G. Chiosis

发表

Heat shock protein 90 in neurodegenerative diseases

Wenjie Luo, Weilin Sun, Tony Taldone, 2010, Molecular Neurodegeneration.

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.

T. Golub, W. Hahn, J. Lamb, 2006, Cancer cell.

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.

Tony Taldone, G. Chiosis, K. Jhaveri, 2012, Biochimica et biophysica acta.

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

G. Chiosis, Y. Janjigian, K. Jhaveri, 2014, Expert opinion on investigational drugs.

RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures.

G. Chiosis, Suiying Huang, J. Koren, 2016, Nano letters.

Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces.

Jan Grimm, Charalambos Kaittanis, Travis M. Shaffer, 2015, Nano letters.

Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia

A. Ferrando, A. Ambesi-Impiombato, J. Mullenders, 2018, Nature Medicine.

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.

N. Rosen, G. Chiosis, P. Munster, 2001, Chemistry & biology.

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.

L. Neckers, G. Chiosis, 2006, ACS chemical biology.

Vancomycin resistance: occurrence, mechanisms and strategies to combat it

G. Chiosis, I. Boneca, 2003, Expert opinion on therapeutic targets.

Designing Drugs Against Hsp90 for Cancer Therapy

Tony Taldone, G. Chiosis, S. Ochiana, 2014 .

A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond.

Tony Taldone, A. Rodina, G. Chiosis, 2019, Cold Spring Harbor perspectives in biology.

Targeting heat shock protein 90 with non‐quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma

P. Schirmacher, G. Chiosis, B. Goeppert, 2009, Hepatology.

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

D. Solit, G. Chiosis, E. Caldas Lopes, 2006, Current opinion in investigational drugs.

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.

S. Armstrong, A. Ferrando, J. Teruya-Feldstein, 2015, Blood.

Adapting to stress — chaperome networks in cancer

G. Chiosis, J. Brodsky, S. Joshi, 2018, Nature Reviews Cancer.

The epichaperome is an integrated chaperome network that facilitates tumour survival

S. Larson, C. Hudis, E. Cesarman, 2016, Nature.

Development and application of Hsp90 inhibitors.

D. Solit, G. Chiosis, 2008, Drug discovery today.

Environment-responsive Nanophores for Therapy and Treatment Monitoring via Molecular MRI Quenching

Travis M. Shaffer, L. Josephson, G. Chiosis, 2014, Nature Communications.

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

C. Leslie, C. Leslie, S. Lowe, 2019, Nature Communications.

Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.

G. Chiosis, J. Thaxton, Zihai Li, 2016, Current topics in medicinal chemistry.

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.

H. Erdjument-Bromage, Weilin Sun, Tony Taldone, 2020, Cell reports.

Study into the cyclization of an epoxy-alcohol to the energetically disfavored product by peptides from non-biased combinatorial libraries

G. Chiosis, 2000 .

Selective Cleavage of D-Ala-D-Lac by Small Molecules: Re-Sensitizing Resistant Bacteria to Vancomycin

G. Chiosis, I. Boneca, I. G. Boneca, 2001, Science.

Development of purine-scaffold small molecule inhibitors of Hsp90.

N. Rosen, D. Solit, G. Chiosis, 2003, Current cancer drug targets.

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.

Y. Hannun, G. Chiosis, B. Ogretmen, 2015, Journal of hepatology.

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

S. Armstrong, P. Stephens, R. Yelensky, 2014, Proceedings of the National Academy of Sciences.

Paradigms for Precision Medicine in Epichaperome Cancer Therapy.

Serge K. Lyashchenko, S. Larson, L. Norton, 2019, Cancer cell.

Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

Maulik R. Patel, Pallav D. Patel, Serge K. Lyashchenko, 2021, Nature Communications.

Unbiased Assessment of H-STS cells as high-fidelity models for gastro-enteropancreatic neuroendocrine tumor drug mechanism of action analysis

Mariano J. Alvarez, Prabhjot S. Mundi, M. Loda, 2019, bioRxiv.

