D. Tsikas

发表

The Effects of Lung Protective Ventilation or Hypercapnic Acidosis on Gas Exchange and Lung Injury in Surfactant Deficient Rabbits

H. Hummler, Katharina Banke, M. Wolfson, 2016, PloS one.

Characterization of the L-Arginine/Nitric Oxide Pathway and Oxidative Stress in Pediatric Patients with Atopic Diseases

K. Jöckel, D. Tsikas, T. Reinehr, 2022, International journal of molecular sciences.

Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment

D. Tsikas, N. Derichs, M. Ballmann, 2020, Journal of clinical medicine.

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results

D. Tsikas, N. Derichs, M. Ballmann, 2020, Journal of clinical medicine.

Post-transplantation plasma malondialdehyde is associated with cardiovascular mortality in renal transplant recipients: a prospective cohort study

G. Navis, D. Tsikas, S. Bakker, 2020, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.

D. Tsikas, T. Thum, S. Bode-Böger, 2000, Circulation research.

DependentSHuman Endothelial Cells : Involvement of LDL Cholesterol Upregulates Synthesis of Asymmetrical Dimethylarginine

D. Tsikas, T. Thum, J. Borlak, 2000 .

Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: a comprehensive review from an analytical and biological perspective.

D. Tsikas, J. Jordan, S. Engeli, 2011, Biochimica et biophysica acta.

Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms.

R. Brandes, D. Tsikas, E. Schwedhelm, 1998, Atherosclerosis.

The role of l-arginine/l-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients

D. Tsikas, U. Bavendiek, J. Bauersachs, 2017, Amino Acids.

Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target

S. Szabó, D. Tsikas, A. Bollenbach, 2020, International journal of molecular sciences.

Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges.

D. Tsikas, 2017, Analytical biochemistry.

Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery

D. Tsikas, G. Theodoridis, H. Gika, 2021, Journal of clinical medicine.

The l-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids

D. Tsikas, U. Schara, Bibiana Beckmann, 2015, Amino Acids.

Spermidine for a Long, Dementia-Free Life?

D. Tsikas, 2017 .

Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low dose aspirin in man.

D. Tsikas, S. Bode-Böger, J. Frölich, 1993, Clinical science.

N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential.

D. Tsikas, D. Giustarini, R. Rossi, 2012, Biochemical pharmacology.

Endothelial dysfunction in patients with peripheral arterial disease and chronic hyperhomocysteinemia: potential role of ADMA

D. Tsikas, B. Hornig, N. Arakawa, 2004, Vascular medicine.

Enhanced Human Tissue Microdialysis Using Hydroxypropyl-ß-Cyclodextrin as Molecular Carrier

D. Tsikas, J. Jordan, S. Engeli, 2013, PloS one.

Dietary eicosapentaenoic acid (EPA) to produce antileukemic cyclopentenone prostaglandin J3?

D. Tsikas, D. Stichtenoth, 2012, Blood.

L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.

D. Tsikas, S. Bode-Böger, J. Frölich, 1998, British journal of clinical pharmacology.

Early Renal Ischemia‐Reperfusion Injury in Humans Is Dominated by IL‐6 Release from the Allograft

J. D. de Fijter, D. Tsikas, Emile de Heer, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension.

D. Tsikas, M. Nowicki, J. Dubiel, 1999, Journal of cardiovascular pharmacology.

Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls.

D. Tsikas, M. Nowicki, J. Dubiel, 1999, Metabolism: clinical and experimental.

Flow Injection Analysis of N-acetyl-L-cysteine Based on the Reduction of Copper(II)-neocuproine Reagent

D. Tsikas, Lea Kukoč-Modun, Maja Biočić, 2016 .

HPLC analysis of human erythrocytic glutathione forms using OPA and N-acetyl-cysteine ethyl ester: evidence for nitrite-induced GSH oxidation to GSSG.

D. Tsikas, D. Giustarini, Bibiana Beckmann, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Phenotyping and outcome on contemporary management in a German cohort of patients with peripartum cardiomyopathy

K. Sliwa, D. Tsikas, J. Jordan, 2013, Basic Research in Cardiology.

Enhancer AVE9488 After Experimental Myocardial Infarction Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase

P. Galuppo, D. Tsikas, G. Ertl, 2008 .

Transcoronary delivery of bone marrow cells to the infarcted murine myocardium

H. Drexler, D. Tsikas, H. Naim, 2006, Basic Research in Cardiology.

Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study

A. Schutte, D. Tsikas, E. Schwedhelm, 2020, Hypertension Research.

LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration.

D. Tsikas, J. Jordan, T. Thum, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

D. Tsikas, J. Frölich, I. Probst, 2014, Oxidative medicine and cellular longevity.

Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients

G. Navis, D. Tsikas, S. Bakker, 2019, Amino Acids.

Plasma ADMA associates with all-cause mortality in renal transplant recipients

G. Navis, D. Tsikas, S. Bakker, 2015, Amino Acids.

Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study.

R. Gans, G. Navis, D. Tsikas, 2022, Nitric oxide : biology and chemistry.

Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients

D. Tsikas, S. Bakker, M. Borst, 2017, Amino Acids.

Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal.

C. V. van Noorden, D. Tsikas, J. Lindeman, 2013, Antioxidants & redox signaling.

No effects of atorvastatin (10 mg/d or 80 mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study.

D. Tsikas, M. Huisman, J. Frölich, 2015, Pharmacological research.

On the importance of the use of proper approaches for comparison of analytical methods for serum nitrate and for evaluation of reference concentrations.

J. Hohlfeld, D. Tsikas, 2009, Clinical biochemistry.

Plasma and tissue homoarginine concentrations in healthy and obese humans

D. Tsikas, J. Jordan, S. Engeli, 2015, Amino Acids.

High urinary homoarginine excretion is associated with low rates of all-cause mortality and graft failure in renal transplant recipients

D. Tsikas, S. Bakker, H. van Goor, 2015, Amino Acids.

Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease.

S. Anker, D. Tsikas, F. Weidemann, 2012, International journal of cardiology.

Enhanced NO Signaling in Patients with Takotsubo Cardiomyopathy: Short-Term Pain, Long-Term Gain?

D. Tsikas, M. Frenneaux, J. Horowitz, 2013, Cardiovascular Drugs and Therapy.

Quantitative analysis of eicosanoids in biological samples by LC-MS/MS: Mission accomplished?

D. Tsikas, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?

D. Tsikas, M. Savvidou, A. Bollenbach, 2018, Amino Acids.

Age-Dependent Impairment of Endothelial Progenitor Cells Is Corrected by Growth Hormone Mediated Increase of Insulin-Like Growth Factor-1

P. Poole‐Wilson, S. Anker, P. Galuppo, 2007, Circulation research.

Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I.

D. Tsikas, J. Bauersachs, T. Thum, 2007, The Journal of clinical endocrinology and metabolism.

Small Interference RNA-Mediated Knockdown of eNOS in EPC

P. Poole‐Wilson, S. Anker, P. Galuppo, 2007 .

Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia

A. Hingorani, K. Nicolaides, P. Vallance, 2003, The Lancet.

WITHDRAWN: Editor's Forum.

D. Tsikas, 2015, Redox biology.

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

D. Tsikas, S. Gambaryan, 2015, Amino Acids.

TEMPORARY REMOVAL: Can nitric oxide synthase activity be unequivocally measured in red blood cells and platelets? If yes, by which assay?

D. Tsikas, 2015 .

Human blood platelets lack nitric oxide synthase activity

D. Tsikas, S. Gambaryan, Anke Böhmer, 2015, Platelets.

WITHDRAWN: Editor's Forum.

D. Tsikas, 2015, Redox biology.

Potential pitfalls with the use of acetoxy (CH(3)COO) drugs in studies on nitric oxide synthase in platelets.

D. Tsikas, S. Gambaryan, H. Meyer, 2013, Nitric oxide : biology and chemistry.

Endogenous nitric oxide synthase inhibitors are responsible for the L‐arginine paradox

D. Tsikas, S. Bode-Böger, J. Frölich, 2000, FEBS letters.

Nitro-fatty Acids Occur in Human Plasma in the Picomolar Range: a Targeted Nitro-lipidomics GC–MS/MS Study

D. Tsikas, A. Zoerner, F. Gutzki, 2009, Lipids.

Redox‐generated isoprostanes are associated with residual platelet activity in aspirin‐treated patients with stable coronary heart disease

D. Tsikas, E. Schwedhelm, R. Maas, 2010, Journal of Thrombosis and Haemostasis.

Acetylsalicylic Acid Inhibits Monocyte Adhesion to Endothelial Cells by an Antioxidative Mechanism

D. Tsikas, E. Schwedhelm, R. Böger, 2004, Journal of cardiovascular pharmacology.

Asymmetric dimethylarginine (ADMA)--a modulator of nociception in opiate tolerance and addiction?

D. Tsikas, G. Galloway, A. Kielstein, 2007, Nitric oxide : biology and chemistry.

Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood

D. Tsikas, Bibiana Beckmann, T. Lücke, 2015, Amino Acids.

Cardiovascular Effects of Systemic Nitric Oxide Synthase Inhibition With Asymmetrical Dimethylarginine in Humans

D. Tsikas, D. Fliser, H. Haller, 2004, Circulation.

Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-α Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes

D. Tsikas, O. Begou, S. Lenzen, 2022, International journal of molecular sciences.

What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine.

