G. Brayer

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Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.

H. Baker, R. MacGillivray, A. Mason, 1998, Biochemistry.

Enzyme-substrate complexes of allosteric citrate synthase: evidence for a novel intermediate in substrate binding.

G. Brayer, A. Ayed, H. Duckworth, 2013, Biochimica et biophysica acta.

Probing the Roles of Key Residues in the Unique Regulatory NADH Binding Site of Type II Citrate Synthase of Escherichia coli*

G. Brayer, H. Duckworth, N. Nguyen, 2003, Journal of Biological Chemistry.

Refined structure of the gene 5 DNA binding protein from bacteriophage fd.

A. McPherson, G. Brayer, A McPherson, 1983, Journal of molecular biology.

Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment.

F Sherman, A. Warshel, G. Brayer, 1992, Journal of molecular biology.

Comparison of the predicted model of α-lytic protease with the X-ray structure

M. James, G. Brayer, L. Delbaere, 1979, Nature.

Evaluation of the Significance of Starch Surface Binding Sites on Human Pancreatic α-Amylase.

S. Withers, G. Brayer, E. Kwan, 2016, Biochemistry.

Structure of human salivary alpha-amylase at 1.6 A resolution: implications for its role in the oral cavity.

Y. Luo, G. Brayer, M. Levine, 1996, Acta crystallographica. Section D, Biological crystallography.

Role of phenylalanine-82 in yeast iso-1-cytochrome c and remote conformational changes induced by a serine residue at this position.

G J Pielak, G. Brayer, G. Louie, 1988, Biochemistry.

Analysis of the bimolecular reduction of ferricytochrome c by ferrocytochrome b5 through mutagenesis and molecular modelling.

G. Brayer, A. Mauk, L. Eltis, 1994, Biochimie.

The structure and function of omega loop A replacements in cytochrome c

J. Fetrow, M. Murphy, G. Brayer, 1993, Protein science : a publication of the Protein Society.

Crystallization of yeast iso-2-cytochrome c using a novel hair seeding technique.

G. Brayer, B. Nall, C. J. Leung, 1989, Journal of molecular biology.

Enhanced thermodynamic stabilities of yeast iso-1-cytochromes c with amino acid replacements at positions 52 and 102.

G. Brayer, A. Berghuis, J. Jaeger, 1991, The Journal of biological chemistry.

The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c.

G. Brayer, A. Berghuis, F. Sherman, 1994, Journal of molecular biology.

Three-dimensional structure of cyanomet-sulfmyoglobin C.

G. Brayer, A. Mauk, S. V. Evans, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Structure, Binding, and Activity of Syd, a SecY-interacting Protein*

G. Brayer, N. Nguyen, R. Maurus, 2009, Journal of Biological Chemistry.

Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.

S. Withers, G. Brayer, H. Suga, 2017, Cell chemical biology.

Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin

Emma L Raven, Christie L Hunter, Harry Tong, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Horse heart metmyoglobin. A 2.8-A resolution three-dimensional structure determination.

G. Brayer, S. V. Evans, 1988, The Journal of biological chemistry.

Replacements in a conserved leucine cluster in the hydrophobic heme pocket of cytochrome c

M. Murphy, G. Brayer, T. P. Lo, 1995, Protein science : a publication of the Protein Society.

Cloning, mutagenesis, and structural analysis of human pancreatic α‐amylase expressed in pichia pastoris

S. Withers, R. MacGillivray, G. Brayer, 2008, Protein science : a publication of the Protein Society.

Structure of the crystalline complex between ribonuclease A and D(pA)4.

A. McPherson, G. Brayer, R. Morrison, 1986, Biophysical journal.

Mechanistic Analysis of Trehalose Synthase from Mycobacterium smegmatis*

S. Withers, G. Brayer, A. Elbein, 2011, The Journal of Biological Chemistry.

Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.

David E. Williams, R. Andersen, G. Brayer, 2016, Journal of natural products.

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02610j

S. Withers, G. Brayer, S. Caner, 2019, Chemical science.

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha amylase

S. Withers, G. Brayer, S. Caner, 2019 .

The mechanism of binding of a polynucleotide chain to pancreatic ribonuclease.

A. McPherson, G. Brayer, D. Cascio, 1986, Science.

Structural characterization of heme ligation in the His64-->Tyr variant of myoglobin.

Y. Luo, G. Brayer, R. Maurus, 1994, The Journal of biological chemistry.

A preliminary structure for the DNA binding protein from bacteriophage IKe.

G. Brayer, 1987, Journal of biomolecular structure & dynamics.

Topological comparison of two helix destabilizing proteins: ribonuclease A and the gene 5 DNA binding protein.