Purine-scaffold Hsp90 inhibitors.

Tony Taldone, G. Chiosis, 2006, Current topics in medicinal chemistry.

Development of a Fluorescence Polarization Assay for the Molecular Chaperone Hsp90

N. Rosen, G. Chiosis, S. Felts, 2004, Journal of biomolecular screening.

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

N. Rosen, G. Chiosis, S. Felts, 2003, Bioorganic & medicinal chemistry letters.

17 AAG : Low Target Binding Affinity and Potent Cell Activity — Finding an Explanation 1

N. Rosen, L. Neckers, G. Chiosis, 2003 .

Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol‐Associated Liver Disease

R. Bataller, G. Chiosis, P. Mandrekar, 2021, Hepatology communications.

HSP90 inhibitors as therapy for multiple myeloma.

G. Chiosis, S. Usmani, 2011, Clinical lymphoma, myeloma & leukemia.

Molecular Chaperones and How Addiction Matters in Cancer Therapy

Tony Taldone, G. Chiosis, M. Lowery, 2013 .

Discovery and development of purine-scaffold Hsp90 inhibitors

Weilin Sun, G. Chiosis, Yanlong Kang, 2008, Expert opinion on drug discovery.

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2013, Chemistry & biology.

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

G. Chiosis, Cristina C. Clement, S. Felts, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of Hsp90 dimerization modulators.

C. Nicchitta, G. Chiosis, Julia Aguirre, 2006, Bioorganic & medicinal chemistry letters.

Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

D. Bolon, L. Neckers, Tony Taldone, 2013, Oncotarget.

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.

D. Bolon, L. Neckers, Tony Taldone, 2013 .

Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

Weilin Sun, G. Chiosis, C. Leifer, 2012, Biochemical and biophysical research communications.

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

J. Snyder, R. Dingledine, P. Thepchatri, 2008, Bioorganic & medicinal chemistry.

Advances in Brief Identification of a Geldanamycin Dimer That Induces the Selective Degradation of HER-Family Tyrosine Kinases 1

N. Rosen, S. Kuduk, G. Chiosis, 2000 .

Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases.

N. Rosen, S. Kuduk, G. Chiosis, 2000, Cancer research.

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.

G. Chiosis, J. Brodsky, 2006, Current topics in medicinal chemistry.

The yeast Hsp110, Sse1p, exhibits high‐affinity peptide binding

G. Chiosis, J. Brodsky, Cristina C. Clement, 2008, FEBS letters.

HSP90 facilitates oncogenic alterations of metabolism in B-cell lymphomas

J. Leonard, S. Manalis, J. Phillip, 2020, bioRxiv.

Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2.

G. Chiosis, T. Seufferlein, M. Cronauer, 2020, Carcinogenesis.

Synthesis of 124I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice

G. Chiosis, N. Pillarsetty, E. Burnazi, 2022, STAR protocols.

Bisubstrate-type chemical probes identify GRP94 as a potential target of cytosine-containing adenosine analogs.

G. Chiosis, O. Burlet-Schiltz, Fanny Assemat, 2020, ACS chemical biology.

Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.

S. Larson, Jason S. Lewis, Tony Taldone, 2016, Journal of labelled compounds & radiopharmaceuticals.

A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor

Tony Taldone, G. Chiosis, Yanlong Kang, 2009 .

Ex vivo treatment response of primary tumors and/or associated metastases for preclinical and clinical development of therapeutics.

G. Chiosis, S. Modi, J. Gerecitano, 2014, Journal of visualized experiments : JoVE.

First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer

S. Larson, C. Hudis, L. Norton, 2020, Clinical Cancer Research.

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90

Tony Taldone, G. Chiosis, R. Immormino, 2019, The Journal of Biological Chemistry.

Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

E. Cesarman, H. Erdjument-Bromage, Tony Taldone, 2017, Molecular Cancer Therapeutics.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

E. Cesarman, R. Blasberg, A. Melnick, 2013, Blood.

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

Maulik R. Patel, Pallav D. Patel, A. Melnick, 2014, ACS chemical biology.

