N. Young

Xingmin Feng, N. Young, J. Maciejewski, 2010, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Acquired aplastic anemia.

N. Young, 1999, Annals of internal medicine.

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.

S. Kajigaya, N. Young, C. Stratakis, 2009, Blood.

Monoclonal gammopathy‐associated pure red cell aplasia

N. Young, A. Zingone, O. Simakova, 2016, British journal of haematology.

Effects of rosuvastatin on the immune system in healthy volunteers with normal serum cholesterol.

Y. Kotliarov, N. Young, M. Fessler, 2019, JCI insight.

Treatment of severe aplastic anaemia with combined immunosuppression: anti‐thymocyte globulin, ciclosporin and mycophenolate mofetil

N. Young, P. Scheinberg, Colin O. Wu, 2006, British journal of haematology.

Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.

N. Young, R. Cohen, C. Dunbar, 1996, Blood.

Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking glutathione S‐transferase genes

N. Young, Johnson M Liu, M. Stacey, 2004, Pediatric blood & cancer.

Regulation of human globin gene expression in mouse erythroleukemia × human fibroblast hybrid cells

W. Anderson, N. Young, M. Willing, 1982, Somatic cell genetics.

GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia.

S. Holland, N. Young, S. Rosenzweig, 2015, Blood.

Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen).

N. Young, K. Brown, J. Hibbs, 1994, The New England journal of medicine.

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

J. P. McCoy, F. Marincola, Manikandan Narayanan, 2014, Cell.

RabbitATG but not horseATG promotes expansion of functional CD4CD25 high FOXP3 regulatory T cells in vitro

P. Munson, N. Raghavachari, Xingmin Feng, 2017 .

Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.

P. Munson, N. Raghavachari, Xingmin Feng, 2007, Blood.

Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.

Thomas E. Hughes, F. Marincola, Y. Kotliarov, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background.

Jichun Chen, N. Young, J. McCoy, 2007, Human molecular genetics.

Effect of anticoagulants on multiplexed measurement of cytokine/chemokines in healthy subjects.

J. P. McCoy, Xingmin Feng, N. Young, 2012, Cytokine.

Telomere Length Dynamics in Normal Individuals and in Patients with Hematopoietic Stem Cell‐Associated Disorders

T. Brümmendorf, P. Lansdorp, N. Young, 2001, Annals of the New York Academy of Sciences.

Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag

Xingmin Feng, N. Young, Colin O. Wu, 2021, Haematologica.

Hematopoietic inhibition by interferon-gamma is partially mediated through interferon regulatory factor-1.

N. Young, C. Selleri, J. Maciejewski, 1995, Blood.

Selective reduction of natural killer T cells in the bone marrow of aplastic anaemia

S. Kajigaya, N. Young, J. Maciejewski, 2002, British journal of haematology.

An invertebrate coagulation system activated by endotoxin: evidence for enzymatic mediation.

N. Young, J. Levin, R. A. Prendergast, 1972, The Journal of clinical investigation.

Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial.

Thomas E. Hughes, G. Marti, S. Pittaluga, 2015, The Lancet. Oncology.

The treatment of severe acquired aplastic anemia.

N. Young, A. Barrett, 1995, Blood.

Phenotypic and functional analysis of bone marrow progenitor cell compartment in bone marrow failure

N. Young, J. Maciejewski, S. Anderson, 1994, British journal of haematology.

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure.

M. Desierto, N. Young, J. Chen, 2010, Blood.

The pathophysiology of acquired aplastic anemia.

N. Young, J. Maciejewski, 1997, The New England journal of medicine.

New Insights into the Pathophysiology of Acquired Cytopenias.

J. Abkowitz, N. Young, L. Luzzatto, 2000, Hematology. American Society of Hematology. Education Program.

The graft-versus-leukemia effect of nonmyeloablative stem cell allografts may not be sufficient to cure chronic myelogenous leukemia

S. Solomon, N. Young, R. Childs, 2003, Bone Marrow Transplantation.

Circulating activated suppressor T lymphocytes in aplastic anemia.

N. Young, J. Djeu, N. Zoumbos, 1985, The New England journal of medicine.

Danazol Treatment for Telomere Diseases.

B. Dumitriu, N. Young, D. Townsley, 2016, The New England journal of medicine.

Current concepts in the pathophysiology and treatment of aplastic anemia.

N. Young, P. Scheinberg, R. Calado, 2006, Blood.

Translational regulation of B19 parvovirus capsid protein production by multiple upstream AUG triplets.

N. Young, K. Ozawa, J. Ayub, 1988, The Journal of biological chemistry.

Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1.

N. Young, S. Koenig, W. Ballou, 2003, The Journal of infectious diseases.

Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients.

N. Young, P. Scheinberg, E. Sloand, 2008, Experimental hematology.

Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia

N. Young, J. Maciejewski, S. Anderson, 1995, British journal of haematology.

Serum sickness and haematopoietic recovery with antithymocyte globulin in bone marrow failure patients

N. Young, A. Nienhuis, M. Frank, 1986, British journal of haematology.

Minimal role of interleukin 6 and toll-like receptor 2 and 4 in murine models of immune-mediated bone marrow failure

Xingmin Feng, Jichun Chen, N. Young, 2021, PloS one.

Natural history of pulmonary fibrosis in two subjects with the same telomerase mutation.

W. Gahl, N. Young, J. Moss, 2011, Chest.

Mutation Subjects With the Same Telomerase Natural History of Pulmonary Fibrosis in Two

W. Gahl, N. Young, J. Moss, 2011 .

Antithymocyte globulin for patients with myelodysplastic syndrome

N. Young, A. Barrett, J. Molldrem, 1997, British journal of haematology.

Gamma-Interferon Gene Expression in the Bone Marrow of Patients with Aplastic Anemia

N. Young, A. Nisticò, 1994, Annals of Internal Medicine.

A prospective clinical and immunologic analysis of patients with serum sickness.

N. Young, K. Yancey, M. Frank, 1984, The New England journal of medicine.

Heterozygous RTEL1 variants in bone marrow failure and myeloid neoplasms.

Soma Das, G. Mufti, Xingmin Feng, 2018, Blood advances.

Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults

Xingmin Feng, Jichun Chen, N. Young, 2020, Stem cells.

Mutations in the SBDS gene in acquired aplastic anemia.

S. Chanock, P. Lansdorp, S. Kajigaya, 2007, Blood.

HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome.

N. Young, A. Barrett, J. Maciejewski, 2002, Blood.

Immunologic effects on the haematopoietic stem cell in marrow failure.

N. Young, V. Giudice, B. Patel, 2021, Best practice & research. Clinical haematology.

A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome

S. Kajigaya, N. Young, R. Calado, 2014, BMC Medical Genetics.

A severe and consistent deficit in marrow and circulating primitive hematopoietic cells (long-term culture-initiating cells) in acquired aplastic anemia.

N. Young, S. Anderson, C. Selleri, 1996, Blood.

Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure.

Xingmin Feng, Jichun Chen, K. Keyvanfar, 2019, Experimental hematology.

Dyskeratosis congenita: The first NIH clinical research workshop

M. Greene, J. Tolar, S. Savage, 2009, Pediatric blood & cancer.

Myelodysplastic syndromes.

P. Greenberg, N. Young, N. Gattermann, 2013, Hematology. American Society of Hematology. Education Program.

A pilot study of the recombinant soluble human tumour necrosis factor receptor (p75)‐Fc fusion protein in patients with myelodysplastic syndrome

N. Geller, N. Young, J. Maciejewski, 2002, British journal of haematology.

Transcript profile of CD4+ and CD8+ T cells from the bone marrow of acquired aplastic anemia patients.

S. Kajigaya, N. Young, A. Risitano, 2004, Experimental hematology.

Brief Communication: Successful Treatment of Pure Red-Cell Aplasia with an AntiInterleukin-2 Receptor Antibody (Daclizumab)

N. Young, P. Scheinberg, J. Maciejewski, 2006, Annals of Internal Medicine.

Age-adjusted recipient pretransplantation telomere length and treatment-related mortality after hematopoietic stem cell transplantation.

M. Robin, N. Young, J. Larghero, 2011, Blood.

Telomere length in leukocyte subpopulations of patients with aplastic anemia.

T. Brümmendorf, N. Young, J. Maciejewski, 2001, Blood.

Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions.

S. Kajigaya, N. Young, L. Anderson, 1991, Proceedings of the National Academy of Sciences of the United States of America.

4 Viruses and bone marrow failure

N. Young, G. Kurtzman, 1989 .

hemoglobinuria cells after erythrocyte transfusion in paroxysmal nocturnal Transfer of glycosylphosphatidylinositol-anchored proteins to deficient

Jichun Chen, K. Keyvanfar, N. Young, 2004 .

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia.

S. Chanock, S. Savage, N. Young, 2006, Experimental hematology.

Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses.

N. Young, A. Barrett, N. Hensel, 1999, Blood.

Human Parvovirus B19 (Preliminary Pages)

N. Young, L. Anderson, 1997 .

Congenital anaemia after transplacental B19 parvovirus infection

N. Young, J. Bellanti, K. Brown, 1994, The Lancet.

Chronic bone marrow failure due to persistent B19 parvovirus infection.

N. Young, G. Kurtzman, B. Cohen, 1987, The New England journal of medicine.

Adeno-associated virus type 2 binds to a 150-kilodalton cell membrane glycoprotein.

N. Young, H. Mizukami, K. Brown, 1996, Virology.

Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells.

R. Samulski, N. Young, A. Nienhuis, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector.

R. Samulski, N. Young, A. Nienhuis, 1994, The Journal of clinical investigation.

Correction of the PNH defect by GPI-anchored protein transfer.

