D. Witte

D. Witte, S. Davies, S. Jodele, 2013, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Immunohistochemical localization of guanylin in the rat small intestine and colon.

M. Currie, M. Cohen, D. Witte, 1995, Biochemical and biophysical research communications.

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.

M. Caligiuri, N. Salomonis, L. Shih, 2018, Cancer discovery.

Angiopoietin-like-4 is a potential angiogenic mediator in arthritis.

D. Witte, S. Kersten, S. Thornton, 2005, Clinical immunology.

Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling

M. Hollenberg, U. Settmacher, D. Witte, 2017, Molecular Pharmacology.

SLC 26 A 9 is expressed in gastric surface epithelial cells , mediates Cl / HCO 3 exchange , and is inhibited by NH 4

D. Witte, G. Shull, J. G. Forte, 2005 .

SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+.

D. Witte, G. Shull, J. G. Forte, 2005, American journal of physiology. Cell physiology.

Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity

G. Gulati, B. Aronow, D. Witte, 2018, Rheumatology.

Validation of the Lupus Nephritis Clinical Indices in Childhood‐Onset Systemic Lupus Erythematosus

B. Rovin, D. Witte, M. Klein-Gitelman, 2016, Arthritis care & research.

Urine Biomarkers to Predict Response to Lupus Nephritis Therapy in Children and Young Adults

G. Gulati, D. Witte, M. Klein-Gitelman, 2017, The Journal of Rheumatology.

The Journal of Rheumatology and Young Adults Urine Biomarkers to Predict Response to Lupus Nephritis Therapy in Children

G. Gulati, D. Witte, M. Klein-Gitelman, 2017 .

Evidence of a Role for Local Complement Expression in a Murine Model of Progressive Glomerulonephritis

D. Witte, T. Welch, M. Frenzke, 2000, Pediatric Research.

Prevalence and Outcome of Allergic Colitis in Healthy Infants with Rectal Bleeding: A Prospective Cohort Study

D. Witte, Mitchell Cohen, M. Rothenberg, 2005, Journal of pediatric gastroenterology and nutrition.

The Fanconi Anemia Pathway Limits Human Papillomavirus Replication

Elizabeth E. Hoskins, G. Nuovo, D. Witte, 2012, Journal of Virology.

Thrombin drives tumorigenesis in colitis-associated colon cancer.

D. Witte, B. Monia, E. Mullins, 2014, Cancer research.

Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels.

D. Witte, J. Huelsken, G. Grabowski, 2008, Molecular genetics and metabolism.

Novel fibrillin 1 mutation in a case of neonatal Marfan syndrome: the increasing importance of early recognition.

R. Hinton, D. Witte, R. Hopkin, 2007, Congenital heart disease.

Beckwith-Wiedemann syndrome and the insulin-like growth factor-II gene. Does the genotype explain the phenotype?

D. Witte, K. Bove, 1994, The American journal of pathology.

Developmental and tissue-specific expression of prosaposin mRNA in murine tissues.

D. Witte, Y. Sun, G. Grabowski, 1994, The American journal of pathology.

Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.

Y. Nikiforov, D. Witte, D. Leroith, 1997, The Journal of clinical investigation.

Molecular differential pathology of rhabdomyosarcoma

W. Cavenee, D. Witte, H. Shimada, 1989, Genes, chromosomes & cancer.

Growth factor production by a human megakaryocytic tumor cell line

M. Lieberman, D. Witte, P. Stambrook, 1988, Journal of cellular physiology.

Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction.

D. Witte, R. Morris, G. Ciraolo, 2001, Experimental hematology.

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.

K. Fujikawa, D. Witte, E. Davie, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Rescue of Prothrombin-deficiency by Transgene Expression in Mice

D. Witte, S. J. Degen, William Y Sun, 2002, Thrombosis and Haemostasis.

Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice.

Ying Sun, C. Vorhees, MichaelT . Williams, 2013, Human molecular genetics.

Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models.