Using 124I-PU-H71 PET imaging to predict intratumoral concentration in patients on a phase I trial of PU-H71.

S. Larson, Jason S. Lewis, Tony Taldone, 2013 .

Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy

S. Larson, C. Hudis, Jason S. Lewis, 2015 .

A purine scaffold Hsp90 inhibitor destabilizes Bcl6 and has specific anti-tumor activity in Bcl6 dependent B-cell lymphomas

J. Walling, Karen L. Bunting, A. Melnick, 2009, Nature Medicine.

Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.

Tony Taldone, G. Chiosis, Sahil Sharma, 2017, Tetrahedron letters.

First-in-Human Trial of Epichaperome-Targeted Positron Emission Tomography in Cancer Patients.

S. Larson, C. Hudis, L. Norton, 2020, Clinical cancer research : an official journal of the American Association for Cancer Research.

NECA derivatives exploit the paralog-specific properties of the Site 3 side pocket of Grp94, the ER Hsp90

G. Chiosis, R. Immormino, D. Gewirth, 2019 .

Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia

M. Rubin, O. Elemento, A. Sboner, 2018, npj Precision Oncology.

Disease-speciﬁc interactome alterations via epichaperomics: the case for Alzheimer’s disease

G. Chiosis, S. Ginsberg, T. Neubert, 2021 .

Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

Valerie A Longo, T. Reiner, G. Chiosis, 2016, Molecular Imaging and Biology.

Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines.

Tony Taldone, G. Chiosis, Yanlong Kang, 2009, Bioorganic & medicinal chemistry letters.

Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives.

N. Rosen, G. Chiosis, B. Lucas, 2001, Journal of combinatorial chemistry.

Heat shock protein 90 in neurodegenerative diseases

Wenjie Luo, Weilin Sun, Tony Taldone, 2010, Molecular Neurodegeneration.

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

Maulik R. Patel, Tony Taldone, A. Rodina, 2013, Beilstein journal of organic chemistry.

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.

N. Rosen, G. Chiosis, L. Sepp-Lorenzino, 2001, Bioorganic & medicinal chemistry letters.

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.

O. Elemento, A. Melnick, Tony Taldone, 2016, Blood.

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE

G. Chiosis, D. Feinstein, L. Lisi, 2013, Journal of Neuroimmunology.

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

N. Rosen, D. Solit, G. Chiosis, 2004, Chemistry & biology.

Interaction of heat-shock protein 90β isoform (HSP90β) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.

E. Solary, G. Chiosis, C. Didelot, 2008, Cell death and differentiation.

Interaction of heat-shock protein 90β isoform (HSP90β) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation

E. Solary, G. Chiosis, C. Didelot, 2008, Cell Death and Differentiation.

Discovery and development of purine-scaffold Hsp90 inhibitors.

G. Chiosis, 2006, Current topics in medicinal chemistry.

α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96

G. Chiosis, Zihai Li, D. Gewirth, 2013, The Journal of Biological Chemistry.

Reticulum Chaperone gp 96 : A for Integrin Binding to Endoplasmic I Domain Is Crucial α 7 Helix Region of α Protein Structure and Folding :

G. Chiosis, Zihai Li, D. Gewirth, 2013 .

Improved guanidinium ion-selectivity by novel calix[4]arene and calix[6]arene receptor molecules on CHEMFETs

D. Reinhoudt, J. Engbersen, G. Chiosis, 1994 .

Heterodimeric JAK-STAT Activation as a Mechanism of Persistence to JAK2 Inhibitor Therapy

B. Bernstein, B. Ebert, Mazhar Adli, 2011, Nature.

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function*

N. Rosen, D. Solit, G. Chiosis, 2002, The Journal of Biological Chemistry.

STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway

G. Chiosis, T. Seufferlein, N. Azoitei, 2017, Oncotarget.

Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes.

G. Chiosis, S. Ginsberg, Sahil Sharma, 2022, Trends in pharmacological sciences.

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.

J. Qi, J. Bradner, R. Levine, 2014, Blood.

How Aberrant N-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View

A. Rodina, G. Chiosis, G. Colombo, 2022, bioRxiv.

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.