D. Tsikas, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry

D. Tsikas, 2010, Amino Acids.

N-(3-Chloro-2-hydroxypropyl)-valine in blood as haemoglobin adduct of epichlorohydrin [Biomonitoring Methods, 2013]

D. Tsikas, W. Rosenberger, F. Gutzki, 2013 .

N‐(3‐Chlor‐2‐hydroxypropyl)‐Valin als Hämoglobinaddukt des Epichlorhydrins [Biomonitoring Methods in German language, 2012]

D. Tsikas, W. Rosenberger, F. Gutzki, 2013 .

Quantification of N-(3-chloro-2-hydroxypropyl)valine in human haemoglobin as a biomarker of epichlorohydrin exposure by gas chromatography-tandem mass spectrometry with stable-isotope dilution.

D. Tsikas, W. Rosenberger, F. Gutzki, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Clinical Evaluation of Extracellular ADMA Concentrations in Human Blood and Adipose Tissue

D. Tsikas, J. Jordan, S. Engeli, 2014, International journal of molecular sciences.

High-performance liquid chromatography ultraviolet assay for human erythrocytic catalase activity by measuring glutathione as o-phthalaldehyde derivative.

D. Tsikas, J. Jordan, Anke Böhmer, 2011, Analytical biochemistry.

GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in humans.

D. Tsikas, T. Thum, Bibiana Beckmann, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Gas chromatography-mass spectrometry of cis-9,10-epoxyoctadecanoic acid (cis-EODA). I. Direct evidence for cis-EODA formation from oleic acid oxidation by liver microsomes and isolated hepatocytes.

D. Tsikas, J. Frölich, F. Gutzki, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia.

D. Tsikas, A. Das, T. Lücke, 2006, Metabolism: clinical and experimental.

Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: An elephant in the room.

D. Tsikas, P. Fanti, D. Giustarini, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Effects of single and combined metformin and l-citrulline supplementation on l-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications

D. Tsikas, D. Fischer, A. Bollenbach, 2018, Amino Acids.

Simultaneous stable-isotope dilution GC–MS measurement of homoarginine, guanidinoacetate and their common precursor arginine in plasma and their interrelationships in healthy and diseased humans

D. Tsikas, N. Maassen, A. Haghikia, 2015, Amino Acids.

Lysine and homoarginine are closely interrelated metabolites in the rat

D. Tsikas, L. Mosoni, D. Rémond, 2022, Amino Acids.

Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men

D. Tsikas, J. Huneau, F. Mariotti, 2019, Nutrients.

Circulating and excretory nitrite and nitrate as indicators of nitric oxide synthesis in humans: methods of analysis

D. Tsikas, D. Stichtenoth, F. Gutzki, 2006, European Journal of Clinical Pharmacology.

Stable-Isotope Dilution GC–MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination

D. Tsikas, A. Bollenbach, P. Hafner, 2022, Molecules.

Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy

D. Tsikas, B. Redfors, 2022, International journal of molecular sciences.

1 Results , meta-analysis and a first evaluation of U NOx R , the urinary nitrate-to-nitrite molar ratio , as a measure of nitrite reabsorption in experimental and clinical settings

D. Tsikas, D. Wedekind, J. Huneau, 2019 .

GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV.

D. Tsikas, N. Maassen, V. Endeward, 2018, Analytical biochemistry.

Asymmetric dimethylarginine (ADMA) and the risk for coronary heart disease: the multicenter CARDIAC study

D. Tsikas, R. Böger, H. Lenzen, 2006, European Journal of Clinical Pharmacology.

Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers

D. Tsikas, J. Frölich, R. Böger, 2004, European Journal of Clinical Pharmacology.

Local nitric oxide levels reflect the degree of allergic airway inflammation after segmental allergen challenge in asthmatics.

N. Krug, J. Hohlfeld, D. Tsikas, 2005, Nitric oxide : biology and chemistry.

Lack of Oxidative Stress during Sustained Therapy with Isosorbide Dinitrate and Pentaerythrityl Tetranitrate in Healthy Humans: A Randomized, Double-Blind Crossover Study

D. Tsikas, J. Frölich, F. Gutzki, 2003, Journal of cardiovascular pharmacology.

[Ureido-¹⁵N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity.

D. Tsikas, J. Jordan, S. Gambaryan, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry.

D. Tsikas, B. Mayer, A. Savva, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Positive correlation between plasma nitrite and performance during high-intensive exercise but not oxidative stress in healthy men.

D. Tsikas, Torge Wittke, N. Maassen, 2010, Nitric oxide : biology and chemistry.

Extra-platelet low-molecular-mass thiols mediate the inhibitory action of S-nitrosoalbumin on human platelet aggregation via S-transnitrosylation of the platelet surface

D. Tsikas, 2021, Amino Acids.

In-source formation of N-acetyl-p-benzoquinone imine (NAPQI), the putatively toxic acetaminophen (paracetamol) metabolite, after derivatization with pentafluorobenzyl bromide and GC-ECNICI-MS analysis.

D. Tsikas, F. Gutzki, Arne Trettin, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of S-nitrosoglutathione in human and rat plasma by high-performance liquid chromatography with fluorescence and ultraviolet absorbance detection after precolumn derivatization with o-phthalaldehyde.

M. Raida, D. Tsikas, P. Pantazis, 1999, Analytical biochemistry.

Rapeseed protein in a high-fat mixed meal alleviates postprandial systemic and vascular oxidative stress and prevents vascular endothelial dysfunction in healthy rats.

D. Tsikas, J. Huneau, D. Tomé, 2009, The Journal of nutrition.

Unique pentafluorobenzylation and collision-induced dissociation for specific and accurate GC-MS/MS quantification of the catecholamine metabolite 3,4-dihydroxyphenylglycol (DHPG) in human urine.

D. Tsikas, J. Tank, J. Jordan, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study.

D. Tsikas, S. Bode-Böger, J. Frölich, 1996, Circulation.

Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II

D. Tsikas, J. Jordan, A. Das, 2011, Amino Acids.

Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria

D. Tsikas, A. Das, Bibiana Beckmann, 2012, Amino Acids.

N-Acetylcysteine (NAC) inhibits renal nitrite and nitrate reabsorption in healthy subjects and in patients undergoing cardiac surgery: risk of nitric oxide (NO) bioavailability loss by NAC?

D. Tsikas, M. Flentje, A. Schwarz, 2014, International journal of cardiology.

Glutathione promotes prostaglandin H synthase (cyclooxygenase)‐dependent formation of malondialdehyde and 15(S)‐8‐iso‐prostaglandin F2α

D. Tsikas, J. Frölich, D. Stichtenoth, 2012, FEBS letters.

Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat

D. Tsikas, B. Redfors, A. A. Kayacelebi, 2017, Amino Acids.

Homoarginine and 3-nitrotyrosine in patients with takotsubo cardiomyopathy.

D. Tsikas, J. Jordan, J. Horowitz, 2014, International journal of cardiology.

Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nε-Carboxymethyl-Lysine, Nε-Carboxyethyl-Lysine and Nε-Hydroxymethyl-Lysine

D. Tsikas, Svetlana Baskal, 2022, International journal of molecular sciences.

Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats

H. Thiele, D. Tsikas, C. Besler, 2021, Amino acids.

Development, validation of a GC–MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine

D. Tsikas, A. Bollenbach, R. Kruger, 2021, Amino acids.

Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond

D. Tsikas, 2020, Journal of clinical medicine.

Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study

A. Schutte, D. Tsikas, E. Schwedhelm, 2020, Journal of Human Hypertension.

L-Arginine/NO Pathway Is Altered in Children with Haemolytic-Uraemic Syndrome (HUS)

D. Tsikas, M. Haubitz, J. Jordan, 2014, Oxidative medicine and cellular longevity.

Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease.

D. Tsikas, J. Bauersachs, T. Becker, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative.

D. Tsikas, J. Frölich, B. Schubert, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Effects of asymmetric dimethylarginine (ADMA) infusion in humans

D. Tsikas, D. Fliser, J. Kielstein, 2006, European Journal of Clinical Pharmacology.

Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets

D. Tsikas, S. Gambaryan, 2021, Journal of enzyme inhibition and medicinal chemistry.

Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by NG-hydroxy-l-arginine, Nω,Nω-dimethyl-l-citrulline and Nω,Nω-dimethyl-Nδ-hydroxy-l-citrulline: results and overview

D. Tsikas, A. Bollenbach, 2018, Amino Acids.

Antihypertensive inorganic nitrate and nitrite: what is the underlying mechanism?

D. Tsikas, J. Frölich, Jessica Y. Schneider, 2013, Hypertension.

S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics

D. Tsikas, A. Bollenbach, Erik Hanff, 2017, World journal of gastroenterology.

L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment.

G. Brabant, D. Tsikas, S. Bode-Böger, 1999, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects.

D. Tsikas, S. Bode-Böger, J. Frölich, 1994, Clinical science.

Elevated urinary excretion of nitric oxide metabolites in young infants with Zellweger syndrome.

D. Tsikas, E. Mayatepek, J. Frölich, 2003, Clinica chimica acta; international journal of clinical chemistry.

Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age.

D. Tsikas, M. Kemper, A. Das, 2007, Clinical chemistry and laboratory medicine.

Analysis of eicosanoids by LC-MS/MS and GC-MS/MS: a historical retrospect and a discussion.