D. Witte, Y. Sun, H. Ran, 2011, Molecular genetics and metabolism.

(Mll-PTD) hematopoietic stem/progenitor cells bias, and myeloid differentiation in Mll partial tandem duplication Stress hematopoiesis reveals abnormal control of self-renewal, lineage

M. Caligiuri, D. Witte, G. Marcucci, 2013 .

Highly Sensitive Blocker Displacement Amplification and Droplet Digital PCR Reveal Low-Level Parental FOXF1 Somatic Mosaicism in Families with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins

Justyna A. Karolak, P. Stankiewicz, P. Szafranski, 2020, The Journal of Molecular Diagnostics.

Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation

D. Witte, S. Potter, M. Valerius, 2002, Mechanisms of Development.

PII: S0925-4773(01)00581-0

D. Witte, S. Potter, M. Valerius, 2001 .

Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Lisa J. Martin, D. Witte, J. Köhl, 2017, Nature.

Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency.

D. Witte, J. Degen, Christine M La Jeunesse, 2003, Blood.

An ACE inhibitor reduces Th2 cytokines and TGF-β1 and TGF-β2 isoforms in murine lupus nephritis

G. Boivin, D. Witte, David E. Adams, 2004 .

Inter-observer variability of the histological classification of lupus glomerulonephritis in children

N. Sebire, D. Witte, H. Brunner, 2015, Lupus.

Case Report: Hemolytic Anemia Following Deceased Donor Renal Transplantation Associated With Tranexamic Acid Administration for Disseminated Intravascular Coagulation.

D. Witte, E. Woodle, R. Alloway, 2015, Transplantation proceedings.

Transgenic Overexpression of β2-Adrenergic Receptors in Airway Smooth Muscle Alters Myocyte Function and Ablates Bronchial Hyperreactivity*

S. Liggett, D. Witte, R. Paul, 1999, The Journal of Biological Chemistry.

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.

D. Witte, M. Kowala, M. Valentine, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Impact of perinatal exposure to equol enantiomers on reproductive development in rodents.

D. Witte, K. Setchell, N. Brown, 2011, Reproductive toxicology.

Mammary gland differentiation by early life exposure to enantiomers of the soy isoflavone metabolite equol.

D. Witte, K. Setchell, Mi‐Ok Kim, 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype

Ying Sun, D. Witte, K. Setchell, 2019, Scientific Reports.

Composition of nephritic factor-generated glomerular deposits in membranoproliferative glomerulonephritis type 2.

D. Witte, A. J. Mcadams, C. West, 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction.

S. Liggett, D. Witte, G. Leikauf, 2000, American journal of physiology. Lung cellular and molecular physiology.

Hepatocyte‐specific expression of the mouse hepatocyte growth factor–like protein

D. Witte, J. Bezerra, Bruce J. Arono, 1993, Hepatology.

Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation

B. Aronow, D. Witte, K. Ess, 1999, Oncogene.

Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span.

D. Witte, H. Du, D. Hui, 2001, Journal of lipid research.

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.

D. Witte, S. J. Degen, J. Degen, 1998, The Journal of clinical investigation.

Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia.

Y. Nikiforov, T. Clemens, D. Witte, 1998, Endocrinology.

Overexpression of Insulin-Like Growth Factor-Binding Protein-4 (IGFBP-4) in Smooth Muscle Cells of Transgenic Mice through a Smooth Muscle α-Actin-IGFBP-4 Fusion Gene Induces Smooth Muscle Hypoplasia.

Y. Nikiforov, T. Clemens, D. Witte, 1998, Endocrinology.

Prothrombin deficiency results in embryonic and neonatal lethality in mice.

D. Witte, T. Bugge, S. J. Degen, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-γ (Mig, CXCL9)

J. L. Kavanaugh, D. Witte, P. Foster, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The juvenile human endocrine pancreas: normal v idiopathic hyperinsulinemic hypoglycemia.

D. Witte, M. Greider, J. Kissane, 1984, Seminars in diagnostic pathology.

Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice

Xianlin Han, Ying Sun, C. Vorhees, 2008, Human molecular genetics.

Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein.

