C. Whitfield

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Genetic Interaction Maps in Escherichia coli Reveal Functional Crosstalk among Cell Envelope Biogenesis Pathways

A. Emili, James Vlasblom, J. Parkinson, 2011, PLoS genetics.

C. Whitfield, C. Raetz, 2002, Annual review of biochemistry.

Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein

James H. Naismith, C. Whitfield, J. Naismith, 2006, Nature.

Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica

C. Whitfield, D. Heinrichs, J. Yethon, 1998, Molecular microbiology.

The Assembly System for the Lipopolysaccharide R2 Core-type ofEscherichia coli Is a Hybrid of Those Found inEscherichia coli K-12 and Salmonella enterica

C. Whitfield, D. Heinrichs, M. Perry, 1998, The Journal of Biological Chemistry.

Pneumoniae Serotype O1. Lipopolysaccharide O Antigen from Klebsiella Role of Rfe and Rfbf in the Initiation Of

C. Whitfield, J. Richards, B. R. Clarke, 1995 .

Synthesis of the D-Galactan I 0 Polysaccharide

C. Whitfield, M. Perry, J. Richards, 2022 .

Periplasmic Events in the Assembly of Bacterial Lipopolysaccharides

C. Whitfield, Emilisa Frirdich, A. Reid, 2007 .

Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis.

C. Whitfield, J. Naismith, R. Ford, 2009, Journal of structural biology.

Periplasmic export machines for outer membrane assembly.

C. Whitfield, J. Naismith, 2008, Current opinion in structural biology.

Analysis of the Topology and Active-Site Residues of WbbF, a Putative O-Polysaccharide Synthase from Salmonella enterica Serovar Borreze

C. Whitfield, B. R. Clarke, S. Wear, 2019, Journal of bacteriology.

Characterization of dTDP-4-dehydrorhamnose 3,5-Epimerase and dTDP-4-dehydrorhamnose Reductase, Required for dTDP-l-rhamnose Biosynthesis in Salmonella enterica Serovar Typhimurium LT2*

C. Whitfield, D. Heinrichs, B. Nidetzky, 1999, The Journal of Biological Chemistry.

In Vitro Reconstruction of the Chain Termination Reaction in Biosynthesis of the Escherichia coli O9a O-Polysaccharide

C. Whitfield, M. R. Richards, T. Lowary, 2011, The Journal of Biological Chemistry.

The biosynthetic origin of ribofuranose in bacterial polysaccharides

Danielle M. Williams, C. Whitfield, T. Lowary, 2022, Nature Chemical Biology.

Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a

C. Whitfield, J. Naismith, K. Harlos, 2012, Acta crystallographica. Section D, Biological crystallography.

UDP-galactofuranose Precursor Required for Formation of the Lipopolysaccharide O Antigen of Klebsiella pneumoniae Serotype O1 Is Synthesized by the Product of the rfbDKPO1 Gene*

J. Brisson, C. Whitfield, R. Köplin, 1997, The Journal of Biological Chemistry.

Structure and Functional Analysis of LptC, a Conserved Membrane Protein Involved in the Lipopolysaccharide Export Pathway in Escherichia coli*

C. Whitfield, C. Dong, A. Tran, 2010, The Journal of Biological Chemistry.

Structure and Functional Analysis of LptC, a Conserved Membrane Protein Involved in the Lipopolysaccharide Export

C. Whitfield, C. Dong, A. Tran, 2010 .

Functional Characterization of the Initiation Enzyme of S-Layer Glycoprotein Glycan Biosynthesis in Geobacillus stearothermophilus NRS 2004/3a

Kinnari B. Patel, C. Whitfield, M. Valvano, 2007, Journal of bacteriology.

Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems.

M. Aebi, N. Callewaert, C. Whitfield, 2006, Proceedings of the National Academy of Sciences of the United States of America.

6.8 Structural Analysis of Cell Surface Polysaccharides from Gram-Negative Bacteria

C. Whitfield, M. Perry, 1998 .

A New Sialidase Mechanism

S. Withers, C. Whitfield, W. Wakarchuk, 2009, The Journal of Biological Chemistry.

A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family

C. Whitfield, T. Lowary, B. R. Clarke, 2020, Nature Chemical Biology.

Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules

C. Whitfield, T. Lowary, O. Ovchinnikova, 2019, Nature Chemical Biology.

Bacterial β-Kdo glycosyltransferases represent a new glycosyltransferase family (GT99)

C. Whitfield, T. Lowary, O. Ovchinnikova, 2016, Proceedings of the National Academy of Sciences.

A widespread three-component mechanism for the periplasmic modification of bacterial glycoconjugates

C. Whitfield, Evan Mann, 2016 .

Biochemical Characterization of Bifunctional 3-Deoxy-β-d-manno-oct-2-ulosonic Acid (β-Kdo) Transferase KpsC from Escherichia coli Involved in Capsule Biosynthesis*

C. Whitfield, T. Lowary, O. Ovchinnikova, 2016, The Journal of Biological Chemistry.

Structure, biosynthesis, and function of bacterial capsular polysaccharides synthesized by ABC transporter-dependent pathways.

C. Whitfield, L. Willis, 2013, Carbohydrate research.

A Membrane-located Glycosyltransferase Complex Required for Biosynthesis of the d-Galactan I Lipopolysaccharide O Antigen in Klebsiella pneumoniae

C. Whitfield, V. Kos, 2010, The Journal of Biological Chemistry.

The compositional analysis of bacterial extracellular polysaccharides by high-performance anion-exchange chromatography.

