J. Schanstra

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Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

M. Girolami, J. Ioannidis, A. Dominiczak, 2010, Science Translational Medicine.

Implementation of proteomic biomarkers: making it work

Raymond Vanholder, Fulvio Magni, David Maahs, 2012, European journal of clinical investigation.

Protein Interactome of Muscle Invasive Bladder Cancer

A. Vlahou, H. Husi, A. Heinzel, 2015, PloS one.

Urinary proteomics based on capillary electrophoresis-coupled mass spectrometry in kidney disease: discovery and validation of biomarkers, and clinical application.

H. Mischak, J. Schanstra, C. Delles, 2010, Advances in chronic kidney disease.

Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease*

M. Girolami, A. Dominiczak, A. Ganser, 2010, Molecular & Cellular Proteomics.

A comparison between MALDI-MS and CE-MS data for biomarker assessment in chronic kidney diseases.

A. Vlahou, H. Mischak, M. Dakna, 2012, Journal of proteomics.

New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis.

A. Vlahou, H. Husi, H. Mischak, 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Body fluid peptide and protein signatures in diabetic kidney diseases.

H. Mischak, J. Jankowski, J. Schanstra, 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future.

A. Dominiczak, H. Mischak, J. Novak, 2007, Journal of proteome research.

Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis

H. Mischak, J. Schanstra, M. Walden, 2006, Nature Medicine.

Clinical proteomics: A need to define the field and to begin to set adequate standards

M. Girolami, A. Dominiczak, D. Hochstrasser, 2007, Proteomics. Clinical applications.

miRNAs in urine: a mirror image of kidney disease?

J. Schanstra, J. Klein, Theofilos G. Papadopoulos, 2015, Expert review of molecular diagnostics.

Omics databases on kidney disease: where they can be found and how to benefit from them

H. Husi, R. Stevens, J. Schanstra, 2016, Clinical kidney journal.

Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

G. Capasso, A. Vlahou, M. Sánchez-Niño, 2017, Scientific Reports.

Classical MALDI-MS versus CE-based ESI-MS proteomic profiling in urine for clinical applications.

H. Husi, H. Mischak, J. Schanstra, 2014, Bioanalysis.

Renal tubular fluid shear stress promotes endothelial cell activation.

J. Schanstra, M. Mercier-Bonin, J. Klein, 2011, Biochemical and biophysical research communications.

CE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics

A. Dominiczak, W. Kolch, H. Mischak, 2008, Proteomics. Clinical applications.

Proteomics of vitreous in neovascular age-related macular degeneration.

J. Schanstra, J. Kopitz, W. Mullen, 2016, Experimental eye research.

Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy

A. Vlahou, H. Husi, H. Mischak, 2017, Scientific Reports.

Clinical proteomics in obstetrics and neonatology

A. Vlahou, H. Mischak, J. Schanstra, 2014, Expert review of proteomics.

A capillary electrophoresis coupled to mass spectrometry pipeline for long term comparable assessment of the urinary metabolome

J. Schanstra, P. Moulos, S. Decramer, 2016, Scientific Reports.

1 Urine in clinical proteomics

Harald, B. Monsarrat, J. Schanstra, 2019 .

Urinary proteome analysis at 5-year followup of patients with nonoperated ureteropelvic junction obstruction suggests ongoing kidney remodeling.

H. Mischak, J. Schanstra, S. Decramer, 2012, The Journal of urology.

Identification of urinary biomarkers by proteomics in newborns: use in obstructive nephropathy.

H. Mischak, J. Schanstra, P. Zürbig, 2008, Contributions to nephrology.

Proteome-Based Systems Biology Analysis of the Diabetic Mouse Aorta Reveals Major Changes in Fatty Acid Biosynthesis as Potential Hallmark in Diabetes Mellitus–Associated Vascular Disease

A. Vlahou, H. Husi, H. Mischak, 2014, Circulation. Cardiovascular genetics.

Connectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease

A. Vlahou, H. Mischak, B. Monsarrat, 2020, Scientific Reports.

Non-invasive markers of ureteropelvic junction obstruction

J. Schanstra, S. Decramer, J. Bascands, 2007, World Journal of Urology.

Molecular structure and transcriptional regulation by nuclear factor-κB of the mouse kinin B1 receptor gene

J. Schanstra, J. Pesquero, J. Bascands, 2005, Biological chemistry.

Populous: a tool for building OWL ontologies from templates

Robert Stevens, Luigi Iannone, Simon Jupp, 2012, BMC Bioinformatics.

Inhibition of IGF-I-induced Erk 1 and 2 activation and mitogenesis in mesangial cells by bradykinin.