B. Brewer, N. Young, J. Moss, 1998, Blood.

A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins.

J. Yu, N. Young, J. Liu, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Research directions in paroxysmal nocturnal hemoglobinuria.

N. Young, R. Ware, C. Parker, 1999, Immunology today.

Parvovirus B19 Infection

N. Young, K. Brown, 1997 .

Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes

N. Young, G. Alkorta-Aranburu, D. del Gaudio, 2017, Leukemia.

Sustained long‐term hematologic recovery despite a marked quantitative defect in the stem cell compartment of patients with aplastic anemia after immunosuppressive therapy

N. Young, E. Sloand, C. Selleri, 2000, American journal of hematology.

Interphase Chromosome Flow-FISH.

K. Keyvanfar, S. Kajigaya, N. Young, 2012, Blood.

The relationship of aplastic anemia and PNH

N. Young, J. Maciejewski, A. Risitano, 2002, International journal of hematology.

Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure Syndromes

N. Young, P. Boccuni, Spencer Green, 1999, Annals of Internal Medicine.

Circulating S100A8 and S100A9 protein levels in plasma of patients with acquired aplastic anemia and myelodysplastic syndromes

S. Kajigaya, N. Young, Foo Cheung, 2019, Cytokine.

Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol‐anchored protein‐deficient clones

N. Young, J. Maciejewski, H. Kook, 2001, British journal of haematology.

Horse versus rabbit antithymocyte globulin in acquired aplastic anemia.

N. Young, P. Scheinberg, A. Biancotto, 2011, The New England journal of medicine.

Coincident myelodysplastic syndrome and T‐cell large granular lymphocytic disease: clinical and pathophysiological features

N. Young, M. Stetler-Stevenson, Y. Saunthararajah, 2001, British journal of haematology.

The problem of clonality in aplastic anemia: Dr Dameshek's riddle, restated.

N. Young, 1992, Blood.

Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia.

N. Young, W. Zeng, J. Maciejewski, 2001, Experimental hematology.

Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein.

N. Young, J. Maciejewski, A. Risitano, 2002, Blood.

Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia

R. Pieters, A. Baruchel, S. Kajigaya, 2012, Leukemia.

Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes

N. Young, C. Dunbar, D. Townsley, 2013, International Journal of Hematology.

Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH/aplastic anemia syndrome.

D. Follmann, N. Young, Y. Saunthararajah, 2001, Blood.

Suppression of Cyclin D 1 (CD1) by on 01910.Na Is Associated with Decreased Survival or Trisomy 8 Myelodysplastic Bone Marrow: A Potential Targetted Therapy for Trisomy 8 MDS.

N. Young, E. Sloand, L. Pfannes, 2008 .

Suppression of Cyclin D1 by on 01910.Na Is Associated with Decreased Survival of Trisomy 8 Myelodyplastic Bone Marrow Progenitors: A Potential Targetted Therapy.

N. Young, E. Sloand, L. Pfannes, 2007 .

Determining which patients with myelodysplastic syndrome will respond to immunosuppressive treatment.

N. Young, E. Sloand, J. Barrett, 2006, Haematologica.

Immunosuppressive Treatment of Acquired Aplastic Anemia and Immune-Mediated Bone Marrow Failure Syndromes

N. Young, 2002, International journal of hematology.

The Etiology of Acquired Aplastic Anemia

N. Young, 2000 .

Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia.

N. Young, 2000, Seminars in hematology.

Biological and immunological characterization of ATG and ALG

N. Young, A. Gratwohl, B. Speck, 1986 .

Alemtuzumab Is Safe and Associated With High Response Rates In Selected Patients With Myelodysplastic Syndrome

N. Young, C. Hourigan, P. Scheinberg, 2013 .

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes

J. P. McCoy, R. Ganetzky, Xingmin Feng, 2011, Haematologica.

Somatic Mutations in "Benign" Disease.

S. Mustjoki, N. Young, 2021, The New England journal of medicine.

VEXAS syndrome

N. Young, P. Grayson, B. Patel, 2021, Blood.

Successful surgical management of neutropenic enterocolitis in two patients with severe aplastic anemia. Case reports and review of the literature.

N. Young, I. Feuerstein, P. Pizzo, 1993, Archives of internal medicine.

Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".

N. Young, J. Maciejewski, 2000, The Journal of clinical investigation.

Detectable mutations precede late myeloid neoplasia in aplastic anemia

N. Young, M. Goswami, C. Hourigan, 2020, Haematologica.

TO WILMS TUMOR PROTEIN ( WT 1 ) IN MYELODYSPLASIA RESPONSIVE TO IMMUNOSUPPRESSIVE THERAPY ( IST )

D. Douek, J. Brenchley, N. Young, 2010 .

Mobilization, collection, and immunomagnetic selection of peripheral blood CD34 cells in recovered aplastic anemia patients

N. Young, P. Scheinberg, J. Maciejewski, 2007, Transfusion.

Pathophysiologic mechanisms in acquired aplastic anemia.

N. Young, 2006, Hematology. American Society of Hematology. Education Program.

Genomic instability in bone marrow failure syndromes

N. Young, J. Maciejewski, Johnson M Liu, 2004, American journal of hematology.

Late complications following treatment for severe aplastic anemia (SAA) with high-dose cyclophosphamide (Cy): follow-up of a randomized trial.

N. Young, J. Maciejewski, J. Tisdale, 2002, Blood.

Long-term follow-up of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab

N. Young, P. Scheinberg, J. Maciejewski, 2010, Haematologica.

Recombinant humanized anti-IL-2 receptor antibody (daclizumab) produces responses in patients with moderate aplastic anemia.

N. Young, J. Maciejewski, E. Sloand, 2003, Blood.

Parvoviruses and Bone Marrow Failure

N. Young, K. Brown, 1996, Stem cells.

A trial of immunotherapy in aplastic anemia and pure red cell aplasia

N. Young, A. Nienhuis, P. Griffith, 1983, Journal of clinical apheresis.

Analysis of natural killer cells in patients with aplastic anemia.

N. Young, N. Zoumbos, P. Gascón, 1986, Blood.

Superior growth of glycophosphatidy linositol-anchored protein-deficient progenitor cells in vitro is due to the higher apoptotic rate of progenitors with normal phenotype in vivo.

N. Young, J. Maciejewski, Guibin Chen, 2002, Experimental hematology.

Acquired Aplastic Anemia

N. Young, 2002, Annals of Internal Medicine.

Hepatitis-associated aplastic anemia.

N. Young, A. Barrett, J. Tisdale, 1997, The New England journal of medicine.

Infection of hematopoietic progenitor cells by human cytomegalovirus.

N. Young, J. Maciejewski, S. S. St. Jeor, 1992, Blood.

Neutropenia associated with large granular lymphocytes responsive to corticosteroids in vitro and in vivo

N. Young, L. Platanias, E. Raefsky, 1987, European journal of haematology.

In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation.

J. P. McCoy, R. Srinivasan, N. Young, 2004, Blood.

Centrosome amplification and aneuploidy in bone marrow failure patients

N. Young, Johnson M Liu, W. Kearns, 2004, Genes, chromosomes & cancer.

Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network, March 2010.

H. Deeg, J. Tolar, S. Savage, 2011, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial

N. Geller, N. Young, A. Barrett, 2000, The Lancet.

High-dose cyclophosphamide for treatment of aplastic anemia.

N. Young, J. Tisdale, 2002, Annals of internal medicine.

Cyclosporine is required to prevent severe acute GVHD following T-cell-depleted peripheral blood stem cell transplantation

N. Young, A. Barrett, R. Childs, 2003, Bone Marrow Transplantation.

HLA‐DR4 predicts haematological response to cyclosporine in T‐large granular lymphocyte lymphoproliferative disorders

N. Young, A. Barrett, Y. Saunthararajah, 2003, British journal of haematology.

Cutaneous manifestations of serum sickness in patients receiving antithymocyte globulin.

N. Young, K. Yancey, M. Frank, 1985, Journal of the American Academy of Dermatology.

A study of human serum sickness.

N. Young, K. Yancey, M. Frank, 1985, The Journal of investigative dermatology.

Clinical and laboratorv studies Cutaneous manifestations of serum sickness patients receiving antithymocyte globulin

N. Young, K. Yancey, M. Frank, 1985 .

mouse model of infusion-induced bone marrow failure Bystander destruction of hematopoietic progenitor and stem cells in a

Jichun Chen, N. Young, R. Calado, 2012 .

Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure.

Jichun Chen, N. Young, R. Calado, 2004, Blood.

Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells

N. Raghavachari, Jichun Chen, M. Desierto, 2010, Haematologica.

Frequent HPRT mutations in paroxysmal nocturnal haemoglobinuria reflect T cell clonal expansion, not genomic instability

N. Young, Guibin Chen, W. Zeng, 2004, British journal of haematology.

Cytogenetic abnormalities in paroxysmal nocturnal haemoglobinuria usually occur in haematopoietic cells that are glycosylphosphatidylinositol‐anchored protein (GPI‐AP) positive

K. Keyvanfar, N. Young, A. Barrett, 2003, British journal of haematology.

Infection of mononucleated phagocytes with human cytomegalovirus.

N. Young, J. Maciejewski, S. Sellers, 1993, Virology.

Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study

N. Young, P. Scheinberg, E. Sloand, 2009, Haematologica.

Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia

N. Young, P. Scheinberg, Colin O. Wu, 2009, British journal of haematology.

Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia.

K. Rezvani, K. Keyvanfar, D. Malide, 2007, Blood.

Cytokine gene polymorphisms in acquired bone marrow failure

N. Young, S. Ramkissoon, E. Sloand, 2007, American journal of hematology.

Retreatment with rabbit anti‐thymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia

N. Young, P. Scheinberg, O. Nuñez, 2006, British journal of haematology.

Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia.

