J. Schlessinger

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Cellular signaling by fibroblast growth factor receptors.

V. P. Eswarakumar, I. Lax, J. Schlessinger, 2005, Cytokine & growth factor reviews.

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

D. Levy, J. Schlessinger, O. Silvennoinen, 1993, Nature.

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

S. Hubbard, J. Schlessinger, M. Mohammadi, 1997, Science.

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

S. Hubbard, J. Schlessinger, M. Mohammadi, 1998, The EMBO journal.

Kinetics of binding, endocytosis, and recycling of EGF receptor mutants

A. Ullrich, J. Schlessinger, S. Felder, 1992, The Journal of cell biology.

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

S. Ariyan, Shuangge Ma, S. Mane, 2015, Nature Genetics.

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

A. Ullrich, J. Schlessinger, A. Honegger, 1990, Molecular and cellular biology.

Novel recognition mode between Vav and Grb2 SH3 domains

Kenji Ogura, Koji Nagata, Fuyuhiko Inagaki, 2001, The EMBO journal.

Solution structure of Grb2 reveals extensive flexibility necessary for target recognition.

J. Schlessinger, K. Ogura, V. Mandiyan, 2001, Journal of molecular biology.

Cell Signaling by Receptor Tyrosine Kinases

J. Schlessinger, M. Lemmon, 2000, Cell.

Epidermal GrowthFactor (EGF)Stimulates Association andKinase Activity ofRaf-1 withtheEGF Receptor

A. Ullrich, A. Zilberstein, J. Schlessinger, 1991 .

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

Michael Karin, Nanxin Li, Joseph Schlessinger, 1994, Cell.

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

E. Pardon, J. Steyaert, I. Lax, 2018, Nature.

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics.

W. Webb, E. Elson, J. Schlessinger, 1976, Biophysical journal.

Dynamics of fluorescence marker concentration as a probe of mobility.

W. Webb, E. Elson, J. Schlessinger, 1976, Biophysical journal.

Lateral transport of a lipid probe and labeled proteins on a cell membrane.

W. Webb, E. Elson, J. Schlessinger, 1977, Science.

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.

J. Schlessinger, M. Mohammadi, B. K. Yeh, 2000, Molecular cell.

Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers.

W. Webb, E. Elson, J. Schlessinger, 1976, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

Joseph Schlessinger, J. Schlessinger, M. Falasca, 2000, Molecular and Cellular Biology.

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Matthew J. Davis, S. Ariyan, K. Kidd, 2012, Nature Genetics.

A. Ullrich, Y. Yarden, J. Downward, 1984, Nature.

Cell Signaling by Receptor Tyrosine Kinases

J. Schlessinger, 2000, Cell.

Structural basis for the activity of drugs that inhibit phosphodiesterases.

Kam Y. J. Zhang, Sung-Hou Kim, M. Milburn, 2004, Structure.

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Kam Y. J. Zhang, K. Flaherty, J. Sosman, 2010, Nature.

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation.

Y. Yarden, J. Schlessinger, 1987, Biochemistry.

Molecular basis of negative co-operativity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.

J. Schlessinger, A. Levitzki, 1974, Journal of molecular biology.

Expression of epidermal growth factor receptors in human brain tumors.

T. Libermann, Y. Yarden, J. Schlessinger, 1984, Cancer research.

Amplification and Overexpression of the EGF Receptor Gene in Primary Human Glioblastomas

P. Echlin, T. Libermann, A. Ullrich, 1985, Journal of Cell Science.

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

Hermona Soreq, Towia A. Libermann, Joseph Schlessinger, 1985, Nature.

Early and multiple origins of metastatic lineages within primary tumors

Atila Iamarino, J. Townsend, D. Rimm, 2016, Proceedings of the National Academy of Sciences.

Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function

J. Fujimoto, I. Wistuba, S. Swisher, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.

J. Schlessinger, M. Mohammadi, F. Giancotti, 1995, The EMBO journal.

Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor

Pedro Cuatrecasas, Joseph Schlessinger, P. Cuatrecasas, 1979, Nature.

Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.

Cristina M Furdui, Joseph Schlessinger, K. Anderson, 2006, Molecular cell.

Signal transduction by receptors with tyrosine kinase activity

Joseph Schlessinger, A. Ullrich, J. Schlessinger, 1990, Cell.

Src and Pyk2 Mediate G-protein-coupled Receptor Activation of Epidermal Growth Factor Receptor (EGFR) but Are Not Required for Coupling to the Mitogen-activated Protein (MAP) Kinase Signaling Cascade*

J. Schlessinger, S. Logan, O. Kranenburg, 2001, The Journal of Biological Chemistry.

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

Kam Y. J. Zhang, Chao Zhang, Kam Y J Zhang, 2005, Nature Biotechnology.

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Kam Y. J. Zhang, James Tsai, Nikolas K. Haass, 2008, Proceedings of the National Academy of Sciences.

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer.

C R King, C. Redmond, S. Paik, 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Fibronectin delays the fusion of L6 myoblasts.

J. Schlessinger, K. Yamada, T. Podleski, 1979, Experimental cell research.

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

J. Schlessinger, J. Ladbury, M. Lemmon, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

E. Peles, B. Rudy, P. Canoll, 1995, Nature.

An FGF4‐FRS2α‐Cdx2 Axis in Trophoblast Stem Cells Induces Bmp4 to Regulate Proper Growth of Early Mouse Embryos

M. Shibuya, J. Schlessinger, Satoshi Tanaka, 2009, Stem cells.

An FGF 4-FRS 2-Cdx 2 Axis in Trophoblast Stem Cells Induces BMP 4 to Regulate Proper Growth of Early Mouse Embryos

M. Shibuya, J. Schlessinger, Satoshi Tanaka, 2009 .

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

Y. Yarden, J. Schlessinger, A. Ullrich, 1991 .

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

Wayne A. Hendrickson, Michael Jaye, Joseph Schlessinger, 1998, Nature.

Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence.

I. Z. Steinberg, J. Schlessinger, J. Hochman, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration

J. Schlessinger, Sangwon Lee, Joseph Amick, 2015, Proceedings of the National Academy of Sciences.

Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif (*)

B. Margolis, J. Schlessinger, V. Mandiyan, 1996, The Journal of Biological Chemistry.

The dynamics of cytoskeletal organization in areas of cell contact.

B. Geiger, J. Schlessinger, T. Kreis, 1984, Cell and muscle motility.

Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor.

I. Lax, J. Schlessinger, D. Kohda, 1997, Journal of biochemistry.

Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro.

A. Ullrich, J. Schlessinger, B. Jallal, 1995, Biochemistry.

Mutational Analysis of the EGF Receptor Proto-Oncogene

A. Ullrich, J. Schlessinger, A. Honegger, 1989 .

Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells.

J. Schlessinger, T. Fleming, M. Ruggiero, 1988, Science.

Molecular Features Involved in Cell Surface Receptor Function and Their Role in Oncogenesis

A. Ullrich, L. Coussens, Y. Yarden, 1987 .

A chimeric, ligand-binding v-erbB/EGF receptor retains transforming potential.

A. Ullrich, J. Schlessinger, H. Riedel, 1987, Science.

Structural and Functional Analysis of Cell Surface Receptors with Tyrosine Kinase Activity

A. Ullrich, L. Coussens, Y. Yarden, 1986 .

Differential pre- and postsynaptic modulation of chemical transmission in the squid giant synapse by tyrosine phosphorylation.

R. Llinás, M. Sugimori, J. Schlessinger, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The epidermal growth factor receptor as a multifunctional allosteric protein.

J. Schlessinger, 1988, Biochemistry.

A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system.