C. Whitfield, W. Keenleyside, V. Sarabia, 1991, Analytical biochemistry.

Conserved glycolipid termini in capsular polysaccharides synthesized by ATP-binding cassette transporter-dependent pathways in Gram-negative pathogens

Jianjun Li, C. Whitfield, M. R. Richards, 2013, Proceedings of the National Academy of Sciences.

Glycosyltransferases Involved in Biosynthesis of the Outer Core Region of Escherichia coli Lipopolysaccharides Exhibit Broader Substrate Specificities Than Is Predicted from Lipopolysaccharide Structures*

C. Whitfield, E. Vinogradov, M. Leipold, 2007, Journal of Biological Chemistry.

Chromosomal and Plasmid-encoded Enzymes Are Required for Assembly of the R3-type Core Oligosaccharide in the Lipopolysaccharide of Escherichia coli O157:H7*

Jianjun Li, C. Whitfield, E. Vinogradov, 2004, Journal of Biological Chemistry.

Salmonella enterica Serovar TyphimuriumwaaP Mutants Show Increased Susceptibility to Polymyxin and Loss of Virulence In Vivo

S. Miller, L. Laroche, D. Malo, 2000, Infection and Immunity.

Assembly of the K 40 Antigen in Escherichia coli : Identification of a Novel Enzyme Responsible for Addition of L-Serine Residues to the Glycan Backbone and Its Requirement for K 40 Polymerization

C. Whitfield, P. Amor, J. Yethon, 1999 .

Assembly of the K40 Antigen in Escherichia coli: Identification of a Novel Enzyme Responsible for Addition ofl-Serine Residues to the Glycan Backbone and Its Requirement for K40 Polymerization

C. Whitfield, P. Amor, J. Yethon, 1999, Journal of bacteriology.

Involvement of waaY, waaQ, andwaaP in the Modification of Escherichia coliLipopolysaccharide and Their Role in the Formation of a Stable Outer Membrane*

C. Whitfield, D. Heinrichs, M. Perry, 1998, The Journal of Biological Chemistry.

Structure of the core oligosaccharide in the serotype O8 lipopolysaccharide from Klebsiella pneumoniae

C. Whitfield, J. Richards, W. Severn, 1996, Journal of bacteriology.

Structures of the O-antigens of Klebsiella serotypes 02 (2a,2e), 02 (2a,2e,2h), and 02 (2a,2f,2g), members of a family of related D-galactan O-antigens in Klebsiella spp

C. Whitfield, M. Perry, R. F. Kelly, 1995 .

Capsules and Extracellular Polysaccharides in Escherichia coli and Salmonella

C. Whitfield, Caitlin Sande, 2021, EcoSal Plus.

Biosynthesis of the Polymannose Lipopolysaccharide O-antigens from Escherichia coli Serotypes O8 and O9a Requires a Unique Combination of Single- and Multiple-active Site Mannosyltransferases*

Jianjun Li, C. Whitfield, W. Wakarchuk, 2012, The Journal of Biological Chemistry.

Biosynthesis of lipopolysaccharide O antigens.

C. Whitfield, 1995, Trends in microbiology.

Overexpression of the waaZ Gene Leads to Modification of the Structure of the Inner Core Region of Escherichia coli Lipopolysaccharide, Truncation of the Outer Core, and Reduction of the Amount of O Polysaccharide on the Cell Surface

C. Whitfield, O. Holst, B. Lindner, 2003, Journal of bacteriology.

Molecular diversity of the genetic loci responsible for lipopolysaccharide core oligosaccharide assembly within the genus Salmonella

C. Whitfield, C. Parker, M. Monteiro, 2002, Molecular microbiology.

Functional Analysis of the Galactosyltransferases Required for Biosynthesis of d-Galactan I, a Component of the Lipopolysaccharide O1 Antigen of Klebsiella pneumoniae

C. Whitfield, A. Clarke, S. Guan, 2001, Journal of bacteriology.

Biosynthesis and assembly of the polysialic acid capsule in Escherichia coli K1. Role of a low-density vesicle fraction in activation of the endogenous synthesis of sialyl polymers.

C. Whitfield, D. Adams, F. Troy, 1984, The Journal of biological chemistry.

Lipopolysaccharide O-antigens—bacterial glycans made to measure

Danielle M. Williams, C. Whitfield, Steven D. Kelly, 2020, The Journal of Biological Chemistry.

In Vitro Characterization of a Multidomain Glycosyltransferase Using Fluorescently Tagged Synthetic Acceptors.

Danielle M. Williams, C. Whitfield, O. Ovchinnikova, 2019, Methods in molecular biology.

Utilization of Fluorescently Tagged Synthetic Acceptor Molecules for In Vitro Characterization of a Dual-Domain Glycosyltransferase Enzyme, KpsC, from Escherichia coli.

C. Whitfield, O. Ovchinnikova, L. Doyle, 2019, Methods in molecular biology.

Glycolipid substrates for ABC transporters required for the assembly of bacterial cell-envelope and cell-surface glycoconjugates.