D. Follmann, N. Young, J. Maciejewski, 2002, Blood.

human primary hematopoietic cells gene, increase telomerase activity in TERT Sex hormones, acting on the

S. Kajigaya, N. Young, C. Stratakis, 2012 .

Establishment of an erythroid cell line from primary CD36+ erythroid progenitor cells.

K. Keyvanfar, S. Kajigaya, N. Young, 2010, Experimental hematology.

Ex Vivo-Generated CD36 (cid:1) Erythroid Progenitors Are Highly Permissive to Human Parvovirus B19 Replication (cid:1)

K. Keyvanfar, S. Kajigaya, N. Young, 2008 .

Ex Vivo-Generated CD36+ Erythroid Progenitors Are Highly Permissive to Human Parvovirus B19 Replication

K. Keyvanfar, S. Kajigaya, N. Young, 2007, Journal of Virology.

Analysis of lymphocyte subsets in patients with aplastic anaemia

N. Young, A. Nienhuis, R. Humphries, 1984, British journal of haematology.

Rapamycin is highly effective in murine models of immune-mediated bone marrow failure

Xingmin Feng, Jichun Chen, P. Muranski, 2017, Haematologica.

Infections in patients with aplastic anemia.

N. Young, P. Scheinberg, T. Walsh, 2009, Seminars in hematology.

Identification of a novel simian parvovirus in cynomolgus monkeys with severe anemia. A paradigm of human B19 parvovirus infection.

N. Young, J. Fikes, M. G. O’Sullivan, 1994, The Journal of clinical investigation.

Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria

N. Young, J. Szer, R. Geller, 2008, British journal of haematology.

Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4

Jichun Chen, N. Young, Yongmin Tang, 2009, British journal of haematology.

Deficient CD 4 CD 25 FOXP 3 T regulatory cells in acquired aplastic anemia

K. Rezvani, K. Keyvanfar, D. Malide, 2007 .

Biological and immunological characterization of ATG and ALG.

N. Young, A. Gratwohl, B. Speck, 1986, Blood.

Biological and immunological characterization of ATG and ALG.

N. Young, A. Gratwohl, B. Speck, 1986, Blood.

Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication.

N. Young, E. Sloand, J. Maciejewski, 1997, Blood.

Upstream sequences within the terminal hairpin positively regulate the P6 promoter of B19 parvovirus.

N. Young, K. McDonagh, T. Shimada, 1991, Virology.

Gene marking and gene therapy directed at primary hematopoietic cells

N. Young, C. Dunbar, 1996, Current opinion in hematology.

T-bet , a Th 1 transcription factor , is up-regulated in T cells from patients with aplastic anemia

K. Keyvanfar, N. Young, E. Solomou, 2006 .

Lymphocytes with Aberrant Expression of Fas or Fas Ligand Attenuate Immune Bone Marrow Failure in a Mouse Model1

Jichun Chen, M. Desierto, N. Young, 2009, The Journal of Immunology.

Telomere content measurement in human hematopoietic cells: Comparative analysis of qPCR and Flow‐FISH techniques

J. P. McCoy, B. Dumitriu, N. Young, 2016, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Indiscriminate activity from the B19 parvovirus p6 promoter in nonpermissive cells.

N. Young, N. Komatsu, T. Shimada, 1991, Virology.

The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells

T. Shimada, S. Kajigaya, N. Young, 1988, Journal of virology.

Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface.

S. Kajigaya, N. Young, S. Anderson, 1992, The Journal of clinical investigation.

Preliminary X-ray crystallographic investigation of human parvovirus B19.

M. Rossmann, S. Kajigaya, N. Young, 1991, Virology.

A genetically engineered cell line that produces empty capsids of B19 (human) parvovirus.

S. Kajigaya, N. Young, S. Fujita, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Human telomere disease due to disruption of the CCAAT box of the TERC promoter.

V. V. D. van der Velden, S. Kajigaya, N. Young, 2011, Blood.

promoter TERC Human telomere disease due to disruption of the CCAAT box of the

S. Kajigaya, N. Young, R. Calado, 2012 .

The role of interleukin-converting enzyme in Fas-mediated apoptosis in HIV-1 infection.

N. Young, J. Maciejewski, E. Sloand, 1998, The Journal of clinical investigation.

CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc).

N. Young, J. Maciejewski, A. Risitano, 2003, Experimental hematology.

Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress

Xingmin Feng, Jichun Chen, M. Desierto, 2018, Liver international : official journal of the International Association for the Study of the Liver.

patients with hematological disorders Functional characterization of natural telomerase mutations found in

Adam Beauchamp, N. Young, R. Calado, 2013 .

anemia Telomere length in leukocyte subpopulations of patients with aplastic

T. Brümmendorf, N. Young, J. Maciejewski, 2012 .

Peptides derived from the unique region of B19 parvovirus minor capsid protein elicit neutralizing antibodies in rabbits.

S. Kajigaya, N. Young, S. Anderson, 1995, Virology.

Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions

S. Kajigaya, N. Young, S. Anderson, 1993, Journal of virology.

The function of lymphocytes in normal and suppressed hematopoiesis

N. Young, N. Zoumbos, Pedro Bascon, 2004, Blut.

Antithymocyte globulin hypersensitivity in bone marrow failure patients.

M. Kaliner, N. Young, A. Nienhuis, 1988, JAMA.

Immune-mediated bone marrow failure in C57BL/6 mice.

Xingmin Feng, Jichun Chen, M. Desierto, 2015, Experimental hematology.

13. Acquired Aplastic Anaemia

N. Young, J. Marsh, 2010 .

Autoimmunity and Its Treatment in Aplastic Anemia

N. Young, 1997, Annals of Internal Medicine.

Analysis of T-cell repertoire in hepatitis-associated aplastic anemia.

N. Young, J. Melenhorst, K. Brown, 2004, Blood.

Gene expression profiling in CD 34 cells to identify differences between aplastic anemia patients and healthy volunteers

S. Kajigaya, N. Young, E. Billings, 2003 .

PD-1 deficiency augments bone marrow failure in a minor-histocompatibility antigen mismatch lymphocyte infusion model.

Xingmin Feng, Jichun Chen, K. Keyvanfar, 2018, Experimental hematology.

MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.

Jichun Chen, M. Desierto, K. Keyvanfar, 2011, Experimental hematology.

Immunosuppressive Treatment Is Associated with Durable Responses and a Survival Advantage in Younger Patients with int-1 Myelodysplastic Syndrome.

P. Greenberg, N. Young, E. Sloand, 2005 .

Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors.

P. Munson, N. Raghavachari, K. Keyvanfar, 2010, The Journal of clinical investigation.

Human parvovirus B 19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E 2 F family of transcription factors

P. Munson, N. Raghavachari, K. Keyvanfar, 2010 .

Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura

J. P. McCoy, N. Young, P. Scheinberg, 2012, Journal of thrombosis and haemostasis : JTH.

A Randomized Trial of Horse Versus Rabbit Antithymocyte Globulin In Severe Acquired Aplastic Anemia

N. Young, P. Scheinberg, E. Sloand, 2010 .

Shared and individual specificities of immunodominant cytotoxic T-cell clones in paroxysmal nocturnal hemoglobinuria as determined by molecular analysis.

C. O'keefe, N. Young, M. Wlodarski, 2004, Experimental hematology.

Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry.

N. Young, J. Maciejewski, A. Risitano, 2002, Blood.

Extensive latent retroviral infection in bone marrow of patients with HTLV-I-associated neurologic disease.

C. Fox, N. Young, R. Fox, 1997, Blood.

Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.

E. Settembre, P. Dormitzer, N. Young, 2017, Vaccine.

Safety and immunogenicity of a candidate parvovirus B19 vaccine.

D. Bernstein, W. Keitel, Gina Simone, 2011, Vaccine.

Parvovirus B19 empty capsids as antigen carriers for presentation of antigenic determinants of dengue 2 virus.

N. Young, G. Amexis, 2006, The Journal of infectious diseases.

Molecular, cellular and clinical aspects of parvovirus B19 infection.

N. Young, K. Brown, J. Liu, 1994, Critical reviews in oncology/hematology.

First continuous propagation of B19 parvovirus in a cell line.

S. Kajigaya, N. Young, N. Komatsu, 1992, Blood.

Aplastic anemia and viral hepatitis. Non-A, Non-B, Non-C?

N. Young, S. Kojima, A. Bacigalupo, 1992, JAMA.

Flaviviruses and bone marrow failure.

N. Young, 1990, JAMA.

Goose parvovirus--an autonomous member of the dependovirus genus?

N. Young, K. Brown, S. Green, 1995, Virology.

Telomere length is inherited with resetting of the telomere set-point

P. Lansdorp, N. Young, R. Calado, 2010, Proceedings of the National Academy of Sciences.

Novel Surrogate Neutralizing Assay Supports Parvovirus B19 Vaccine Development for Children with Sickle Cell Disease

E. Settembre, P. Dormitzer, N. Young, 2021, Vaccines.

Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia.

N. Young, K. Brown, Susan Wong, 2003, The Journal of infectious diseases.

Parvovirus B19: implications for transfusion medicine. Summary of a workshop

N. Young, K. Brown, B. Alving, 2001, Transfusion.

A second neutralizing epitope of B19 parvovirus implicates the spike region in the immune response

S. Kajigaya, N. Young, N. Frickhofen, 1991, Journal of virology.

Immune response to B19 parvovirus and an antibody defect in persistent viral infection.