J. Schanstra, J. Bascands, C. Pécher, 2002, Kidney international.

Proteome analysis in the assessment of ageing

H. Mischak, J. Schanstra, B. Schumacher, 2014, Ageing Research Reviews.

Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive

J. Schanstra, J. Klein, J. Bascands, 2015, Front. Pharmacol..

Hnf-1β Transcription Factor Is an Early Hif-1α-Independent Marker of Epithelial Hypoxia and Controls Renal Repair

J. Schanstra, D. Chauveau, J. Bascands, 2013, PloS one.

Anomalies of the TCF2 gene are the main cause of fetal bilateral hyperechogenic kidneys.

J. Schanstra, C. Bellanné-Chantelot, S. Beaufils, 2007, Journal of the American Society of Nephrology : JASN.

Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group

J. Schanstra, M. Liebau, F. Schaefer, 2022, Nature Reviews Urology.

The CKD plasma lipidome varies with disease severity and outcome.

H. Mischak, K. Weinberger, J. Schanstra, 2019, Journal of clinical lipidology.

Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice.

H. Mischak, J. Schanstra, J. Klein, 2016, Kidney international.

Urinary Peptides as Potential Non-Invasive Biomarkers for Lupus Nephritis: Results of the Peptidu-LUP Study

J. Schanstra, L. Chiche, E. Daugas, 2021, Journal of clinical medicine.

Renal fibrosis: Insight from proteomics in animal models and human disease

J. Schanstra, A. Charonis, J. Klein, 2011, Proteomics.

Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy.

D. Maahs, H. Mischak, G. Navis, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Apelin affects the mouse aging urinary peptidome with minimal effects on kidney

J. Schanstra, C. Dray, P. Valet, 2019, Scientific Reports.

Bradykinin and renal fibrosis: have we ACE'd it?

J. Schanstra, J. Bascands, 2004, Journal of the American Society of Nephrology : JASN.

In vivo bradykinin B2 receptor activation reduces renal fibrosis.

J. Schanstra, J. Bascands, E. Neau, 2002, The Journal of clinical investigation.

B2 receptor activation reduces Erk1 and Erk2 phosphorylation induced by insulin-like growth factor-1, platelet-derived growth factor-BB, and high glucose in rat isolated glomeruli.

J. Schanstra, J. Bascands, C. Pécher, 2002, Canadian journal of physiology and pharmacology.

Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis

A. Vlahou, H. Mischak, B. Julian, 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Unmasking Silent Endothelial Activation in the Cardiovascular System Using Molecular Magnetic Resonance Imaging

J. Schanstra, D. Chauveau, D. Vivien, 2015, Theranostics.

MO379: Collagen-Derived Peptides in CKD: A Link to Fibrosis

A. Vlahou, H. Mischak, J. Jankowski, 2022, Nephrology Dialysis Transplantation.

Collagen-Derived Peptides in CKD: A Link to Fibrosis

A. Vlahou, H. Mischak, J. Jankowski, 2021, Toxins.

Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome

H. Mischak, J. Schanstra, P. Zürbig, 2020, Scientific Reports.

Expression and distribution of kinin B1 receptor in the rat brain and alterations induced by diabetes in the model of streptozotocin

J. Schanstra, J. Chabot, M. Campos, 2005, Synapse.

Proteomics based identification of KDM5 histone demethylases associated with cardiovascular disease

A. Vlahou, H. Mischak, J. Schanstra, 2019, EBioMedicine.

[Bradykinin receptors: towards new pathophysiological roles].

J. Schanstra, J. Bascands, R. Couture, 2003, Medecine sciences : M/S.

Specificity and Kinetics of Haloalkane Dehalogenase*

J. Kingma, D. Janssen, J. Schanstra, 1996, The Journal of Biological Chemistry.

Unifying the integration, analysis and interpretation of multi-omic datasets: Exploration of the disease networks of Obstructive Nephropathy in children

Ilias Maglogiannis, Aristotelis A. Chatziioannou, Ioannis Valavanis, 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

The use of urinary proteomics in the assessment of suitability of mouse models for ageing

A. Vlahou, H. Busch, H. Mischak, 2017, PloS one.

Proteomic urinary biomarker approach in renal disease: from discovery to implementation

H. Mischak, J. Schanstra, 2015, Pediatric Nephrology.

Delayed Treatment with Plasminogen Activator Inhibitor-1 Decoys Reduces Tubulointerstitial Fibrosis

J. Schanstra, J. Klein, J. Bascands, 2009, Experimental biology and medicine.

Value of Urine Peptides in Assessing Kidney and Cardiovascular Disease

H. Mischak, J. Schanstra, A. Latosinska, 2020, Proteomics. Clinical applications.

Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs.

J. Schanstra, J. Häggström, P. Zürbig, 2019, Veterinary journal.

CE‐MS in biomarker discovery, validation, and clinical application

H. Mischak, J. Schanstra, 2011, Proteomics. Clinical applications.

Implementation of Proteomics Biomarkers in Nephrology: From Animal Models to Human Application?