A. McPherson, G. Brayer, 1985, Journal of biomolecular structure & dynamics.

A model for intracellular complexation between gene-5 protein and bacteriophage fd DNA.

A. McPherson, G. Brayer, 1985, European journal of biochemistry.

Mechanism of DNA binding to the gene 5 protein of bacteriophage fd.

A. McPherson, G. Brayer, 1984, Biochemistry.

Crystallization and preliminary diffraction data for iso-1-cytochrome c from yeast.

G. Brayer, C. Sherwood, Chris S. Sherwood, 1985, Journal of molecular biology.

Expression and characterization of human factor IX. Factor IXthr-397 and factor IXval-397.

L. Pedersen, P. Charifson, G. Brayer, 1991, The Journal of biological chemistry.

Thermodynamic cycles as probes of structure in unfolded proteins.

J. Chen, Y. Luo, G. Brayer, 1996, Biochemistry.

Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment.

G. Brayer, A. Berghuis, Michael B. Smith, 1994, Journal of molecular biology.

Preliminary crystallographic analyses of the N-terminal lobe of recombinant human serum transferrin.

R. MacGillivray, A. Mason, R. Woodworth, 1992, Journal of molecular biology.

FTIR analysis of the interaction of azide with horse heart myoglobin variants.

G. Brayer, R. Maurus, A. Mauk, 1994, Biochemistry.

The Biological Crystallization Resource: Facilitating Knowledge-Based Protein Crystallizations†

G. Brayer, Chunmin Li, Kevin Kirkwood, 2007 .

Luminal Substrate “Brake” on Mucosal Maltase-glucoamylase Activity Regulates Total Rate of Starch Digestion to Glucose

G. Brayer, B. Hamaker, S. Baker, 2007, Journal of pediatric gastroenterology and nutrition.

Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit.

G. Brayer, B. Hamaker, B. Nichols, 2008, The Journal of nutrition.

Crystal structure studies and inhibition kinetics of tripeptide chloromethyl ketone inhibitors with Streptomyces griseus protease B.

L. Delbaere, M. James, G. Brayer, 1980, Journal of molecular biology.

Canine hemophilia B resulting from a point mutation with unusual consequences.

G. Brayer, K. High, H. Reisner, 1989, Proceedings of the National Academy of Sciences of the United States of America.

High-resolution refinement of yeast iso-1-cytochrome c and comparisons with other eukaryotic cytochromes c.

G. Brayer, G. Louie, G D Brayer, 1990, Journal of molecular biology.

Structural model for the trialkyltin binding site on cat hemoglobin.

G. Brayer, A. Mauk, F. Taketa, 1985, Journal of biomolecular structure & dynamics.

A charge-transfer complex: bis(2,4,6-trimethyl-1-pyridyl)iodonium perchlorate

M. James, G. Brayer, 1982 .

Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein.

M. Murphy, G. Brayer, B. Nall, 1992, Journal of molecular biology.

High-resolution study of the three-dimensional structure of horse heart metmyoglobin.

G. Brayer, S. V. Evans, 1990, Journal of molecular biology.

Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure.

L. Delbaere, M. James, G. Brayer, 1985, Journal of molecular biology.

Molecular structure of the α-lytic protease from Myxobacter 495 at 2·8 Å resolution☆

L. Delbaere, M. James, G. Brayer, 1979 .

Molecular structure of crystalline Streptomyces griseus protease A at 2.8 A resolution. I. Crystallization, data collection and structural analysis.

L. Delbaere, M. James, G. Brayer, 1978, Journal of molecular biology.

Molecular structure of crystalline Streptomyces griseus protease A at 2.8 A resolution. II. Molecular conformation, comparison with alpha-chymotrypsin and active-site geometry.

L. Delbaere, M. James, G. Brayer, 1978, Journal of molecular biology.

Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity.

S. Withers, G. Brayer, R. Maurus, 2008, Biochemistry.

The Search for Novel Human Pancreatic α‐Amylase Inhibitors: High‐Throughput Screening of Terrestrial and Marine Natural Product Extracts

S. Withers, R. Andersen, G. Brayer, 2008, Chembiochem : a European journal of chemical biology.

Mechanism-based inhibition of yeast alpha-glucosidase and human pancreatic alpha-amylase by a new class of inhibitors. 2-Deoxy-2,2-difluoro-alpha-glycosides.

S. Withers, G. Brayer, S G Withers, 1995, The Journal of biological chemistry.

Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.

S. Withers, G. Brayer, E. H. Rydberg, 2002, Biochemistry.

The structure of human pancreatic α‐amylase at 1.8 Å resolution and comparisons with related enzymes

S. Withers, Y. Luo, G. Brayer, 1995, Protein science : a publication of the Protein Society.

Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis.

