D. Alexander

发表

DNA Damage–Induced Bcl-xL Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH

A. Green, R. Zhao, D. Oxley, 2006, PLoS biology.

Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target

D. Alexander, 2005 .

Either of the CD45RB and CD45RO Isoforms Are Effective in Restoring T Cell, But Not B Cell, Development and Function in CD45-Null Mice1

D. Alexander, C. Louis-dit-Sully, N. Holmes, 2003, The Journal of Immunology.

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.

D. Alexander, C. Carret, N. Holmes, 2007, Immunity.

Signal transduction and regulation

D. Alexander, 2003 .

Selective coupling of the T cell antigen receptor to phosphoinositide‐derived diacylglycerol production in HPB‐ALL T cells correlates with CD45‐regulated p59fyn activity

D. Alexander, M. Biffen, M. Shiroo, 1993, European journal of immunology.

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

D. Alexander, Andrew J. H. Smith, A. Smith, 1996, The Journal of experimental medicine.

Long wavelength fluorophores and cell-by-cell correction for autofluorescence significantly improves the accuracy of flow cytometric energy transfer measurements on a dual-laser benchtop flow cytometer.

J. Szöllősi, D. Alexander, J. Gratama, 2002, Cytometry.

Differential Association of CD45 Isoforms with CD4 and CD8 Regulates the Actions of Specific Pools of p56lck Tyrosine Kinase in T Cell Antigen Receptor Signal Transduction*

D. Alexander, J. Gamble, P. Beverley, 2002, The Journal of Biological Chemistry.

The application of fluorescence resonance energy transfer to the investigation of phosphatases.

D. Alexander, J. Szöllösi, 2003, Methods in enzymology.

CD3 antigen‐mediated calcium signals and protein kinase C activation are higher in CD45R0+ than in CD45RA+ human T lymphocyte subsets

D. Alexander, N. Miller, A. Robinson, 1993, European journal of immunology.

Does co‐aggregation of the CD45 and CD3 antigens inhibit T cell antigen receptor complex‐mediated activation of phospholipase C and protein kinase C?

D. Alexander, M. Glennie, M. Biffen, 1992, European journal of immunology.

A Protein Kinase C Pseudosubstrate Peptide Blocks G—Protein and Mitogenic Lectin Induced Phosphorylation of the CD3 Antigen in Human T—Lymphocytes

M. Crumpton, D. Alexander, D. Cantrell, 1990 .

Alefacept selectively promotes NK cell‐mediated deletion of CD45R0+ human T cells

D. Alexander, M. Subramanyam, G. Morgan, 2003, European journal of immunology.

The Phosphotyrosine Phosphatase SHP-2 Participates in a Multimeric Signaling Complex and Regulates T Cell Receptor (TCR) coupling to the Ras/Mitogen-activated Protein Kinase (MAPK) Pathway in Jurkat T Cells

D. Alexander, J. Frearson, 1998, The Journal of experimental medicine.

Immune signalling: SHP-2 docks at multiple ports

D. Alexander, G. Huyer, 1999, Current Biology.

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function.

D. Alexander, Denis R. Alexander, 2000, Seminars in immunology.

Protein tyrosine phosphatases in T-cell development, apoptosis and signalling.

D. Alexander, J. Frearson, 1996, Immunology today.

Explorer The differential regulation of Lck kinase phosphorylation sites by CD 45 is critical for T cell receptor signaling responses

D. Alexander, C. Carret, N. Holmes, 2017 .

Defective depletion of CD45-null thymocytes by the Staphylococcus aureus enterotoxin B superantigen.

D. Alexander, N. Holmes, L. A. Conroy, 1996, Immunology letters.

The CD45 tyrosine phosphatase regulates CD3‐induced signal transduction and T cell development in recombinase‐deficient mice: restoration of pre‐TCR function by active p56lck

D. Alexander, N. Holmes, S. Pingel, 1999, European journal of immunology.

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

D. Alexander, J. Stone, N. Holmes, 1997, Journal of immunology.

A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation.

M. Crumpton, D. Alexander, D. Cantrell, 1990, The Biochemical journal.

The CD45 phosphotyrosine phosphatase

D. Alexander, 2004 .

7 via TCR but Not P2X Regulatory T Cells Are Resistant to Apoptosis

D. Alexander, J. Elliott, J. Cooper, 2007 .

CD4+ T cell hyper-responsiveness in CD45 transgenic mice is independent of isoform.

D. Alexander, N. Holmes, R. Salmond, 2008, International immunology.

CD45 isoforms in T cell signalling and development.

