G. Chessari

发表

Quantitative determination of intermolecular interactions with fluorinated aromatic rings.

J. G. Vinter, C. Hunter, H. Adams, 2001, Chemistry.

Modeling water molecules in protein-ligand docking using GOLD.

Richard D. Taylor, C. Murray, Robin Taylor, 2005, Journal of medicinal chemistry.

From fragment to clinical candidate--a historical perspective.

Gianni Chessari, G. Chessari, A. Woodhead, 2009, Drug discovery today.

Recent developments in fragment-based drug discovery.

M. Congreve, G. Chessari, A. Woodhead, 2008, Journal of medicinal chemistry.

Diverse, high-quality test set for the validation of protein-ligand docking performance.

Paul N. Mortenson, C. Murray, M. Verdonk, 2007, Journal of medicinal chemistry.

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.

G. Chessari, P. Williams, E. J. Lewis, 2015, Journal of medicinal chemistry.

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

Gianni Chessari, Brent Graham, Christopher W Murray, 2010, Journal of medicinal chemistry.

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma

P. Johnston, D. Longley, G. Chessari, 2013, Cell Death and Disease.

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Andrew J. Woodhead, Gianni Chessari, Brent Graham, 2012, Nature chemical biology.

Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase.

Gianni Chessari, Christopher W Murray, Miles Congreve, 2007, Journal of medicinal chemistry.

Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.

Gianni Chessari, Chris Abell, Christopher W Murray, 2006, Journal of medicinal chemistry.

Rotor synchronization of radiofrequency and gradient pulses in high-resolution magic angle spinning NMR.

J. Wieruszeski, G. Lippens, G. Chessari, 2001, Journal of magnetic resonance.

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

G. Chessari, P. Williams, E. Chiarparin, 2017, Journal of medicinal chemistry.

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy

M. Salto‐Tellez, D. Longley, G. Chessari, 2016, Oncotarget.

Noncovalent functional-group-arene interactions.

J. G. Vinter, C. Hunter, G. Chessari, 2007, Angewandte Chemie.

Electrostatic Complementarity in Structure-Based Drug Design.

G. Chessari, Benjamin D Cons, David G Twigg, 2022, Journal of medicinal chemistry.

Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.

James M. Morrell, G. Chessari, S. Neidle, 2003, Journal of medicinal chemistry.

C–H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD)

Paul N. Mortenson, G. Chessari, R. S. Holvey, 2021, Chemical science.

X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.

C. Murray, G. Chessari, M. O’Reilly, 2022, Journal of medicinal chemistry.

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one

G. Chessari, P. Williams, G. Saxty, 2018, Journal of medicinal chemistry.

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.

Gianni Chessari, Mark Sylvester, Rutger H A Folmer, 2007, Journal of medicinal chemistry.

Application of fragment screening by X-ray crystallography to beta-secretase.

Gianni Chessari, Christopher W Murray, Miles Congreve, 2007, Journal of medicinal chemistry.

Cation encapsulation within a ten-oxygen spheroidal cavity of conformationally preorganized 1,5-3,7-calix[8]bis-crown-3 derivatives

G. Chessari, P. Neri, M. Piattelli, 1997 .

Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.

Gianni Chessari, Stephen Neidle, John Mann, 2003, Nucleic acids research.

Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.

Gianni Chessari, Brent Graham, Jose Cosme, 2010, Journal of medicinal chemistry.

CHAPTER 4 – Structural biology and anticancer drug design

Dominic Tisi, Gianni Chessari, Andrew James Woodhead, 2008 .

ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

G. Chessari, J. Lyons, N. Thompson, 2018, Molecular Cancer Therapeutics.

Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator.

Gianni Chessari, Mladen Vinković, Miles Congreve, 2008, Journal of medicinal chemistry.

Recent Developments in Fragment-Based Drug Discovery

M. Congreve, G. Chessari, A. Woodhead, 2008 .

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.

M. Noble, J. Endicott, G. Chessari, 2021, Journal of medicinal chemistry.

Resin dynamics contributes to the NMR line broadening of organic molecules grafted onto a polystyrene resin.

J. Wieruszeski, G. Lippens, G. Chessari, 2002, Journal of magnetic resonance.

Accelerated Chemical Reaction Optimization Using Multi-Task Learning

Mohammed I. Jeraal, Kobi C. Felton, G. Chessari, 2023, ACS central science.

Meaningful machine learning models and machine-learned pharmacophores from fragment screening campaigns

Lucy J. Colwell, Richard J. Hall, C. Murray, 2022, ArXiv.

Illustration of Current Challenges in Molecular Docking

Gianni Chessari, Christopher William Murray, Marcel L. Verdonk, 2007 .

An evaluation of force-field treatments of aromatic interactions.

Gianni Chessari, J. G. Vinter, Martin J Packer, 2002, Chemistry.

Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.

M. Congreve, C. Murray, G. Chessari, 2010, Journal of medicinal chemistry.