C. Whitfield, Sean D Liston, Evan Mann, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

The Klebsiella pneumoniae O12 ATP-binding Cassette (ABC) Transporter Recognizes the Terminal Residue of Its O-antigen Polysaccharide Substrate*

C. Whitfield, B. R. Clarke, M. Kimber, 2016, The Journal of Biological Chemistry.

KpsC and KpsS are retaining 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) transferases involved in synthesis of bacterial capsules

C. Whitfield, L. Willis, 2013, Proceedings of the National Academy of Sciences.

Domain Organization of the Polymerizing Mannosyltransferases Involved in Synthesis of the Escherichia coli O8 and O9a Lipopolysaccharide O-antigens*

C. Whitfield, W. Wakarchuk, E. Vinogradov, 2012, The Journal of Biological Chemistry.

Identification of the methyl phosphate substituent at the non-reducing terminal mannose residue of the O-specific polysaccharides of Klebsiella pneumoniae O3, Hafnia alvei PCM 1223 and Escherichia coli O9/O9a LPS.

C. Whitfield, E. Vinogradov, E. Katzenellenbogen, 2012, Carbohydrate research.

Coordination of Polymerization, Chain Termination, and Export in Assembly of the Escherichia coli Lipopolysaccharide O9a Antigen in an ATP-binding Cassette Transporter-dependent Pathway*

C. Whitfield, B. R. Clarke, Laura K. Greenfield, 2009, The Journal of Biological Chemistry.

Mutants of Escherichia coli O9:K30 with altered synthesis and expression of the capsular K30 antigen.

C. Whitfield, G. Schoenhals, L. Graham, 1989, Journal of general microbiology.

Structures of Lipopolysaccharides from Klebsiella pneumoniae

C. Whitfield, E. Vinogradov, M. Perry, 2002, The Journal of Biological Chemistry.

Biosynthesis of a Novel 3-Deoxy-D-manno-oct-2-ulosonic Acid-containing Outer Core Oligosaccharide in the Lipopolysaccharide of Klebsiella pneumoniae*

C. Whitfield, E. Vinogradov, Emilisa Frirdich, 2004, Journal of Biological Chemistry.

Protein synthesis is required for in vivo activation of polysialic acid capsule synthesis in Escherichia coli K1

C. Whitfield, E. Vimr, J. Costerton, 1984, Journal of bacteriology.

Investigation of the Structural Requirements in the Lipopolysaccharide Core Acceptor for Ligation of O Antigens in the Genus Salmonella

C. Whitfield, E. Vinogradov, Natalia A. Kaniuk, 2004, Journal of Biological Chemistry.

The UDP-glucose Dehydrogenase of Escherichia coli K-12 Displays Substrate Inhibition by NAD That Is Relieved by Nucleotide Triphosphates*

C. Whitfield, M. Kimber, J. Bean, 2013, The Journal of Biological Chemistry.

Review: Lipopolysaccharide inner core oligosaccharide structure and outer membrane stability in human pathogens belonging to the Enterobacteriaceae

C. Whitfield, Emilisa Frirdich, 2005, Journal of endotoxin research.

Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.

J. Errey, C. Whitfield, J. Naismith, 2009, Organic & biomolecular chemistry.

[16] Identification of rcs Genes in Escherichia coli O9:K30:H12 and Involvement in Regulation of Expression of Group IA K30 Capsular Polysaccharide

C. Whitfield, P. Jayaratne, W. Keenleyside, 1995 .

Coexpression of colanic acid and serotype-specific capsular polysaccharides in Escherichia coli strains with group II K antigens

C. Whitfield, D. Bronner, W. Keenleyside, 1993, Journal of bacteriology.

expression of group I capsular of the role of the rcs regulatory system in Escherichia coli O 9 : K 30 : H 12 and examination Characterization of rcsB and rcsC from

C. Whitfield, P. Jayaratne, W. Keenleyside, 2022 .

Pivotal Roles of the Outer Membrane Polysaccharide Export and Polysaccharide Copolymerase Protein Families in Export of Extracellular Polysaccharides in Gram-Negative Bacteria

C. Whitfield, J. Naismith, Iain L Mainprize, 2009, Microbiology and Molecular Biology Reviews.

A plasmid‐encoded rfbO:54 gene cluster is required for biosynthesis of the O:54 antigen in Salmonella enterica serovar Borreze

C. Whitfield, M. Perry, C. Poppe, 1994, Molecular microbiology.

Lipopolysaccharide as a target for the development of novel therapeutics in gram-negative bacteria.

C. Whitfield, J. Yethon, 2001, Current drug targets. Infectious disorders.

Architecture of a channel-forming O-antigen polysaccharide ABC transporter

C. Whitfield, J. Zimmer, Y. Bi, 2017, Nature.

The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli

C. Whitfield, J. Naismith, C. Botting, 2007, Proceedings of the National Academy of Sciences.

Association of alginate from Pseudomonas aeruginosa with two forms of heparin-binding lectin isolated from rat lung

C. Whitfield, H. Ceri, H. McArthur, 1986, Infection and immunity.

Crystallization and preliminary crystallographic analysis of the bacterial capsule assembly-regulating tyrosine phosphatases Wzb of Escherichia coli and Cps4B of Streptococcus pneumoniae

C. Whitfield, J. Naismith, G. Hagelueken, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Chapter 17 – Capsule and lipopolysaccharide

C. Whitfield, L. Willis, 2013 .

Characterisation of coliphage K30, a bacteriophage specific for Escherichia coli capsular serotype K30

C. Whitfield, M. Lam, 1986 .

Bacteriophage-mediated Glucosylation Can Modify Lipopolysaccharide O-Antigens Synthesized by an ATP-binding Cassette (ABC) Transporter-dependent Assembly Mechanism*

C. Whitfield, O. Ovchinnikova, Jerry D. King, 2015, The Journal of Biological Chemistry.

Bacteriophage-mediated glucosylation can modify lipopolysaccharide O antigens synthesized by an ABC transporter-dependent assembly mechanism*

C. Whitfield, O. Ovchinnikova, Jerry D. King, 2015 .

Assembly of Bacterial Capsular Polysaccharides and Exopolysaccharides.