P. D’Eustachio, J. Schlessinger, O. Silvennoinen, 1993, The Journal of biological chemistry.

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

J. Schlessinger, E. Chambaz, I. Borrello, 1988, The Journal of biological chemistry.

Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.

A. Ullrich, J. Schlessinger, A. Honegger, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

J. Schlessinger, D. Littman, I. Dikic, 1997, The Journal of experimental medicine.

The binding of complement by complexes formed between a rabbit antibody and oligosaccharides of increasing size.

J. Schlessinger, D. Givol, W. Riesen, 1976, Journal of immunology.

Vav: A potential link between tyrosine kinases and Ras‐like GTPases in hematopoietic cell signaling

B. Margolis, J. Schlessinger, P. Hu, 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.

How receptor tyrosine kinases activate Ras.

J. Schlessinger, J. Schlessinger, 1993, Trends in biochemical sciences.

Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.

A. Ullrich, B. Margolis, J. Schlessinger, 1992, The Journal of biological chemistry.

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

A. Ullrich, B. Margolis, J. Schlessinger, 1992, Nature.

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

J. Schlessinger, E. Skolnik, A. Ullrich, 1992 .

Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells

B. Margolis, J. Schlessinger, G. G. Deanin, 1992 .

Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis.

A. Ullrich, A. Zilberstein, B. Margolis, 1990, Science.

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor

A. Ullrich, A. Zilberstein, B. Margolis, 1990, Molecular and cellular biology.

Lateral transport on cell membranes: mobility of concanavalin A receptors on myoblasts.

W. Webb, E. Elson, K. Jacobson, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Polypeptide-Hormone-Induced Receptor Clustering and Internalization

T. Libermann, Y. Yarden, I. Lax, 1983 .

Diffusion and patching of macromolecules on planar lipid bilayer membranes.

W. Webb, D. E. Wolf, E. Elson, 1977, Biochemistry.

Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.

B. Margolis, J. Schlessinger, N. Li, 1994, Oncogene.

Characterization of internalization and endosome formation of epidermal growth factor in transfected NIH-3T3 cells by computerized image- intensified three-dimensional fluorescence microscopy

Z. Kam, J. Schlessinger, M. Benveniste, 1989, The Journal of cell biology.

FcERi-Mediated Tyrosine Phosphorylation ofMultiple Proteins, Including Phospholipase C-ylandtheReceptor W1Y2 Complex, inRBL-2H3RatBasophilic Leukemia Cells

B. Margolis, J. Schlessinger, J. Oliver, 1992 .

Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling*

J. Schlessinger, I. Dikic, I. Dikic, 1998, The Journal of Biological Chemistry.

Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin.

J. Schlessinger, O. Silvennoinen, G. Barnea, 1994, The Journal of biological chemistry.

Three forms of RPTP‐β are differentially expressed during gliogenesis in the developing rat brain and during glial cell differentiation in culture

P. Canoll, J. Schlessinger, J. Musacchio, 1996, Journal of neuroscience research.

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions

J. Buxbaum, J. Schlessinger, M. Chao, 2002, Nature Genetics.

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

A. Ullrich, J. Schlessinger, R. Prywes, 1986, The Journal of biological chemistry.

Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

A. Ullrich, T. Graf, J. Schlessinger, 1988, The EMBO journal.

Kinetic parameters of the protein tyrosine kinase activity of EGF‐receptor mutants with individually altered autophosphorylation sites.

A. Ullrich, J. Schlessinger, A. Honegger, 1988, The EMBO journal.

Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice.

M. Sela, J. Schlessinger, M. Pirak, 1988, Journal of the National Cancer Institute.

An insertional mutant of epidermal growth factor receptor allows dissection of diverse receptor functions.

A. Ullrich, J. Schlessinger, A. Ullrich, 1987, The EMBO journal.

Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice

P. De Camilli, R. Baron, J. Schlessinger, 2007, The Journal of cell biology.

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.

A. Takaoka, J. Schlessinger, N. Tanaka, 1999, The EMBO journal.

Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal growth factor.