J. Schanstra, J. Klein, 2018, Proteomics. Clinical applications.

Urinary peptidomics in kidney disease and drug research

H. Mischak, J. Schanstra, M. Krochmal, 2018, Expert opinion on drug discovery.

Title Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease

W. Spooner, W. Kolch, H. Mischak, 2022 .

7 The role of the renal kallikrein-kinin system in physiology and pathology

J. Schanstra, J. Klein, J. Bascands, 2011 .

Bradykinin B(1) receptor-mediated changes in renal hemodynamics during endotoxin-induced inflammation.

J. Schanstra, J. Bascands, I. Tack, 2000, Journal of the American Society of Nephrology : JASN.

B2 kinin receptor upregulation by cAMP is associated with BK-induced PGE2 production in rat mesangial cells.

J. Schanstra, C. Hirtz, J. Pesquero, 1998, American journal of physiology. Renal physiology.

Differential induction of functional B1-bradykinin receptors along the rat nephron in endotoxin induced inflammation.

J. Schanstra, J. Pesquero, J. Bascands, 1998, Kidney international.

B 2 kinin receptor upregulation by cAMP is associated with BK-induced PGE 2 production in rat mesangial cells

J. Schanstra, C. Hirtz, J. Pesquero, 1998 .

Physiopathologie des uropathies obstructives : apport des animaux génétiquements modifiés

J. Schanstra, J. Bascands, 2003 .

Role of Kinin B2 Receptor Signaling in the Recruitment of Circulating Progenitor Cells With Neovascularization Potential

G. Angelini, P. MacDonald, J. Schanstra, 2008, Circulation research.

Serum and urinary biomarkers of collagen type‐I turnover predict prognosis in patients with heart failure

A. Vlahou, J. Staessen, L. Thijs, 2021, Clinical and translational medicine.

Induction of Functional Bradykinin B1-Receptors in Normotensive Rats and Mice Under Chronic Angiotensin-Converting Enzyme Inhibitor Treatment

J. Schanstra, J. Bascands, E. Neau, 2002, Circulation.

A single dose of estrogen during hemorrhagic shock protects against Kidney Injury whereas estrogen restoration in ovariectomized mice is ineffective

J. Schanstra, J. Arnal, I. Tack, 2020, Scientific Reports.

Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes

J. Schanstra, D. Bachvarov, J. Pesquero, 2006, Biological chemistry.

Increased urine acylcarnitines in diabetic ApoE-/- mice: Hydroxytetradecadienoylcarnitine (C14:2-OH) reflects diabetic nephropathy in a context of hyperlipidemia.

J. Schanstra, T. Koal, K. Klavins, 2017, Biochemical and biophysical research communications.

Implementation of proteomic biomarkers: making it work PERSPECTIVE

M. Manns, A. Vlahou, T. Attwood, 2012 .

Congenital ureteropelvic junction obstruction: human disease and animal models

J. Schanstra, S. Decramer, J. Klein, 2011, International journal of experimental pathology.

Functional rescue of a defective angiotensin II AT1 receptor mutant by the Mas protooncogene

J. Schanstra, C. Costa-Neto, J. Pesquero, 2007, Regulatory Peptides.

The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts.

J. Schanstra, C. Hirtz, J. Pesquero, 1998, The Journal of clinical investigation.

Ibrutinib does not prevent kidney fibrosis following acute and chronic injury

J. Schanstra, J. Belliere, S. Faguer, 2021, Scientific Reports.

Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells.

N. Chassaing, J. Schanstra, M. Pontoglio, 2017, Journal of the American Society of Nephrology : JASN.

Gene expression profiling in the remnant kidney model of wild type and kinin B1 and B2 receptor knockout mice.

J. Schanstra, D. Bachvarov, J. Bascands, 2007, Kidney international.

Pargyline reduces renal damage associated with ischaemia-reperfusion and cyclosporin.

J. Schanstra, A. Parini, C. Guilbeau-Frugier, 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Identification of Symptomatic Fetuses Infected with Cytomegalovirus Using Amniotic Fluid Peptide Biomarkers

Y. Ville, J. Schanstra, C. Froment, 2016, PLoS pathogens.

The low affinity p75 neurotrophin receptor is down-regulated in congenital anomalies of the kidney and the urinary tract: Possible involvement in early nephrogenesis.

J. Schanstra, J. Saulnier-Blache, S. Decramer, 2020, Biochemical and biophysical research communications.

Refining Kidney Survival in 383 Genetically Characterized Patients With Nephronophthisis

N. Klopp, J. Gerss, H. Omran, 2022, Kidney international reports.

Epidermal growth factor and kidney disease: a long-lasting story.