C. Whitfield, S. Wear, Caitlin Sande, 2020, Annual review of microbiology.

Formation of the K30 (group I) capsule in Escherichia coli O9:K30 does not require attachment to lipopolysaccharide lipid A-core

C. Whitfield, W. Keenleyside, P. MacLachlan, 1993, Journal of bacteriology.

Surface Polysaccharides in Mutants of Xanthomonas campestris

C. Whitfield, I. Sutherland, R. Cripps, 1981 .

Naismith Gram-Negative Bacteria Extracellular Polysaccharides in Copolymerase Protein Families in Export of Polysaccharide Export and Polysaccharide Pivotal Roles of the Outer Membrane

C. Whitfield, Iain L Mainprize, L. Cuthbertson, 2009 .

Molecular and functional analysis of genes required for expression of group IB K antigens in Escherichia coli : characterization of the his‐region containing gene clusters for multiple cell‐surface polysaccharides

C. Whitfield, P. Amor, 1997, Molecular microbiology.

Distribution of the rol gene encoding the regulator of lipopolysaccharide O-chain length in Escherichia coli and its influence on the expression of group I capsular K antigens

C. Whitfield, P. Amor, C. Dodgson, 1996, Journal of bacteriology.

Application of a new nomenclature for bacterial surface polysaccharide genes.

D. Maskell, C. Whitfield, M. Skurnik, 1996 .

Clonally diverse rfb gene clusters are involved in expression of a family of related D-galactan O antigens in Klebsiella species

C. Whitfield, R. F. Kelly, 1996, Journal of bacteriology.

Molecular cloning of the rfb region of Klebsiella pneumoniae serotype O1:K20: the rfb gene cluster is responsible for synthesis of the D-galactan I O polysaccharide

C. Whitfield, B. R. Clarke, Chris Whitfield, 1992, Journal of bacteriology.

Monoclonal Antibodies That Distinguish Inner Core, Outer Core, and Lipid A Regions of Pseudomonas aeruginosa Lipopolysaccharide

K., C. Whitfield, D., 2022 .

Two-step purification of outer membrane proteins.

C. Whitfield, J. Naismith, I. Booth, 2006, International journal of biological macromolecules.

Comparative analysis of flagellin sequences from Escherichia coli strains possessing serologically distinct flagellar filaments with a shared complex surface pattern

C. Whitfield, G. Schoenhals, 1993, Journal of bacteriology.

6.7 Isolation and Purification of Cell Surface Polysaccharides from Gram-Negative Bacteria

C. Whitfield, M. Perry, 1998 .

Membrane proteins correlated with expression of the polysialic acid capsule in Escherichia coli K1

C. Whitfield, E. Vimr, J. Costerton, 1985, Journal of bacteriology.

Outer membrane protein K of Escherichia coli: purification and pore-forming properties in lipid bilayer membranes

R. Hancock, C. Whitfield, J. Costerton, 1983, Journal of bacteriology.

The purification, crystallization and structural elucidation of dTDP-D-glucose 4,6-dehydratase (RmlB), the second enzyme of the dTDP-L-rhamnose synthesis pathway from Salmonella enterica serovar typhimurium.

C. Whitfield, J. Naismith, M. Giraud, 2000, Acta crystallographica. Section D, Biological crystallography.

Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium.

C. Whitfield, J. Naismith, G. Leonard, 1999, Acta crystallographica. Section D, Biological crystallography.

Purification, crystallization and preliminary structural studies of dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC), the third enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar typhimurium.

C. Whitfield, J. Naismith, M. Giraud, 1999, Acta crystallographica. Section D, Biological crystallography.

Functional and Structural Characterization of Polysaccharide Co-polymerase Proteins Required for Polymer Export in ATP-binding Cassette Transporter-dependent Capsule Biosynthesis Pathways*

C. Whitfield, R. Ford, L. Willis, 2011, The Journal of Biological Chemistry.

Glucose Metabolism in Xanthomonas campestris

C. Whitfield, I. Sutherland, R. Cripps, 1982 .

A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose.

L. Major, C. Whitfield, J. Naismith, 2003, Biochemical Society transactions.

The LptA Protein of Escherichia coli Is a Periplasmic Lipid A-binding Protein Involved in the Lipopolysaccharide Export Pathway*

C. Whitfield, M. Trent, A. Tran, 2008, Journal of Biological Chemistry.

Characterization of GlaKP, a UDP-Galacturonic Acid C4-Epimerase from Klebsiella pneumoniae with Extended Substrate Specificity

C. Whitfield, Emilisa Frirdich, 2005, Journal of bacteriology.

Capsules and Secreted Extracellular Polysaccharides

C. Whitfield, S. Wear, Caitlin Sande, 2018 .

Modulation of the surface architecture of Gram‐negative bacteria by the action of surface polymer:lipid A–core ligase and by determinants of polymer chain length

C. Whitfield, P. Amor, Reinhard Ko¨plin, 1997, Molecular microbiology.

Transfer and expression of the genetic determinants for O and K antigen synthesis in Escherichia coli O9:K(A)30 and Klebsiella sp. O1:K20, in Escherichia coli K12.