Andrea Brancale, Gabriela Chiosis, Ernest Hamel, 2006, Journal of medicinal chemistry.

Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma

C. Iacobuzio-Donahue, S. Leach, C. Haglund, 2020, Proceedings of the National Academy of Sciences.

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.

N. Rosen, G. Chiosis, A. Shtil, 2002, Bioorganic & medicinal chemistry.

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

Gabriela Chiosis, Neal Rosen, N. Rosen, 2005, Journal of medicinal chemistry.

The uranyl unit as electrophilic catalyst of acyl transfer reactions

D. Reinhoudt, G. Chiosis, F. V. Veggel, 1996 .

Preorganized metallomacrocycles: Selective receptor for NH3

D. Reinhoudt, G. Chiosis, F. V. Veggel, 1994 .

About the reaction of aryl fluorides with sodium sulfide: investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via SNAr displacement of fluorine

Pallav D. Patel, Tony Taldone, G. Chiosis, 2012 .

Reaction of 2-Naphthylamine with Sodium Iodate/Sodium Sulfite: Synthesis of 2-Amino-1-iodonaphthalene

Tony Taldone, G. Chiosis, D. Zatorska, 2012 .

Measuring the Pharmacodynamic Effects of a Novel Hsp90 Inhibitor on HER2/neu Expression in Mice Using 89Zr-DFO-Trastuzumab

Valerie A Longo, Jason S. Lewis, Tony Taldone, 2010, PloS one.

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

Tony Taldone, G. Chiosis, J. Panek, 2010, The Journal of organic chemistry.

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

Gabriela Chiosis, G. Chiosis, R. Immormino, 2006, Journal of medicinal chemistry.

Hsp90: the vulnerable chaperone.

D. Solit, G. Chiosis, M. Vilenchik, 2004, Drug discovery today.

Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol.

N. Rosen, D. Solit, G. Chiosis, 2003, Angewandte Chemie.

A Purine Analog Synergizes with Chloroquine (CQ) by Targeting Plasmodium falciparum Hsp90 (PfHsp90)

I. Crandall, Tony Taldone, G. Chiosis, 2013, PloS one.

The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders

O. Arancio, G. Chiosis, S. Ginsberg, 2021, Journal of neurochemistry.

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

V. Seshan, Nathalie Saurat, M. Tomishima, 2018, Nature Communications.

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

Gabriela Chiosis, Tony Taldone, Hardik J Patel, 2011, Expert opinion on drug discovery.

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

Gabriela Chiosis, Neal Rosen, N. Rosen, 2002, Blood.

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

Paul Greengard, Gabriela Chiosis, Fei Dou, 2007, Proceedings of the National Academy of Sciences.

Pre‐clinical efficacy of PU‐H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

U. Mony, A. Moreira, Tony Taldone, 2014, Molecular oncology.

Targeting chaperones in transformed systems – a focus on Hsp90 and cancer

G. Chiosis, 2006, Expert opinion on therapeutic targets.

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.

R. Gascoyne, M. Marra, M. Hirst, 2010, The Journal of clinical investigation.

HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.

S. Fröhling, H. Kestler, G. Chiosis, 2014, Cancer research.

Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2014, Journal of medicinal chemistry.

Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators.

Wenjie Luo, Weilin Sun, A. Rodina, 2011, Assay and drug development technologies.

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

Gabriela Chiosis, Wenjie Luo, A. Rodina, 2008, BMC Neuroscience.

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33

S. Fröhling, H. Kestler, H. Döhner, 2012, The Journal of experimental medicine.

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention

G. Chiosis, J. Koren, Sarah Kishinevsky, 2013, Journal of Alzheimer's disease & Parkinsonism.

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

C. Sander, S. Leach, W. Jarnagin, 2021, Communications Biology.

Disease‐specific interactome alterations via epichaperomics: the case for Alzheimer’s disease

G. Chiosis, S. Ginsberg, T. Neubert, 2021, The FEBS journal.

Chaperome Networks - Redundancy and Implications for Cancer Treatment.

