suppresses Vein Graft Neointima Formation

K. Sunagawa, Y. Kawashima, S. Kimura, 2008, Circulation.

Solubility and Dissolution Rate

Y. Kawashima, 2006 .

pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin

Y. Kawashima, F. Cui, Na Liang, 2015, International journal of nanomedicine.

Biodegradable Microsphere‐Loaded Tacrolimus Enhanced the Effect on Mice Islet Allograft and Reduced the Adverse Effect on Insulin Secretion

Y. Kawashima, Xiao‐Kang Li, M. Fujino, 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles: Formulation, characterization and in vivo evaluation

Y. Kawashima, F. Cui, Na Liang, 2010, Journal of microencapsulation.

A novel insulin-sodium oleate complex for oral administration: preparation, characterization and in vivo evaluation

Y. Kawashima, K. Shi, F. Cui, 2008 .

Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2005, International journal of pharmaceutics.

Prolonged Anti-Inflammatory Action of DL-Lactide/Glycolide Copolymer Nanospheres Containing Betamethasone Sodium Phosphate for an Intra-Articular Delivery System in Antigen-Induced Arthritic Rabbit

Y. Kawashima, H. Takeuchi, E. Horisawa, 2002, Pharmaceutical Research.

Observations in simultaneous microencapsulation of 5-fluorouracil and leucovorin for combined pH-dependent release.

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

Y. Kawashima, F. Cui, Na Liang, 2020, Polymers.

Surface-modified Antiasthmatic Dry Powder Aerosols Inhaled Intratracheally Reduce the Pharmacologically Effective Dose

Y. Kawashima, H. Takeuchi, T. Hino, 1998, Pharmaceutical Research.

A New Powder Design Method to Improve Inhalation Efficiency of Pranlukast Hydrate Dry Powder Aerosols by Surface Modification with Hydroxypropylmethylcellulose Phthalate Nanospheres

Y. Kawashima, H. Takeuchi, T. Hino, 1998, Pharmaceutical Research.

Interfacial Chemical Properties of Powder and Spherical Agglomeration in Liquid

Y. Kawashima, M. Nakashima, H. Takenaka, 1979 .

Tumor-targeting micelles based on folic acid and α-tocopherol succinate conjugated hyaluronic acid for paclitaxel delivery.

Y. Kawashima, Xin Zhang, F. Cui, 2019, Colloids and surfaces. B, Biointerfaces.

Improved Inhalation Behavior of Steroid KSR-592 in Vitro with Jethaler® by Polymorphic Transformation to Needle-Like Crystals (β-Form)

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2002, Pharmaceutical Research.

Simultaneous particulate design of primary and agglomerated crystals of steroid by spherical agglomeration in liquid for dry powder inhalation

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2003 .

A new spherically agglomerated drug composite system with lactose for dry powder inhalation

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2003 .

Primary crystal growth during spherical agglomeration in liquid: designing an ideal dry powder inhalation system

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2002 .

Particle design of Wogon extract dry powder for inhalation aerosols with granulation method

Y. Kawashima, T. Niwa, H. Takeuchi, 1998 .

Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan.

Y. Kawashima, H. Takeuchi, S. Frokjaer, 2007, International journal of pharmaceutics.

The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan-sodium tripolyphosphate complex.

S. Lin, Y. Kawashima, T. Handa, 1985, Chemical & pharmaceutical bulletin.

Design and evaluation of inhalable chitosan-modified poly (DL-lactic-co-glycolic acid) nanocomposite particles.

Y. Kawashima, H. Takeuchi, Mingshi Yang, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Shear-induced phase inversion and size control of water/oil/water emulsion droplets with porous membrane

Y. Kawashima, T. Niwa, H. Takeuchi, 1991 .

Formulation development of inhalation powders for FK888 with carrier lactose using Spinhaler and its absorption in healthy volunteers.

Y. Kawashima, A. Ohike, R. Ibuki, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Comparison of the lung absorption of FK224 inhaled from a pressurized metered dose inhaler and a dry powder inhaler by healthy volunteers.