C. Whitfield, D. Laakso, M. K. Homonylo, 1988, Canadian journal of microbiology.

Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity.

Jonathan M Stokes, Jonathan M. Stokes, S. French, 2016, Cell chemical biology.

Monoclonal antibodies against serotype specific and conserved epitopes in morphotype E Escherichia coli flagellins.

C. Whitfield, G. Schoenhals, 1990, FEMS microbiology letters.

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

Jonathan M Stokes, Jonathan M. Stokes, C. MacNair, 2017, Nature Microbiology.

Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30.

C. Whitfield, J. Naismith, K. Beis, 2004, Acta crystallographica. Section D, Biological crystallography.

Lateral transfer of rfb genes: a mobilizable ColE1-type plasmid carries the rfbO:54 (O:54 antigen biosynthesis) gene cluster from Salmonella enterica serovar Borreze

C. Whitfield, W. Keenleyside, 1995, Journal of bacteriology.

The rcsA gene of Klebsiella pneumoniae O1:K20 is involved in expression of the serotype-specific K (capsular) antigen

C. Whitfield, K. McCallum, 1991, Infection and immunity.

Phosphorylation of Wzc, a Tyrosine Autokinase, Is Essential for Assembly of Group 1 Capsular Polysaccharides in Escherichia coli*

C. Whitfield, J. Hocking, Chris Whitfield, 2001, The Journal of Biological Chemistry.

Trapped translocation intermediates establish the route for export of capsular polysaccharides across Escherichia coli outer membranes

C. Whitfield, J. Naismith, Iain L Mainprize, 2014, Proceedings of the National Academy of Sciences.

Use of a bacteriophage-encoded glycanase enzyme in the generation of lipopolysaccharide O side chain deficient mutants of Escherichia coli O9:K30 and Klebsiella O1:K20: role of O and K antigens in resistance to complement-mediated serum killing.

C. Whitfield, D. Laakso, K. McCallum, 1989, Canadian journal of microbiology.

Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate.

C. Whitfield, Stephen W B Fullerton, J. Naismith, 2003, Biochemistry.

Functional Expression of Enterobacterial O-Polysaccharide Biosynthesis Enzymes in Bacillus subtilis

C. Whitfield, P. Messner, C. Schäffer, 2002, Applied and Environmental Microbiology.

Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides

C. Whitfield, J. Naismith, S. McMahon, 2018, Proceedings of the National Academy of Sciences.

Biosynthesis and assembly of capsular polysaccharides in Escherichia coli.

C. Whitfield, 2006, Annual review of biochemistry.

RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.

J. Errey, L. Major, C. Whitfield, 2007, Journal of Molecular Biology.

Single polysaccharide assembly protein that integrates polymerization, termination, and chain-length quality control

Danielle M. Williams, C. Whitfield, T. Lowary, 2017, Proceedings of the National Academy of Sciences.

The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway.

C. Whitfield, J. Naismith, M. Giraud, 2001, Journal of molecular biology.

Biosynthesis and export of bacterial lipopolysaccharides.

C. Whitfield, M. Trent, Chris Whitfield, 2014, Annual review of biochemistry.

Expression of two structurally distinct D-galactan O antigens in the lipopolysaccharide of Klebsiella pneumoniae serotype O1

C. Whitfield, M. Perry, J. Richards, 1991, Journal of Bacteriology.

Regulation of expression of group IA capsular polysaccharides inEscherichia coli and related extracellular polysaccharides in other bacteria

C. Whitfield, W. Keenleyside, 1995, Journal of Industrial Microbiology.

A Novel Outer Membrane Protein, Wzi, Is Involved in Surface Assembly of the Escherichia coli K30 Group 1 Capsule

C. Whitfield, J. Naismith, Andrea Rahn, 2003, Journal of bacteriology.

Domain Interactions Control Complex Formation and Polymerase Specificity in the Biosynthesis of the Escherichia coli O9a Antigen*

C. Whitfield, M. R. Richards, T. Lowary, 2014, The Journal of Biological Chemistry.

Synthesis of lipopolysaccharide O-antigens by ABC transporter-dependent pathways.

C. Whitfield, Laura K. Greenfield, 2012, Carbohydrate research.

Nonreducing Terminal Modifications Determine the Chain Length of Polymannose O Antigens of Escherichia coli and Couple Chain Termination to Polymer Export via an ATP-binding Cassette Transporter*

C. Whitfield, B. R. Clarke, L. Cuthbertson, 2004, Journal of Biological Chemistry.

Bacterial polysaccharide synthesis and gene nomenclature.