N. Young, R. Blaese, G. Kurtzman, 1989, The Journal of clinical investigation.

Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy.

D. W. Jenkins, N. Young, A. Nienhuis, 1989, The New England journal of medicine.

Parvovirus B19 infection and hematopoiesis.

N. Young, K. Brown, 1995, Blood reviews.

Parvovirus particles as platforms for protein presentation.

S. Kajigaya, N. Young, S. Smith‐Gill, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A trial of recombinant human interleukin‐1 in patients with severe refractory aplastic anaemia

N. Young, A. Nienhuis, S. Anderson, 1992, British journal of haematology.

Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo.

N. Young, A. Chaudhuri, E. Sloand, 1999, Blood.

Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression.

J. Hoofnagle, T. Liang, N. Young, 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Is there a direct effect of antithymocyte globulin on hematopoiesis?

N. Young, J. Maciejewski, Guibin Chen, 2004, The hematology journal : the official journal of the European Haematology Association.

Analysis of the expression of glycosylphosphatidylinositol anchored proteins on platelets from patients with paroxysmal nocturnal hemoglobinuria.

N. Young, S. Anderson, E. Sloand, 1996, Thrombosis research.

High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.

N. Young, A. Barrett, A. Gratwohl, 2003, Blood.

Myelodysplasia and Bone Marrow Manifestations of Somatic UBA1 Mutated Autoinflammatory Disease

D. Kastner, N. Young, S. Burgess, 2020 .

Patterns of Infection in Patients with Aplastic Anemia and the Emergence of Aspergillus As a Major Cause of Death

S. Steinberg, N. Young, P. Pizzo, 1992, Medicine.

Long Term Outcome of Pediatric Patients with Severe Aplastic Anemia Treated with Anti-Thymocyte Globulin and Cyclosporine.

N. Young, P. Scheinberg, Colin O. Wu, 2007 .

HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha.

N. Young, J. Maciejewski, F. Weichold, 1994, Journal of immunology.

The Enigma of the Aplastic Anemia/PNH Syndrome

N. Young, J. Maciejewski, A. Risitano, 2003 .

Donor-derived MDS/AML in families with germline GATA2 mutation.

J. Klco, S. Holland, N. Young, 2018, Blood.

Immunosuppression and stem cell stimulation to treat AA: clinical and biologic implications

N. Young, 2019, HemaSphere.

Viruses and bone marrow failure.

N. Young, S. Rosenfeld, 1984, Blood reviews.

Hematologic and hematopoietic consequences of B19 parvovirus infection.

N. Young, 1988, Seminars in hematology.

Secondary colony formation after long‐term bone marrow culture using peripheral blood and bone marrow of HIV‐infected patients

N. Young, J. Maciejewski, E. Sloand, 1997, AIDS.

VP1u phospholipase activity is critical for infectivity of full-length parvovirus B19 genomic clones.

S. Kajigaya, N. Young, M. Söderlund-Venermo, 2008, Virology.

Acquired sideroblastic anaemia following progesterone therapy

N. Young, R. Brodsky, E. Fibach, 1994, British journal of haematology.

Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure.

N. Young, J. Hibbs, J. Maciejewski, 1994, Experimental hematology.

Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines.

N. Young, C. Lai, S. Nakao, 1989, Blood.

A novel homozygous RTEL1 variant in a consanguineous Lebanese family: phenotypic heterogeneity and disease anticipation

E. Chouery, S. Kajigaya, N. Young, 2019, Human Genetics.

A functionally active retrovirus vector for gene therapy in Fanconi anemia group C.

M. Buchwald, N. Young, A. Nienhuis, 1994, Blood.

PTPN22 620W allele is not associated with aplastic anemia

N. Young, R. Calado, S. Graf, 2007, American journal of hematology.

Moderate-dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution.

B. Dumitriu, N. Young, P. Scheinberg, 2014, Blood.

The Third Consensus Conference on the treatment of aplastic anemia

Feng-kui Zhang, N. Young, K. Ozawa, 2011, International journal of hematology.

Codon Optimization of Human Parvovirus B19 Capsid Genes Greatly Increases Their Expression in Nonpermissive Cells

S. Kajigaya, N. Young, N. Zhi, 2010, Journal of Virology.

Characterization of a virus that causes transient aplastic crisis.

N. Young, R. Humphries, P. Mortimer, 1984, The Journal of clinical investigation.

Pathophysiology of Acquired Bone Marrow Failure

N. Young, P. Scheinberg, K. Hosokawa, 2017 .

A mouse model of lymphocyte infusion-induced bone marrow failure.

Jichun Chen, N. Young, A. Wolk, 2004, Experimental hematology.

Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA

P. Lansdorp, N. Young, E. Sloand, 2003, The Lancet.

Oral manifestations in patients with aplastic anemia.

S. Pillemer, N. Young, M. Brennan, 2001, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

T. Ried, N. Young, Chuanfeng Wu, 2013, The Journal of clinical investigation.

Telomere maintenance and human bone marrow failure.

N. Young, R. Calado, 2008, Blood.

Danazol Treatment for Telomere Diseases.

B. Dumitriu, Jianhua Yao, N. Young, 2016, The New England journal of medicine.

Bone marrow failure and the telomeropathies.

B. Dumitriu, N. Young, D. Townsley, 2014, Blood.

BONE MARROW FAILURE Bone marrow failure and the telomeropathies

B. Dumitriu, N. Young, D. Townsley, 2014 .

Bone marrow failure and the new telomere diseases: practice and research

N. Young, 2012, Hematology.

Telomere diseases.

N. Young, R. Calado, 2009, The New England journal of medicine.

No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

B. Dumitriu, N. Young, R. Calado, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Decreased infection-related mortality and improved survival in severe aplastic anemia in the past two decades.

N. Young, P. Scheinberg, T. Walsh, 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Granulocyte transfusions in severe aplastic anemia: an eleven-year experience

N. Young, P. Scheinberg, T. Walsh, 2009, Haematologica.

Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.

W. Linehan, N. Young, A. Barrett, 2000, The New England journal of medicine.

Overcoming graft rejection in heavily transfused and allo‐immunised patients with bone marrow failure syndromes using fludarabine‐based haematopoietic cell transplantation

N. Geller, R. Srinivasan, N. Young, 2006, British journal of haematology.

Th17 immune responses contribute to the pathophysiology of aplastic anemia.

M. Desierto, K. Keyvanfar, N. Young, 2010, Blood.

Limited heterogeneity of T cell receptor BV usage in aplastic anemia.

N. Young, W. Zeng, G. Chen, 2001, The Journal of clinical investigation.

Decreased interleukin 1 production in aplastic anaemia

N. Young, K. Matsushima, S. Nakao, 1989, British journal of haematology.

Alemtuzumab (Campath) Monotherapy for Severe Aplastic Anemia.

N. Young, P. Scheinberg, E. Sloand, 2010 .

Alemtuzumab treatment of intermediate-1 myelodysplasia patients is associated with sustained improvement in blood counts and cytogenetic remissions.

N. Young, P. Scheinberg, A. Barrett, 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR β-CDR3 sequencing

N. Young, J. Maciejewski, A. Risitano, 2004, The Lancet.

Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome.

D. Follmann, N. Young, O. Nuñez, 2003, JAMA.

Diagnosis and management of paroxysmal nocturnal hemoglobinuria.

Neal Young, Lucio Luzzatto, Taroh Kinoshita, 2005, Blood.

Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3.

N. Young, C. Selleri, J. Maciejewski, 1997, Blood.

Allogeneic transplantation using CD34+ selected peripheral blood progenitor cells combined with non‐mobilized donor T cells for refractory severe aplastic anaemia

N. Young, D. Stroncek, R. Childs, 2017, British journal of haematology.

Novel transcription map for the B19 (human) pathogenic parvovirus

N. Young, T. Shimada, G. Kurtzman, 1987, Journal of virology.

Prevalence of the newly described human circovirus, TTV, in United States blood donors

N. Young, K. Brown, B. Dickstein, 2000, Transfusion.

2 B19 parvovirus

N. Young, 1995 .

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

Yuri Kotliarov, Wei Wang, Manikandan Narayanan, 2014, Cell.

Peromyscus leucopus mice: a potential animal model for haematological studies

Jichun Chen, M. Desierto, S. Kajigaya, 2014, International journal of experimental pathology.

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

N. Young, Chuanfeng Wu, C. Dunbar, 2017, Blood.

Hemoglobin switching in sheep.

N. Young, A. Nienhuis, P. Kretschmer, 1980 .

Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin

N. Young, J. Djeu, G. Scala, 1985 .

Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin.

N. Young, J. Djeu, G. Scala, 1985, Blood.

PERSISTENT B19 PARVOVIRUS INFECTION AS A CAUSE OF SEVERE CHRONIC ANAEMIA IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKAEMIA

N. Young, G. Kurtzman, P. Meyers, 1988, The Lancet.

Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro.

H. Mitsuya, N. Young, T. Kinoshita, 2002, Blood.

Somatic mosaicism in inherited bone marrow failure syndromes.

N. Young, M. Wlodarski, Fernanda Gutierrez-Rodrigues, 2021, Best practice & research. Clinical haematology.

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.

G. Mufti, N. Young, S. Heck, 2016, Blood.

A human parvovirus-like virus inhibits haematopoietic colony formation in vitro

R. Purcell, N. Young, R. Humphries, 1983, Nature.

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

J. Mullikin, D. Kastner, W. Gahl, 2020, The New England journal of medicine.

Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing

K. Zhao, S. Kajigaya, N. Young, 2013, Proceedings of the National Academy of Sciences.

Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis.

William M. Lee, M. Manns, A. E. Yeo, 2003, The Journal of infectious diseases.