J. Schanstra, J. Klein, J. Bascands, 2016, Kidney international.

A nest in renal fibrosis?

J. Schanstra, J. Bascands, J. Klein, 2007, Kidney international.

A universal predictive and mechanistic urinary peptide signature in acute kidney injury

A. Mebazaa, H. Mischak, J. Schanstra, 2022, Critical Care.

Molecular determinants of LPS-induced acute renal inflammation: Implication of the kinin B1 receptor.

J. Schanstra, D. Bachvarov, J. Bascands, 2009, Biochemical and biophysical research communications.

Participation of transmembrane proline 82 in angiotensin II AT1 receptor signal transduction

J. Schanstra, C. Costa-Neto, J. Pesquero, 2007, Regulatory Peptides.

The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design

J. Schanstra, D. Oepkes, E. Levtchenko, 2019, Clinical kidney journal.

Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).

J. Schanstra, J. Bascands, J. Girolami, 1999, International journal of molecular medicine.

Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function

M. Mori, J. Schanstra, C. Nakaie, 2006, Biological chemistry.

Lysophosphatidic acid and renal fibrosis.

Julie Klein, David Salant, Philippe Valet, 2008, Biochimica et biophysica acta.

Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor.

J. Schanstra, P. Bruneval, J. Bascands, 2003, American journal of physiology. Heart and circulatory physiology.

Receptor 2 Tuft Area in Mice Lacking the Bradykinin B Decreased Renal No Excretion and Reduced Glomerular

J. Schanstra, P. Bruneval, J. Bascands, 2022 .

Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients

Pieter, D. Stamatialis, H. Mischak, 2019, Scientific Reports.

Addressing the challenge of dening valid proteomic biomarkers and classiers.

Mark Girolami, Alexandros Kalousis, Harald Mischak, 2011 .

Urinary biomarkers for renal tract malformations

H. Mischak, J. Schanstra, P. Zürbig, 2016, Expert review of proteomics.

Title : Urinary biomarkers for renal tract malformations

H. Mischak, J. Schanstra, P. Magalhães, 2016 .

Urinary peptides in heart failure: a link to molecular pathophysiology

A. Vlahou, G. Filippatos, J. McMurray, 2021, European journal of heart failure.

Obstructive nephropathy: insights from genetically engineered animals.

Jean-Loup Bascands, J. Schanstra, J. Bascands, 2005, Kidney international.

The KUPKB: a novel Web application to access multiomics data on kidney disease

Robert Stevens, Simon Jupp, Julie Klein, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease.

A. Raaijmakers, J. Oury, R. Favre, 2020, Kidney international.

Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups

H. Mischak, J. Schanstra, D. Gaya, 2017, Scientific Reports.

Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease

W. Spooner, W. Kolch, H. Mischak, 2016, BMC Bioinformatics.

Long Term Metabolic Syndrome Induced by a High Fat High Fructose Diet Leads to Minimal Renal Injury in C57BL/6 Mice

H. Mischak, J. Schanstra, B. Payre, 2013, PloS one.

Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers

Alexandros Kalousis, Mark A. Girolami, Walter Kolch, 2010, BMC Bioinformatics.

Comprehensive human urine standards for comparability and standardization in clinical proteome analysis

Martin Norling, Walter Kolch, Harald Mischak, 2010, Proteomics. Clinical applications.

Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments.

A. Dominiczak, H. Mischak, J. Novak, 2009, Mass spectrometry reviews.

The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease

H. Mischak, J. Coon, M. Dakna, 2009, Proteomics.

Urine in Clinical Proteomics*

Harald Mischak, Joost P. Schanstra, Bernard Monsarrat, 2008, Molecular & Cellular Proteomics.

Kinin B1 Receptor Deficiency Leads to Leptin Hypersensitivity and Resistance to Obesity

M. Mori, J. Schanstra, P. Even, 2008, Diabetes.

Capillary electrophoresis–mass spectrometry in urinary proteome analysis: current applications and future developments

H. Mischak, J. Schanstra, J. Metzger, 2009, Analytical and bioanalytical chemistry.

Combination of the fetal urinary metabolome and peptidome for the prediction of postnatal renal outcome in fetuses with PUV.

J. Schanstra, P. Moulos, S. Decramer, 2018, Journal of proteomics.

Ldlr-/- and ApoE-/- mice better mimic the human metabolite signature of increased carotid intima media thickness compared to other animal models of cardiovascular disease.