D. Tsikas, A. Zoerner, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

STAT 3-mediated regulation of miR-199 a-5 p links cardiomyocyte and endothelial cell function in the heart : A key role for ubiquitin-conjugation enzymes

M. Muckenthaler, H. Drexler, D. Tsikas, 2010 .

URINARY NO3− EXCRETION AS AN INDICATOR OF NITRIC OXIDE FORMATION IN VIVO DURING ORAL ADMINISTRATION OF l‐ARGININE OR l‐NAME IN RATS

D. Tsikas, S. Bode-Böger, J. Frölich, 1996, Clinical and experimental pharmacology & physiology.

Development and validation of GC–MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity

D. Tsikas, D. Haffner, S. Ückert, 2019, Amino Acids.

Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection.

D. Tsikas, B. Krausse-Opatz, H. Zeidler, 2009, Microbial pathogenesis.

Nebivolol decreases systemic oxidative stress in healthy volunteers.

D. Tsikas, E. Schwedhelm, J. Frölich, 2000, British journal of clinical pharmacology.

Endopeptidase inhibition attenuates the contraction induced by big endothelin‐1 of isolated human penile erectile tissue

D. Tsikas, M. Kuczyk, S. Ückert, 2018, Andrologia.

Importance of Prostanoids for Bronchial Smooth Muscle Tone

D. Tsikas, A. Becker, J. Frölich, 1993 .

GC–MS measurement of biological NG-hydroxy-l-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor

D. Tsikas, S. Bakker, A. Bollenbach, 2019, Amino Acids.

Investigation of NG-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS.

D. Tsikas, A. Bollenbach, Erik Hanff, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Clinical-chemistry laboratory relevant hemolysis is unlikely to compromise human plasma concentration of free asymmetric dimethylarginine (ADMA).

D. Tsikas, J. Jordan, N. Maassen, 2012, Clinical biochemistry.

Human plasma concentrations of malondialdehyde (MDA) and the F2-isoprostane 15(S)-8-iso-PGF(2alpha) may be markedly compromised by hemolysis: evidence by GC-MS/MS and potential analytical and biological ramifications.

D. Tsikas, N. Maassen, Maria-Theresia Suchy, 2010, Clinical biochemistry.

of Analytical Chemistry in Nitric Oxide Clinical Research -Nitrosoalbumin Plasma Levels in Health and Disease: Facts or Artifacts? Value S

D. Tsikas, J. Frölich, 2011 .

S-nitrosoalbumin and other S-nitrosothiols in the blood: is their quantity of no relevance?

D. Tsikas, 2004, Circulation research.

Measurement of S-nitrosoalbumin by gas chromatography--mass spectrometry. III. Quantitative determination in human plasma after specific conversion of the S-nitroso group to nitrite by cysteine and Cu(2+) via intermediate formation of S-nitrosocysteine and nitric oxide.

D. Tsikas, J. Frölich, J. Sandmann, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

S-nitrosoalbumin plasma levels in health and disease: facts or artifacts? Value of analytical chemistry in nitric oxide clinical research.

D. Tsikas, J. Frölich, 2002, Circulation research.

The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts

D. Tsikas, M. Kuczyk, S. Ückert, 2020, Journal of clinical medicine.

GC-MS and GC-MS/MS measurement of ibuprofen in 10-μL aliquots of human plasma and mice serum using [α-methylo-2H3]ibuprofen after ethyl acetate extraction and pentafluorobenzyl bromide derivatization: Discovery of a collision energy-dependent H/D isotope effect and pharmacokinetic application to inh

D. Tsikas, H. Tillmann, C. Bernasconi, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A proposal for comparing methods of quantitative analysis of endogenous compounds in biological systems by using the relative lower limit of quantification (rLLOQ).

D. Tsikas, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease

D. Tsikas, M. Kużniewski, A. Surdacki, 2019, Amino Acids.

Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.

G. Geginat, D. Tsikas, H. Hof, 2012, Molecular immunology.

N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations

D. Tsikas, M. Mikuteit, 2022, Amino Acids.

Enzymatic synthesis of dioxygen‐18 labelled 8‐epi‐prostanglandin F2α and its use in quantitative GC‐tandem MS

D. Tsikas, O. Jahn, E. Schwedhelm, 1997 .

This information is current as Dendritic Cells Dampens the Reactivity of 2 Prostaglandin E Bronchial Epithelial Cell-Derived

D. Tsikas, F. Lasitschka, M. Belvisi, 2011 .

Determination of 3-nitrotyrosine in human urine at the basal state by gas chromatography-tandem mass spectrometry and evaluation of the excretion after oral intake.

D. Tsikas, D. Stichtenoth, F. Gutzki, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry.

D. Tsikas, E. Schwedhelm, J. Frölich, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis of 3‐nitro‐L‐[2H3]tyrosine for use as an internal standard for quantification of 3‐nitro‐L‐tyrosine by gas chromatography‐mass spectrometry

D. Tsikas, E. Schwedhelm, J. Sandmann, 1998 .

Utilizing immunoaffinity chromatography (IAC) cross-reactivity in GC-MS/MS exemplified at the measurement of prostaglandin E1 in human plasma using prostaglandin E2-specific IAC columns.

D. Tsikas, J. Heeren, L. Scheja, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Comprehensive analysis of the l-arginine/l-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth

B. Bohnhorst, D. Tsikas, A. Das, 2017, Amino Acids.

Renal carbonic anhydrases are involved in the reabsorption of endogenous nitrite.

D. Tsikas, Bibiana Beckmann, K. Chobanyan-Jürgens, 2012, Nitric oxide : biology and chemistry.

Stable-isotope dilution GC-MS approach for nitrite quantification in human whole blood, erythrocytes, and plasma using pentafluorobenzyl bromide derivatization: nitrite distribution in human blood.

D. Tsikas, J. Tank, J. Jordan, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.

D. Tsikas, E. Schwedhelm, S. Bode-Böger, 2004, Nitric oxide : biology and chemistry.

Circulating and excretory nitrite and nitrate: their value as measures of nitric oxide synthesis, bioavailability and activity is inherently limited.

D. Tsikas, 2015, Nitric oxide : biology and chemistry.

Stable-isotope dilution LC-MS/MS measurement of nitrite in human plasma after its conversion to S-nitrosoglutathione.

D. Tsikas, J. Jordan, Erik Hanff, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

9- and 10-Nitro-oleic acid do not interfere with the GC-MS quantitative determination of nitrite and nitrate in biological fluids when measured as their pentafluorobenzyl derivatives.

D. Tsikas, F. Gutzki, Anja Mitschke, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry.

D. Tsikas, 2004, Methods in molecular biology.

Gas chromatographic-tandem mass spectrometric quantification of human plasma and urinary nitrate after its reduction to nitrite and derivatization to the pentafluorobenzyl derivative.

D. Tsikas, E. Schwedhelm, J. Frölich, 1999, Journal of chromatography. B, Biomedical sciences and applications.

High-performance liquid chromatographic analysis of nitrite and nitrate in human plasma as S-nitroso-N-acetylcysteine with ultraviolet absorbance detection.

D. Tsikas, J. Frölich, J. Sandmann, 1999, Journal of chromatography. B, Biomedical sciences and applications.

On the mercapturic acid pathway of nitric oxide: is S‐nitrosoglutathione present in the bile?

D. Tsikas, R. Rossi, A. Zoerner, 2010, Hepatology.

The L-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications.

D. Tsikas, J. Klempnauer, A. M. zu Vilsendorf, 2009, Nitric oxide : biology and chemistry.

Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers.

D. Tsikas, J. Frölich, D. Stichtenoth, 2005, Kidney international.

A validated, rapid UPLC-MS/MS method for simultaneous ivabradine, reboxetine, and metoprolol analysis in human plasma and its application to clinical trial samples.

D. Tsikas, J. Tank, J. Jordan, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Enhanced renal allograft rejection by inhibitors of nitric oxide synthase: a nonimmunologic influence on alloreactivity.

D. Tsikas, B. Klanke, E. Gröne, 1996, Laboratory investigation; a journal of technical methods and pathology.

Measurement of physiological S-nitrosothiols: a problem child and a challenge.

D. Tsikas, 2003, Nitric oxide : biology and chemistry.

Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal segmental glomerulosclerosis (FSGS).

D. Tsikas, J. Ehrich, M. Kemper, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Plasma nitrite concentration decreases after hyperoxia‐induced oxidative stress in healthy humans

D. Tsikas, Z. Dujic, D. Modun, 2012, Clinical physiology and functional imaging.

Discovery and microassay of a nitrite-dependent carbonic anhydrase activity by stable-isotope dilution gas chromatography–mass spectrometry

C. Supuran, D. Tsikas, Erik Hanff, 2015, Amino Acids.

Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology

Guoyao Wu, D. Tsikas, 2015, Amino Acids.

Short-Term Supplementation of Sodium Nitrate vs. Sodium Chloride Increases Homoarginine Synthesis in Young Men Independent of Exercise

D. Tsikas, N. Maassen, F. Mariotti, 2022, International journal of molecular sciences.

Synthesis of homoagmatine and GC–MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat

D. Tsikas, B. Redfors, Bibiana Beckmann, 2019, Amino Acids.

Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.

D. Tsikas, E. Schwedhelm, D. Atzler, 2019, Analytical biochemistry.

Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection

D. Tsikas, A. Bollenbach, Erik Hanff, 2019, Amino Acids.

The l-arginine/NO pathway, homoarginine, and nitrite-dependent renal carbonic anhydrase activity in young people with type 1 diabetes mellitus

D. Tsikas, Bibiana Beckmann, T. Lücke, 2015, Amino Acids.

Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica

R. Gold, D. Tsikas, A. Haghikia, 2015, Amino Acids.

Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system?