Y. Yarden, I. Lax, J. Schlessinger, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Phospholipase Cgamma activation and phosphoinositide hydrolysis are essential for embryonal development.

J. Schlessinger, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Induction of Urokinase-type Plasminogen Activator by Fibroblast Growth Factor (FGF)-2 Is Dependent on Expression of FGF Receptors and Does Not Require Activation of Phospholipase Cγ1*

J. Schlessinger, M. Mohammadi, D. Moscatelli, 1996, The Journal of Biological Chemistry.

FGFR1: FGF receptor-1 (vertebrates) (fms-like kinase, flk)

M. Jaye, I. Lax, J. Schlessinger, 1995 .

Phospholipase C‐gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF‐1.

J. Downing, A. Ullrich, A. Zilberstein, 1989, The EMBO journal.

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

A. Zilberstein, J. Schlessinger, S. Rhee, 1991, Cell.

Substrate phosphorylation specificity of the human c-kit receptor tyrosine kinase.

A. Ullrich, J. Schlessinger, R. Lammers, 1991, The Journal of biological chemistry.

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

P. Greengard, P. De Camilli, A. Czernik, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor.

M. Sela, J. Schlessinger, E. Aboud-Pirak, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies.

T. Libermann, Y. Yarden, I. Lax, 1983, The Journal of biological chemistry.

Analysis and Transfection of Human Acidic Fibroblast Growth Factor (aFGF) cDNA Clones and Structural Analysis of the Human aFGF Gene reveals Features Shared within a Family of Homologous Proteins

M. Jaye, J. Schlessinger, G. Crumley, 1990 .

Annotated References Oncologic, Endocrine and Metabolic

R. Shenkar, D. Venzon, J. Schlessinger, 1994 .

Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-Induced Conformational Changes in the Dimer Interface

J. Schlessinger, M. Lemmon, Jessica P. Dawson, 2005, Molecular and Cellular Biology.

Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.

T. Shimazaki, H. Okano, M. Shibuya, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane

Hongying Shen, I. Lax, J. Schlessinger, 2012, Proceedings of the National Academy of Sciences.

Signaling by receptor tyrosine kinases : a subject collection from Cold Spring Harbor perspectives in biology

J. Schlessinger, M. Lemmon, 2014 .

Indirect immunotargeting of CIS‐PT to human epidermoid carcinoma KB using the avidin‐biotin system

M. Wilchek, M. Sela, J. Schlessinger, 1991, International journal of cancer.

Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells

J. Schlessinger, H. Kanety, C. Hopkins, 1986, The Journal of cell biology.

Overexpression of epidermal growth factor receptor in NIH-3T3- transfected cells slows its lateral diffusion and rate of endocytosis

Z. Kam, J. Schlessinger, M. Benveniste, 1988, The Journal of cell biology.

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling

A. Ullrich, I. Lax, J. Schlessinger, 1988, Molecular and cellular biology.

The Docking Protein FRS2α Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development

K. Manova, I. Lax, J. Schlessinger, 2005, Molecular and Cellular Biology.

Development Factor Responses during Early Mouse Component of Multiple Fibroblast Growth Is an Essential α The Docking Protein FRS 2

K. Manova, M. Shibuya, I. Lax, 2005 .

Design of protein-binding proteins from the target structure alone

Samer F. Halabiya, H. Ruohola-Baker, S. Savvides, 2022, Nature.

Exome sequencing identifies recurrent somatic RAC 1 mutations in melanoma

Matthew J. Davis, S. Ariyan, K. Kidd, 2016 .

JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2017, ACS medicinal chemistry letters.

Monoclonal antibodies associated with sodium channel block nerve impulse and stain nodes of Ranvier

V. Lev-Ram, J. Schlessinger, Z. Eshhar, 1984, Brain Research.

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α)

A. Poliakov, I. Lax, J. Schlessinger, 2018, Proceedings of the National Academy of Sciences.

Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.