D. Maskell, C. Whitfield, M. Skurnik, 1996, Trends in microbiology.

Translocation of group 1 capsular polysaccharide to the surface of Escherichia coli requires a multimeric complex in the outer membrane

C. Whitfield, J Drummelsmith, C Whitfield, 2000, The EMBO journal.

The C-terminal Domain of the Escherichia coli WaaJ Glycosyltransferase Is Important for Catalytic Activity and Membrane Association*

C. Whitfield, M. Leipold, Natalia A. Kaniuk, 2007, Journal of Biological Chemistry.

Lipopolysaccharide O antigen size distribution is determined by a chain extension complex of variable stoichiometry in Escherichia coli O9a

C. Whitfield, R. Morris, S. Berry, 2014, Proceedings of the National Academy of Sciences.

Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a

C. Whitfield, J. Naismith, B. R. Clarke, 2012, Molecular microbiology.

The C-terminal Domain of the Nucleotide-binding Domain Protein Wzt Determines Substrate Specificity in the ATP-binding Cassette Transporter for the Lipopolysaccharide O-antigens in Escherichia coli Serotypes O8 and O9a*

C. Whitfield, J. Powers, L. Cuthbertson, 2005, Journal of Biological Chemistry.

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

N. Kawasaki, C. Whitfield, Y. Iwakura, 2016, The Journal of Biological Chemistry.

Bioinformatics analysis of diversity in bacterial glycan chain-termination chemistry and organization of carbohydrate binding modules linked to ABC transporters.

C. Whitfield, M. Kimber, Evan Mann, 2019, Glycobiology.

Biosynthesis and expression of cell-surface polysaccharides in gram-negative bacteria.

C. Whitfield, M. Valvano, 1993, Advances in microbial physiology.

ABC Transporters Involved in Export of Cell Surface Glycoconjugates

C. Whitfield, V. Kos, L. Cuthbertson, 2010, Microbiology and Molecular Biology Reviews.

Structure and Assembly of Escherichia coli Capsules.

C. Whitfield, 2009, EcoSal Plus.

Molecular insights into the assembly and diversity of the outer core oligosaccharide in lipopolysaccharides from Escherichia coli and Salmonella

C. Whitfield, Emilisa Frirdich, Natalia A. Kaniuk, 2003, Journal of endotoxin research.

Peptidoglycan Association of Murein Lipoprotein Is Required for KpsD-Dependent Group 2 Capsular Polysaccharide Expression and Serum Resistance in a Uropathogenic Escherichia coli Isolate

Alexander R. Abbas, C. Whitfield, W. Sandoval, 2017, mBio.

UDP-galactopyranose mutase has a novel structure and mechanism

C. Whitfield, J. Naismith, D. Sanders, 2001, Nature Structural Biology.

Structural Insight into a Novel Formyltransferase and Evolution to a Nonribosomal Peptide Synthetase Tailoring Domain.

C. Whitfield, T. Schmeing, O. Ovchinnikova, 2018, ACS chemical biology.

Klebsiella pneumoniae O1 and O2ac antigens provide prototypes for an unusual strategy for polysaccharide antigen diversification

C. Whitfield, T. Lowary, B. R. Clarke, 2019, The Journal of Biological Chemistry.

Gene products required for surface expression of the capsular form of the group 1 K antigen in Escherichia coli (O9a:K30)

C. Whitfield, J. Drummelsmith, 1999, Molecular microbiology.

Full-length, Oligomeric Structure of Wzz Determined by Cryoelectron Microscopy Reveals Insights into Membrane-Bound States.

D. Clare, C. Whitfield, C. A. Siebert, 2017, Structure.

Biochemical and Structural Analysis of Bacterial O-antigen Chain Length Regulator Proteins Reveals a Conserved Quaternary Structure*

C. Whitfield, R. Ford, M. Kimber, 2009, Journal of Biological Chemistry.

Distribution of Core Oligosaccharide Types in Lipopolysaccharides from Escherichia coli

C. Whitfield, D. Heinrichs, K. Ziebell, 2000, Infection and Immunity.

Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode.

Gordon Leonard, James H Naismith, Iain D Kerr, 2002, Structure.

The molecular basis of regulation of bacterial capsule assembly by Wzc

C. Robinson, Peijun Zhang, C. Whitfield, 2021, Nature Communications.

PELDOR spectroscopy distance fingerprinting of the octameric outer-membrane protein Wza from Escherichia coli.

Gregor Hagelueken, Olav Schiemann, James H Naismith, 2009, Angewandte Chemie.

O-Antigen Modulates Infection-Induced Pain States

C. Heckman, A. Schaeffer, C. Whitfield, 2012, PloS one.

Structural variation in the O‐specific polysaccharides of Klebsiella pneumoniae serotype O1 and O8 lipopolysaccharide: evidence for clonal diversity in rfb genes

C. Whitfield, M. Perry, J. Richards, 1993, Molecular microbiology.

Bacterial extracellular polysaccharides.

C. Whitfield, C Whitfield, 1988, Canadian journal of microbiology.

Functional Analysis of Conserved Gene Products Involved in Assembly of Escherichia coli Capsules and Exopolysaccharides: Evidence for Molecular Recognition between Wza and Wzc for Colanic Acid Biosynthesis

C. Whitfield, A. Reid, 2005, Journal of bacteriology.

Polymorphism, duplication, and IS1-mediated rearrangement in the chromosomal his-rfb-gnd region of Escherichia coli strains with group IA and capsular K antigens

C. Whitfield, P. Amor, J. Drummelsmith, 1997, Journal of bacteriology.

The rcsA gene of Escherichia coli O9:K30:H12 is involved in the expression of the serotype-specific group I K (capsular) antigen