D. Tsikas, A. A. Kayacelebi, A. Kayacelebi, 2014, Circulation journal : official journal of the Japanese Circulation Society.

Asymmetric dimethylarginine, arginine and homoarginine at 11–13 weeks’ gestation and preeclampsia: a case–control study

K. Nicolaides, D. Tsikas, J. Jordan, 2013, Journal of Human Hypertension.

Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate

G. Juckel, D. Tsikas, T. Legenbauer, 2020, Journal of clinical medicine.

Stable isotope gas chromatography-tandem mass spectrometry determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples.

S. Szabó, D. Tsikas, Arthur J. L. Cooper, 2012, Analytical biochemistry.

Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?

D. Tsikas, T. Becker, Erik Hanff, 2017, Nitric oxide : biology and chemistry.

Oxidized and nitrated oleic acid in biological systems: analysis by GC-MS/MS and LC-MS/MS, and biological significance.

D. Tsikas, J. Jordan, A. Zoerner, 2011, Biochimica et biophysica acta.

Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients

J. Geleijnse, G. Rimbach, D. Tsikas, 2019, Nutrients.

Application of a stable-isotope dilution technique to study the pharmacokinetics of human 15N-labelled S-nitrosoalbumin in the rat: possible mechanistic and biological implications.

D. Tsikas, A. Warnecke, D. Stichtenoth, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Investigations of S-transnitrosylation reactions between low- and high-molecular-weight S-nitroso compounds and their thiols by high-performance liquid chromatography and gas chromatography-mass spectrometry.

D. Tsikas, J. Frölich, F. Gutzki, 1999, Analytical biochemistry.

Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. II. Quantitative determination of S-nitrosoalbumin in human plasma using S-[15N]nitrosoalbumin as internal standard.

D. Tsikas, J. Frölich, D. Stichtenoth, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. I. Preparation, purification, isolation, characterization and metabolism of S-[15N]nitrosoalbumin in human blood in vitro.

D. Tsikas, J. Frölich, F. Gutzki, 1999, Journal of chromatography. B, Biomedical sciences and applications.

GC-ECNICI-MS/MS of eicosanoids as pentafluorobenzyl-trimethylsilyl (TMS) derivatives: Evidence of CAD-induced intramolecular TMS ether-to-ester rearrangement using carboxy-18O-labelled eicosanoids and possible implications in quantitative analysis.

D. Tsikas, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Is circulating nitrite a directly acting vasodilator?

D. Tsikas, J. Frölich, 2002, Clinical science.

Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets

C. Supuran, D. Tsikas, S. Gambaryan, 2016, Amino Acids.

Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC–MS and GC–MS/MS

D. Tsikas, Bibiana Beckmann, G. Warnecke, 2015, Amino Acids.

GC–MS and GC–MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples

D. Tsikas, J. Jordan, Bibiana Beckmann, 2014, Amino Acids.

Specific transport of S‐nitrosocysteine in human red blood cells: Implications for formation of S‐nitrosothiols and transport of NO bioactivity within the vasculature

D. Tsikas, Kathrin S. Schwedhelm, J. Sandmann, 2005, FEBS letters.

Measurement of S -Nitrosoglutathione in Plasma by Liquid Chromatography-Tandem Mass Spectrometry.

D. Tsikas, Erik Hanff, E. Hanff, 2018, Methods in molecular biology.

UPLC-MS/MS measurement of S-nitrosoglutathione (GSNO) in human plasma solves the S-nitrosothiol concentration enigma.

D. Tsikas, J. Jordan, Mario Schmidt, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Even and carbon dioxide independent distribution of nitrite between plasma and erythrocytes of healthy humans at rest.

H. Hummler, D. Tsikas, N. Maassen, 2013, Nitric oxide : biology and chemistry.

Artifactual-free analysis of S-nitrosoglutathione and S-nitroglutathione by neutral-pH, anion-pairing, high-performance liquid chromatography. Study on peroxynitrite-mediated S-nitration of glutathione to S-nitroglutathione under physiological conditions.

D. Tsikas, J. Frölich, K. Denker, 2001, Journal of chromatography. A.

Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol.

D. Tsikas, 2020, Analytical biochemistry.

Analysis of leukotriene B4 as free acid and its δ-lactone by high-performance liquid chromatography: a study on the stability and formation of leukotriene B4 δ-lactone

D. Tsikas, J. Frölich, J. Fauler, 1993 .

High-performance liquid chromatography of glutathione conjugates

D. Tsikas, G. Brunner, 1992 .

Ion-exchange high-performance liquid chromatographic determination of leukotrienes after precolumn derivatisation with o-phthaldialdehyde

D. Tsikas, G. Brunner, 1988 .

Nitric oxide inhibits thesecretion ofT-helper 1- andT-helper 2-associated cytokines inactivated humanTcells

D. Tsikas, H. Bauer, C. Neumann, 1997 .

Extra-platelet NO and NO(+)-containing drugs are potent inhibitors of platelet aggregation in humans by cGMP-dependent and cGMP-independent mechanisms.

D. Tsikas, M. Flentje, D. Stichtenoth, 2012, Blood.

S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)–Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants: Results and overview

D. Tsikas, S. Ückert, D. Giustarini, 2017, Journal of pharmaceutical analysis.

Plasma nitrite concentrations decrease after hyperoxia-induced oxidative stress in healthy humans

D. Tsikas, Z. Dujic, D. Modun, 2012, BMC Pharmacology and Toxicology.

GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine

D. Tsikas, G. Theodoridis, Kathrin Drabert, 2019, Journal of pharmaceutical analysis.

Capillary isotachophoretic determination of cysteinyl leukotrienes.

D. Tsikas, J. Frölich, J. Fauler, 1991, Journal of chromatography.

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

D. Tsikas, A. Bollenbach, A. A. Kayacelebi, 2018, Cardiovascular Diabetology.

Nitric oxide synthesis in chronic renal failure. Are plasma S-nitrosothiol levels elevated?

D. Tsikas, J. Frölich, J. Kielstein, 2004, Clinica chimica acta; international journal of clinical chemistry.

Are plasma S-nitrosothiol levels elevated in chronic renal failure?

D. Tsikas, J. Frolich, 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Letters and Replies

D. Tsikas, 2003 .

Effect of captopril on prostacyclin and nitric oxide formation in healthy human subjects: interaction with low dose acetylsalicylic acid.

D. Tsikas, S. Bode-Böger, J. Frölich, 2003, British journal of clinical pharmacology.

Acute application of antioxidants protects against hyperoxia‐induced reduction of plasma nitrite concentration

D. Tsikas, Ana Šešelja-Perišin, D. Modun, 2015, Clinical physiology and functional imaging.

Gas chromatography-mass spectrometry of cis-9,10-epoxyoctadecanoic acid (cis-EODA). II. Quantitative determination of cis-EODA in human plasma.

D. Tsikas, J. Frölich, F. Gutzki, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Plasma Arginine and Urinary Nitrate and Nitrite Excretion in Bronchopulmonary Dysplasia

L. Gortner, D. Tsikas, J. Kreuder, 2004, Neonatology.

In vitro effects of a novel class of nitric oxide (NO) donating compounds on isolated human erectile tissue.

C. Stief, D. Tsikas, U. Jonas, 2002, European urology.

Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. Jakoby.

D. Tsikas, A. Surdacki, 2020, Analytical biochemistry.

Analysis of eicosanoids, amino acids, organic acids, and microRNAs.

D. Tsikas, A. Zoerner, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Assessment of urinary F(2)-isoprostanes in experimental and clinical studies: mass spectrometry versus ELISA.

D. Tsikas, Maria-Theresia Suchy, 2012, Hypertension.

GC-ECNICI-MS analysis of S-nitrosothiols and nitroprusside after treatment with aqueous sulphide (S2-) and derivatization with pentafluorobenzyl bromide: Evidence of S-transnitrosylation and formation of nitrite and nitrate.

D. Tsikas, Mario Schmidt, Erik Hanff, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

GC-MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate.

D. Tsikas, A. Surdacki, H. Meyer, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Electrospray ionization mass spectrometry of low-molecular-mass S-nitroso compounds and their thiols.

M. Raida, D. Tsikas, W. Forssmann, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Gas chromatographic-mass spectrometric detection of S-nitroso-cysteine and S-nitroso-glutathione.

D. Tsikas, J. Frölich, F. Gutzki, 1999, Analytical biochemistry.

Local and Systemic Alterations of the L-Arginine / Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and E ﬀ ects of Antibiotic Treatment

D. Tsikas, N. Derichs, M. Ballmann, 2020 .

Determination of asymmetric dimethylarginine in biological fluids: a paradigm for a successful analytical story

D. Tsikas, 2008, Current opinion in clinical nutrition and metabolic care.

Homoarginine in health and disease

D. Tsikas, 2022, Current opinion in clinical nutrition and metabolic care.

Course of transforming growth factor ß1 in the systemic and cavernous blood of healthy males through different penile conditions

D. Tsikas, M. Kuczyk, S. Ückert, 2018, Andrologia.

Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood

D. Tsikas, Bibiana Beckmann, T. Lücke, 2015, Amino Acids.

Affinity chromatography as a method for sample preparation in gas chromatography/mass spectrometry.

D. Tsikas, 2001, Journal of biochemical and biophysical methods.

Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants

G. Navis, D. Tsikas, S. Bakker, 2019, Amino Acids.

Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine.