D. Alexander, G. Morgan, J. Cooper, 2004, Immunology letters.

CTLA-4 Suppresses Proximal TCR Signaling in Resting Human CD4+ T Cells by Inhibiting ZAP-70 Tyr319 Phosphorylation: A Potential Role for Tyrosine Phosphatases1

D. Alexander, C. Guntermann, 2002, The Journal of Immunology.

A Therapeutic CD4 Monoclonal Antibody Inhibits TCR-ζ Chain Phosphorylation, ζ-Associated Protein of 70-kDa Tyr319 Phosphorylation, and TCR Internalization in Primary Human T Cells1

P. Lipp, D. Alexander, S. Harding, 2002, The Journal of Immunology.

A tyrosine‐phosphorylated 110–120‐kDa protein associates with the C‐terminal SH2 domain of phosphotyrosine phosphatase‐1D in T cell receptor‐stimulated T cells

D. Alexander, J. Frearson, T. Yi, 1996, European journal of immunology.

CD45 tyrosine phosphatase‐activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

D. Alexander, L. Goff, M. Biffen, 1992, The EMBO journal.

Phosphatidylserine exposure in B lymphocytes: a role for lipid packing.

C. Higgins, D. Alexander, A. Sardini, 2006, Blood.

Null Mice Cell , Development and Function in Are Effective in Restoring T Cell , But Not B Either of the CD 45 RB and CD 45 RO Isoforms

D. Alexander, C. Louis-dit-Sully, N. Holmes, 2003 .

Cutting Edge: TREM-Like Transcript-1, a Platelet Immunoreceptor Tyrosine-Based Inhibition Motif Encoding Costimulatory Immunoreceptor that Enhances, Rather than Inhibits, Calcium Signaling via SHP-2 1

Kenneth G. C. Smith, W. Ouwehand, J. Trowsdale, 2004, The Journal of Immunology.

A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69.

D. Alexander, H. Waldmann, M. Glennie, 1998, Cellular immunology.

Dephosphorylation of the human T lymphocyte CD3 antigen.

M. Crumpton, J. Rothbard, D. Alexander, 1989, European journal of biochemistry.

Kinases and phosphatases in T-cell activation.

D. Alexander, D. Cantrell, 1989, Immunology today.

The CD45 tyrosine phosphatase regulates specific pools of antigen receptor‐associated p59fyn and CD4‐associated p56lck tyrosine in human T‐cells.

D. Alexander, A. Venkitaraman, M. Biffen, 1994, The EMBO journal.

The role of CD45 in T-cell activation--resolving the paradoxes?

D. Alexander, M. Biffen, M. Shiroo, 1992, Immunology today.

The CD45 tyrosine phosphatase regulates Campath-1H (CD52)-induced TCR-dependent signal transduction in human T cells.

D. Alexander, G. Hale, S. Damjanovich, 2000, International immunology.

SHP2 forecast for the immune system: fog gradually clearing.

D. Alexander, R. Salmond, Robert J. Salmond, 2006, Trends in immunology.

Separation at neural pH of a 32P-labelled membrane protein associated with the sodium-plus-magnesium ion-activated adenosine triphosphatase from ox brain.

D. Alexander, R. Rodnight, 1970, The Biochemical journal.

CTLA-4 Suppresses Proximal TCR Signaling

D. Alexander, C. Guntermann, 2002 .

A Potential Role for Tyrosine Phosphatases Phosphorylation : 319 Inhibiting ZAP-70 Tyr T Cells by + in Resting Human CD 4 CTLA-4 Suppresses Proximal TCR Signaling

D. Alexander, C. Guntermann, 2002 .

The src Homology 2 Domain-Containing Tyrosine Phosphatase 2 Regulates Primary T-Dependent Immune Responses and Th Cell Differentiation1

D. Alexander, L. Clements, R. Salmond, 2005, The Journal of Immunology.

FK 506 and cyclosporin each block antigen‐induced T cell receptor signalling that is dependent on CD 4 co‐receptor and operates in the absence of detectable cytoplasmic calcium fluxes

D. Alexander, S. Metcalfe, J. Turner, 1994, Transplant international : official journal of the European Society for Organ Transplantation.

CD 45-Nul l Transgenic Mice Reveal a Positive Regulatory Role for CD 45 in Early Thymocyte Deve lopment , in the Selection o f CD 4 + CD 8 + Thyrnocytes , and in B Cell Maturation

D. Alexander, N. Holmes, Alison Smith, 2003 .

A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity.

