Tony Taldone

发表

Heat shock protein 90 in neurodegenerative diseases

Wenjie Luo, Weilin Sun, Tony Taldone, 2010, Molecular Neurodegeneration.

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.

Tony Taldone, G. Chiosis, K. Jhaveri, 2012, Biochimica et biophysica acta.

Human iPSC-based modeling of late-onset disease via progerin-induced aging.

D. Krainc, M. Tomishima, Y. Ganat, 2013, Cell stem cell.

Designing Drugs Against Hsp90 for Cancer Therapy

Tony Taldone, G. Chiosis, S. Ochiana, 2014 .

A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond.

Tony Taldone, A. Rodina, G. Chiosis, 2019, Cold Spring Harbor perspectives in biology.

The epichaperome is an integrated chaperome network that facilitates tumour survival

S. Larson, C. Hudis, E. Cesarman, 2016, Nature.

Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease.

Tony Taldone, Alexander Bolaender, Liza Shrestha, 2016, Current topics in medicinal chemistry.

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.

H. Erdjument-Bromage, Weilin Sun, Tony Taldone, 2020, Cell reports.

Paradigms for Precision Medicine in Epichaperome Cancer Therapy.

Serge K. Lyashchenko, S. Larson, L. Norton, 2019, Cancer cell.

Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

Maulik R. Patel, Pallav D. Patel, Serge K. Lyashchenko, 2021, Nature Communications.

Purine-scaffold Hsp90 inhibitors.

Tony Taldone, G. Chiosis, 2006, Current topics in medicinal chemistry.

Molecular Chaperones and How Addiction Matters in Cancer Therapy

Tony Taldone, G. Chiosis, M. Lowery, 2013 .

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2013, Chemistry & biology.

Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

D. Bolon, L. Neckers, Tony Taldone, 2013, Oncotarget.

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.

D. Bolon, L. Neckers, Tony Taldone, 2013 .

HSP90 facilitates oncogenic alterations of metabolism in B-cell lymphomas

J. Leonard, S. Manalis, J. Phillip, 2020, bioRxiv.

Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.

S. Larson, Jason S. Lewis, Tony Taldone, 2016, Journal of labelled compounds & radiopharmaceuticals.

A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor

Tony Taldone, G. Chiosis, Yanlong Kang, 2009 .

First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer

S. Larson, C. Hudis, L. Norton, 2020, Clinical Cancer Research.

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90

Tony Taldone, G. Chiosis, R. Immormino, 2019, The Journal of Biological Chemistry.

Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

E. Cesarman, H. Erdjument-Bromage, Tony Taldone, 2017, Molecular Cancer Therapeutics.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

E. Cesarman, R. Blasberg, A. Melnick, 2013, Blood.

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

Maulik R. Patel, Pallav D. Patel, A. Melnick, 2014, ACS chemical biology.

Structure elucidation and inhibitory effects on human platelet aggregation of chlorogenic acid from Wrightia tinctoria

Tony Taldone, Sunil Kumar, S. Zito, 2013, Journal of complementary & integrative medicine.

A direct link between the Passerini reaction and α-lactams

Tony Taldone, I. Lengyel, V. Cesare, 2004 .

Using 124I-PU-H71 PET imaging to predict intratumoral concentration in patients on a phase I trial of PU-H71.

S. Larson, Jason S. Lewis, Tony Taldone, 2013 .

Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy

S. Larson, C. Hudis, Jason S. Lewis, 2015 .

Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.

Tony Taldone, G. Chiosis, Sahil Sharma, 2017, Tetrahedron letters.

First-in-Human Trial of Epichaperome-Targeted Positron Emission Tomography in Cancer Patients.

S. Larson, C. Hudis, L. Norton, 2020, Clinical cancer research : an official journal of the American Association for Cancer Research.

Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines.

Tony Taldone, G. Chiosis, Yanlong Kang, 2009, Bioorganic & medicinal chemistry letters.

Heat shock protein 90 in neurodegenerative diseases

Wenjie Luo, Weilin Sun, Tony Taldone, 2010, Molecular Neurodegeneration.

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

Maulik R. Patel, Tony Taldone, A. Rodina, 2013, Beilstein journal of organic chemistry.

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.

O. Elemento, A. Melnick, Tony Taldone, 2016, Blood.

gammaherpesvirus-associated malignancies Targeting the Hsp90-associated viral oncoproteome in

E. Cesarman, R. Blasberg, A. Melnick, 2013 .

Stability of Doxycycline in Feed and Water and Minimal Effective Doses in Tetracycline-Inducible Systems.

Tony Taldone, E. Riedel, N. Lipman, 2016, Journal of the American Association for Laboratory Animal Science : JAALAS.

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.

J. Qi, J. Bradner, R. Levine, 2014, Blood.

About the reaction of aryl fluorides with sodium sulfide: investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine

Pallav D. Patel, Tony Taldone, G. Chiosis, 2012 .

Reaction of 2-Naphthylamine with Sodium Iodate/Sodium Sulfite: Synthesis of 2-Amino-1-iodonaphthalene

Tony Taldone, G. Chiosis, D. Zatorska, 2012 .