C. Meisinger, W. Rathmann, M. Waldenberger, 2018, Atherosclerosis.

Omics Derived Biomarkers and Novel Drug Targets for Improved Intervention in Advanced Prostate Cancer

H. Mischak, J. Schanstra, A. Latosinska, 2020, Diagnostics.

Label-free Quantitative Urinary Proteomics Identifies the Arginase Pathway as a New Player in Congenital Obstructive Nephropathy*

B. Monsarrat, J. Schanstra, O. Burlet-Schiltz, 2014, Molecular & Cellular Proteomics.

Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity

B. Wirth, J. Schanstra, O. Burlet-Schiltz, 2021, The Journal of pathology.

Lysophosphatidic acid-1-receptor targeting agents for fibrosis

Julie Klein, Philippe Valet, Jean-Loup Bascands, 2011, Expert opinion on investigational drugs.

LPA1 receptor activation promotes renal interstitial fibrosis.

J. Chun, J. Schanstra, P. Valet, 2007, Journal of the American Society of Nephrology : JASN.

Ethanol metabolism in a peroxisome-deficient mutant of the yeast Hansenula polymorpha

J. Schanstra, M. Veenhuis, G. Sulter, 1991 .

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

J. Schanstra, P. Heeringa, J. Pradère, 2013, Biochemical and biophysical research communications.

Proteomic Analysis of Mouse Kidney Tissue Associates Peroxisomal Dysfunction with Early Diabetic Kidney Disease

A. Vlahou, H. Mischak, J. Schanstra, 2021, bioRxiv.

Asymptomatic circulating T-cell clone cause renal polymorphic inflammatory fibrosis

J. Schanstra, D. Chauveau, L. Ysebaert, 2017, Clinical and Experimental Nephrology.

Increased urinary lysophosphatidic acid in mouse with subtotal nephrectomy: potential involvement in chronic kidney disease

J. Schanstra, C. Vinel, J. Bertrand-Michel, 2016, Journal of Physiology and Biochemistry.

Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury.

J. Schanstra, D. Chauveau, C. Guilbeau-Frugier, 2015, Journal of the American Society of Nephrology : JASN.

The HNF1B score is a simple tool to select patients for HNF1B gene analysis.

P. Calvas, N. Chassaing, J. Schanstra, 2014, Kidney international.

Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration

H. Husi, H. Mischak, J. Jankowski, 2014, PloS one.

Blockade of the kinin B1 receptor ameloriates glomerulonephritis.

D. Salant, J. Schanstra, P. Heeringa, 2010, Journal of the American Society of Nephrology : JASN.

Homologous and heterologous induction of the human bradykinin B1-receptor and B1-receptor localisation along the rat nephron.

J. Schanstra, J. Pesquero, J. Bascands, 1999, Immunopharmacology.

Avacopan as First-Line Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Steroid-Sparing Option

J. Schanstra, D. Chauveau, J. Belliere, 2022, Kidney international reports.

Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group

J. Schanstra, M. Liebau, F. Schaefer, 2022, Nature Reviews Urology.

Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease

A. Vlahou, H. Mischak, J. Schanstra, 2018, Journal of Translational Medicine.

Omics Tools for Exploration of Renal Disorders

Bernd Mayer, Joost P. Schanstra, Christoph Aufricht, 2016 .

Hepatocyte nuclear factor‐1β shapes the energetic homeostasis of kidney tubule cells

J. Schanstra, D. Chauveau, M. Malet‐Martino, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Data Sharing Under the General Data Protection Regulation

J. Ioannidis, A. Vlahou, R. Apweiler, 2021, Hypertension.

Transcriptional regulation of the rat bradykinin B2 receptor gene: identification of a silencer element.

Michael Bader, J. Schanstra, J. Estève, 2002, Molecular pharmacology.

Engineering proteins for environmental applications.

D. Janssen, J. Schanstra, 1994, Current opinion in biotechnology.

Is the time ripe for kidney tissue proteomics?

M. Baumann, T. Luider, J. Schanstra, 2011, Proteomics. Clinical applications.

Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction

Panagiotis Moulos, Julie Klein, Joost Schanstra, 2017, BMC Systems Biology.

Molecular Changes in Tissue Proteome during Prostate Cancer Development: Proof-of-Principle Investigation

A. Vlahou, H. Mischak, J. Schanstra, 2020, Diagnostics.

Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides.

A. Vlahou, H. Husi, J. Staessen, 2015, Journal of the American Society of Nephrology : JASN.

Proteomic Analysis of Vitreous Humor in Retinal Vein Occlusion

J. Schanstra, J. Kopitz, W. Mullen, 2015, PloS one.

Risk profile, quality of life and care of patients with moderate and advanced CKD: The French CKD-REIN Cohort Study

C. Jacquelinet, Z. Massy, J. Schanstra, 2019, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells

Joost P. Schanstra, Audrey Casemayou, Cécile Caubet, 2015, PloS one.