Gabriela Chiosis, Pengrong Yan, Tai Wang, 2020, Advances in experimental medicine and biology.

Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies.

Gabriela Chiosis, Swathi Merugu, Sahil Sharma, 2020, Methods in enzymology.

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

K. Manova-Todorova, H. Erdjument-Bromage, Wenjie Luo, 2020, Nature Communications.

Chaperome heterogeneity and its implications for cancer study and treatment

G. Chiosis, M. Dunphy, D. Gewirth, 2018, The Journal of Biological Chemistry.

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

C. Rudin, A. Melnick, R. Levine, 2015, Cell reports.

Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors

G. Giaccone, H. Dienemann, P. Schirmacher, 2011, Clinical Cancer Research.

Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.

J. Leonard, A. Melnick, K. Elenitoba-Johnson, 2015, The Journal of clinical investigation.

Improved targeting of JAK 2 leads to increased therapeutic ef fi cacy in myeloproliferative neoplasms

J. Qi, J. Bradner, R. Levine, 2014 .

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.

K. Ross, M. Gönen, J. Bradner, 2010, The Journal of clinical investigation.

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors

H. Hieronymus, S. Achilefu, M. Schwaiger, 2018, The Journal of experimental medicine.

HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment

G. Chiosis, J. Lee, C. Zhen, 2017, Oncogene.

Monitoring Afatinib Treatment in HER2-Positive Gastric Cancer with 18F-FDG and 89Zr-Trastuzumab PET

Jason S. Lewis, G. Chiosis, Y. Janjigian, 2013, The Journal of Nuclear Medicine.

Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone

G. Chiosis, T. Seufferlein, N. Azoitei, 2019, Scientific Reports.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

S. Larson, Jason S. Lewis, A. Melnick, 2011, Nature chemical biology.

Reply to ‘H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines’

Mariano J. Alvarez, Prabhjot S. Mundi, M. Loda, 2019, Nature Genetics.

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Pallav D. Patel, Weilin Sun, Tony Taldone, 2013, Nature chemical biology.

Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma

R. DePinho, G. Chiosis, Zihai Li, 2013, Clinical Cancer Research.

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas

J. Leonard, S. Manalis, J. Phillip, 2021, Cancer Research.

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

Pallav D. Patel, Weilin Sun, Tony Taldone, 2010, PLoS neglected tropical diseases.

PREPARATION OF A DIVERSE PURINE-SCAFFOLD LIBRARY VIA ONE-STEP PALLADIUM CATALYZED CROSS-COUPLING

Maulik R. Patel, Weilin Sun, Tony Taldone, 2013 .

Measuring Tumor Epichaperome Expression Using [124I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer.

Tony Taldone, A. Rodina, G. Chiosis, 2020, JCO precision oncology.

The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

H. Cai, Lixin Sun, G. Chiosis, 2008, The Journal of Neuroscience.

Discovery and development of heat shock protein 90 inhibitors.

Gabriela Chiosis, Tony Taldone, Weilin Sun, 2009, Bioorganic & medicinal chemistry.

High-Throughput Screening Fluorescence Polarization Assay for Tumor-Specific Hsp90

Gabriela Chiosis, Raymond Dingledine, R. Dingledine, 2007, Journal of biomolecular screening.

Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines.

P. Laird, A. Melnick, M. Figueroa, 2008, Cancer research.

Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

Gabriela Chiosis, Hatice U. Osmanbeyoglu, Petar Jelinic, 2018, Nature Communications.

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

J. Massagué, A. Chiang, P. Wipf, 2007, Nature chemical biology.

Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2014, Journal of medicinal chemistry.

Radioiodinated PARP1 tracers for glioblastoma imaging

T. Reiner, G. Chiosis, W. Weber, 2015, EJNMMI Research.

Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.

G. Chiosis, Liza Shrestha, Hardik J. Patel, 2016, Cell chemical biology.

17AAG: low target binding affinity and potent cell activity--finding an explanation.