S. Wattler, M. Nehls, G. Brayer, 2007, The Journal of nutrition.

High-resolution three-dimensional structure of horse heart cytochrome c.

G. Brayer, G. Louie, G D Brayer, 1990, Journal of molecular biology.

Structural and mechanistic studies of chloride induced activation of human pancreatic α‐amylase

S. Withers, G. Brayer, C. Overall, 2005, Protein science : a publication of the Protein Society.

Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.

S. Withers, G. Brayer, L. K. Williams, 2012, Journal of medicinal chemistry.

Acarbose rearrangement mechanism implied by the kinetic and structural analysis of human pancreatic alpha-amylase in complex with analogues and their elongated counterparts.

S. Withers, G. Brayer, Shin Numao, 2004, Biochemistry.

The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif.

S. Withers, David E. Williams, R. Andersen, 2015, Nature chemical biology.

The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates.

L. Delbaere, G. Brayer, G D Brayer, 1985, Journal of molecular biology.

Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis.

L. Delbaere, M. James, G. Brayer, 1980, Journal of molecular biology.

Structure of the complex formed between the bacterial-produced inhibitor chymostatin and the serine enzyme Streptomyces griseus protease A.

L. Delbaere, G. Brayer, 1980, Journal of molecular biology.

Crystal and molecular structure of paclitaxel (taxol).

D. Mastropaolo, A. Camerman, N. Camerman, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and testing of 2-deoxy-2,2-dihaloglycosides as mechanism-based inhibitors of alpha-glycosidases.

S. Withers, G. Brayer, J. McCarter, 2008, The Journal of organic chemistry.

Crystallographic and kinetic investigations of the covalent complex formed by a specific tetrapeptide aldehyde and the serine protease from Streptomyces griseus.

L. Delbaere, M. James, G. Brayer, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Amino acid sequence alignment of bacterial and mammalian pancreatic serine proteases based on topological equivalences.

L. Delbaere, M. James, G. Brayer, 1978, Canadian journal of biochemistry.

Structural basis of collagen fiber degradation by cathepsin K

G. Brayer, N. Nguyen, Xin Du, 2014, Proceedings of the National Academy of Sciences.

A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket.

Y. Luo, G. Brayer, C. Overall, 1997, Biochimica et biophysica acta.

Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.

M. D. Joshi, S. Withers, J. Nielsen, 2001, Biochemistry.

Yeast iso-1-cytochrome c. A 2.8 A resolution three-dimensional structure determination.

G. Brayer, G. Louie, W. Hutcheon, 1988, Journal of molecular biology.

Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.

R T MacGillivray, G. Brayer, G. Louie, 1985, The Journal of biological chemistry.

Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes.

G. Brayer, A. Ayed, H. Duckworth, 2001, Biochemistry.

Mutagenic, electrochemical, and crystallographic investigation of the cytochrome b5 oxidation-reduction equilibrium: involvement of asparagine-57, serine-64, and heme propionate-7.

G. Brayer, W. Funk, M. R. Mauk, 1990, Biochemistry.

Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase.

S. Withers, G. Brayer, Ran Zhang, 2009, Biochemistry.

Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.

M. D. Joshi, S. Withers, G. Brayer, 2000, Journal of molecular biology.

Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.

S. Withers, Y. Wang, G. Brayer, 2000, Biochemistry.

Protein structure refinement: Streptomyces griseus serine protease A at 1.8 A resolution.

L. Delbaere, M. James, G. Brayer, 1979, Journal of molecular biology.

Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants.

G. Brayer, R. Maurus, A. Mauk, 1995, Biochemistry.

Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases.

G. Brayer, A. Ayed, H. Duckworth, 2003, Biochemistry.

Electrostatic modification of the active site of myoglobin: characterization of the proximal Ser92Asp variant.

G. Brayer, D. Burk, R. Maurus, 1996, Biochemistry.

Structural basis for regulation in gram-negative bacterial citrate synthases.

G. Brayer, H. Duckworth, L. Donald, 1987, Biochemical Society symposium.

Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide

S. Withers, L. Foster, R. Andersen, 2016, ACS central science.

Large-scale purification and biochemical characterization of crystallization-grade porin protein P from Pseudomonas aeruginosa.

R. Hancock, G. Brayer, C. Kay, 1988, Biochimica et biophysica acta.

Crystal structures of two mutants (K206Q, H207E) of the N‐lobe of human transferrin with increased affinity for iron

A. Mason, R. Woodworth, M. Murphy, 2008, Protein science : a publication of the Protein Society.

Crystal structure of RNase A complexed with d(pA)4.