Improving peptide relative quantification in MALDI‐TOF MS for biomarker assessment

A. Vlahou, H. Husi, H. Mischak, 2013, Proteomics.

Laminar Shear Stress Regulates Endothelial Kinin B1 Receptor Expression and Function: Potential Implication in Atherogenesis

J. Schanstra, A. Ahluwalia, M. Perretti, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

A. Vlahou, H. Mischak, J. Schanstra, 2019, JCI insight.

Urinary lysophopholipids are increased in diabetic patients with nephropathy.

S. Hadjadj, J. Schanstra, R. Roussel, 2017, Journal of diabetes and its complications.

Lysophosphatidic Acid Protects Against Endotoxin-Induced Acute Kidney Injury

J. Schanstra, J. Saulnier-Blache, J. Bascands, 2017, Inflammation.

A low molecular weight urinary proteome profile of human kidney aging

H. Mischak, J. Coon, M. Dakna, 2016 .

A database of naturally occurring human urinary peptides and proteins for use in clinical applications

A. Dominiczak, A. Ganser, W. Kolch, 2007 .

Urinary proteome analysis identifies infants but not older children requiring pyeloplasty

H. Mischak, E. Schiffer, J. Ehrich, 2010, Pediatric Nephrology.

Fetal Urinary Peptides to Predict Postnatal Outcome of Renal Disease in Fetuses with Posterior Urethral Valves (PUV)

H. Mischak, M. Dakna, B. Monsarrat, 2013, Science Translational Medicine.

Comparison of the amniotic fluid and fetal urine peptidome for biomarker discovery in renal developmental disease

J. Schanstra, P. Zürbig, S. Decramer, 2020, Scientific Reports.

A single-center study to evaluate the efficacy of a fetal urine peptide signature predicting postnatal renal outcome in fetuses with posterior urethral valves

J. Schanstra, M. Tkaczyk, S. Decramer, 2019, Pediatric Nephrology.

The role of urinary peptidomics in kidney disease research.

H. Mischak, J. Schanstra, J. Klein, 2016, Kidney international.

Klein Fetuses with Posterior Urethral Valves ( PUV ) Fetal Urinary Peptides to Predict Postnatal Outcome of Renal Disease in

H. Mischak, M. Dakna, B. Monsarrat, 2013 .

Haploinsufficiency of the mouse Tshz3 gene leads to kidney dysfunction

J. Schanstra, P. Zürbig, X. Caubit, 2021, bioRxiv.

Machine Learning-Based Urine Peptidome Analysis to Predict and Understand Mechanisms of Progression to Kidney Failure

C. Jacquelinet, H. Mischak, J. Schanstra, 2022, Kidney international reports.

Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

G. Capasso, A. Vlahou, M. Sánchez-Niño, 2017, Scientific Reports.

Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker

A. Vlahou, R. Klein, J. Staessen, 2017, Kidney international reports.

Comparison of Urine and Plasma Peptidome Indicates Selectivity in Renal Peptide Handling

A. Vlahou, H. Mischak, J. Jankowski, 2018, Proteomics. Clinical applications.

Proteomics as a Quality Control Tool of Pharmaceutical Probiotic Bacterial Lysate Products

Günter Klein, Harald Mischak, Kurt Zimmermann, 2013, PloS one.

Validity and reproducibility of a short food frequency questionnaire among patients with chronic kidney disease

F. Clavel-Chapelon, C. Jacquelinet, J. Schanstra, 2017, BMC Nephrology.

Urinary proteome signature of Renal Cysts and Diabetes syndrome in children

G. Remuzzi, H. Mischak, J. Schanstra, 2019, Scientific Reports.

Discovery and validation of urinary biomarkers for detection of renal cell carcinoma.

A. Vlahou, H. Husi, H. Mischak, 2014, Journal of proteomics.

Advances in urinary proteome analysis and biomarker discovery in pediatric renal disease

H. Mischak, J. Ehrich, J. Schanstra, 2010, Pediatric Nephrology.

The urinary proteome in diabetes and diabetes‐associated complications: New ways to assess disease progression and evaluate therapy

D. Maahs, H. Mischak, J. Schanstra, 2008, Proteomics. Clinical applications.

Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation

J. Schanstra, J. Klein, J. Bascands, 2019, EBioMedicine.

Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction

J. Staessen, L. Thijs, T. Kuznetsova, 2018, Journal of the American Society of Hypertension : JASH.

Prediction of acute coronary syndromes by urinary proteome analysis

J. Shaw, J. Staessen, D. Maahs, 2017, PloS one.

Urinary Peptide Analysis Differentiates Pancreatic Cancer From Chronic Pancreatitis

M. Manns, H. Husi, H. Mischak, 2016, Pancreas.

Implementation of CE-MS-identified proteome-based biomarker panels in drug development and patient management.

H. Mischak, J. Schanstra, A. Stępczyńska, 2016, Bioanalysis.

Pretransplant urinary proteome analysis does not predict development of chronic kidney disease after liver transplantation

J. Schanstra, P. Moulos, L. Rostaing, 2015, Liver international : official journal of the International Association for the Study of the Liver.