C. Whitfield, P. Jayaratne, W. Keenleyside, 1992, Journal of bacteriology.

A high-molecular-weight fraction of smooth lipopolysaccharide in Klebsiella serotype O1:K20 contains a unique O-antigen epitope and determines resistance to nonspecific serum killing

C. Whitfield, B. Clarke, G. Schoenhals, 1989, Infection and immunity.

O-antigen seroepidemiology of Klebsiella clinical isolates and implications for immunoprophylaxis of Klebsiella infections

C. Whitfield, A. Cross, M. Trautmann, 1997, Clinical and diagnostic laboratory immunology.

Unique lipid anchor attaches Vi antigen capsule to the surface of Salmonella enterica serovar Typhi

C. Whitfield, O. Ovchinnikova, Sean D Liston, 2016, Proceedings of the National Academy of Sciences.

Purification and Characterization of WaaP from Escherichia coli, a Lipopolysaccharide Kinase Essential for Outer Membrane Stability*

C. Whitfield, J. Yethon, 2001, The Journal of Biological Chemistry.

A coiled-coil domain acts as a molecular ruler in LPS chain length regulation

D. Svergun, C. Whitfield, J. Naismith, 2014, Nature Structural &Molecular Biology.

Three-dimensional Structure of Wza, the Protein Required for Translocation of Group 1 Capsular Polysaccharide across the Outer Membrane of Escherichia coli*

C. Whitfield, J. Naismith, K. Beis, 2004, Journal of Biological Chemistry.

Structure, assembly and regulation of expression of capsules in Escherichia coli

I S Roberts, C. Whitfield, I. Roberts, 1999, Molecular microbiology.

Periplasmic Protein-Protein Contacts in the Inner Membrane Protein Wzc Form a Tetrameric Complex Required for the Assembly of Escherichia coli Group 1 Capsules*

C. Whitfield, J. Naismith, K. Beis, 2006, Journal of Biological Chemistry.

Effect of pH and acrylamide concentration on the separation of lipopolysaccharides in polyacrylamide gels

C. Whitfield, A. Kropinski, J. Lam, 1988, Current Microbiology.

Wzi Is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia coli

C. Whitfield, J. Naismith, M. Wear, 2013, Structure.

The Role of Galacturonic Acid in Outer Membrane Stability in Klebsiella pneumoniae*

C. Whitfield, E. Vinogradov, Emilisa Frirdich, 2005, Journal of Biological Chemistry.

The Klebsiella pneumoniae O Antigen Contributes to Bacteremia and Lethality during Murine Pneumonia

T. Standiford, J. Younger, C. Whitfield, 2004, Infection and Immunity.

Structural analysis of the O-antigen side chain polysaccharides in the lipopolysaccharides of Klebsiella serotypes O2(2a), O2(2a,2b), and O2(2a,2c)

C. Whitfield, M. Perry, S. Yu, 1992, Journal of bacteriology.

Biosynthesis and Regulation of Expression of Group 1 Capsules in Escherichia coli and Related Extracellular Polysaccharides in Other Bacteria

C. Whitfield, Andrea Rahn, J. Drummelsmith, 2002 .

A Novel Pathway for O-Polysaccharide Biosynthesis in Salmonella enterica Serovar Borreze*

C. Whitfield, W. Keenleyside, 1996, The Journal of Biological Chemistry.

Relationships between rfb gene clusters required for biosynthesis of identical D-galactose-containing O antigens in Klebsiella pneumoniae serotype O1 and Serratia marcescens serotype O16

C. Whitfield, D. Bronner, M. Szabó, 1995, Journal of bacteriology.

Identification of an ATP‐binding cassette transport system required for translocation of lipopolysaccharide O‐antigen side‐chains across the cytoplasmic membrane of Klebsiella pneumoniae serotype O1

C. Whitfield, B. R. Clarke, D. Bronner, 1994, Molecular microbiology.

Characterization of the polysaccharide antigen of Klebsiella pneumoniae O:9 lipopolysaccharide.

C. Whitfield, M. Perry, L. Maclean, 1993, Carbohydrate research.

Monoclonal antibodies against the capsular K antigen of Escherichia coli (O9:K30(A):H12): characterisation and use in analysis of K antigen organisation on the cell surface.

C. Whitfield, J. Lam, L. A. MacDonald, 1988, Canadian journal of microbiology.

Mutation of the Lipopolysaccharide Core Glycosyltransferase Encoded by waaG Destabilizes the Outer Membrane of Escherichia coli by Interfering with Core Phosphorylation

C. Whitfield, M. Perry, J. Yethon, 2000, Journal of bacteriology.

Assembly of the R1-type core oligosaccharide of Escherichia coli lipopolysaccharide

C. Whitfield, D. Heinrichs, M. Perry, 1999 .

Conserved Organization in the cps Gene Clusters for Expression of Escherichia coli Group 1 K Antigens: Relationship to the Colanic Acid Biosynthesis Locus and the cps Genes from Klebsiella pneumoniae

C. Whitfield, Andrea Rahn, J. Drummelsmith, 1999, Journal of bacteriology.

The Assembly System for the Outer Core Portion of R1- and R4-type Lipopolysaccharides of Escherichia coli

C. Whitfield, D. Heinrichs, P. Amor, 1998, The Journal of Biological Chemistry.

The Assembly System for the Lipopolysaccharide R 2 Core-type of Escherichia coli Is a Hybrid of Those Found in Escherichia coli K-12 and Salmonella enterica STRUCTURE

C. Whitfield, D. Heinrichs, M. Perry, 1998 .

Biosynthesis and assembly of Group 1 capsular polysaccharides in Escherichia coli and related extracellular polysaccharides in other bacteria.