D. Tsikas, J. Frölich, F. Gutzki, 2000, Journal of chromatography. A.

Effects of chronic oral l-arginine administration on the l-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: l-Arginine prevents renal loss of nitrite, the major NO reservoir

D. Tsikas, J. Huneau, J. Frölich, 2015, Amino Acids.

A. Schutte, D. Tsikas, C. Mels, 2020, Amino Acids.

Unaltered l-arginine/NO pathway in a MELAS patient: Is mitochondrial NO synthase involved in the MELAS syndrome?

D. Tsikas, M. Obermann, A. Das, 2016, International journal of cardiology.

Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection

D. Tsikas, A. Bollenbach, Erik Hanff, 2019, Amino Acids.

Simultaneous stable-isotope dilution GC–MS measurement of homoarginine, guanidinoacetate and their common precursor arginine in plasma and their interrelationships in healthy and diseased humans

D. Tsikas, N. Maassen, A. Haghikia, 2016, Amino Acids.

Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica

R. Gold, D. Tsikas, A. Haghikia, 2015, Amino Acids.

Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients

G. Navis, D. Tsikas, S. Bakker, 2019, Amino Acids.

Simultaneous GC-ECNICI-MS measurement of nitrite, nitrate and creatinine in human urine and plasma in clinical settings.

D. Tsikas, U. Bavendiek, N. Maassen, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Comments on Boelaert et al. Determination of Asymmetric and Symmetric Dimethylarginine in Serum from Patients with Chronic Kidney Disease: UPLC–MS/MS versus ELISA. Toxins 2016, 8, 149

D. Tsikas, Bibiana Beckmann, P. Araujo, 2016, Toxins.

Accurate measurement of nitrate, nitrite, and S-nitrosothiols in biological samples by mass spectrometry.

D. Tsikas, P. Araujo, Anke Böhmer, 2013, Free radical biology & medicine.

Analysis of NO and its metabolites by mass spectrometry. Comment on 'Detection of nitric oxide in tissue samples by ESI-MS' by Z. Shen, A. Webster, K. J. Welham, C. E. Dyer, J. Greenman and S. J. Haswell.

D. Tsikas, Bibiana Beckmann, J. Sandmann, 2011, The Analyst.

Quantification of Circulating Asymmetric Dimethylarginine (ADMA) in Humans: Consideration of Reference Intervals and Inter-Individual Variability in Method Validation

D. Tsikas, 2010 .

Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry

D. Tsikas, 2010, Amino Acids.

D. Tsikas, A. Bollenbach, 2018, Amino Acids.

The l-arginine/NO pathway, homoarginine, and nitrite-dependent renal carbonic anhydrase activity in young people with type 1 diabetes mellitus

D. Tsikas, Bibiana Beckmann, T. Lücke, 2015, Amino Acids.

Elevated plasma and urine levels of ADMA and 15(S)‐8‐iso‐PGF2α in end‐stage liver disease

D. Tsikas, J. Klempnauer, T. Becker, 2003, Hepatology.

Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality

D. Tsikas, A. Bollenbach, S. Bakker, 2021, Amino Acids.

What is more valuable in the creation of an alliance, democratic values or hegemonic state? The cases of the Delian League and NATO

D. Tsikas, 2020 .

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

D. Tsikas, D. Giustarini, R. Rossi, 2009, Critical reviews in clinical laboratory sciences.

Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.

D. Tsikas, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pentafluorobenzyl bromide-A versatile derivatization agent in chromatography and mass spectrometry: I. Analysis of inorganic anions and organophosphates.

D. Tsikas, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature.

D. Tsikas, Anke Böhmer, 2017, Nitric oxide : biology and chemistry.

Determination of nitrite as pentafluorobenzyl derivative by RP-HPLC and UV detection with and without ion-pair extraction

D. Tsikas, J. Frölich, 1992 .

Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells.

D. Tsikas, Mario Schmidt, A. Pich, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase

S. Blankenberg, D. Tsikas, S. Willems, 2011, Circulation.

Capillary isotachophoretic analysis of β-lactam antibiotics and their precursors

D. Tsikas, G. Brunner, A. Hofrichter, 1990 .

Determination of N-Acetyl-l-cysteine Ethyl Ester (NACET) by Flow Injection Analysis and Spectrophotometric Detection Using Different Thiol-Sensitive Ligands

D. Tsikas, D. Modun, Lea Kukoč-Modun, 2021, Molecules.

LC-MS/MS analysis of uncommon paracetamol metabolites derived through in vitro polymerization and nitration reactions in liquid nitrogen.

D. Tsikas, J. Jordan, Arne Trettin, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Application of capillary isotachophoresis to the analysis of glutathione conjugates.

D. Tsikas, G. Brunner, 1989, Journal of chromatography.

Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC-MS and GC-MS/MS as pentafluorobenzyl ether derivative.

Jens Jordan, D. Tsikas, J. Jordan, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Tandem mass spectrometric quantification of 8-iso-prostaglandin F2α and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2α in human urine

D. Tsikas, T. Durand, E. Schwedhelm, 2000 .

Development, validation and biomedical applications of stable-isotope dilution GC-MS and GC-MS/MS techniques for circulating malondialdehyde (MDA) after pentafluorobenzyl bromide derivatization: MDA as a biomarker of oxidative stress and its relation to 15(S)-8-iso-prostaglandin F2α and nitric oxide

D. Tsikas, N. Maassen, J. Frölich, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Unusual collision-induced dissociation of fluorated and non-fluorated alpha-nitrotoluene analogs in a gas chromatograph triple-stage quadrupole mass spectrometer under electron-capturing negative-ion chemical ionization conditions.

D. Tsikas, E. Schwedhelm, J. Frölich, 2005, Journal of chromatography. A.

Simultaneous derivatization and quantification of the nitric oxide metabolites nitrite and nitrate in biological fluids by gas chromatography/mass spectrometry.

D. Tsikas, 2000, Analytical chemistry.

Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period

B. Bohnhorst, D. Tsikas, A. Das, 2022, Amino Acids.

Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine

D. Tsikas, A. Bollenbach, R. Kruger, 2022, Molecules.

GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization

D. Tsikas, 2021, Molecules.

Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction

M. Bahls, H. Thiele, D. Tsikas, 2021, Scientific Reports.

GC-MS approach revealing hidden nitrite reactions in hemolysate using 18O-labelled nitrite and cysteine-based thiols.

D. Tsikas, 2020 .

Long-term effects of NO3- on the relationship between oxygen uptake and power after three weeks of supplemented HIHVT.

D. Tsikas, N. Maassen, M. Maassen, 2018, Journal of applied physiology.

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

D. Tsikas, D. Wedekind, J. Huneau, 2018, Amino Acids.

Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity, and plasma testosterone levels in hypogonadal men.

D. Tsikas, M. Kinzel, 2017, Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.

Simultaneous pentafluorobenzyl derivatization and GC-ECNICI-MS measurement of nitrite and malondialdehyde in human urine: Close positive correlation between these disparate oxidative stress biomarkers.

D. Tsikas, S. Bakker, Bibiana Beckmann, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evidence of the chemical reaction of (18)O-labelled nitrite with CO2 in aqueous buffer of neutral pH and the formation of (18)OCO by isotope ratio mass spectrometry.

D. Tsikas, V. Endeward, G. Gros, 2016, Nitric oxide : biology and chemistry.

The l-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids

D. Tsikas, U. Schara, Bibiana Beckmann, 2015, Amino Acids.

Blood pressure-lowering effects of propofol or sevoflurane anaesthesia are not due to enhanced nitric oxide formation or bioavailability.

D. Tsikas, J. Jordan, S. Engeli, 2015, British journal of clinical pharmacology.

Discovery and microassay of a nitrite-dependent carbonic anhydrase activity by stable-isotope dilution gas chromatography–mass spectrometry

C. Supuran, D. Tsikas, M. Zinke, 2015, Amino Acids.

Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?

D. Tsikas, J. Jordan, A. Hahn, 2014, International journal of cardiology.

Trapping of NAPQI, the intermediate toxic paracetamol metabolite, by aqueous sulfide (S²⁻) and analysis by GC-MS/MS.

D. Tsikas, J. Jordan, T. Thum, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

¹⁸O-Labeled nitrous acid and nitrite: Synthesis, characterization, and oxyhemoglobin-catalyzed oxidation to ¹⁸O-labeled nitrate.

D. Tsikas, F. Gutzki, Anke Böhmer, 2012, Analytical biochemistry.

Measurement of nitrite in urine by gas chromatography-mass spectrometry.

D. Tsikas, Bibiana Beckmann, Dimitrios Tsikas, 2012, Methods in molecular biology.

Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria

D. Tsikas, A. Das, Bibiana Beckmann, 2012, Amino Acids.

GC-MS and HPLC methods for peroxynitrite (ONOO- and O15NOO-) analysis: a study on stability, decomposition to nitrite and nitrate, laboratory synthesis, and formation of peroxynitrite from S-nitrosoglutathione (GSNO) and KO2.

D. Tsikas, 2011, The Analyst.

Effects of successive air and nitrox dives on human vascular function

D. Tsikas, Z. Dujic, J. Marinovic, 2011, European Journal of Applied Physiology.

GC-MS determination of creatinine in human biological fluids as pentafluorobenzyl derivative in clinical studies and biomonitoring: Inter-laboratory comparison in urine with Jaffé, HPLC and enzymatic assays.