Identification of ageing-associated naturally occurring peptides in human urine

A. Vlahou, H. Mischak, M. Dakna, 2015, Oncotarget.

Prevalence of atheromatous and non-atheromatous cardiovascular disease by age in chronic kidney disease.

C. Jacquelinet, Z. Massy, J. Schanstra, 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study

C. Jacquelinet, Z. Massy, J. Schanstra, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

A urinary proteome‐based classifier for the early detection of decline in glomerular filtration

A. Vlahou, J. Staessen, H. Mischak, 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The COV50 classifier predicts frailty and future death, independent from SARS-CoV-2 infection

A. Vlahou, J. Staessen, H. Mischak, 2023, medRxiv.

The B 1-agonist [ des-Arg 10 ]-kallidin Activates Transcription Factor NFk B and Induces Homologous Upregulation of the Bradykinin B 1 – receptor in Cultured Human Lung Fibroblasts

J. Schanstra, C. Hirtz, J. Pesquero, 1998 .

Induction of B1 receptors in streptozotocin diabetic rats: possible involvement in the control of hyperglycemia-induced glomerular Erk 1 and 2 phosphorylation.

J. Schanstra, J. Bascands, E. Neau, 2002, Canadian journal of physiology and pharmacology.

Systems biology: opening new avenues in clinical research.

Mark Girolami, Matthias Dehmer, Paul Perco, 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The tryptophan pathway and nicotinamide supplementation in ischaemic acute kidney injury

J. Schanstra, J. Klein, B. Marcheix, 2021, Clinical kidney journal.

Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy

J. Schanstra, A. Ahluwalia, J. Pesquero, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PRYNT: a tool for prioritization of disease candidates from proteomics data using a combination of shortest-path and random walk algorithms

J. Schanstra, J. Klein, Julien Aligon, 2021, Scientific Reports.

Lysophosphatidic Acid Protects Against Endotoxin-Induced Acute Kidney Injury

J. Schanstra, J. Saulnier-Blache, J. Bascands, 2017, Inflammation.

Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions.

J. Schanstra, F. Lopez, J. Estève, 2005, Biochemical and biophysical research communications.

Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease

A. Vlahou, H. Mischak, J. Schanstra, 2018, Journal of Translational Medicine.

A0221 Myocardial Proteomic Signatures in End-Stage Dilated and Ischemic Cardiomyopathy Compared with Normal Human Hearts

A. Vlahou, J. Staessen, L. Thijs, 2018, Journal of Hypertension.

Uniform Manifold Approximation and Projection-based Assessment of Chronic Kidney Disease Aetiologies based on Urinary Peptidomics

A. Vlahou, H. Mischak, J. Schanstra, 2023, medRxiv.

Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome

H. Mischak, J. Schanstra, P. Zürbig, 2020, Scientific Reports.

Urinary proteome signature of Renal Cysts and Diabetes syndrome in children

G. Remuzzi, H. Mischak, J. Schanstra, 2019, Scientific Reports.

Calcineurin Inhibitors Downregulate HNF-1&bgr; and May Affect the Outcome of HNF1B Patients After Renal Transplantation

N. Chassaing, J. Schanstra, L. Rostaing, 2016, Transplantation.

Apelin affects the mouse aging urinary peptidome with minimal effects on kidney

J. Schanstra, C. Dray, P. Valet, 2019, Scientific reports.

University of Groningen Prediction of Chronic Kidney Disease Stage 3 by CKD 273 , a Urinary Proteomic Biomarker

A. Vlahou, R. Klein, J. Staessen, 2022 .

A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation*

Jean-Loup Bascands, J. Schanstra, J. Estève, 2002, The Journal of Biological Chemistry.

Longitudinal uric acid has nonlinear association with kidney failure and mortality in chronic kidney disease

C. Jacquelinet, K. Leffondré, J. Schanstra, 2023, Scientific Reports.

The KUPNetViz: a biological network viewer for multiple -omics datasets in kidney diseases

Robert Stevens, Simon Jupp, Panagiotis Moulos, 2013, BMC Bioinformatics.

[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway].

J. Schanstra, J. Bascands, J. Duchêne, 2002, Nephrologie.

[Renal urinary shear stress: a novel actor in nephropathies].

J. Schanstra, M. Essig, J. Klein, 2013, Medecine sciences : M/S.

Establishment of a European Network for Urine and Kidney Proteomics.

A. Vlahou, T. Attwood, H. Mischak, 2008, Journal of proteomics.

2nd Combined Working Group and Management Committee Meeting of Urine and Kidney Proteomics COST Action 29–30 March 2009, Nafplio, Greece

A. Vlahou, T. Attwood, H. Mischak, 2009, Proteomics. Clinical applications.

Developing a kidney and urinary pathway knowledge base

Robert Stevens, Simon Jupp, Julie Klein, 2011, J. Biomed. Semant..