Vaccine Design Informed by Virus-Induced Immunity.

N. Young, J. Hankins, J. Hurwitz, 2020, Viral immunology.

Prevalence of GBV‐C/HGV, a novel ‘hepatitis’ virus, in patients with aplastic anaemia

N. Young, K. Brown, S. Wong, 1997, British journal of haematology.

Hemoglobin switching in sheep: Only the γ gene is in the active conformation in fetal liver but all the β and γ genes are in the active conformation in bone marrow

N. Young, A. Nienhuis, J. Kantor, 1978 .

Human Serum Sickness: A Prospective Analysis of 35 Patients Treated with Equine Anti‐Thymocyte Globulin for Bone Marrow Failure

N. Young, M. Frank, L. Bielory, 1988, Medicine.

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia

B. Dumitriu, Xingmin Feng, M. Desierto, 2017, The New England journal of medicine.

Eltrombopag and improved hematopoiesis in refractory aplastic anemia.

B. Dumitriu, Xingmin Feng, N. Young, 2012, The New England journal of medicine.

Decay-accelerating factor is present on paroxysmal nocturnal hemoglobinuria erythroid progenitors and lost during erythropoiesis in vitro

N. Young, H. Müller-Eberhard, M. Frank, 1985, The Journal of experimental medicine.

Parvovirus B19 infection and bone marrow transplantation

N. Young, B. Hertenstein, N. Frickhofen, 2005, Annals of Hematology.

The Simian Parvoviruses

N. Young, K. Brown, 1997, Reviews in medical virology.

Human Parvovirus B19: Pathogenesis of Disease

N. Young, K. Brown, 1997 .

Human parvovirus B19 can infect cynomolgus monkey marrow cells in tissue culture

N. Young, K. Brown, S. Anderson, 1995, Journal of virology.

The transcriptional regulator YY1 binds to the 5'-terminal region of B19 parvovirus and regulates P6 promoter activity

S. Kajigaya, N. Young, S. Jane, 1994, Journal of virology.

Prospects for a human B19 parvovirus vaccine

N. Young, M. Collett, 1994 .

Viruses and the blood.

N. Young, J. Hibbs, 1992, Bailliere's clinical haematology.

Feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro

N. Young, L. Platanias, L. Lustig, 1989 .

Feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro.

N. Young, L. Platanias, L. Lustig, 1989, Blood.

Functional mapping of the genome of the B19 (human) parvovirus by in vitro translation after negative hybrid selection

N. Young, K. Ozawa, J. Ayub, 1988, Journal of virology.

B19 parvovirus replicates in circulating cells of acutely infected patients.

N. Young, G. Kurtzman, P. Gascón, 1988, Blood.

Replication of the B19 parvovirus in human bone marrow cell cultures.

N. Young, K. Ozawa, G. Kurtzman, 1986, Science.

Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia.

N. Young, L. Anderson, P. Tattersall, 1986, Blood.

Pathogenesis of Parvovirus-induced Disease in Humans

N. Young, M. Anderson, J. Pattison, 1986 .

Studies of interferon as a regulator of hematopoietic cell proliferation.

N. Young, L. Platanias, N. Zoumbos, 1985, Journal of immunology.

The epidemiology of acquired aplastic anemia

N. Young, D. Kaufman, 2008, Haematologica.

Nonisotopic detection of microRNA using digoxigenin labeled RNA probes.

S. Kajigaya, N. Young, L. Mainwaring, 2006, Molecular and cellular probes.

A plasma microRNA signature as a biomarker for acquired aplastic anemia

Xingmin Feng, M. Desierto, S. Kajigaya, 2017, Haematologica.

Heterozygous RTEL1 variants in bone marrow failure and myeloid neoplasms.

Soma Das, G. Mufti, Xingmin Feng, 2018, Blood advances.

Mitochondrial DNA mutations in single human blood cells.

S. Kajigaya, N. Young, Yong-Gang Yao, 2015, Mutation research.

Parvovirus B19 as a cause of acquired chronic pure red cell aplasia

J. Abkowitz, N. Young, N. Frickhofen, 1994, British journal of haematology.

Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector.

R. Samulski, N. Young, A. Nienhuis, 1992, Proceedings of the National Academy of Sciences of the United States of America.

T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

Yanling Xie, Xingmin Feng, K. Keyvanfar, 2017, The Journal of Immunology.

Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most-primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures.

N. Young, J. Maciejewski, E. Sloand, 1998, Blood.

Effects of Systemically Administered Hydrocortisone on the Human Immunome

J. P. McCoy, F. Marincola, G. Trinchieri, 2016, Scientific Reports.

Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas

D. Beer, C. Harris, B. Dumitriu, 2014, PloS one.

Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia

T. Ried, N. Young, R. Calado, 2012, Leukemia.

Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group.

S. Shapiro, P. Leaverton, N. Young, 1991, Blood.

External Contamination in Single Cell mtDNA Analysis

H. Bandelt, N. Young, Yong-Gang Yao, 2007, PloS one.

Pathogenic TERT promoter variants in telomere diseases

M. Pirooznia, S. Kajigaya, N. Young, 2018, Genetics in Medicine.

Hematopoietic-specific microRNA expression in human cells.

J Philip McCoy, J. P. McCoy, K. Keyvanfar, 2006, Leukemia research.

Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo.

N. Young, J. Djeu, N. Zoumbos, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Expression and modulation of cellular receptors for interferon‐γ, tumour necrosis factor, and Fas on human bone marrow CD34+ cells

N. Young, J. Maciejewski, S. Anderson, 1997, British journal of haematology.

Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro.

N. Young, S. Anderson, C. Selleri, 1995, Blood.

Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy.

Jichun Chen, D. Malide, S. Kajigaya, 2010, Blood.

Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression

G. Trinchieri, S. Sen, Xingmin Feng, 2020, International journal of molecular sciences.

Persistent parvovirus B19 infections in humans.

N. Young, N. Frickhofen, 1989, Microbial pathogenesis.

Somatic Mutations in UBA1 Define a Distinct Subset of Relapsing Polychondritis Patients With VEXAS

D. Kastner, N. Young, Marcus Y. Chen, 2021, Arthritis & rheumatology.

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia

E. Estey, S. Chanock, M. Hills, 2009, Proceedings of the National Academy of Sciences.

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.

S. Chanock, P. Lansdorp, S. Kajigaya, 2005, The New England journal of medicine.

Expression of interferon-gamma by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity.

N. Young, Y. Hanazono, S. Sellers, 1999, Experimental hematology.

The Spectrum of Hepatic Involvement in Patients With Telomere Disease

N. Young, D. Kleiner, S. Lingala, 2019, Hepatology.

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

S. Miyano, B. Dumitriu, Y. Shiraishi, 2015, The New England journal of medicine.

Persistent parvovirus B19 infection

N. Young, K. Brown, 1995 .

50 Years of Seminars in Hematology

N. Young, P. Beris, 2013 .

Clonality in context: hematopoietic clones in their marrow environment.

N. Young, J. Cooper, 2017, Blood.

Induction of nitric oxide synthase is involved in the mechanism of Fas‐mediated apoptosis in haemopoietic cells

N. Young, B. Rotoli, C. Selleri, 1997, British journal of haematology.

Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients.

N. Young, A. Barrett, C. Dunbar, 1997, Human gene therapy.

A trial of recombinant human superoxide dismutase in patients with Fanconi anaemia

N. Young, S. Anderson, J. Liu, 1993, British journal of haematology.

A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus

N. Young, T. Shimada, J. Liu, 1992, Journal of virology.

A putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicity

S. Kajigaya, N. Young, M. Momoeda, 1994, Journal of virology.

Impaired hematopoiesis in paroxysmal nocturnal hemoglobinuria/aplastic anemia is not associated with a selective proliferative defect in the glycosylphosphatidylinositol-anchored protein-deficient clone.

N. Young, J. Maciejewski, S. Anderson, 1997, Blood.

Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

Xingmin Feng, S. Kajigaya, N. Young, 2020, BMC Genomics.

Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS

B. Dumitriu, K. Rezvani, Xingmin Feng, 2016, British journal of haematology.

Parvovirus B19 in human disease.

N. Young, K. Brown, 1997, Annual review of medicine.

Defective stromal cell function in a mouse model of infusion-induced bone marrow failure.

Jichun Chen, N. Young, R. Calado, 2005, Experimental hematology.

Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

N. Young, P. Scheinberg, R. Calado, 2010, JAMA.

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome.

S. Chanock, P. Lansdorp, N. Young, 2003, Blood.

Intracellular interferon-γ in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia

D. Follmann, N. Young, J. Maciejewski, 2002 .

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

B. Dumitriu, N. Young, M. Bevans, 2014, Blood.

Paroxysmal nocturnal hemoglobinuria and myelodysplastic sydromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure

N. Young, 2009, Haematologica.

Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.

N. Young, C. Nathan, C. Selleri, 1995, The Journal of clinical investigation.

Mitochondrial DNA sequence variation in single cells from leukemia patients.

J. P. McCoy, S. Kajigaya, N. Young, 2006, Blood.

Current concepts in the pathophysiology and treatment of aplastic anemia.

N. Young, Neal S Young, 2013, Hematology. American Society of Hematology. Education Program.

Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor.

M. Rossmann, S. Kajigaya, N. Young, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single‐cell RNA sequencing of monocytes

S. Kajigaya, N. Young, Shouguo Gao, 2021, Journal of leukocyte biology.

Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens.

N. Young, M. Wlodarski, J. Maciejewski, 2002, Blood.

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells.

Xin Zhao, Shouguo Gao, Xingmin Feng, 2017, Blood.