Y. Kawashima, A. Ohike, R. Ibuki, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Future Perspectives of PLGA Nanospheres for Advanced DDSs and Continuous Preparation Systems for Spherical Crystallizers

Y. Kawashima, 2019, Spherical Crystallization as a New Platform for Particle Design Engineering.

FK506 Microparticles Mitigate Experimental Colitis with Minor Renal Calcineurin Suppression

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2005, Pharmaceutical Research.

New Particle Design and Its Preparation of NFkB Decoy Oligodeoxynucleotide (NDON) Loaded PLGA Nanospheres for Gene Delivery

Y. Kawashima, Hiroyuki Tsujimoto, K. Hara, 2007 .

Tabletting of solid dispersion particles consisting of indomethacin and porous silica particles.

Y. Kawashima, H. Takeuchi, S. Tanimura, 2005, Chemical & pharmaceutical bulletin.

Effectiveness of submicronized chitosan-coated liposomes in oral absorption of indomethacin

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2012, Journal of liposome research.

Drug Release from Tablets Containing Cellulose Acetate Phthalate As an Additive or Enteric-Coating Material

Y. Kawashima, Shan‐Yang Lin, Shan-yang Lin, 1987, Pharmaceutical Research.

Utilization of poly(DL-lactide-co-glycolide) nanoparticles for preparation of mini-depot tablets by direct compression.

Y. Kawashima, H. Takeuchi, M. Kobayashi, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Effects of Granulation Method and Drug Dissolved in Binder Solution on Compressibility of Granules

Y. Kawashima, T. Niwa, H. Takeuchi, 1990 .

PLGA Nanoparticle Design and Preparation for DDS and Medical Device

Y. Kawashima, Hiroyuki Tsujimoto, 2018 .

Fabrication of PLGA nano-particles utilizing the Marangoni phenomenon

Y. Kawashima, N. Miwa, Hiromitsu Yamamoto, 2012 .

Application 51 – PLGA nanoparticle design and preparation for DDS & medical device

Y. Kawashima, Hiroyuki Tsujimoto, 2012 .

Preparation of prolonged-release matrix tablet of acetaminophen with pulverized low-substituted hydroxypropylcellulose via wet granulation

Y. Kawashima, T. Niwa, H. Takeuchi, 1993 .

The Role of Binders in the Prevention of Capping within a Tablet

Y. Kawashima, K. Sugimori, S. Mori, 1989 .

Particle size control of poly(dl-lactide-co-glycolide) nanospheres for sterile applications.

R. Morishita, Y. Kawashima, Y. Kousaka, 2009, International journal of pharmaceutics.

pH-sensitive microparticles for oral drug delivery

Y. Kawashima, A. Lamprecht, 2006 .

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Y. Kawashima, F. Cui, Na Liang, 2018, International journal of molecular sciences.

Size-Dependency of DL-Lactide/Glycolide Copolymer Particulates for Intra-Articular Delivery System on Phagocytosis in Rat Synovium

Hirofumi Takeuchi, Katsuaki Kubota, Y. Kawashima, 2002, Pharmaceutical Research.

Solid-state characterization of sertraline base-β-cyclodextrin inclusion complex.

Y. Kawashima, T. Furuishi, Hiromitsu Yamamoto, 2015, Journal of pharmaceutical and biomedical analysis.

Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems.

Hirofumi Takeuchi, Y. Kawashima, H. Takeuchi, 2005, Advanced drug delivery reviews.

Interaction of fentanyl with various cyclodextrins in aqueous solutions

Y. Kawashima, C. Takahashi, T. Loftsson, 2016, The Journal of pharmacy and pharmacology.

Crystallographic evaluation of the conformation of quetiapine included in β-cyclodextrin.

Y. Kawashima, Hiromitsu Yamamoto, N. Ogawa, 2020, International journal of pharmaceutics.

Crystallographic and theoretical studies of an inclusion complex of β-cyclodextrin with fentanyl.

Y. Kawashima, C. Takahashi, T. Loftsson, 2017, International journal of pharmaceutics.

Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-β-cyclodextrin for oral insulin delivery.