D. Witte, H. Du, G. Grabowski, 1996, Journal of lipid research.

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

D. Witte, J. Degen, E. Plow, 2004, The Journal of clinical investigation.

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

B. Nielsen, D. Witte, L. Lund, 1998, Oncogene.

Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.

Nikolaos M. Nikolaidis, D. Witte, M. Rothenberg, 2004, American Journal of Respiratory Cell and Molecular Biology.

Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage.

D. Witte, H. Du, G. Grabowski, 1998, Human molecular genetics.

Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis.

D. Witte, D. Glass, M. Passo, 1996, The Journal of rheumatology.

Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue.

D. Witte, D. Glass, H. Brunner, 2002, The Journal of rheumatology.

Temporally and spatially restricted expression of apolipoprotein J in the developing heart defines discrete stages of valve morphogenesis

B. Aronow, D. Witte, J. Harmony, 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

Platelet activation releases megakaryocyte-synthesized apolipoprotein J, a highly abundant protein in atheromatous lesions.

B. Aronow, D. Witte, R. Gruppo, 1993, The American journal of pathology.

Apolipoprotein J: a membrane policeman?

B. Aronow, D. Witte, J. Harmony, 1992 .

Differential Contribution of IL-4 and STAT6 vs STAT4 to the Development of Lupus Nephritis1

F. Finkelman, D. Witte, C. Jacob, 2003, The Journal of Immunology.

Correction of GSK3 b at young age prevents muscle pathology in mice with myotonic dystrophy type 1

J. Woodgett, D. Witte, J. Puymirat, 2018 .

Tetrasomy 15q25.2 → qter identified with SNP microarray in a patient with multiple anomalies including complex cardiovascular malformation

R. Hinton, D. Witte, R. Hopkin, 2012, American journal of medical genetics. Part A.

Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus.

D. Witte, P. Devarajan, H. Brunner, 2006, Arthritis and rheumatism.

Analyses of temporal regulatory elements of the prosaposin gene in transgenic mice.

Ying Sun, D. Witte, G. Grabowski, 2003, The Biochemical journal.

Temporal and Spatial Expression of Murine Acid β-Glucosidase mRNA

D. Witte, G. Grabowski, E. Ponce, 2001 .

Microarray Analysis of Focal Segmental Glomerulosclerosis

B. Aronow, D. Witte, S. Potter, 2004, American Journal of Nephrology.

Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury.

D. Witte, J. Fagin, D. Hui, 2001, Endocrinology.

The Peptidoglycan-Associated Lipoprotein OprL Helps Protect a Pseudomonas aeruginosa Mutant Devoid of the Transactivator OxyR from Hydrogen Peroxide-Mediated Killing during Planktonic and Biofilm Culture

D. Hassett, D. Witte, B. Britigan, 2008, Journal of bacteriology.

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

D. Witte, S. J. Degen, E. Mullins, 2009, Blood.

Fetal surgical management of congenital heart block in a hydropic fetus: lessons learned from a clinical experience.

D. Witte, T. Crombleholme, P. Manning, 2011, The Journal of thoracic and cardiovascular surgery.

Detection of SYT-SSX Rearrangements in Synovial Sarcomas by Real-Time One-Step RT-PCR

M. Nikiforova, Y. Nikiforov, D. Witte, 2005, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility.

T. Clemens, D. Witte, J. Fagin, 1999, Endocrinology.

Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.

L. Alhonen, D. Witte, A. Lentsch, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Spermidine / spermine-N 1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice

L. Alhonen, D. Witte, A. Lentsch, 2009 .

CNS, lung, and lymph node involvement in Gaucher disease type 3 after 11 years of therapy: clinical, histopathologic, and biochemical findings.

Ying Sun, D. Witte, K. Setchell, 2015, Molecular genetics and metabolism.

Gaucher disease mouse models: point mutations at the acid β-glucosidase locus combined with low-level prosaposin expression lead to disease variants Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500202-JLR200

D. Witte, G. Grabowski, B. Quinn, 2005, Journal of Lipid Research.

Viable Mouse Models of Acid β-Glucosidase Deficiency

D. Witte, G. Grabowski, B. Quinn, 2003 .

Murine Acid α-Glucosidase: Cell-Specific mRNA Differential Expression during Development and Maturation

D. Witte, G. Grabowski, R. Hirschhorn, 1999 .

FXR-Gankyrin axis is involved in development of pediatric liver cancer

D. Witte, G. Tiao, Anita Gupta, 2017, Carcinogenesis.

Differential expression of complement C3 and C4 in the human kidney.