N. Rosen, L. Neckers, G. Chiosis, 2003, Molecular cancer therapeutics.

Cancer Therapy : Preclinical Molecular Chaperone gp 96 Is a Novel Therapeutic Target of Multiple Myeloma

R. DePinho, G. Chiosis, Zihai Li, 2013 .

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.

G. Chiosis, J. Brodsky, P. Thibodeau, 2015, Journal of molecular biology.

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1

G. Chiosis, Zihai Li, S. Usmani, 2010, Journal of hematology & oncology.

The anti-myeloma activity of a novel purine scaffold HSP 90 inhibitor PUH 71 is via inhibition of both HSP 90 A and HSP 90 B 1

G. Chiosis, Zihai Li, S. Usmani, 2010 .

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.

Maulik R. Patel, Pallav D. Patel, Tony Taldone, 2013, Journal of medicinal chemistry.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

A. Melnick, Tony Taldone, A. Rodina, 2009, Proceedings of the National Academy of Sciences.

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

G. Chiosis, M. Kircher, Suchetan Pal, 2020, Nature Biomedical Engineering.

Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR.

N. Rosen, G. Chiosis, M. Vilenchik, 2003, Chemistry & biology.

Targeting Hsp90: small-molecule inhibitors and their clinical development.

Tony Taldone, G. Chiosis, R. Maharaj, 2008, Current opinion in pharmacology.

Design of a fluorescence polarization assay platform for the study of human Hsp70.

Tony Taldone, G. Chiosis, J. Brodsky, 2008, Bioorganic & medicinal chemistry letters.

Adapting to stress — chaperome networks in cancer

G. Chiosis, J. Brodsky, S. Joshi, 2018, Nature Reviews Cancer.

A global view of Hsp90 functions

G. Chiosis, C. Dickey, Jill L. Johnson, 2013, Nature Structural &Molecular Biology.

Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.

G. Chiosis, C. Didelot, C. Garrido, 2007, Current medicinal chemistry.

RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells

C. Leslie, Yuning Hong, A. Kentsis, 2023, Nature communications.

Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity

Tony Taldone, G. Chiosis, D. Gewirth, 2019, Proteins.

Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.

Tony Taldone, G. Chiosis, D. Gewirth, 2019 .

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.

Tony Taldone, G. Chiosis, Erica M. Gomes-DaGama, 2011, Bioorganic & medicinal chemistry letters.

Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.

Gabriela Chiosis, Yanlong Kang, G. Chiosis, 2006, Journal of medicinal chemistry.

HSP 90 is a therapeutic target in JAK 2-dependent myeloproliferative neoplasms in mice and humans

K. Ross, M. Gönen, J. Bradner, 2018 .

Protein chaperones: a composition of matter review (2008 – 2013)

Maulik R. Patel, Tony Taldone, G. Chiosis, 2014, Expert opinion on therapeutic patents.

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Maulik R. Patel, Pallav D. Patel, Weilin Sun, 2015, Journal of medicinal chemistry.

Proteomic interrogation of HSP90 and insights for medical research

M. Quadroni, G. Chiosis, S. Joshi, 2017, Expert review of proteomics.

Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

S. Gambhir, T. Massoud, G. Chiosis, 2012, Proceedings of the National Academy of Sciences.

Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.

S. Schreiber, J. Qi, J. Bradner, 2014, Cancer research.

Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.

Gabriela Chiosis, Ramasamy Paulmurugan, Sanjiv Sam Gambhir, 2008, Cancer research.

Synthesis of 8-arylsulfoxyl/sulfonyl adenines

G. Chiosis, Huazhong He, Laura Llauger, 2004 .

General method for the synthesis of 8-arylsulfanyl adenine derivatives.

N. Rosen, G. Chiosis, Huazhong He, 2004, The Journal of organic chemistry.

Synthesis of 8-Arylsulfoxyl/Sulfonyl Adenines.

G. Chiosis, Huazhong He, Laura Llauger, 2005 .

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

K. Manova-Todorova, H. Erdjument-Bromage, Wenjie Luo, 2020, Nature Communications.

Selective targeting of the stress chaperome as a therapeutic strategy.