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using 89Zr-DFO-Trastuzumab

Valerie A Longo, Jason S. Lewis, Tony Taldone, 2010, PloS one.

Alpha-glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats.

Tony Taldone, Sunil Kumar, Bo Hu, 2008, Carbohydrate research.

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

Tony Taldone, G. Chiosis, J. Panek, 2010, The Journal of organic chemistry.

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90)

I. Crandall, Tony Taldone, G. Chiosis, 2013, PloS one.

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

V. Seshan, Nathalie Saurat, M. Tomishima, 2018, Nature Communications.

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

A. Mrejeru, D. Krainc, D. Sulzer, 2016, Stem cell reports.

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

Gabriela Chiosis, Tony Taldone, Hardik J Patel, 2011, Expert opinion on drug discovery.

Pre‐clinical efficacy of PU‐H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

U. Mony, A. Moreira, Tony Taldone, 2014, Molecular oncology.

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2014, Journal of medicinal chemistry.

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

C. Sander, S. Leach, W. Jarnagin, 2021, Communications Biology.

Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies.

Gabriela Chiosis, Swathi Merugu, Sahil Sharma, 2020, Methods in enzymology.

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

K. Manova-Todorova, H. Erdjument-Bromage, Wenjie Luo, 2020, Nature Communications.

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

C. Rudin, A. Melnick, R. Levine, 2015, Cell reports.

Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.

J. Leonard, A. Melnick, K. Elenitoba-Johnson, 2015, The Journal of clinical investigation.

Improved targeting of JAK 2 leads to increased therapeutic ef fi cacy in myeloproliferative neoplasms

J. Qi, J. Bradner, R. Levine, 2014 .

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.

K. Ross, M. Gönen, J. Bradner, 2010, The Journal of clinical investigation.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

S. Larson, Jason S. Lewis, A. Melnick, 2011, Nature chemical biology.

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Pallav D. Patel, Weilin Sun, Tony Taldone, 2013, Nature chemical biology.

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas

J. Leonard, S. Manalis, J. Phillip, 2021, Cancer Research.

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

Pallav D. Patel, Weilin Sun, Tony Taldone, 2010, PLoS neglected tropical diseases.

PREPARATION OF A DIVERSE PURINE-SCAFFOLD LIBRARY VIA ONE-STEP PALLADIUM CATALYZED CROSS-COUPLING

Maulik R. Patel, Weilin Sun, Tony Taldone, 2013 .

Measuring Tumor Epichaperome Expression Using [124I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer.

Tony Taldone, A. Rodina, G. Chiosis, 2020, JCO precision oncology.

Discovery and development of heat shock protein 90 inhibitors.

Gabriela Chiosis, Tony Taldone, Weilin Sun, 2009, Bioorganic & medicinal chemistry.

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2014, Journal of medicinal chemistry.

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.

Maulik R. Patel, Pallav D. Patel, Tony Taldone, 2013, Journal of medicinal chemistry.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

A. Melnick, Tony Taldone, A. Rodina, 2009, Proceedings of the National Academy of Sciences.

Targeting Hsp90: small-molecule inhibitors and their clinical development.

Tony Taldone, G. Chiosis, R. Maharaj, 2008, Current opinion in pharmacology.

Design of a fluorescence polarization assay platform for the study of human Hsp70.

Tony Taldone, G. Chiosis, J. Brodsky, 2008, Bioorganic & medicinal chemistry letters.

Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity

Tony Taldone, G. Chiosis, D. Gewirth, 2019, Proteins.

Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.

Tony Taldone, G. Chiosis, D. Gewirth, 2019 .

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.

Tony Taldone, G. Chiosis, Erica M. Gomes-DaGama, 2011, Bioorganic & medicinal chemistry letters.

HSP 90 is a therapeutic target in JAK 2-dependent myeloproliferative neoplasms in mice and humans

K. Ross, M. Gönen, J. Bradner, 2018 .

Protein chaperones: a composition of matter review (2008 – 2013)

Maulik R. Patel, Tony Taldone, G. Chiosis, 2014, Expert opinion on therapeutic patents.

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Maulik R. Patel, Pallav D. Patel, Weilin Sun, 2015, Journal of medicinal chemistry.

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

K. Manova-Todorova, H. Erdjument-Bromage, Wenjie Luo, 2020, Nature Communications.

Selective targeting of the stress chaperome as a therapeutic strategy.

Gabriela Chiosis, Tony Taldone, Pallav D. Patel, 2014, Trends in pharmacological sciences.

Design, synthesis, and evaluation of small molecule Hsp90 probes.

Pallav D. Patel, Tony Taldone, A. Rodina, 2011, Bioorganic & medicinal chemistry.

Paralog-selective Hsp 90 inhibitors define tumor-specific regulation of Her 2

Pallav D. Patel, Weilin Sun, Tony Taldone, 2014 .

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.

J. Qi, J. Bradner, R. Levine, 2014, Blood.

Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

Tony Taldone, Tony Taldone, T. Talele, 2008, Bioorganic & medicinal chemistry letters.

Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex

S. Larson, Jason S. Lewis, A. Melnick, 2012 .