D. Tsikas, F. Gutzki, W. Will, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evidence by gas chromatography-mass spectrometry of ex vivo nitrite and nitrate formation from air nitrogen oxides in human plasma, serum, and urine samples.

D. Tsikas, J. Jordan, S. Engeli, 2010, Analytical biochemistry.

Nitrite correlates with 3-nitrotyrosine but not with the F(2)-isoprostane 15(S)-8-iso-PGF(2alpha) in urine of rheumatic patients.

D. Tsikas, D. Stichtenoth, V. V. Pham, 2009, Nitric oxide : biology and chemistry.

M. Manns, M. Gebel, D. Tsikas, 2009, Critical care medicine.

A critical review and discussion of analytical methods in the L-arginine/nitric oxide area of basic and clinical research.

D. Tsikas, 2008, Analytical biochemistry.

ReviewMethods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids

D. Tsikas, 2005, Free radical research.

Chronic angiotensin II receptor blockade reduces (intra)renal vascular resistance in patients with type 2 diabetes.

D. Tsikas, D. Fliser, H. Haller, 2005, Journal of the American Society of Nephrology : JASN.

Trouble with the analysis of nitrite, nitrate, S-nitrosothiols and 3-nitrotyrosine: freezing-induced artifacts?

D. Tsikas, J. Frölich, 2004, Nitric oxide : biology and chemistry.

Mass spectrometry-validated HPLC method for urinary nitrate.

D. Tsikas, 2004, Clinical chemistry.

Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease

D. Tsikas, J. Frölich, A. Hahn, 2015, Amino Acids.

GC–MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine

D. Tsikas, Bibiana Beckmann, A. Bollenbach, 2019, Amino Acids.

Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes

P. Galuppo, D. Tsikas, G. Ertl, 2007, Diabetes.

Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology

Guoyao Wu, D. Tsikas, 2015, Amino Acids.

Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans

D. Tsikas, J. Huneau, E. Schwedhelm, 2015, Amino Acids.

GC–MS and GC–MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples

D. Tsikas, J. Jordan, Bibiana Beckmann, 2014, Amino Acids.

Elevated dimethylarginine dimethylaminohydrolase (DDAH) activity in rheumatoid arthritis and spondyloarthritis.

D. Tsikas, K. Chobanyan-Jürgens, D. Stichtenoth, 2011, Nitric oxide : biology and chemistry.

Inhibition of proteasome‐mediated glucocorticoid receptor degradation restores nitric oxide bioavailability in myocardial endothelial cells in vitro

D. Tsikas, J. Bauersachs, N. Roewer, 2014, Biology of the cell.

Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets

C. Supuran, D. Tsikas, S. Gambaryan, 2016, Amino Acids.

D. Tsikas, D. Haffner, S. Ückert, 2019, Amino Acids.

Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin.

D. Tsikas, S. Bode-Böger, J. Frölich, 1995, Journal of applied physiology.

Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids

D. Tsikas, 2022, Amino Acids.

GC-MS Studies on the Conversion and Derivatization of γ-Glutamyl Peptides to Pyroglutamate (5-Oxo-Proline) Methyl Ester Pentafluoropropione Amide Derivatives

D. Tsikas, A. Bollenbach, 2022, Molecules.

Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study

A. Kaiser, D. Tsikas, R. Kruger, 2022, Amino Acids.

GC-MS Discrimination of Citrulline from Ornithine and Homocitrulline from Lysine by Chemical Derivatization: Evidence of Formation of N5-Carboxy-ornithine and N6-Carboxy-lysine

D. Tsikas, A. Bollenbach, Svetlana Baskal, 2021, Molecules.

Two-Step Derivatization of Amino Acids for Stable-Isotope Dilution GC–MS Analysis: Long-Term Stability of Methyl Ester-Pentafluoropropionic Derivatives in Toluene Extracts

D. Tsikas, A. Bollenbach, Svetlana Baskal, 2021, Molecules.

Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry.

D. Tsikas, A. Bollenbach, 2020, Analytical biochemistry.

GC-MS and LC-MS/MS pilot studies on the guanidine (NG)-dimethylation in native, asymmetrically and symmetrically NG-dimethylated arginine-vasopressin peptides and proteins in human red blood cells.

D. Tsikas, S. Gambaryan, A. Pich, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy

D. Tsikas, S. Lenzen, A. Jörns, 2019, Amino Acids.

GC–MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine

D. Tsikas, Bibiana Beckmann, A. Bollenbach, 2019, Amino Acids.

High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients

D. Tsikas, S. Bakker, H. van Goor, 2019, Amino Acids.

Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns

D. Tsikas, Julian Eigendorf, Sven Haufe, 2019, Nutrients.

Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.

D. Tsikas, A. Bollenbach, E. Hanff, 2018, Analytical biochemistry.

GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index.

D. Tsikas, Bibiana Beckmann, A. Bollenbach, 2018, Analytical biochemistry.

Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine.

D. Tsikas, J. Jordan, Bibiana Beckmann, 2011, Analytical biochemistry.

De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards.

D. Tsikas, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Ion-pair extraction of histamine from biological fluids and tissues for its determination by high-performance liquid chromatography with fluorescence detection.

D. Tsikas, C. Toledano, G. Brunner, 1993, Journal of chromatography.

High-performance liquid chromatographic determination of plasma histamine after pre-column derivatisation with o-phthaldialdehyde

D. Tsikas, R. Czerwonka, G. Brunner, 1988 .

Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate

D. Tsikas, M. Kuczyk, S. Ückert, 2019, World Journal of Urology.

Mass spectrometry and 3-nitrotyrosine: strategies, controversies, and our current perspective.

D. Tsikas, M. Duncan, 2014, Mass spectrometry reviews.

Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin

D. Tsikas, Bibiana Beckmann, J. Kielstein, 2015, Amino Acids.

D. Tsikas, D. Giustarini, D. Modun, 2014, Oxidative medicine and cellular longevity.

Targeted stable-isotope dilution GC-MS/MS analysis of the endocannabinoid anandamide and other fatty acid ethanol amides in human plasma.

D. Tsikas, J. Jordan, S. Engeli, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.

M. Muckenthaler, H. Drexler, D. Tsikas, 2011, European heart journal.

Measurement of nitrite in plasma and serum: still a challenging analytical task

D. Tsikas, 2012, Clinical Chemistry and Laboratory Medicine.

ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.

D. Tsikas, B. Hornig, N. Arakawa, 2003, Cardiovascular research.

Clostridium difficile Toxins A and B Directly Stimulate Human Mast Cells

Gudrun Brandes, Ingo Just, D. Tsikas, 2007, Infection and Immunity.

CLOSTRIDIUM DIFFICILE TOXIN A AND B DIRECTLY STIMULATE HUMAN MAST CELLS

D. Tsikas, I. Just, G. Brandes, 2007 .

Identifying and quantifying contaminants contributing to endogenous analytes in gas chromatography/mass spectrometry.

D. Tsikas, 2010, Analytical chemistry.

Effects of single and combined metformin and l-citrulline supplementation on l-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications

D. Tsikas, D. Fischer, A. Bollenbach, 2018, Amino Acids.

Simplified HPLC method for urinary and circulating creatinine.

D. Tsikas, J. Frölich, Alexander Wolf, 2004, Clinical chemistry.

Urinary 8-iso-Prostaglandin F2&agr; as a Risk Marker in Patients With Coronary Heart Disease: A Matched Case-Control Study

D. Tsikas, E. Schwedhelm, R. Maas, 2004 .

Quantitative analysis of biomarkers, drugs and toxins in biological samples by immunoaffinity chromatography coupled to mass spectrometry or tandem mass spectrometry: A focused review of recent applications.

D. Tsikas, Dimitrios Tsikas, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Enzymatic Detoxification using Lipophilic Hollow-Fiber Membranes: IV. Glutathione Conjugation Reactions

D. Tsikas, G. Brunner, 1989, The International journal of artificial organs.

Nitric oxide inhibits the secretion of T‐helper 1‐ and T‐helper 2‐associated cytokines in activated human T cells‘pa

D. Tsikas, D. Stichtenoth, H. Bauer, 1997 .

Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity.

D. Tsikas, J. Jordan, S. Engeli, 2012, Analytical biochemistry.

Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo.

D. Tsikas, S. Bode-Böger, J. Frölich, 1998, Cardiovascular research.

Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells.

P. Galuppo, D. Tsikas, G. Ertl, 2006, Cardiovascular research.

Analysis of nitrite and nitrate as 1-nitro-2,4,6-trimethoxybenzene derivatives by reversed-phase HPLC with UV-detection

D. Tsikas, J. Frölich, F. Gutzki, 1992 .

GC-MS/MS and LC-MS/MS studies on unlabelled and deuterium-labelled oleic acid (C18:1) reactions with peroxynitrite (O=N-O-O⁻) in buffer and hemolysate support the pM/nM-range of nitro-oleic acids in human plasma.

D. Tsikas, J. Jordan, A. Zoerner, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects

D. Tsikas, J. Jordan, F. Luft, 2014, Obesity.

Endocannabinergic modulation of central serotonergic activity in healthy human volunteers

G. Juckel, D. Tsikas, J. Epplen, 2023, Annals of General Psychiatry.

Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction.

D. Tsikas, J. Jordan, S. Engeli, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Cross-validated stable-isotope dilution GC-MS and LC-MS/MS assays for monoacylglycerol lipase (MAGL) activity by measuring arachidonic acid released from the endocannabinoid 2-arachidonoyl glycerol.