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

H. Lähdesmäki, S. Mustjoki, S. Ogawa, 2021, Leukemia.

Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia.

B. Dumitriu, S. Ogawa, Xingmin Feng, 2015, Blood.

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

S. Ogawa, N. Young, 2015, The New England journal of medicine.

Differential gene expression in hematopoietic progenitors from paroxysmal nocturnal hemoglobinuria patients reveals an apoptosis/immune response in ‘normal’ phenotype cells

N. Young, E. Billings, W. Zeng, 2005, Leukemia.

Treatment of Diamond‐Blackfan anaemia with haematopoietic growth factors, granulocyte‐macrophage colony stimulating factor and interleukin 3: sustained remissions following IL‐3

D A Smith, N. Young, A. Nienhuis, 1991, British journal of haematology.

Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia

N. Young, A. Nienhuis, E. Leonard, 1989, British journal of haematology.

Anti-K562 cell monoclonal antibodies recognize hematopoietic progenitors.

N. Young, S. P. Hwang-Chen, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro.

N. Young, J. Djeu, N. Zoumbos, 1984, Journal of immunology.

Anemia of Central Origin.

N. Young, Kazusa Ishii, 2015, Seminars in hematology.

Molecular Analysis of TCR Clonotypes in LGL: A Clonal Model for Polyclonal Responses1

C. O'keefe, N. Young, M. Wlodarski, 2004, The Journal of Immunology.

Long-term outcome of fludarabine-based reduced-intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria.

N. Geller, N. Young, P. Scheinberg, 2014, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Review in translational hematology Diagnosis and management of paroxysmal nocturnal hemoglobinuria

N. Young, L. Luzzatto, R. Ware, 2005 .

1 Diagnosis and Management of Paroxysmal Nocturnal Hemoglobinuria :

Wendell, N. Young, L. Luzzatto, 2005 .

IFN-γ-mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure.

Xingmin Feng, Jichun Chen, M. Desierto, 2015, Blood.

Bone Marrow Failure Syndromes

N. Young, 2000 .

Different haematopoietic growth factors have different capacity in overcoming the in vitro interferon gamma‐induced suppression of bone marrow progenitor cells

N. Young, N. Zoumbos, B. Baranski, 1990, European journal of haematology.

Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo.

N. Young, J. Maciejewski, A. Chaudhuri, 2000, Blood.

A multicenter trial of antithymocyte globulin in aplastic anemia and related diseases

J. Fay, A. Huang, N. Young, 1988 .

What Causes Aplastic Anaemia: Results of Transplants from Genetically-Identical Twins

A. Gennery, N. Young, M. Eapen, 2023, Research square.

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

B. Dumitriu, Xingmin Feng, N. Young, 2017, Experimental hematology.

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Heather D. Huntsman, Xingmin Feng, N. Young, 2019, Blood.

Mitochondrial DNA Sequence Heterogeneity of Single CD34+ Cells After Nonmyeloablative Allogeneic Stem Cell Transplantation

J. P. McCoy, S. Kajigaya, N. Young, 2007, Stem cells.

Large granular lymphocyte (LGL)-like clonal expansions in paroxysmal nocturnal hemoglobinuria (PNH) patients

C. O'keefe, P. Muranski, N. Young, 2005, Leukemia.

A multicenter trial of antithymocyte globulin in aplastic anemia and related diseases.

J. Fay, A. Huang, N. Young, 1988, Blood.

Interferon-gamma-induced gene expression in CD34 cells: identification of pathologic cytokine-specific signature profiles.

S. Kajigaya, N. Young, J. Maciejewski, 2006, Blood.

The management of paroxysmal nocturnal hemoglobinuria: recent advances in diagnosis and treatment and new hope for patients.

N. Young, H. Schrezenmeier, P. Hillmen, 2009, Seminars in hematology.

Alemtuzumab in T-cell large granular lymphocytic leukaemia: a phase 2 study

M. Raffeld, B. Dumitriu, Xingmin Feng, 2015, The Lancet. Haematology.

Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria.

N. Young, J. Maciejewski, A. Risitano, 2008, Blood.

Soluble Urokinase Plasminogen Activator Receptor Is Increased in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Thrombosis and Inhibits Plasmin Generation In Vitro and Promotes Thrombosis in the Mouse Model.

Jichun Chen, N. Young, E. Sloand, 2006 .

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.

N. Young, J. Maciejewski, L. Luzzatto, 2006, The New England journal of medicine.

How I treat acquired aplastic anemia.

N. Young, P. Scheinberg, 2012, Blood.

In vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia

J. P. McCoy, S. Donaldson, Kazuya Sato, 2014, Haematologica.

Rapid donor T‐cell engraftment increases the risk of chronic graft‐versus‐host disease following salvage allogeneic peripheral blood hematopoietic cell transplantation for bone marrow failure syndromes

N. Geller, N. Young, D. Stroncek, 2013, American journal of hematology.

Characterization of the hematopoietic defect in paroxysmal nocturnal hemoglobinuria.

N. Young, R. Humphries, M. Frank, 1986, Experimental hematology.

Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine

N. Young, P. Scheinberg, M. Marte, 2010, Haematologica.

Acquired Aplastic Anemia: New Genetics, New Genomics

B. Dumitriu, S. Ogawa, N. Young, 2014 .

Genetic defects underlying paroxysmal nocturnal hemoglobinuria that arises out of aplastic anemia.

N. Young, R. Brodsky, S. Nagarajan, 1995, Blood.

Thrombotic Complications in PNH

N. Young, E. Sloand, 2000 .

Prospects for the Treatment of Aplastic Anemia

N. Young, 1990 .

Lymphocyte phenotype and lymphokines following anti‐thymocyte globulin therapy in patients with aplastic anaemia

N. Young, L. Platanias, L. Bielory, 1987, British journal of haematology.

Experimental infection of cynomolgus monkeys with simian parvovirus

N. Young, M. G. O’Sullivan, D. Anderson, 1997, Journal of virology.

Functional characterization of telomerase RNA variants found in patients with hematologic disorders.

P. Lansdorp, N. Young, R. Calado, 2005, Blood.

Regional patterns in the incidence of aplastic anemia in Thailand

S. Shapiro, P. Leaverton, N. Young, 1999, American journal of hematology.

Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia.

N. Young, J. Kimball, S. Rosenfeld, 1995, Blood.

Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition.

N. Young, C. Selleri, J. Maciejewski, 1996, Blood.

Functional characterization of natural telomerase mutations found in patients with hematologic disorders.

Yuying Liang, Peter M Lansdorp, Adam Beauchamp, 2007, Blood.

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia.

S. Fischer, N. Young, P. Scheinberg, 2006, Blood.

Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia.

N. Young, P. Scheinberg, Colin O. Wu, 2012, Blood.

Recombinant viral-like particles of parvovirus B19 as antigen carriers of anthrax protective antigen.

S. Kajigaya, N. Young, S. Leppla, 2006, In vivo.

Epidemiology and pathology of erythroviruses.

N. Young, K. Brown, 2000, Contributions to microbiology.

LACK OF EVIDENCE FOR PARVOVIRUS B19 VIRAEMIA IN CHILDREN WITH CHRONIC NEUTROPENIA

N. Young, K. Brown, S. Green, 1994, British journal of haematology.

Deficit of circulating CD19+CD24hiCD38hi regulatory B cells in severe aplastic anaemia

Xingmin Feng, S. Kajigaya, N. Young, 2020, British journal of haematology.

Aplastic anemia: pathophysiology and treatment.

N. Young, A. Bacigalupo, J. Marsh, 2010, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Aplastic anemia

N. Young, P. Scheinberg, R. Calado, 2008, Current opinion in hematology.

T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.

K. Keyvanfar, N. Young, E. Solomou, 2006, Blood.

High prevalence of hepatitis C viremia among aplastic anemia patients and controls from Thailand.

N. Young, J. Hibbs, S. Issaragrisil, 1992, The American journal of tropical medicine and hygiene.

Perforin gene mutations in patients with acquired aplastic anemia.

S. Chanock, D. Malide, N. Young, 2006, Blood.

Lymphocytes and lymphokines in aplastic anemia: pathogenic role and implications for pathogenesis.

N. Young, L. Platanias, E. Leonard, 1987, Blood cells.

Most of the VP1 unique region of B19 parvovirus is on the capsid surface.

S. Kajigaya, N. Young, M. Momoeda, 1995, Virology.

A new syndrome of familial aplastic anemia and chronic liver disease.

N. Young, A. Zipursky, B. Alter, 1997, Acta haematologica.

Regulatory Mutations in GATA2 Associated with Aplastic Anemia

B. Dumitriu, S. Holland, N. Young, 2012 .

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia.

Xingmin Feng, Jichun Chen, N. Young, 2018, Blood.

Deep sequencing and flow cytometric characterization of expanded effector memory CD8+CD57+ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia

Xingmin Feng, N. Young, Fanmao Zhang, 2018, Haematologica.

Minor Antigen H60-Mediated Aplastic Anemia Is Ameliorated by Immunosuppression and the Infusion of Regulatory T Cells

Jichun Chen, K. Keyvanfar, N. Young, 2007, The Journal of Immunology.

Interferon-γ Perturbs Key Signaling Pathways Induced By Thrombopoietin, but Not Eltrombopag, in Human Hematopoietic Stem/Progenitor Cells

N. Young, C. Dunbar, A. Larochelle, 2016 .

Telomere length and associations with somatic mutations and clinical outcomes in acute myeloid leukemia.