P. Parren, D. Alexander, J. Cambier, 2007, Cancer research.

Inhibits, Calcium Signaling via SHP-2 Immunoreceptor that Enhances, Rather than Inhibition Motif Encoding Costimulatory Platelet Immunoreceptor Tyrosine-Based Cutting Edge: TREM-Like Transcript-1, a

Kenneth G. C. Smith, W. Ouwehand, J. Trowsdale, 2004 .

Mobilization of intracellular Ca2+ by adenine nucleotides in human T-leukaemia cells: evidence for ADP-specific and P2y-purinergic receptors.

D. Alexander, M. Biffen, 1994, The Biochemical journal.

Development of T‐leukaemias in CD45 tyrosine phosphatase‐deficient mutant lck mice

D. Alexander, N. Coleman, R. Tooze, 2000, The EMBO journal.

An oncogenic tyrosine kinase inhibits DNA repair and DNA-damage-induced Bcl-xL deamidation in T cell transformation.

R. Zhao, D. Alexander, Feng Yang, 2004, Cancer cell.

Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders.

A. Green, R. Zhao, G. Follows, 2008, The New England journal of medicine.

Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells

D. Alexander, S. Turner, 2006, Leukemia.

The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction

D. Alexander, J. Frearson, 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

The role of intracellular signalling pathways regulating thymocyte and leukemic T cell apoptosis.

D. Alexander, L. A. Conroy, 1996, Leukemia.

Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase

K. Maclennan, D. Alexander, S. Turner, 2003, Oncogene.

Oncogenic Tyrosine Kinases, DNA Repair and Survival: The Role of Bcl-xL Deamidation in Transformation and Genotoxic Therapies

D. Alexander, 2004, Cell cycle.

What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?

D. Alexander, S. Turner, 2005, Leukemia.

The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms.

S. Cook, D. Alexander, S. Turner, 2007, Cellular signalling.

Protein kinase C activation inhibits TCR-mediated calcium influx but not inositol trisphosphate production in HPB-ALL T cells.

D. Alexander, E. Shivnan, 1995, Journal of immunology.

Guanine nucleotide regulation of inositol phospholipid hydrolysis and CD3-antigen phosphorylation in permeabilized T lymphocytes.

D. Alexander, D. Cantrell, J. Graves, 1990, The Biochemical journal.

Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

K. Linton, C. Higgins, D. Alexander, 2005, Nature Cell Biology.

Kinase Regulation: Competing Phosphatases in JAK Dephosphorylation

D. Alexander, 2002, Current Biology.

The role of phosphatases in signal transduction.

D. Alexander, 1990, The New biologist.

Biochemical and functional analysis of mice deficient in expression of the CD45‐associated phosphoprotein LPAP

T. Giese, D. Alexander, B. Schraven, 1999, European journal of immunology.

Tyrosine phosphatases in T-cell development and signalling.

D. Alexander, J. Frearson, J. Stone, 1997, Biochemical Society Transactions.

A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes.

M. Crumpton, D. Alexander, D. Cantrell, 1989, The Biochemical journal.

Regulatory T Cells Are Resistant to Apoptosis via TCR but Not P2X71

C. Higgins, D. Alexander, J. Elliott, 2007, The Journal of Immunology.

CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy.

D. Alexander, S. Turner, H. Merz, 2006, Anticancer research.

Approaches to Define Antigen Receptor-induced Serine Kinase Signal Transduction Pathways*

D. Alexander, A. Laurence, D. Cantrell, 2003, The Journal of Biological Chemistry.

Isolation of a digitoxin‐bound protein from a brain membrane preparation containing Na+, K+‐activated ATPase

D. Alexander, 1974, FEBS letters.

Biochemical and functional analysis of mice deficient in expression of the CD45‐associated phosphoprotein LPAP

T. Giese, D. Alexander, B. Schraven, 1999, European journal of immunology.

The CD45 tyrosine phosphatase regulates CD3‐induced signal transduction and T cell development in recombinase‐deficient mice: restoration of pre‐TCR function by active p56lck

D. Alexander, N. Holmes, S. Pingel, 1999, European journal of immunology.

Inhibitors of Protein Kinases and Protein Phosphates Contributors

L. Meijer, D. Fabbro, M. Yacoub, 2005 .

FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal.

D. Alexander, S. Metcalfe, J. Turner, 1994, Cellular Immunology.

D. Alexander, J. Frearson, 1998, The Journal of experimental medicine.