D. Tsikas, J. Jordan, S. Engeli, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction

P. Galuppo, D. Tsikas, G. Ertl, 2008, Circulation.

Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review

D. Tsikas, S. Bakker, A. Post, 2019, Nutrients.

Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice.

J. Romijn, D. Tsikas, L. Havekes, 2013, The Journal of nutritional biochemistry.

Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.

P. Poole‐Wilson, S. Anker, D. Tsikas, 2005, Journal of the American College of Cardiology.

Casein Compared with Whey Proteins Affects the Organization of Dietary Fat during Digestion and Attenuates the Postprandial Triglyceride Response to a Mixed High-Fat Meal in Healthy, Overweight Men.

C. Lopez, D. Tsikas, J. Huneau, 2015, The Journal of nutrition.

Letter by Tsikas and Cooper regarding article, "dysregulation of hydrogen sulfide (H2S) producing enzyme cystathionine γ-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia".

D. Tsikas, Arthur James Cooper, 2014, Circulation.

Gas chromatography-mass spectrometry analysis of nitrite in biological fluids without derivatization.

D. Tsikas, Dimitrios Tsikas, Anja Mitschke, 2010, Analytical chemistry.

Analytical capillary isotachophoresis of bis(2-ethylhexyl) hydrogenphosphate and 2-ethylhexyl dihydrogenphosphate

D. Tsikas, G. Brunner, R. Velásquez, 1993 .

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

D. Tsikas, S. Gambaryan, 2015, Amino Acids.

Inhibition of platelet aggregation by S‐nitroso‐cysteine via cGMP‐independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets

M. Raida, D. Tsikas, J. Frölich, 1999, FEBS letters.

026 Determination of histamine in food by combined ion-pair extraction and reversed-phase HPLC with fluorescence detection

D. Tsikas, G. Brunner, R. Velásquez, 1992 .

Enzymatic and chemical labelling of prostaglandin E1 and 13,14-dihydro-15-keto-prostaglandin E1

D. Tsikas, J. Frölich, D. Stichtenoth, 1993 .

The l-arginine/NO pathway in the MELAS syndrome: An insufficiently explored and controversial research area.

D. Tsikas, M. Obermann, A. Das, 2017, International journal of cardiology.

Study of the effect of thiols on the vasodilatory potency of S-nitrosothiols by using a modified aortic ring assay.

D. Tsikas, D. Giustarini, R. Rossi, 2011, Toxicology and applied pharmacology.

Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS?

D. Tsikas, 2017, International journal of cardiology.

Analytical challenges in the assessment of NO synthesis from L-arginine in the MELAS syndrome.

D. Tsikas, M. Obermann, F. Mariotti, 2017, International journal of cardiology.

Protocols for the measurement of the F2-isoprostane, 15(S)-8-iso-prostaglandin F2α, in biological samples by GC-MS or GC-MS/MS coupled with immunoaffinity column chromatography.

D. Tsikas, Maria-Theresia Suchy, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Incorrect and inconsistent use of homocysteine's nomenclature: a potential source of misunderstandings

D. Tsikas, 2003, European journal of clinical investigation.

Endothelial nitric oxide synthase, cyclooxygenase-2, and essential hypertension: is there an interaction?

D. Tsikas, D. Stichtenoth, Dimitrios Tsikas, 2013, Hypertension.

Plasma and tissue homoarginine concentrations in healthy and obese humans

D. Tsikas, J. Jordan, S. Engeli, 2015, Amino Acids.

The hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury.

D. Tsikas, J. Lindeman, J. Bierau, 2017, American journal of physiology. Renal physiology.

Reliable Quantification of Endogenous Free 3-Nitrotyrosine in Human Plasma by GC–ECD or GC–MS in Health and Disease?

D. Tsikas, 2009 .

Recent methodological advances in the mass spectrometric analysis of free and protein-associated 3-nitrotyrosine in human plasma.

D. Tsikas, K. Caidahl, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Methodological considerations on the detection of 3-nitrotyrosine in the cardiovascular system.

D. Tsikas, E. Schwedhelm, J. Frölich, 2002, Circulation Research.

Measurement of nitrotyrosine in plasma by immunoassays is fraught with danger: commercial availability is no guarantee of analytical reliability

D. Tsikas, 2010, Clinical chemistry and laboratory medicine.

An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies

A. Schutte, D. Tsikas, A. Bollenbach, 2020, Journal of clinical medicine.

Re‐evaluation of the immunohistochemical distribution of isoforms of nitric oxide synthase in the human prostate: A light and electron microscopical study

D. Tsikas, M. Kuczyk, S. Ückert, 2021, Andrologia.

Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro.

C. Stief, D. Tsikas, U. Jonas, 2003, Urology.

Effects of various nitric oxide donating agents on the contractility and cyclic nucleotide turnover of human seminal vesicles in vitro.

C. Stief, D. Tsikas, U. Jonas, 2002, Urology.

Analysis of leukotrienes, prostaglandins, thromboxane B2 and their metabolites by capillary isotachophoresis

D. Tsikas, J. Frölich, J. Fauler, 1993, Electrophoresis.

Doubts concerning functional endothelial nitric oxide synthase in human erythrocytes.

D. Tsikas, Bibiana Beckmann, Anke Böhmer, 2012, Blood.

Specific GC-MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC-MS/MS reports.

D. Tsikas, J. Jordan, A. Zoerner, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard.

D. Tsikas, 2023, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Nitro-oleic acid and epoxy-oleic acid are not altered in obesity and type 2 diabetes.

D. Tsikas, J. Jordan, S. Engeli, 2014, Cardiovascular research.

Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: Is LC superfluous?

D. Tsikas, E. Schwedhelm, J. Martens-Lobenhoffer, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Tsikas et al. 15-deoxy-Δ12,14-PGJ2: An interesting but unapproachable pharmacological target [corrected]?

D. Tsikas, Bibiana Beckmann, Jonas Niemann, 2014, International Journal of Cardiology.

but unapproachable pharmacological target

D. Tsikas, Bibiana Beckmann, Jonas Niemann, 2014 .

Potentiation of Lipotoxicity in Human EndoC-βH1 Β-cells by Glucose is Dependent on the Structure of Free Fatty Acids.

D. Tsikas, T. Plötz, S. Lenzen, 2023, Molecular Nutrition & Food Research.

Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease

D. Tsikas, J. Borlak, J. Klempnauer, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Divergence in urinary 8-iso-PGF2α (iPF2α-III, 15-F2t-IsoP) levels from gas chromatography–tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF2α: Possible methodological, mechanistic and clinical implicati

J. Hohlfeld, D. Tsikas, E. Schwedhelm, 2003 .

Elevated Serum Oleic Acid Epoxide Concentration in Acetaminophen (Paracetamol) Poisoning

D. Tsikas, 2018 .

Does Oxidative Stress Change During Orthotopic Liver Transplantation

D. Tsikas, 2017 .

Enzymatic detoxification using lipophilic hollow-fiber membranes: III. Oxidation reactions of sulfides.

D. Tsikas, Y. Yamamoto, G. Brunner, 1989, Artificial organs.

Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox

D. Tsikas, 2017 .

GC-MS Studies on Derivatization of Creatinine and Creatine by BSTFA and Their Measurement in Human Urine

D. Tsikas, Bibiana Beckmann, Olga-Aggeliki Begou, 2021, Molecules.

Development of a Machine for Extracorporeal Removal of Lipophilic and Hydrophilic Toxins in Liver Failure

D. Tsikas, B. Mathieu, G. Brunner, 1992 .

DDAH activity is not associated with oxidative stress in elderly patients with peripheral arterial occlusive disease

D. Tsikas, J. Frölich, V. V. Pham, 2014, Experimental Gerontology.

Pitfalls in the measurement of tissue DDAH activity: is DDAH sensitive to nitrosative and oxidative stress?

D. Tsikas, Kristine Chobanyan, 2008, Kidney international.

Mass Spectrometric Analysis of F2-Isoprostanes: Markers and Mediators in Human Disease

D. Tsikas, E. Schwedhelm, R. Böger, 2007 .

Albumin from human serum does not contain asymmetric dimethylarginine (ADMA).

D. Tsikas, Bibiana Beckmann, 2009, Clinical biochemistry.

Simultaneous GC-MS/MS measurement of malondialdehyde and 4-hydroxy-2-nonenal in human plasma: Effects of long-term L-arginine administration.

D. Tsikas, J. Frölich, Bibiana Beckmann, 2017, Analytical biochemistry.

D. Tsikas, Bibiana Beckmann, J. Kielstein, 2015, Amino Acids.

Stable-isotope dilution GC-MS method for ethanol in vapour ethanol and microdialysis systems based on carbonate-catalyzed extractive pentafluorobenzoylation.

H. Frieling, D. Tsikas, J. Jordan, 2012, The Analyst.

Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease

D. Tsikas, M. Kużniewski, A. Surdacki, 2019, Amino Acids.

Quantification of carbonate by gas chromatography-mass spectrometry.

D. Tsikas, K. Chobanyan-Jürgens, 2010, Analytical chemistry.

Homocysteine and copper ions: is their interaction responsible for cardiovascular-related damage?

D. Tsikas, 2021, Amino Acids.

Role of carbon monoxide and nitric oxide in adult rat hepatocytes proliferating in vitro: Effects of CAS 1609.