B. Dumitriu, R. Levine, N. Young, 2016, Leukemia research.

Eltrombopag added to immunosuppression for children with treatment‐naïve severe aplastic anaemia

N. Young, Fernanda Gutierrez-Rodrigues, D. Townsley, 2021, British journal of haematology.

Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes

S. Kajigaya, N. Young, Christopher K. E. Bleck, 2018, Haematologica.

Immune pathophysiology of acquired aplastic anaemia

N. Young, 1996, European journal of haematology. Supplementum.

Generation of Neutralizing Human Monoclonal Antibodies against Parvovirus B19 Proteins

S. Zolla-Pazner, M. Gorny, N. Young, 1999, Journal of Virology.

Parvovirus B19 integration into human CD36+ erythroid progenitor cells.

N. Young, Susan Wong, Thiago Y. Oliveira, 2017, Virology.

Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow.

J. P. McCoy, S. Kajigaya, N. Young, 2004, Blood.

and granulocytes cells, T cells, B cells, + Mitochondrial DNA spectra of single human CD34

S. Kajigaya, N. Young, K. Nakayama, 2011 .

Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes.

J. P. McCoy, S. Kajigaya, N. Young, 2005, Blood.

Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes.

J. P. McCoy, S. Kajigaya, N. Young, 2004, Blood.

SARS-CoV-2 infection associated with aplastic anemia and pure red cell aplasia

N. Young, Mingyi Chen, Weina Chen, 2022, Blood Advances.

5-AZACYTIDINE FOR BETA-THALASSAEMIA?

T. Ley, N. Young, A. Nienhuis, 1983, The Lancet.

Role of perforin-mediated cell apoptosis in murine models of infusion-induced bone marrow failure.

Jichun Chen, M. Desierto, N. Young, 2009, Experimental hematology.

Eltrombopag for patients with moderate aplastic anemia or uni-lineage cytopenias.

B. Dumitriu, N. Young, M. Albitar, 2020, Blood advances.

Telomere Length of peripheral leukocytes is shortened in Ocular Sarcoidosis patients

B. Dumitriu, N. Young, R. Nussenblatt, 2013 .

Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.

K. Keyvanfar, S. Kajigaya, N. Young, 2018, Blood cells, molecules & diseases.

CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation

K. Keyvanfar, S. Kajigaya, N. Young, 2018, International journal of oncology.

Whole transcriptome sequencing identifies increased CXCR2 expression in PNH granulocytes

Yanling Xie, Xingmin Feng, K. Keyvanfar, 2017, British journal of haematology.

Regulatory T Cells Immunosuppression and the Infusion of Anemia Is Ameliorated by Minor Antigen H 60-Mediated Aplastic

Jichun Chen, K. Keyvanfar, N. Young, 2007 .

Paroxysmal nocturnal hemoglobinuria with copy number‐neutral 6pLOH in GPI (+) but not in GPI (−) granulocytes

S. Kajigaya, N. Young, Y. Kanakura, 2014, European journal of haematology.

FOXP3-Positive Regulatory T-Cells in Acquired Aplastic Anemia.

K. Rezvani, K. Keyvanfar, D. Malide, 2006 .

Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na.

N. Young, P. Scheinberg, E. Sloand, 2012, Leukemia research.

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.

D. Douek, J. Brenchley, N. Young, 2011, Blood.

Multiple Layers of Chimerism in a Single-Stranded DNA Virus Discovered by Deep Sequencing

E. Koonin, K. Zhao, Jungang Li, 2015, Genome biology and evolution.

Antithymocyte Globulin for Treatment of the Bone Marrow Failure Associated with Myelodysplastic Syndromes

N. Young, A. Barrett, Y. Saunthararajah, 2002, Annals of Internal Medicine.

Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy.

John Barrett, Neal Young, Peter Greenberg, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Should irradiated blood products be given routinely to all patients with aplastic anaemia undergoing immunosuppressive therapy with antithymocyte globulin (ATG)? A survey from the European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party

N. Young, J. Passweg, A. Tichelli, 2010, British journal of haematology.

The Immune System as Mediator of Virus‐Associated Bone Marrow Failure: B19 Parvovirus and Epstein‐Barr Virus

N. Young, B. Baranski, G. Kurtzman, 1989, Annals of the New York Academy of Sciences.

Blood consult: paroxysmal nocturnal hemoglobinuria and its complications.

N. Young, D. Townsley, 2013, Blood.

Subunit interaction in B19 parvovirus empty capsids

D. Alling, N. Young, C. Saxinger, 2005, Archives of Virology.

Relative incidence of agranulocytosis and aplastic anemia

S. Shapiro, N. Young, D. Kaufman, 2006, American journal of hematology.

Eltrombopag mobilizes iron in patients with aplastic anemia.

L. Sokoll, N. Young, C. Dunbar, 2018, Blood.

Transfer of glycosylphosphatidylinositol-anchored proteins to deficient cells after erythrocyte transfusion in paroxysmal nocturnal hemoglobinuria.

Jichun Chen, K. Keyvanfar, N. Young, 2004, Blood.

Autoimmune aspects of aplastic anemia.

N. Young, B. Baranski, 1988, In vivo.

Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 study.

M. Raffeld, B. Dumitriu, Xingmin Feng, 2016, The Lancet. Haematology.

Long-term outcomes in severe aplastic anemia patients treated with immunosuppression and eltrombopag: a phase 2 study.

N. Young, Fernanda Gutierrez-Rodrigues, Colin O. Wu, 2021, Blood.

Prolonged cyclosporine administration after antithymocyte globulin delays but does not prevent relapse in severe aplastic anemia

N. Young, P. Scheinberg, Colin O. Wu, 2014, American journal of hematology.

Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia

B. Dumitriu, N. Young, P. Scheinberg, 2014, American journal of hematology.

Nucleotide sequencing and generation of an infectious clone of adeno-associated virus 3.

N. Young, H. Mizukami, S. Muramatsu, 1996, Virology.

Safety and efficacy of eculizumab with concomitant erythropoietin therapy in patients with paroxysmal nocturnal hemoglobinuria (PNH)

N. Young, L. Luzzatto, R. Brodsky, 2007 .

the treatment of patients with paroxysmal nocturnal hemoglobinuria Multicenter phase 3 study of the complement inhibitor eculizumab for

N. Young, J. Maciejewski, A. Risitano, 2008 .

Long-term adaptation to hypoxia preserves hematopoietic stem cell function.

Jichun Chen, K. Keyvanfar, N. Young, 2016, Experimental hematology.

Safety and Efficacy of the Terminal Complement Inhibitor Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria: Interim Shepherd Phase III Clinical Study.

N. Young, J. Maciejewski, H. Schrezenmeier, 2006 .

Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment.

N. Young, 2005, Current hematology reports.

Etiologic mechanisms of hematopoietic failure.

N. Young, N. Frickhofen, J. Liu, 1990, The American journal of pediatric hematology/oncology.

Telomere Length of Peripheral Blood Leukocytes Predicts Relapse and Clonal Evolution after Immunosuppressive Therapy in Severe Aplastic Anemia

N. Young, P. Scheinberg, R. Calado, 2008 .

A Pilot Study Of Rituximab In Patients With Moderate Aplastic Anemia, Diamond-Blackfan Anemia and Pure Red Cell Aplasia

N. Young, P. Scheinberg, A. Wiestner, 2013 .

Parvovirus infection and its treatment

N. Young, 1996, Clinical and experimental immunology.

Pancytopenia secondary to parvovirus B19 infection in a child with acute lymphoblastic leukemia, mimicking leukemic relapse

N. Young, K. Brown, J. Cullen, 1995, American journal of hematology.

Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research.

David A. Chambers, P. Ridker, M. Ezzati, 2017, Global heart.

Sequencing and characterization of A-2 plaque virus: A new member of the Picornaviridae family.

N. Young, K. Brown, Z. Liu, 2000, Virology.

Reducing Health Inequities in the U.S.: Recommendations From the NHLBI's Health Inequities Think Tank Meeting.

David A Chambers, Viola Vaccarino, David A. Chambers, 2016, Journal of the American College of Cardiology.

Early and late gene expression in UT-7 cells infected with B19 parvovirus.

S. Kajigaya, N. Young, N. Komatsu, 1993, Virology.

Inhibition of interleukin-1beta-converting enzyme in human hematopoietic progenitor cells results in blockade of cytokine-mediated apoptosis and expansion of their proliferative potential.

N. Young, E. Sloand, J. Maciejewski, 1998, Experimental hematology.

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection

N. Young, R. Braylan, K. Calvo, 2018, American journal of clinical pathology.

Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL

Xingmin Feng, S. Kajigaya, N. Young, 2022, Blood.

Mitochondrial DNA mutations in patients with myelodysplastic syndromes.

S. Kajigaya, N. Young, M. Shin, 2003, Blood.

Bethesda Handbook of Clinical Hematology

Griffin P. Rodgers, N. Young, G. Rodgers, 2008 .

Attenuation of immune‐mediated bone marrow damage in conventionally housed mice

G. Trinchieri, S. Sen, Xingmin Feng, 2020, Molecular carcinogenesis.

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice.

Jichun Chen, M. Desierto, K. Keyvanfar, 2008, Experimental hematology.

Decreased TCR ζ‐chain expression in T cells from patients with acquired aplastic anaemia

N. Young, Susan Wong, E. Solomou, 2007, British journal of haematology.

Circulating Cytokine Profiles of Patients with Acquired Aplastic Anemia and Myelodysplastic Syndrome

J. P. McCoy, R. Ganetzky, Xingmin Feng, 2008 .

Why Current Publication May Distort Science

John P. A. Ioannidis, Omar Al-Ubaydli, Neal S. Young, 2008 .