Y. Kawashima, Na Liang, Siyi Li, 2021, Carbohydrate polymers.

Preparation of enteric-coated microcapsules for tableting by spray-drying technique and in vitro simulation of drug release from the tablet in GI tract.

S. Lin, Y. Kawashima, H. Takenaka, 1980, Journal of pharmaceutical sciences.

Method of evaluation of the bitterness of clarithromycin dry syrup.

Y. Kawashima, T. Yajima, S. Itai, 2002, Chemical & pharmaceutical bulletin.

Improvements in flowability and compressibility of pharmaceutical crystals for direct tabletting by spherical crystallization with a two-solvent system

Y. Kawashima, T. Niwa, H. Takeuchi, 1994 .

Particle design of tolbutamide in the presence of soluble polymer or surfactant by the spherical crystallization technique: improvement of dissolution rate.

Y. Kawashima, H. Takeuchi, T. Handa, 1987, Journal of pharmaceutical sciences.

Spherical Crystallization: Direct Spherical Agglomeration of Salicylic Acid Crystals During Crystallization

Y. Kawashima, Y Kawashima, M Okumura, 1982, Science.

Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method.

Yoshiaki, Kawashima, Y. Kawashima, 1999, International journal of pharmaceutics.

The improved compaction properties of mannitol after a moisture-induced polymorphic transition.

Peter York, Robert T Forbes, Y. Kawashima, 2003, International journal of pharmaceutics.

Physicochemical properties to determine the buoyancy of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Basic study for stabilization of w/o/w emulsion and its application to transcatheter arterial embolization therapy.

Y. Kawashima, T. Hino, Y Kawashima, 2000, Advanced drug delivery reviews.

In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2004 .

The influence of three poly(oxyethylene)poly(oxypropylene) surface-active block copolymers on the solubility behavior of indomethacin.

S. Lin, Y. Kawashima, 1986, Pharmaceutica acta Helvetiae.

A Novel Evaluation Method of Gastric Mucoadhesive Property in Vitro and the Mucoadhesive Mechanism of Tetracycline-Sucralfate Acidic Complex for Eradication of Helicobacter pylori

Y. Kawashima, H. Takeuchi, T. Hino, 2004, Pharmaceutical Research.

The Acidic Complexation of Tetracycline with Sucralfate for its Mucoadhesive Preparation

Y. Kawashima, H. Takeuchi, T. Hino, 2004, Drug development and industrial pharmacy.

Formulation design of ointment base suitable for healing of lesions in treatment of bedsores.

Y. Kawashima, H. Takeuchi, T. Hino, 2001, Chemical & pharmaceutical bulletin.

Mixed base of hydrophilic ointment and purified lanolin to improve the drug release rate and absorption of water of minocycline hydrochloride ointment for treatment of bedsores.

Y. Kawashima, H. Takeuchi, T. Hino, 1999, Chemical & pharmaceutical bulletin.

Crystallisation of amorphous mannitol is retarded using boric acid.

Y. Kawashima, P. York, R. Forbes, 2003, International journal of pharmaceutics.

O/W Emulsion of n-Alkylbenzene/Ionic Surfactant/Water Systems

Y. Kawashima, Y. Doi, Y. Moroi, 2004 .

Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions.

Shohei Sugimoto, Hirofumi Takeuchi, Y. Kawashima, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Temperature- and Moisture-Induced Crystallization of Amorphous Lactose in Composite Particles with Sodium Alginate Prepared by Spray-Drying

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2000, Pharmaceutical development and technology.

Preparation of spherical wax matrices of sulfamethoxazole by wet spherical agglomeration technique using a CMSMPR agglomerator

Y. Kawashima, Yoshiaki Kawashima, Yoshisuke Kurachi, 1982 .

Preparation of spherical matrixes of prolonged-release drugs from liquid suspension.

Y. Kawashima, H. Ohno, H. Takenaka, 1981, Journal of pharmaceutical sciences.

Design of sustained-release nitrendipine microspheres having solid dispersion structure by quasi-emulsion solvent diffusion method.