D. Tsikas, P. Krause, I. Probst, 2010, Nitric oxide : biology and chemistry.

Diet and Exercise and Serum Markers of Oxidative Stress—Letter

D. Tsikas, Julian Eigendorf, 2017, Cancer Prevention Research.

Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy.

D. Tsikas, E. Hanff, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first.

D. Tsikas, 2017, Atherosclerosis.

Low nitric oxide in Primary Ciliary Dyskinesia due to impaired NOS activity – data driven hypothesis

D. Tsikas, C. Koerner-Rettberg, T. Lücke, 2022, Klinische Pädiatrie.

The dilemma of oxidative stress personified by the diprosopus 8-iso-prostaglandin F2α and prostaglandin F2α

D. Tsikas, 2017 .

Bronchial Epithelial Cell-Derived Prostaglandin E2 Dampens the Reactivity of Dendritic Cells

D. Tsikas, F. Lasitschka, M. Belvisi, 2011, The Journal of Immunology.

Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients

D. Tsikas, S. Bakker, A. Bollenbach, 2021, Amino Acids.

Plasma nitrite concentrations decrease after hyperoxia-induced oxidative stress in healthy humans

D. Tsikas, D. Modun, M. Krnić, 2012, BMC Pharmacology and Toxicology.

GC–MS measurement of biological NG-hydroxy-l-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor

D. Tsikas, S. Bakker, A. Bollenbach, 2019, Amino Acids.

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

D. Tsikas, D. Wedekind, J. Huneau, 2018, Amino Acids.

Nitric oxide, peroxynitrite, S-nitrosothiols and thiols are unlikely to exert their effects on recombinant cyclooxygenase-1 and cyclooxygenase-2 activity in vitro by modifying cysteine moieties.

D. Tsikas, Jonas Niemann, 2012, Nitric oxide.

Potential problems and pitfalls with the use of S‐nitrosoglutathione and other S‐nitrosothiols in physiology‐oriented basic science

D. Tsikas, 2012, The Journal of physiology.

Synthesis of [14,15,17,17,18,18‐2H6]‐leukotriene B4

D. Tsikas, J. Frölich, J. Fauler, 1992 .

Accurate quantification of dimethylamine (DMA) in human plasma and serum by GC-MS and GC-tandem MS as pentafluorobenzamide derivative in the positive-ion chemical ionization mode.

D. Tsikas, D. Stichtenoth, F. Gutzki, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Peripheral endocannabinoid microdialysis: in vitro characterization and proof-of-concept in human subjects

D. Tsikas, J. Jordan, S. Engeli, 2012, Analytical and Bioanalytical Chemistry.

Analytical tools and protocols in oxidative stress.

D. Tsikas, G. Theodoridis, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Growth hormone treatment improves markers of systemic nitric oxide bioavailability via the insulin-like growth factor-1 Importance for endothelial progenitor cells.

D. Tsikas, G. Ertl, J. Bauersachs, 2007, Journal of Stem Cells and Regenerative Medicine.

Arginase enzymes in the human prostate: A molecular biological and immunohistochemical approach

D. Tsikas, M. Kuczyk, S. Ückert, 2019, Andrologia.

Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic an

J. Hohlfeld, D. Tsikas, E. Schwedhelm, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Comment on: Ott et al. Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes 2011;60:572–576

D. Tsikas, J. Tank, J. Jordan, 2011, Diabetes.

Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC–MS and GC–MS/MS

D. Tsikas, Bibiana Beckmann, G. Warnecke, 2015, Amino Acids.

Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology—part I

D. Tsikas, 2021, Amino Acids.

Comments on the article "Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells (Nitric Oxide 22 (2010) 259-265)".

D. Tsikas, 2011, Nitric oxide : biology and chemistry.

Gas chromatographic–mass spectrometric analysis of the tripeptide glutathione in the electron-capture negative-ion chemical ionization mode

D. Tsikas, Anke Böhmer, E. Hanff, 2016, Amino Acids.

Sensitivity enhancement of a GC-MS/MS method for asymmetric dimethylarginine (ADMA) by plasma ultrafiltrate reduction.

D. Tsikas, Bibiana Beckmann, F. Gutzki, 2008, Analytical biochemistry.

GC-MS Studies on Nitric Oxide Autoxidation and S-Nitrosothiol Hydrolysis to Nitrite in pH-Neutral Aqueous Buffers: Definite Results Using 15N and 18O Isotopes

D. Tsikas, 2023, Molecules.

Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II

D. Tsikas, J. Jordan, A. Das, 2012, Amino Acids.

Asymmetrical dimethylarginine, oxidative stress, and atherosclerosis.

D. Tsikas, K. Chobanyan-Jürgens, D. Stichtenoth, 2011, Hypertension.

Severe glycerol intoxication after Menière's disease diagnostic – case report and overview of kinetic data

U. Bingel, D. Tsikas, I. Just, 2009, Clinical toxicology.

Is S‐nitrosoglutathione formed in nitric oxide synthase incubates?

D. Tsikas, J. Frölich, J. Sandmann, 2000, FEBS letters.

Effects of Short-Term Sodium Nitrate versus Sodium Chloride Supplementation on Energy and Lipid Metabolism during High-Intensity Intermittent Exercise in Athletes

D. Tsikas, N. Maassen, V. Shushakov, 2023, Applied Sciences.

Glucuronide conjugation of phenols in isolated rabbit hepatocytes measured by high-pressure liquid chromatography

D. Tsikas, M. Sawa, G. Brunner, 1988 .

High-performance liquid chromatography of glutathione conjugates

D. Tsikas, G. Brunner, 1992 .

Comment on absorption of aminoethyl cysteine ketimine decarboxylated dimer in mice: effect on plasma antioxidant potential.

D. Tsikas, Arthur J. L. Cooper, T. Denton, 2013, Journal of agricultural and food chemistry.

Nitric oxide and hypertension.

D. Tsikas, J. Jordan, Sven Haufe, 2012, Journal of hypertension.

Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolism

A. S. Yatsenko, D. Tsikas, H. Shcherbata, 2023, bioRxiv.

Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans.

D. Tsikas, D. Tsikas, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Malondialdehyde-Induced Post-Translational Modification of Human Hemoglobin

D. Tsikas, 2023, Journal of proteome research.

l-Arginine/nitric oxide pathway and oxidative stress in adults with ADHD: Effects of methylphenidate treatment.

G. Juckel, D. Tsikas, Beatrice Hanusch, 2023, Nitric oxide : biology and chemistry.

Fibrotic Diseases of the Human Urinary and Genital Tract: Current Understanding and Potential Strategies for Treatment

D. Tsikas, M. Kuczyk, S. Ückert, 2023, Journal of clinical medicine.

GC–MS and GC–MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations

D. Tsikas, 2023, Journal of Mass Spectrometry and Advances in the Clinical Lab.

D. Tsikas, J. Huneau, J. Frölich, 2015, Amino Acids.

Application of Gas Chromatography—Mass Spectrometry and Gas Chromatography—Tandem Mass Spectrometry to Assess in vivo Synthesis of Prostaglandins, Thromboxane, Leukotrienes, Isoprostanes and Related Compounds in Humans

D. Tsikas, 1999 .

Helicobacter pylori produces histamine and spermidine.

D. Tsikas, J. Frölich, G. Brunner, 1996, Zeitschrift für Gastroenterologie - German Journal of Gastroenterology.

Pentafluoropropionic Anhydride Derivatization and GC-MS Analysis of Histamine, Agmatine, Putrescine, and Spermidine: Effects of Solvents and Starting Column Temperature

D. Tsikas, Bibiana Beckmann, G. Brunner, 2023, Molecules.

Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects

F. Klawonn, D. Tsikas, S. Steffens, 2023, Amino Acids.

Letter by Tsikas regarding article, "dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase".

D. Tsikas, 2012, Circulation.

Determination of nitric oxide metabolites by means of the Griess assay and gas chromatography–mass spectrometry in the cavernous and systemic blood of healthy males and patients with erectile dysfunction during different functional conditions of the penis

D. Tsikas, U. Jonas, S. Ückert, 2000, Urological Research.

Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects

D. Tsikas, J. Jordan, F. Luft, 2014, Obesity.

Assessment of urinary F(2)-isoprostanes in experimental and clinical studies: mass spectrometry versus ELISA.

D. Tsikas, Maria-Theresia Suchy, 2012, Hypertension.

High urinary homoarginine excretion is associated with low rates of all-cause mortality and graft failure in renal transplant recipients

D. Tsikas, S. Bakker, H. van Goor, 2015, Amino Acids.

Stable-isotope dilution LC-MS/MS measurement of nitrite in human plasma after its conversion to S-nitrosoglutathione.

D. Tsikas, J. Jordan, Anke Böhmer, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

GC-MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate.

D. Tsikas, A. Surdacki, H. Meyer, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase

S. Blankenberg, D. Tsikas, S. Willems, 2011, Circulation.

Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay.

G. Geginat, D. Tsikas, H. Hof, 2012, Molecular immunology.

RELEASE OF HISTAMINE BY H2-RECEPTOR ANTAGONISTS?

D. Tsikas, R. Czerwonka, G. Brunner, 1987, The Lancet.

Mass Spectrometry-Based Evaluation of the Bland–Altman Approach: Review, Discussion, and Proposal

D. Tsikas, 2023, Molecules.

Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-α antibody-based therapy

D. Tsikas, S. Lenzen, A. Jörns, 2019, Amino Acids.

Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans

D. Tsikas, J. Huneau, E. Schwedhelm, 2015, Amino Acids.