Gabriela Chiosis, Tony Taldone, Pallav D. Patel, 2014, Trends in pharmacological sciences.

Design, synthesis, and evaluation of small molecule Hsp90 probes.

Pallav D. Patel, Tony Taldone, A. Rodina, 2011, Bioorganic & medicinal chemistry.

Paralog-selective Hsp 90 inhibitors define tumor-specific regulation of Her 2

Pallav D. Patel, Weilin Sun, Tony Taldone, 2014 .

Emerging Hsp90 inhibitors: from discovery to clinic.

A. Rodina, G. Chiosis, K. Moulick, 2006, Anti-cancer agents in medicinal chemistry.

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.

J. Qi, J. Bradner, R. Levine, 2014, Blood.

Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex

S. Larson, Jason S. Lewis, A. Melnick, 2012 .

Blood-brain-barrier–permeable Hsp90 inhibitor reduces soluble tau burden in a mouse model of Alzheimer's disease

G. Chiosis, J. Koren, M. C. Inda, 2013, Alzheimer's & Dementia.

Small molecule microarrays: from proteins to mammalian cells - are we there yet?

Jeffrey L Brodsky, Gabriela Chiosis, G. Chiosis, 2005, Trends in biotechnology.

Structural and functional complexity of HSP90 in cellular homeostasis and disease

L. Neckers, G. Chiosis, J. Trepel, 2023, Nature Reviews Molecular Cell Biology.

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

Jason C. Young, K. Manova-Todorova, H. Erdjument-Bromage, 2023, Nature communications.

Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94

A. Burlingame, C. Nicchitta, G. Chiosis, 2006, Protein science : a publication of the Protein Society.

Selective inhibition of hsp90 paralogs: Structure and binding studies uncover the role of helix 1 in Grp94-selective ligand binding

G. Chiosis, D. Gewirth, P. Seidler, 2023, bioRxiv.

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Pallav D. Patel, Weilin Sun, Tony Taldone, 2013, Nature chemical biology.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

E. Cesarman, R. Blasberg, A. Melnick, 2013, Blood.

Targeting heat shock protein 90 with non‐quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma

P. Schirmacher, G. Chiosis, B. Goeppert, 2009, Hepatology.

Protein chaperones: a composition of matter review (2008 – 2013)

Maulik R. Patel, Tony Taldone, G. Chiosis, 2014, Expert opinion on therapeutic patents.

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.

Ryan D. Morin, R. Gascoyne, M. Marra, 2010, The Journal of clinical investigation.

HSP90 inhibitors as therapy for multiple myeloma.

G. Chiosis, S. Usmani, 2011, Clinical lymphoma, myeloma & leukemia.

Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions

G. Chiosis, Y. Janjigian, K. Jhaveri, 2014, Expert opinion on investigational drugs.

Experimental traumatic brain injury increases epichaperome formation

A. Rodina, G. Chiosis, J. Henchir, 2023, Neurobiology of Disease.

Editorial (Thematic Issue: Heat Shock Proteins in Disease - From Molecular Mechanisms to Therapeutics).

G. Chiosis, 2016, Current topics in medicinal chemistry.

Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

Valerie A Longo, T. Reiner, G. Chiosis, 2016, Molecular Imaging and Biology.

BCL6 Mediates a Stress Tolerance Phenotype through Its BTB Domain

A. Melnick, G. Chiosis, T. Fernando, 2014 .

Introducing dysfunctional Protein-Protein Interactome (dfPPI) - A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease.

G. Chiosis, T. Roychowdhury, Souparna Chakrabarty, 2024, Current opinion in structural biology.

Cracking the chaperone code through the computational microscope

G. Chiosis, E. Moroni, Chiranjeevi Pasala, 2024, Cell stress & chaperones.

Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

L. Neckers, Tony Taldone, G. Chiosis, 2013, Oncotarget.

Stress biology: Complexity and multifariousness in health and disease

Marc L. Mendillo, G. Chiosis, L. Sistonen, 2024, Cell stress & chaperones.