Y. Kawashima, Mingshi Yang, Dongmei Cun, 2003, Journal of controlled release : official journal of the Controlled Release Society.

The Transport Mechanism of an Organic Cation, Disopyramide, by Brush‐border Membranes. Comparison Between Renal Cortex and Small Intestine of the Rat

Y. Kawashima, K. Iseki, H. Saitoh, 1993, The Journal of pharmacy and pharmacology.

Design of pH-sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus.

Y. Kawashima, H. Takeuchi, A. Lamprecht, 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

A novel pH-dependent gradient-release delivery system for nitrendipine II. Investigations of the factors affecting the release behaviors of the system.

Y. Kawashima, Mingshi Yang, F. Cui, 2004, International journal of pharmaceutics.

Pharmacokinetic and immunosuppressive effects of tacrolimus‐loaded biodegradable microspheres

Y. Kawashima, T. Uno, H. Kawarasaki, 2004, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan.

S. Lin, Y. Kawashima, T. Handa, 1985, Journal of pharmaceutical sciences.

Controlled Release Theophylline Tablet with Acrylic Polymers Prepared by Spray-Drying Technique in Aqueous System

Y. Kawashima, H. Takeuchi, T. Handa, 1990 .

Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method.

T Niwa, K. Itoh, Y. Kawashima, 1990, Journal of pharmaceutical sciences.

Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method.

Hirofumi Takeuchi, Y. Kawashima, H. Takeuchi, 2005, International journal of pharmaceutics.

Particle design of tolbutamide by the spherical crystallization technique. III. Micromeritic properties and dissolution rate of tolbutamide spherical agglomerates prepared by the quasi-emulsion solvent diffusion method and the solvent change method.

Y. Kawashima, T. Niwa, H. Takeuchi, 1990, Chemical & pharmaceutical bulletin.

Particle Design of Tolbutamide by the Spherical Cystallization Technique. II. : Factors Causing Polymorphism of Tolbutamide Spherical Agglomerates

Y. Kawashima, T. Niwa, H. Takeuchi, 1989 .

Crystal modification of phenytoin with polyethylene glycol for improving mechanical strength, dissolution rate and bioavailability by a spherical crystallization technique.

Y. Kawashima, H. Takeuchi, T. Handa, 1986, Chemical & pharmaceutical bulletin.

Direct preparation of spherically agglomerated salicylic acid crystals during crystallization.

Y. Kawashima, H. Takenaka, M. Okumura, 1984, Journal of pharmaceutical sciences.

Improved flowability and compactibility of spherically agglomerated crystals of ascorbic acid for direct tableting designed by spherical crystallization process

Hirofumi Takeuchi, Y. Kawashima, H. Takeuchi, 2003 .

Reduced acid-neutralizing velocity of spray-dried agglomerated magnesium carbonate.

Y. Kawashima, H. Takenaka, 1974, Journal of pharmaceutical sciences.

Preparation of prolonged-release spherical micro-matrix of ibuprofen with acrylic polymer by the emulsion-solvent diffusion method for improving bioavailability.

Y. Kawashima, T. Niwa, H. Takeuchi, 1989, Chemical & pharmaceutical bulletin.

Improvement of solubility and dissolution rate of poorly water‐soluble salicylic acid by a spray‐drying technique

Y. Kawashima, H. Takenaka, M. Saito, 1975, The Journal of pharmacy and pharmacology.

In vitro and in vivo evaluation of riboflavin-containing microballoons for a floating controlled drug delivery system in healthy humans.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2004, International journal of pharmaceutics.

Improvement in the water solubility of drugs with a solid dispersion system by spray drying and hot‐melt extrusion with using the amphiphilic polyvinyl caprolactam‐polyvinyl acetate‐polyethylene glycol graft copolymer and d‐mannitol

Y. Kawashima, C. Takahashi, Hiromitsu Yamamoto, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation.

Y. Kawashima, K. Shi, Yoshiaki Kawashima, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Spherical solid dispersion containing amorphous tolbutamide embedded in enteric coating polymers or colloidal silica prepared by spray-drying technique.