A. McPherson, G. Brayer, R. Morrison, 1986, Journal of molecular biology.

Thermal stability of hydrophobic heme pocket variants of oxidized cytochrome c

G. Brayer, B. Nall, T. P. Lo, 1999, Protein science : a publication of the Protein Society.

Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase

G. Brayer, M. Trellet, A. Bonvin, 2019, ACS chemical biology.

A polypeptide chain-refolding event occurs in the Gly82 variant of yeast iso-1-cytochrome c.

G. Brayer, G. Louie, Gordon V. Louie, 1989, Journal of molecular biology.

Mapping antibody binding sites on cytochrome c with synthetic peptides: Are results representative of the antigenic structure of proteins?

G. Brayer, H. Bosshard, T. P. Lo, 1993, Protein science : a publication of the Protein Society.

Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.

G. Brayer, N. Nguyen, D. Brömme, 2017, The Biochemical journal.

The proximal ligand variant His93Tyr of horse heart myoglobin.

G. Brayer, D. Burk, R. Maurus, 1995, Biochemistry.

Glucose lowering effect of montbretin A in Zucker Diabetic Fatty rats

S. Withers, R. Andersen, G. Brayer, 2015, Molecular and Cellular Biochemistry.

Active Site of α-Lytic Protease

M. James, G. Brayer, C. Bauer, 1981 .

The 2.8 A resolution structure of Streptomyces griseus protease B and its homology with alpha-chymotrypsin and Streptomyces griseus protease A.

L. Delbaere, M. James, G. Brayer, 1979, Canadian Journal of Biochemistry.

Cooperative interactions of the gene 5 protein.

A. McPherson, G. Brayer, 1984, Journal of biomolecular structure & dynamics.

Mechanistic and structural contributions of critical surface and internal residues to cytochrome c electron transfer reactivity.

G. Brayer, A. Berghuis, A. Mauk, 1996, Biochemistry.

Oxidation state-dependent conformational changes in cytochrome c.

G. Brayer, A. Berghuis, 1992, Journal of molecular biology.

In Situ Extension as an Approach for Identifying Novel α-Amylase Inhibitors*

Christopher M Overall, S. Withers, G. Brayer, 2004, Journal of Biological Chemistry.

The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode.

Ran Zhang, S. Withers, G. Brayer, 2013, Glycobiology.

Structural and spectroscopic studies of azide complexes of horse heart myoglobin and the His-64-->Thr variant.

G. Brayer, N. Nguyen, R. Maurus, 1998, The Biochemical journal.

Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.

S. Withers, G. Brayer, C. Overall, 2002, Biochemistry.

Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase.

S. Withers, G. Brayer, L. McIntosh, 1999, Biochemistry.

Structural studies of the roles of residues 82 and 85 at the interactive face of cytochrome c.

G. Brayer, G. Louie, M. Smith, 1994, Biochemistry.

Synthesis and characterisation of novel chromogenic substrates for human pancreatic α-amylase

S. Withers, G. Brayer, Hongming Chen, 2004 .

Glucosyl epi‐cyclophellitol allows mechanism‐based inactivation and structural analysis of human pancreatic α‐amylase

S. Withers, G. Brayer, N. Nguyen, 2016, FEBS letters.

Critical evaluation of comparative model building of Streptomyces griseus trypsin.

R J Read, R. Read, M. James, 1984, Biochemistry.

Preliminary diffraction data for crystals of ribonucleases A and B and their complexes with deoxy(pA)4 and deoxy(pA)6.

A. McPherson, G. Brayer, 1982, The Journal of biological chemistry.

Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models.

Evgenia V. Dueva, M. Gleave, A. Zoubeidi, 2019, The Journal of clinical investigation.

Montbretin A analogue M06-MbA in complex with Human pancreatic alpha-amylase

S. Withers, G. Brayer, S. Caner, 2019 .

Oxidation state-dependent conformational changes in cytochrome c.

G. Brayer, A. Berghuis, 1992, Journal of molecular biology.

The structure of the Mycobacterium smegmatis trehalose synthase reveals an unusual active site configuration and acarbose-binding mode.

S. Withers, G. Brayer, N. Nguyen, 2013, Glycobiology.

Glucose lowering effect of montbretin A in Zucker Diabetic Fatty rats

S. Withers, R. Andersen, G. Brayer, 2015, Molecular and Cellular Biochemistry.

Structural and functional effects of multiple mutations at distal sites in cytochrome c.

G. Brayer, F. Sherman, G. Mclendon, 1995, Biochemistry.

HUMAN SERUM TRANSFERRIN

R. MacGillivray, A. Mason, R. Woodworth, 2000 .