C. Whitfield, Anne Paiment, 2003, Carbohydrate research.

Impact of Phosphorylation of Specific Residues in the Tyrosine Autokinase, Wzc, on Its Activity in Assembly of Group 1 Capsules in Escherichia coli

C. Whitfield, J. Hocking, Anne Paiment, 2002, Journal of bacteriology.

Substrate recognition by a carbohydrate-binding module in the prototypical ABC transporter for lipopolysaccharide O-antigen from Escherichia coli O9a

C. Whitfield, B. Liu, M. Al-Abdul-Wahid, 2019, The Journal of Biological Chemistry.

Identification of Residues Involved in Catalytic Activity of the Inverting Glycosyl Transferase WbbE from Salmonella enterica Serovar Borreze

C. Whitfield, W. Keenleyside, A. Clarke, 2001, Journal of bacteriology.

Serotype-specific monoclonal antibodies against the H12 flagellar antigen of Escherichia coli.

C. Whitfield, T. Beveridge, J. Lam, 1988, Journal of general microbiology.

Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state.

C. Whitfield, Stephen W B Fullerton, J. Naismith, 2005, Journal of molecular biology.

The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step

C. Whitfield, T. Lowary, J. Klassen, 2022, Nature Communications.

Inhibiting fatty acid synthesis overcomes colistin resistance

C. MacNair, S. French, L. Carfrae, 2023, Nature Microbiology.

The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex

C. Whitfield, J. Naismith, D. Bhella, 2023, Open Biology.

A coiled-coil domain acts as a molecular ruler in LPS chain length regulation

D. Svergun, C. Whitfield, J. Naismith, 2014, Nature structural & molecular biology.

Substrate binding by a bacterial ABC transporter involved in polysaccharide export

C. Whitfield, M. Kimber, L. Cuthbertson, 2007, Proceedings of the National Academy of Sciences.

C. Whitfield, J. Powers, L. Cuthbertson, 2005 .

Toward a structural understanding of the dehydratase mechanism.

D. Maskell, C. Whitfield, J. Naismith, 2002, Structure.

Crystal Structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly

C. Whitfield, J. Naismith, G. Hagelueken, 2009, Journal of molecular biology.

Investigation of core machinery for biosynthesis of Vi antigen capsular polysaccharides in Gram-negative bacteria

C. Whitfield, A. Preston, O. Ovchinnikova, 2021, The Journal of biological chemistry.

Development of mass cytometry methods for bacterial discrimination.

O. Ornatsky, C. Whitfield, V. Baranov, 2011, Analytical biochemistry.

Molecular basis for the structural diversity in serogroup O2-antigen polysaccharides in Klebsiella pneumoniae

C. Whitfield, B. Liu, T. Lowary, 2018, The Journal of Biological Chemistry.

Translocation of Group 1 Capsular Polysaccharide in Escherichia coli Serotype K30

G. Harauz, C. Whitfield, J. Naismith, 2003, Journal of Biological Chemistry.

Stop and go: regulation of chain length in the biosynthesis of bacterial polysaccharides

C. Whitfield, K. Larue, 2008, Nature Structural &Molecular Biology.

High-Throughput "FP-Tag" Assay for the Identification of Glycosyltransferase Inhibitors.

S. Withers, David E. Williams, R. Andersen, 2019, Journal of the American Chemical Society.

The Klebsiella pneumoniae O2a Antigen Defines a Second Mechanism for O Antigen ATP-binding Cassette Transporters*

C. Whitfield, V. Kos, L. Cuthbertson, 2009, Journal of Biological Chemistry.

Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1

C. Whitfield, J. Richards, B. R. Clarke, 1995, Journal of bacteriology.

Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

C. Whitfield, P. Howell, D. Nivens, 2011, Front. Microbio..

THE CRYSTAL STRUCTURE OF DTDP-D-GLUCOSE 4,6-DEHYDRATASE (RMLB)FROM SALMONELLA ENTERICA SEROVAR TYPHIMURIUM

C. Whitfield, J. Naismith, M. Giraud, 2001 .

Identification of a second glycoform of the clinically prevalent O1 antigen from Klebsiella pneumoniae

C. Whitfield, T. Lowary, O. Ovchinnikova, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism and linkage specificities of the dual retaining β-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis

C. Whitfield, T. Lowary, O. Ovchinnikova, 2023, The Journal of biological chemistry.

Structural and Functional Variation in Outer Membrane Polysaccharide Export (OPX) Proteins from the Two Major Capsule Assembly Pathways Present in Escherichia coli

C. Whitfield, S. Kapadia, Caitlin Sande, 2019, Journal of bacteriology.

Structure and Assembly of Escherichia coli Capsules.

C. Whitfield, 2009, EcoSal Plus.

Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length

C. Whitfield, B. R. Clarke, O. Ovchinnikova, 2023, mBio.

Transcriptional organization and regulation of the Escherichia coli K30 group 1 capsule biosynthesis (cps) gene cluster

C. Whitfield, Andrea Rahn, 2003, Molecular microbiology.

Transition transferases prime bacterial capsule polymerization.

C. Whitfield, J. Cifuente, O. Ovchinnikova, 2024, Nature chemical biology.