Y. Kawashima, H. Takeuchi, T. Handa, 1987, Chemical & pharmaceutical bulletin.

Current status and approaches to developing press-coated chronodelivery drug systems.

Y. Kawashima, Shan-yang Lin, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Spray-Dried Lactose Composite Particles Containing an Ion Complex of Alginate-Chitosan for Designing a Dry-Coated Tablet Having a Time-Controlled Releasing Function

Hirofumi Takeuchi, Y. Kawashima, H. Takeuchi, 2001, Pharmaceutical Research.

Compaction Properties of Composite Particles Consisting of Lactose with Sodium Alginate Prepared by Spray-Drying

Y. Kawashima, H. Takeuchi, T. Hino, 1999, Pharmaceutical Research.

Drug Release Properties of the Microcapsules of Adriamycin Hydrochloride with Ethylcellulose Prepared by a Phase Separation Technique

Y. Kawashima, A. Kasai, H. Takenaka, 1984 .

A novel pH-dependent gradient-release delivery system for nitrendipine: I. Manufacturing, evaluation in vitro and bioavailability in healthy dogs.

Liang Wang, Mingshi Yang, Y. Kawashima, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Preparation of controlled releasing acrylic polymer microspheres of acebutolol hydrochloride and those powder coated microspheres with sodium alginate in a polymeric spherical crystallization system

Y. Kawashima, T. Niwa, H. Takeuchi, 1996 .

Design and evaluation of poly(DL-lactic-co-glycolic acid) nanocomposite particles containing salmon calcitonin for inhalation.

Y. Kawashima, H. Takeuchi, Mingshi Yang, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Preparation and characterization of a new controlled release ibuprofen suspension for improving suspendability

Y. Kawashima, T. Niwa, H. Takeuchi, 1991 .

Preparation and characteristics of microcapsules containing enoxacin by one continuous process of agglomeration and microencapsulation.

Y. Kawashima, H. Makita, Y. Nakamura, 1993, Journal of microencapsulation.

Micromeritic properties of sulfamethoxazole microcapsules prepared by gelatin-acacia coacervation.

S. Lin, Y. Kawashima, Y Kawashima, 1980, Journal of pharmaceutical sciences.

Reactivity of singlet oxygen generated by the photosensitization of tetraphenylporphyrin in liposomes

Y. Kawashima, H. Takeuchi, M. Nakagaki, 1988 .

Characterization of polymorphs of tranilast anhydrate and tranilast monohydrate when crystallized by two solvent change spherical crystallization techniques.

Y. Kawashima, T. Niwa, H. Takeuchi, 1991, Journal of pharmaceutical sciences.

Antibacterial activities of polymeric poly(DL-lactide-co-glycolide) nanoparticles and Soluplus® micelles against Staphylococcus epidermidis biofilm and their characterization

Y. Kawashima, C. Takahashi, Shoko Saito, 2015 .

Chitosan-modified poly(d,l-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects

Kohei Tahara, Y. Kawashima, N. Hirashima, 2009, European Journal of Pharmaceutics and Biopharmaceutics.

Formulation of nanoparticle-eluting stents by a cationic electrodeposition coating technology: efficient nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries.

K. Sunagawa, Y. Kawashima, K. Sueishi, 2009, JACC. Cardiovascular interventions.

Preparation of multiple unit hollow microspheres (microballoons) with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behavior (in vivo)

Y. Kawashima, T. Niwa, H. Takeuchi, 1991 .

Improved Static Compression Behaviors and Tablettabilities of Spherically Agglomerated Crystals Produced by the Spherical Crystallization Technique with a Two-Solvent System

Y. Kawashima, T. Niwa, H. Takeuchi, 1995, Pharmaceutical Research.

Preparation of Agglomerated Crystals for Direct Tabletting and Microencapsulation by the Spherical Crystallization Technique with a Continuous System

Y. Kawashima, T. Niwa, H. Takeuchi, 1994, Pharmaceutical Research.

Visualization of the Penetrative and Mucoadhesive Properties of Chitosan and Chitosan-Coated Liposomes Through the Rat Intestine

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2006, Journal of liposome research.