D. Witte, T. Welch, L. Beischel, 1993, The Journal of clinical investigation.

Lysosomal acid lipase deficiency: correction of lipid storage by adenovirus-mediated gene transfer in mice.

D. Witte, H. Du, D. Ameis, 2002, Human gene therapy.

Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

D. Witte, J. Degen, E. Plow, 2004 .

Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression.

D. Witte, D. Roopenian, R. Colbert, 2000, Arthritis and rheumatism.

Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b

D. Witte, H. Lehnert, Dave Witte, 2017, Scientific Reports.

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility

D. Witte, H. Lehnert, B. Rauch, 2017, International journal of molecular sciences.

Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.

David A. Williams, D. Witte, J. Cancelas, 2008, Blood.

Rac 1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells

David A. Williams, D. Witte, J. Cancelas, 2008 .

In vitro establishment and characterization of a human megakaryoblastic cell line.

M. Lieberman, B. Aronow, D. Witte, 1990, Blood.

Apolipoprotein J/Clusterin Prevents a Progressive Glomerulopathy of Aging

B. Aronow, D. Witte, J. Bissler, 2002, Molecular and Cellular Biology.

RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5

M. Hollenberg, D. Witte, H. Lehnert, 2019, Cancers.

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

D. Witte, M. Carroll, T. Welch, 2001, Clinical immunology.

A Fetus With Hypoplastic Left Heart Syndrome and Tricuspid Stenosis With Evolving Hydrops Fetalis

D. Witte, E. Michelfelder, A. Divanovic, 2012, Pediatric Cardiology.

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits

Ying Sun, Y. Hannun, C. Vorhees, 2010, Human molecular genetics.

Specific saposin C deficiency: CNS impairment and acid β-glucosidase effects in the mouse

Ying Sun, Y. Hannun, C. Vorhees, 2009, Human molecular genetics.

D. Witte, G. Grabowski, B. Quinn, 2005, Journal of Lipid Research.

Isolation and characterization of the human prosaposin promoter.

D. Witte, Y. Sun, G. Grabowski, 1998, Gene.

Pierson Syndrome: A Novel Cause of Congenital Nephrotic Syndrome

D. Witte, J. Goebel, J. Kogan, 2006, Pediatrics.

Emergence and Compartmentalization of Fatal Multi-Drug-Resistant Cytomegalovirus Infection in a Patient With Autosomal-Recessive Severe Combined Immune Deficiency

D. Witte, N. Lurain, M. Schleiss, 2004, Journal of pediatric hematology/oncology.

The Noninvasive Urinary Polyomavirus Haufen Test Predicts BK Virus Nephropathy in Children After Hematopoietic Cell Transplantation: A Pilot Study

D. Witte, S. Furth, U. Beier, 2016, Transplantation.

C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis

D. Witte, A. Davis, M. Frenzke, 2002, Clinical and experimental immunology.

Early-Lethal Costello Syndrome Due to Rare HRAS Tandem Base Substitution (c.35_36GC>AA; p.G12E)–Associated Pulmonary Vascular Disease

D. Witte, K. Gripp, R. Hopkin, 2014, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice

D. Witte, M. J. Danton, J. Degen, 2007, American journal of hematology.

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif

D. Witte, J. Degen, C. Lajeunesse, 2007 .

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

D. Witte, J. Degen, C. Lajeunesse, 2007, The Journal of clinical investigation.

Granular cell astrocytoma of the cerebellum: report of the first case.

L. Miles, D. Witte, A. Saad, 2006, American journal of clinical pathology.

Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus

G. Gulati, D. Witte, Bin Huang, 2018, Pediatric Nephrology.

Highest ADA expressing mouse tissues also exhibit cell-type specific coordinate up-regulation of purine degradative enzymes.