Viruses as Agents of Haematological Disease

N. Young, 1995 .

T Cell Landscape of Immune Aplastic Anemia Reveals a Convergent Antigen-Specific Signature

H. Lähdesmäki, S. Mustjoki, Xingmin Feng, 2019, Blood.

AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization

R. Germain, N. Young, J. Tsang, 2018, npj Vaccines.

Isolation of antibodies specific to sickle hemoglobin by affinity chromatography using a synthetic peptide.

A. Schechter, N. Young, B. Furie, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Aplastic Anemia: Pathophysiology and Treatment of immune-mediated

N. Young, A. Bacigalupo, J. Marsh, 2012 .

Multiple antigenic peptides as vaccine platform for the induction of humoral responses against dengue-2 virus.

N. Young, G. Amexis, 2007, Viral immunology.

Comparative Transcriptomic Analysis of the Hematopoietic System between Human and Mouse by Single Cell RNA Sequencing

Xingmin Feng, S. Kajigaya, N. Young, 2021, Cells.

Cyclosporine Taper Does Not Prevent Relapse in Severe Aplastic Anemia

N. Young, P. Scheinberg, Colin O. Wu, 2011 .

JAK2 Inhibition with TG101348 Inhibits Monosomy 7 Myelodysplastic Syndromes (MDS) Bone Marrow Cells In Vitro: a Potential Targeted Therapy for Monosomy 7 MDS

N. Young, E. Sloand, M. Olnes, 2010 .

B19 parvovirus.

N. Young, 1995, Bailliere's Clinical Haematology.

Modest truncation of the major capsid protein abrogates B19 parvovirus capsid formation

S. Kajigaya, N. Young, M. Momoeda, 1995, Journal of virology.

Interleukin-23 receptor (IL-23R) gene polymorphisms in acquired aplastic anemia

S. Kajigaya, N. Young, R. Calado, 2009, Annals of Hematology.

Treatment of Severe Aplastic Anemia with Combined Immunosuppression: Antithymocyte Globulin (ATG), Cyclosporine A (CSA), and Mycophenolate Mofetil (MMF).

N. Young, P. Scheinberg, Colin O. Wu, 2005 .

A Murine Model of Bone Marrow Failure Mediated by Disparity in Minor Histocompatibility Antigens.

Jichun Chen, N. Young, 2005 .

Evidence for T-Cell Oligoclonal Expansion in Aplastic Anemia Associated with Telomerase Complex Mutations: Pathophysiological and Clinical Implications.

N. Young, R. Calado, T. Bruno, 2005 .

Sex Hormones Up-Regulate Telomerase Activity of Normal Human Hematopoietic Cells and Restore Telomerase Activity in Carriers of Telomerase Complex Mutations.

S. Kajigaya, N. Young, R. Calado, 2005 .

Myelodysplasia with Trisomy 8 Is Associated with a Cytotoxic CD8 T Cell Immune Response to Wilms Tumor-1 Protein (WT1).

D. Douek, K. Rezvani, N. Young, 2004 .

Tumor Necrosis Factor-Alpha and Interleukin-6 Promoter Gene Polymorphisms in Acquired Bone Marrow Failure Syndromes.

N. Young, L. Mainwaring, S. Ramkissoon, 2004 .

Granulocyte Colony Stimulating Factor Preferentially Causes Proliferation of Pre-Existing Monosomy 7 Cells in Aplastic Anemia and Myelodysplastic Syndrome Because of Abnormal Truncated GCSF-Receptors on These Cells.

N. Young, L. Mainwaring, S. Ramkissoon, 2004 .

Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS.

J. Abkowitz, N. Young, M. Safford, 1990, Annals of internal medicine.

Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.

J. P. McCoy, Xingmin Feng, S. Kajigaya, 2013, Stem cell research.

Disease Telomere Diseases

N. Young, R. Calado, 2009 .

Comprehensive analysis of single-cell RNA sequencing data from healthy human marrow hematopoietic cells

Xingmin Feng, S. Kajigaya, N. Young, 2020, BMC research notes.

COVID‐19 infection in patients with severe aplastic anaemia

N. Young, O. Rios, B. Patel, 2021, British journal of haematology.

Absence of SBDS mutations in sporadic paediatric acute myeloid leukaemia

R. Pieters, A. Baruchel, S. Kajigaya, 2013, British journal of haematology.

Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation.

W. Linehan, N. Young, A. Barrett, 2000, The New England journal of medicine.

Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major.

C. McLaren, N. Young, G. Brittenham, 1994, The New England journal of medicine.

VEXAS syndrome

N. Young, P. Grayson, B. Patel, 2022, International Journal of Hematology.

Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo.

N. Young, A. Chaudhuri, E. Sloand, 1999, Blood.

Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport.

S. Kajigaya, N. Young, Yong-Gang Yao, 2013, Mutation research.

Inherited Bone Marrow Failure Syndromes: Molecular Features

N. Young, A. Shimamura, J. Marsh, 2006 .

Single-Cell RNA-Seq Reveals the Differentiation Hierarchy of Normal Human Bone Marrow and a Distinct Transcriptome Signature of Monosomy 7 Cells

Xingmin Feng, M. Desierto, K. Keyvanfar, 2016 .

5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.

T. Ley, N. Young, A. Nienhuis, 1982, The New England journal of medicine.

Optimization and standardization of fluorescent cell barcoding for multiplexed flow cytometric phenotyping

Xingmin Feng, S. Kajigaya, N. Young, 2017, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21.

B. Dumitriu, N. Young, 2012, Cell stem cell.

Human parvovirus-associated red cell aplasia in the absence of underlying hemolytic anemia.

D. Horn, N. Young, P. Mortimer, 1986, The American journal of pediatric hematology/oncology.

Hematopoietic Aging Biomarkers in Peromyscus leucopus Mice

Xingmin Feng, Jichun Chen, S. Kajigaya, 2017, Journal of aging science.

T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect

N. Young, A. Barrett, J. Tisdale, 1998, Bone Marrow Transplantation.

AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization

R. Germain, N. Young, J. Tsang, 2018, npj Vaccines.

High prevalence of GB virus C/hepatitis G virus in healthy persons in Ho Chi Minh City, Vietnam.

Tran Van Be, N. Young, K. Brown, 1997, The Journal of infectious diseases.

A Prospective Clinical and Immunologic Analysis of Patients with Serum Sickness

N. Young, K. Yancey, M. Frank, 1984 .

Functional Characterization of Telomerase RNA Variants Found in Patients with Hematological Disorders.

P. Lansdorp, N. Young, R. Calado, 2004 .

Clinical relevance of parvovirus B19 as a cause of anemia in patients with human immunodeficiency virus infection.

J. Abkowitz, N. Young, K. Brown, 1997, Journal of Infectious Diseases.

Functional characterization of natural telomerase mutations found in patients with hematological disorders

N. Young, R. Calado, H. Ly, 2006 .

Parvovirus B19.

N. Young, K. Brown, 2004, The New England journal of medicine.

Immune pathophysiology of aplastic anemia

N. Young, J. Maciejewski, A. Risitano, 2002, International journal of hematology.

Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death.

N. Young, J. Maciejewski, S. Anderson, 1995, Journal of cellular physiology.

Parvovirus B19.

N. Young, K. Brown, 2004, The New England journal of medicine.

RMRP mutations in hematological disorders

S. Kajigaya, N. Young, R. Calado, 2007, Clinical genetics.

Effect of anticoagulants on multiplexed measurement of cytokine/chemokines in healthy subjects.

Xingmin Feng, N. Young, M. Langweiler, 2012, Cytokine.

Fluorescent Cell Barcoding As New Flow Cytometric Technique for Multiplexed Phenotyping and Signaling Profiling in Hematologic Patients

Xingmin Feng, S. Kajigaya, N. Young, 2016 .

Acquired aplastic anemia.

N. Young, 1999, Journal of the American Medical Association (JAMA).

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure.

M. Desierto, N. Young, J. Chen, 2010, Blood.

MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.

Jichun Chen, M. Desierto, K. Keyvanfar, 2011, Experimental hematology.

Epstein-Barr Virus and Risk of Multiple Sclerosis—Reply

N. Young, S. Rosenfeld, 2003 .

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

F. Marincola, Manikandan Narayanan, D. Chaussabel, 2014, Cell.

Constitutional telomerase mutations are genetic risk factors for cirrhosis

S. Chanock, N. Young, M. Zago, 2011, Hepatology.

Genetic and transcriptional analysis of spindle checkpoint genes in bone marrow failure patients.

N. Young, Johnson M Liu, W. Zeng, 2003, Blood cells, molecules & diseases.

Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia

B. Dumitriu, N. Young, C. Hourigan, 2014, Leukemia research reports.

Cytokine signature profiles in acquired aplastic anemia and myelodysplastic syndromes

R. Ganetzky, Xingmin Feng, N. Young, 2010, Haematologica.

Treatment with the Terminal Complement Inhibitor Eculizumab Improves Anemia in Patients with Paroxysmal Nocturnal Hemoglobinuria: Phase III Triumph Study Results.

N. Young, J. Szer, U. Dührsen, 2006 .

Reactivation of hepatitis B with reappearance of hepatitis B surface antigen after chemotherapy and immunosuppression.

J. Hoofnagle, T. Liang, N. Young, 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Bone marrow failure and the telomeropathies.

B. Dumitriu, N. Young, D. Townsley, 2014, Blood.

Aplastic Anaemia

N. Young, 1979 .

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag.

M. Desierto, N. Young, P. Scheinberg, 2019, Blood.

The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease).

R. Holman, N. Young, L. Anderson, 1986, The Journal of infectious diseases.

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

T. Ried, N. Young, Chuanfeng Wu, 2013, The Journal of clinical investigation.

Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

N. Young, P. Scheinberg, R. Calado, 2010, JAMA.