Urinary peptides predict future death

A. Vlahou, J. Staessen, H. Mischak, 2023 .

Systems biology to battle vascular disease.

M. Girolami, A. Dominiczak, I. Fournier, 2010, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients

D. Stamatialis, H. Mischak, D. Fliser, 2019, Scientific Reports.

Integrative analysis of CAKUT multi-omics data

R. Kaliyaperumal, J. Schanstra, N. Queralt-Rosinach, 2023, bioRxiv.

Renal tubular fluid shear stress facilitates monocyte activation toward inflammatory macrophages.

J. Schanstra, M. Mercier-Bonin, J. Klein, 2012, American journal of physiology. Renal physiology.

Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study

A. Vlahou, J. Staessen, A. Campbell, 2023, medRxiv.

2nd Combined Working Group and Management Committee Meeting of Urine and Kidney Proteomics COST Action 29–30 March 2009, Nafplio, Greece

A. Vlahou, T. Attwood, H. Mischak, 2009, PROTEOMICS - Clinical Applications.

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

J. Schanstra, P. Heeringa, J. Pradère, 2013, Biochemical and biophysical research communications.

The protective effect of angiotensin converting enzyme inhibition in experimental renal fibrosis in mice is not mediated by bradykinin B2 receptor activation

J. Schanstra, J. Bascands, E. Neau, 2003, Thrombosis and Haemostasis.

Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

M. Girolami, J. Ioannidis, A. Dominiczak, 2010, Science Translational Medicine.

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

A. Vlahou, H. Mischak, J. Schanstra, 2019, JCI insight.

Comprehensive human urine standards for comparability and standardization in clinical proteome analysis

A. Vlahou, W. Kolch, H. Mischak, 2010, Proteomics. Clinical applications.

Engineering enzymes and microorganisms for the transformation of synthetic compounds

D. Janssen, J. Schanstra, T. Bosma, 1997 .

Kinetics of halide release of haloalkane dehalogenase: evidence for a slow conformational change.

J. Schanstra, D B Janssen, J P Schanstra, 1996, Biochemistry.

Kinetic characterization and X-ray structure of a mutant of haloalkane dehalogenase with higher catalytic activity and modified substrate range.

I. S. Ridder, G. Heimeriks, K. H. Kalk, 1996, Biochemistry.

Construction of an expression and site-directed mutagenesis system of haloalkane dehalogenase in Escherichia coli.

F. Pries, D. Janssen, J. Schanstra, 1993, Protein expression and purification.

Urinary peptidomic liquid biopsy for non-invasive differential diagnosis of chronic kidney disease

A. Vlahou, J. Schanstra, A. Latosinska, 2023, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification

J. Schanstra, D. Ramel, M. Laffargue, 2023, International journal of molecular sciences.

Ontologies Come of Age with the {iKUP} Browser

Robert Stevens, Simon Jupp, Panagiotis Moulos, 2011 .

Program Committee Additional Reviewers Contents Preface Iii Generic Multilevel Approach Designing Domain Ontologies Based on Xml Schemas Extending Ontologies with Free Keywords in a Collaborative Annotation Envi- Ronment Ontologies Come of Age with the Ikup Browser Dynamic Is-a Hierarchy Generation

K. Baclawski, M. Musen, J. Bateman, 2022 .

Using semantic web technologies to manage complexity and change in biomedical data

Robert Stevens, Simon Jupp, Julie Klein, 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Clinical proteomics in obstetrics and neonatology

A. Vlahou, H. Mischak, J. Schanstra, 2014, Expert review of proteomics.

Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios

A. Vlahou, J. Schanstra, M. Mokou, 2023, Journal of Translational Medicine.

Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease

J. Schanstra, J. Valdivielso, P. Stenvinkel, 2023, Science Translational Medicine.

Metabolic and cardiovascular adaptations to an 8-week lifestyle weight loss intervention in younger and older obese men.

J. Schanstra, C. Dray, P. Valet, 2021, American journal of physiology. Endocrinology and metabolism.

Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease

Walter Kolch, William Spooner, Harald Mischak, 2016, BMC Bioinformatics.

Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction

J. Staessen, L. Thijs, T. Kuznetsova, 2018, Journal of the American Society of Hypertension : JASH.

Analysis of pediatric obstructive nephropathy using protein antibody arrays and computational techniques

Ilias Maglogiannis, J. Schanstra, A. Chatziioannou, 2010, Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine.

Nestin expression in the kidney with an obstructed ureter.

M. Nangaku, J. Schanstra, K. Hiromura, 2007, Kidney international.