B. Aronow, D. Witte, J. Hutton, 1991, Advances in experimental medicine and biology.

The Na,K-ATPase α2 Isoform Is Expressed in Neurons, and Its Absence Disrupts Neuronal Activity in Newborn Mice*

J. Ramirez, G. Boivin, D. Witte, 2003, The Journal of Biological Chemistry.

Tungiasis in North America: a report of 2 cases in internationally adopted children.

D. Witte, V. Garcia, A. Lucky, 2001, The Journal of pediatrics.

Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis

D. Witte, A. Omoloja, L. Canessa, 2008, Pediatric Nephrology.

Abnormal differentiation in MC3T3-E1 preosteoblasts expressing a dominant-negative type I collagen mutation.

D. Witte, R. Wenstrup, J. Florer, 1996, Connective tissue research.

Viable mouse models of acid beta-glucosidase deficiency: the defect in Gaucher disease.

D. Witte, G. Grabowski, B. Quinn, 2003, The American journal of pathology.

Turnover and Distribution of Intravenously Administered Mannose-Terminated Human Acid β-Glucosidase in Murine and Human Tissues

Ying Sun, D. Witte, K. Bove, 1996, Pediatric Research.

Hepatic teratomas in children.

F. Askin, D. Witte, J. Kissane, 1983, Pediatric pathology.

The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer.

D. Witte, Mi‐Ok Kim, N. Brown, 2010, Carcinogenesis.

Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping

W. Cavenee, D. Witte, H. Scrable, 1987, Nature.

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction.

H. Meiselman, D. Witte, P. Malik, 2009, Blood.

DEK promotes HPV positive and negative head and neck cancer cell proliferation

Grace E. Hallenbeck, D. Witte, P. Lambert, 2014, Oncogene.

DEK proto-oncogene expression interferes with the normal epithelial differentiation program.

Elizabeth E. Hoskins, D. Witte, P. Lambert, 2009, The American journal of pathology.

Placental transfer of ganciclovir in a woman with acquired immunodeficiency syndrome and cytomegalovirus disease.

D. Witte, M. Schleiss, T. Siddiqi, 2002, The Pediatric infectious disease journal.

Guanylin mRNA expression in human intestine and colorectal adenocarcinoma.

M. Cohen, D. Witte, J. Hawkins, 1998, Laboratory investigation; a journal of technical methods and pathology.

A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)

D. Witte, P. de Blank, C. Fuller, 2020, Journal of Neuro-Oncology.

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

Arun K. Ramani, M. Brudno, B. Aronow, 2016, Acta Neuropathologica Communications.

Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder

Bo Chen, Piotr Dittwald, Erwin Brosens, 2013, Genome research.

Chd7 Cooperates with Sox10 and Regulates the Onset of CNS Myelination and Remyelination

Donna M. Martin, D. Witte, D. Choo, 2016, Nature Neuroscience.

DIPG-27. CLEE011XUS17T (NCT 02607124): A PHASE I/II STUDY OF RIBOCICLIB (LEE011) FOLLOWING RADIATION THERAPY IN CHILDREN WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

D. Witte, C. Fuller, Q. Lu, 2017 .

Neural system-enriched gene expression: relationship to biological pathways and neurological diseases.

B. Aronow, A. Jegga, L. Coolen, 2004, Physiological genomics.

The role of small GTPases of the Rho/Rac family in TGF‐β‐induced EMT and cell motility in cancer

D. Witte, H. Lehnert, H. Ungefroren, 2018, Developmental Dynamics.

Expression of guanylin is downregulated in mouse and human intestinal adenomas.

M. Cohen, D. Witte, J. Groden, 2000, Biochemical and biophysical research communications.

Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation.

D. Witte, Mitchell Cohen, J. Rudolph, 2002, The American journal of pathology.

Saposin C-LBPA interaction in late-endosomes/lysosomes.

Xiaoyang Qi, D. Witte, X. Qi, 2005, Experimental cell research.