Ionic liquid-incorporated polymeric nanoparticles as carriers for prevention and at an earlier stage of periodontal disease

Y. Kawashima, M. Tanemura, C. Takahashi, 2019 .

Aqueous colloidal polymer dispersions of biodegradable DL-lactide/glycolide copolymer as basis for latex films: A new approach for the development of biodegradable depot systems

Y. Kawashima, T. Niwa, H. Takeuchi, 1995 .

Improvement of pulmonary absorption of cyclopeptide FK224 in rats by co-formulating with beta-cyclodextrin.

Y. Kawashima, A. Ohike, R. Ibuki, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel

Y. Kawashima, Pengfei Yan, F. Cui, 2019, Journal of Materials Science.

Visualization of silver-decorated poly (DL-lactide-co-glycolide) nanoparticles and their efficacy against Staphylococcus epidermidis.

Y. Kawashima, T. Asaka, M. Tanemura, 2017, Materials science & engineering. C, Materials for biological applications.

Morphological study of efficacy of clarithromycin-loaded nanocarriers for treatment of biofilm infection disease

Y. Kawashima, T. Asaka, M. Tanemura, 2017, Medical Molecular Morphology.

Nanomedical system for nucleic acid drugs created with the biodegradable nanoparticle platform

Y. Kawashima, K. Tahara, Hiromitsu Yamamoto, 2012, Journal of microencapsulation.

Die wall pressure measurement for evaluation of compaction property of pharmaceutical materials.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2004, International journal of pharmaceutics.

Effect of lubrication on the compaction properties of pharmaceutical excipients as measured by die wall pressure

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2005 .

Characterization of die wall pressure to predict capping of flat- or convex-faced drug tablets of various sizes

Shoichi Mori, Y. Kawashima, Yoshiaki Kawashima, 1989 .

Introduction of New Index for the Prediction of Capping Tendency of Tablets

Yoshiaki Kawashima, Ken-ichi Sugimori, Shoichi Mori, 1989 .

Moisture induced polymorphic transition of mannitol and its morphological transformation.

Peter York, Robert T Forbes, Y. Kawashima, 2002, International journal of pharmaceutics.

Carrier systems for the treatment of inflammatory bowel disease

Y. Kawashima, A. Lamprecht, C. Lehr, 2002 .

Prolonged circulation time of doxorubicin-loaded liposomes coated with a modified polyvinyl alcohol after intravenous injection in rats.

Y. Kawashima, H. Takeuchi, T. Hino, 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Preparations of solid particulates of theophylline--ethylenediamine complex by a spray-drying technique.

S. Lin, Y. Kawashima, Y. Ando, 1982, Journal of pharmaceutical sciences.

Polymer coating of liposomes with a modified polyvinyl alcohol and their systemic circulation and RES uptake in rats.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2000, Journal of controlled release : official journal of the Controlled Release Society.

In Vivo Evaluation of Two Novel Controlled-Release Nitrendipine Formulations

Y. Kawashima, Mingshi Yang, Dongmei Cun, 2005, Drug development and industrial pharmacy.

Computer simulation of agglomeration by a two-dimensional random addition model — agglomeration kinetics and micromeritic properties of agglomerate accompanied by compaction process

Yoshiaki Kawashima, Toshiyuki Niwa, Tetsuro Handa, 1989 .

An experimental study of the kinetics of the spherical crystallization of aylline sodium theophylline monohydrate

Y. Kawashima, H. Takenaka, M. Naito, 1983 .

An experimental study of the kinetics of spherical agglomeration in a stirred vessel

Y. Kawashima, C. E. Capes, Y. Kawashima, 1974 .

Uniform and improved bioavailability of newly developed rapid and sustained release suspensions of ibuprofen microspheres

Y. Kawashima, T. Niwa, H. Takeuchi, 1994 .

Preparation of directly compressible powders of a physical mixture and a complex of theophylline-phenobarbital using spray-drying

Y. Kawashima, M. Ueda, H. Takenaka, 1984 .

Direct preparation of solid particulates of aminopyrine-barbital complex (pyrabital) from droplets by a spray-drying technique.