A novel pathogenic variant in OFD1 results in X‐linked Joubert syndrome with orofaciodigital features and pituitary aplasia

D. Witte, R. Hopkin, R. Lombardo, 2019, American journal of medical genetics. Part A.

Laser Capture Microdissection-Microarray Analysis of Focal Segmental Glomerulosclerosis Glomeruli

D. Witte, S. Potter, P. Devarajan, 2007, Nephron Experimental Nephrology.

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene.

B. Aronow, D. Witte, S. Potter, 1989, Genes & development.

Dissecting a locus control region: facilitation of enhancer function by extended enhancer-flanking sequences

B. Aronow, D. Witte, S. Potter, 1995, Molecular and cellular biology.

, D enhancer-flanking sequences . enhancer function by extended Dissecting a locus control region : facilitation of

B. Aronow, D. Witte, S. Potter, 1995 .

Discordant Expression of Osteoblast Markers in MC3T3-E1 Cells that Synthesize a High Turnover Matrix (*)

D. Witte, R. Wenstrup, J. Fowlkes, 1996, The Journal of Biological Chemistry.

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.

D. Witte, R. Muraoka, S. Waltz, 1999, The Journal of clinical investigation.

Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials.

David A. Williams, C. von Kalle, D. Witte, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b

D. Witte, H. Lehnert, R. Zeiser, 2017, Scientific Reports.

Effect of dietary lysine level and environmental temperature during the finishing phase on the intramuscular fat content of pork.

D. Witte, M. Ellis, F. Mckeith, 2000, Journal of animal science.

Influence of dietary lysine level, pre-slaughter fasting, and rendement napole genotype on fresh pork quality.

D. Witte, M. Ellis, F. Mckeith, 2004, Meat science.

Antibodies to Estrogen, Progesterone, Glucocorticoid, Vitamin D Receptors and Autoantibodies to Androgen Receptor

D. Witte, S. Liao, A. Roy, 1987 .

Midgestational lethality in mice lacking the parathyroid hormone (PTH)/PTH-related peptide receptor is associated with abrupt cardiomyocyte death.

E. Gruenstein, C. Kuan, T. Clemens, 2003, Endocrinology.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

F. Finkelman, D. Witte, M. Flick, 2010, Cancer research.

Megakaryoblastic leukemia in an infant: Establishment of a megakaryocytic tumor cell line in athymic nude mice

D. Witte, Richard E. Harris, B. Lampkin, 1986 .

Laboratory Medicine and Biorepositories

John A. Lynch, Jeremy J. Corsmo, David P. Witte, 2016 .

The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury.

Hector Melin-Aldana, K. Kaestner, D. Prows, 2002, American journal of respiratory cell and molecular biology.

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

C. Naeve, D. Witte, M. Kirstein, 1997, Oncogene.

In vitro establishment and characterization of a human megakaryoblastic cell line

M. Lieberman, B. Aronow, D. Witte, 1990 .

Developmental Expression of Magmas in Murine Tissues and Its Co-expression with the GM-CSF Receptor

D. Witte, P. Jubinsky, M. Short, 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Highly sensitive blocker displacement amplification and droplet digital PCR reveal very low-level parental FOXF1 somatic mosaicism in families with ACDMPV.

Justyna A. Karolak, P. Stankiewicz, P. Szafranski, 2020, Journal of Molecular Diagnostics.

Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

M. Capecchi, D. Witte, S. Potter, 1995, Nature.

Cytomegalovirus and recurrent idiopathic membranoproliferative glomerulonephritis type 1: cause or consequence?

D. Witte, M. Braun, S. Wenderfer, 2007, Transplantation.

Diagnosis of cytomegalovirus infection in pediatric Menetrier's disease by in situ hybridization

M. Cohen, D. Witte, Mitchell Cohen, 1996, Journal of clinical microbiology.

Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues.

D. Witte, T. van Dyke, D. Askew, 1997, The American journal of pathology.

cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia.

C. Naeve, A. Look, N. Copeland, 1999, The American journal of pathology.

Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice.

D. Witte, P. Tipping, J. Degen, 2001, American journal of physiology. Renal physiology.

Expression and regulation of small proline-rich protein 2 in allergic inflammation.