S. Lin, Y. Kawashima, M. Ueda, 1983, Journal of Pharmacy and Science.

Spray Drying Agglomeration. I. Physicochemical Properties of Agglomerated Synthetic Aluminium Silicate or Magnesium Carbonate

Y. Kawashima, T. Yoneyama, H. Takenaka, 1971 .

The Effects of Interfacial Physical Properties on the Cohesive Forces of Moist Powder in Air and in Liquid

Y. Kawashima, H. Takenaka, J. Hishida, 1981 .

Surface Modification of Liposomes with Various Hydrophilic Polymers Bearing Hydrophobic Anchors and Their Circulation Properties.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2002 .

Passive targeting of doxorubicin with polymer coated liposomes in tumor bearing rats.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2001, Biological & pharmaceutical bulletin.

Enhanced Tumour Accumulation of Doxorubicin with Polymer‐coated Liposomes in Rats

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 1999 .

Hybrid-modified poly(D,L-lactide-co-glycolide) nanospheres for a novel cellular drug delivery system.

Kohei Tahara, Y. Kawashima, Yoshiaki Kawashima, 2010, International journal of pharmaceutics.

Indomethacin sustained-release suppositories containing sugar ester.

Y. Kawashima, T. Nakajima, A. Furuya, 1990, Chemical & pharmaceutical bulletin.

Drug releasing properties and tensile strength of dry-coated tablets prepared with spray-dried composite particles of lactose and sodium alginate

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2001 .

Optimization of ionic liquid-incorporated PLGA nanoparticles for treatment of biofilm infections.

Y. Kawashima, M. Fuji, M. Tanemura, 2019, Materials science & engineering. C, Materials for biological applications.

Development of Agglomerated Crystals of Ascorbic Acid for Direct Tableting by Spherical Crystallization Technique and Evaluation of Their Compactibilities

Y. Kawashima, H. Takeuchi, T. Hino, 2001 .

Chemical stability enhancement and cytotoxicity reduction of papain loaded in PLGA nanospheres

Y. Kawashima, J. Manosroi, A. Manosroi, 2014 .

Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS, by Changing Their Intraparticle Porosity

Y. Kawashima, T. Niwa, H. Takeuchi, 1992 .

Spherical Crystallization as a Novel Particle Design Technique for the Development of Pharmaceutical Preparations

Y. Kawashima, 1987 .

Multifunctional micelles self-assembled from hyaluronic acid conjugate for enhancing anti-tumor effect of paclitaxel

Y. Kawashima, Wei Zhao, Na Liang, 2020 .

A novel method for modifying AFM probe to investigate the interaction between biomaterial polymers (chitosan-coated PLGA) and mucin film.

Y. Kawashima, H. Takeuchi, Hiromitsu Yamamoto, 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Effects of polyethylene glycol on the size of agglomerated crystals of phenytoin prepared by the spherical crystallization technique.

Y. Kawashima, H. Takeuchi, T. Handa, 1986, Chemical & pharmaceutical bulletin.

Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique.

M. Ogawa, S. Lin, Y. Kawashima, 1985, Journal of pharmaceutical sciences.

Wet Spherical Agglomeration of Binary Mixtures. II. Mechanism and Kinetics of Agglomeration and the Crushing Strength of Agglomerates

Y. Kawashima, H. Takagi, H. Takenaka, 1981 .

Properties of liposomes coated with hydrophobically modified chitosan in oral liposomal drug delivery.

Y. Kawashima, H. Takeuchi, H. Yamamoto, 2006, Die Pharmazie.

A novel method for measuring rigidity of submicron-size liposomes with atomic force microscopy.

Y. Kawashima, H. Takeuchi, Y. Tozuka, 2008, International journal of pharmaceutics.

Mechanical properties, dissolution behavior and stability to oxidation of L-ascorbylmonostearate microcapsules prepared by a spray-drying polycondensation technique.

Y. Kawashima, Y. Ando, H. Takenaka, 1982, Chemical & pharmaceutical bulletin.