Anil Mishra, Eric B Brandt, Marsha Wills-Karp, 2005, American journal of respiratory cell and molecular biology.

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

D. Witte, Raphael Kopan, M. Little, 2018, Proceedings of the National Academy of Sciences.

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling

U. Settmacher, D. Witte, H. Lehnert, 2017, International journal of molecular sciences.

A submicroscopic deletion in Xq26 associated with familial situs ambiguus.

L. Shaffer, D. Schlessinger, A. Ballabio, 1997, American journal of human genetics.

Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

Arun K. Ramani, M. Brudno, B. Aronow, 2016, Acta neuropathologica communications.

Effect of Rotavirus Strain on the Murine Model of Biliary Atresia

R. Ward, D. Witte, G. Tiao, 2006, Journal of Virology.

Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.

K. Komurov, D. Supp, D. Witte, 2020, Cell stem cell.

Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

Ying Sun, B. Aronow, C. Vorhees, 2008, BMC Neuroscience.

Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.

Ying Sun, D. Witte, J. Matsuda, 2007, Human Molecular Genetics.

Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes

Linda Yang, Lei Wang, Yi Zheng, 2007, Proceedings of the National Academy of Sciences.

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer

U. Settmacher, D. Witte, H. Lehnert, 2016, Journal of clinical medicine.

The use of a hydroxylapatite-filter steroid receptor assay method in the study of the modulation of androgen receptor interaction.

D. Witte, S. Liao, K. Schilling, 1984, Journal of steroid biochemistry.

Reduction of Atherosclerotic Plaques by Lysosomal Acid Lipase Supplementation

D. Witte, H. Du, M. Levine, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice.

D. Witte, D. Hui, D. Kuhel, 2000, The American journal of pathology.

Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.

Qutayba Hamid, Anil Mishra, D. Witte, 2003, The Journal of clinical investigation.

Regulated expression of complement factor B in the human kidney.

D. Witte, T. Welch, M. Frenzke, 1996, Kidney international.

Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5

M. Hollenberg, U. Settmacher, D. Witte, 2016, Oncotarget.

Acute non-proliferative glomerulitis: a cause of renal failure unique to children

D. Witte, A. J. Mcadams, C. West, 2000, Pediatric Nephrology.

Crescentic glomerulonephritis in childhood: acute nonproliferative glomerulitis versus dense deposit disease.

D. Witte, C. West, C. F. Strife, 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

P. Pandolfi, C. Cordon-Cardo, J. Teruya-Feldstein, 2007, Cancer research.

An artificial tendon with durable muscle interface

D. Witte, D. Melvin, J. Mayerson, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Biobanking in Pediatric Research

Michael G. Barnes, John A. Lynch, Jeremy J. Corsmo, 2012 .

A central role for a single c-Myb binding site in a thymic locus control region

B. Aronow, D. Witte, J. Hutton, 1995, Molecular and cellular biology.

Lack of guanylyl cyclase C, the receptor for Escherichia coli heat‐stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model

D. Witte, E. Mann, Mitchell Cohen, 2005, International journal of cancer.

The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine.

D. Witte, E. Mann, R. Giannella, 1996, Biochemical and biophysical research communications.

The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland

D. Witte, K. Goss, Jenifer R Prosperi, 2009, Journal of cellular physiology.

Alterations in creatine kinase in fresh muscle and cell cultures in duchenne dystrophy

D. Witte, L. Stern, L. Kaeding, 1981, Annals of neurology.

Megakaryoblastic leukemia in an infant. Establishment of a megakaryocytic tumor cell line in athymic nude mice.

D. Witte, B. Lampkin, L. Jenski, 1986, Cancer.

DNA microarray analysis reveals novel gene expression profiles in collagen-induced arthritis.

B. Aronow, D. Witte, E. Giannini, 2002, Clinical immunology.

Posterior distal femoral and proximal tibial metaphyseal stripes at MR imaging in children and young adults.

B. Dardzinski, D. Witte, J. Bean, 2002, Radiology.

Prosaposin: threshold rescue and analysis of the "neuritogenic" region in transgenic mice.

Ying Sun, D. Witte, X. Qi, 2002, Molecular genetics and metabolism.

Conditional expression of human acid β-glucosidase improves the visceral phenotype in a Gaucher disease mouse model Published, JLR Papers in Press, July 21, 2006.

D. Witte, G. Grabowski, B. Quinn, 2006, Journal of Lipid Research.

Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model.

Ying Sun, D. Witte, G. Grabowski, 2006, Journal of lipid research.

Prosaposin: promoter analysis and central-nervous-system-preferential elements for expression in vivo.

D. Witte, Y. Sun, G. Grabowski, 2000, The Biochemical journal.

Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism

D. Witte, K. Bove, Ammar Husami, 2016, PloS one.

Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.

D. Witte, N. Leslie, Z. Khuchua, 2016, Human pathology.

MicroRNA's role as biomarkers of lupus nephritis in children

D. Witte, P. Devarajan, H. Brunner, 2014, Pediatric Rheumatology.

Rotavirus Replication in the Cholangiocyte Mediates the Temporal Dependence of Murine Biliary Atresia

D. Witte, G. Tiao, S. Mohanty, 2013, PloS one.

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5

M. Hollenberg, D. Witte, H. Lehnert, 2019, Cancers.

Thrombocytopenia and proteinuria: answer

D. Witte, A. Omoloja, E. Broxson, 2009, Pediatric Nephrology.

Excessive IL-10 and IL-18 Trigger HLH-Like Hyperinflammation and Enhanced Myelopoiesis.

D. Witte, Xiaomei Yan, G. Huang, 2022, Journal of Allergy and Clinical Immunology.

Successful Simultaneous Liver-Kidney Transplantation in the Presence of Multiple High-Titered Class I and II Antidonor HLA Antibodies

D. Witte, R. Alloway, S. Tremblay, 2016, Transplantation direct.

Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype

D. Witte, K. Setchell, H. Ran, 2019, Scientific Reports.

Erratum to “Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation” [Mech. Dev. 110 (2002) 151–164]

D. Witte, S. Potter, M. Valerius, 2002, Mechanisms of Development.

The role of mannosylated enzyme and the mannose receptor in enzyme replacement therapy.

D. Witte, H. Du, M. Levine, 2005, American journal of human genetics.

Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility.

D. Witte, S. Potter, H. Hsieh-Li, 1995, Development.

Endogenously expressed multimeric self-cleaving hammerhead ribozymes ablate mutant collagen in cellulo.

D. Witte, I. Toudjarska, R. Wenstrup, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Novel cell lines promote the discovery of genes involved in early heart development.

D. Witte, S. Potter, K. Yutzey, 2001, Developmental biology.

TGF-β1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK.

U. Settmacher, D. Witte, H. Lehnert, 2017, Oncology reports.

The Proximal Convoluted Tubule is a Target for the Uroguanylin-regulated Natriuretic Response

D. Witte, J. Lorenz, A. McDonough, 2006, Journal of pediatric gastroenterology and nutrition.

An ACE inhibitor reduces Th2 cytokines and TGF-beta1 and TGF-beta2 isoforms in murine lupus nephritis.

G. Boivin, D. Witte, David E. Adams, 2004, Kidney international.

Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.

B. Aronow, D. Witte, T. Kimball, 2000, The Journal of clinical investigation.

Guanylin mRNA is expressed in villous enterocytes of the rat small intestine and superficial epithelia of the rat colon.

L. G. Lewis, M. Currie, M. Cohen, 1993, Biochemical and Biophysical Research Communications - BBRC.

Development of a Novel Renal Activity Index of Lupus Nephritis in Children and Young Adults

B. Rovin, D. Witte, L. Tucker, 2016, Arthritis care & research.

A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction.

H. Meiselman, D. Witte, P. Malik, 2009, Blood.

Thrombocytopenia and proteinuria: question

D. Witte, A. Omoloja, E. Broxson, 2009, Pediatric Nephrology.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

F. Finkelman, D. Witte, M. Flick, 2010, Cancer research.

The ultrastructure of the placenta in maternal diabetes mellitus

D. Witte, C. Brownscheidle, 1980 .