A. Ullrich, K. Siddle, J. Schlessinger, 1993, The Journal of biological chemistry.

A step towards treating KRAS-mutant NSCLC.

R. Herbst, J. Schlessinger, J. Boyer, 2013, The Lancet. Oncology.

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.

Guoping Cai, David L Rimm, Soldano Ferrone, 2017, Cancer discovery.

BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3----q26.

S. O’Brien, M. Jaye, J. Schlessinger, 1992, Cytogenetics and cell genetics.

Growth Factors, Growth-Factor Receptors and Oncogenes

T. Libermann, J. Schlessinger, A. Avivi, 1985, Bio/Technology.

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.

T. Libermann, C. Heldin, L. Claesson‐Welsh, 1988, Cancer research.

Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants.

A. Ullrich, J. Schlessinger, R. Ballotti, 1989, The Journal of biological chemistry.

Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.

I. Wistuba, J. Lee, S. Swisher, 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

J. Schlessinger, S. Hakomori, E. Bremer, 1986, The Journal of biological chemistry.

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

A. Ullrich, I. Lax, J. Schlessinger, 1992, The Journal of biological chemistry.

Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.

J. Schlessinger, M. Mohammadi, A. Sorokin, 1994, The Journal of biological chemistry.

Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen

T. Libermann, Y. Yarden, I. Lax, 1983, Bioscience reports.

Small molecule combats cancer-causing KRAS protein at last

R. Herbst, J. Schlessinger, 2019, Nature.

Homogeneity and variability in the structure of azurin molecules studied by fluorescence decay and circular polarization.

A. Grinvald, I. Z. Steinberg, J. Schlessinger, 1975, Biochemistry.

Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis.

A. Saltzman, C. Croce, K. Huebner, 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Cloning, Expression of the Human Substance K Receptor, and Analysis of Its Role in Mitogenesis

A. Saltzman, C. Croce, M. Jaye, 1991, Annals of the New York Academy of Sciences.

Regulation of cell proliferation by epidermal growth factor.

T. Libermann, Y. Yarden, I. Lax, 1983, CRC critical reviews in biochemistry.

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

Jonathan A. Cooper, J. Schlessinger, A. Mondino, 1993, Molecular and cellular biology.

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

J. Schlessinger, J. Ladbury, V. Mandiyan, 1994, The Journal of biological chemistry.

Epidermal growth factor induces redistribution of actin and alpha-actinin in human epidermal carcinoma cells.

B. Geiger, J. Schlessinger, 1981, Experimental cell research.

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

A. Ullrich, B. Margolis, J. Schlessinger, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Retroviral gene transfer of epidermal growth factor receptor into HL60 cells results in a partial block of retinoic acid-induced granulocytic differentiation.

E. Gilboa, J. Schlessinger, B. Gansbacher, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Noncontiguous regions in the extracellular domain of EGF receptor define ligand-binding specificity.

A. Ullrich, I. Lax, J. Schlessinger, 1991, Cell regulation.

FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial‐temporal patterns of expression of their transcripts

I. Lax, J. Schlessinger, N. Gotoh, 2004, FEBS letters.

FGFR4: FGF receptor-4 (vertebrates)

M. Jaye, I. Lax, J. Schlessinger, 1995 .

FGFR2: FGF receptor-2 (vertebrates) (Bacterial expressed) kinase, bek, Keratinocyte growth factor receptor)

M. Jaye, I. Lax, J. Schlessinger, 1995 .

- FGFR3: FGF receptor-3 (vertebrates)

M. Jaye, I. Lax, J. Schlessinger, 1995 .

Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes

C. Kahn, J. Schlessinger, E. Obberghen, 1980, Nature.

Lateral and rotational diffusion of EGF–receptor complex: Relationship to receptor‐mediated endocytosis

J. Schlessinger, 1983, Biopolymers.

Adenosine 3',5'-monophosphate modulates thyrotropin receptor clustering and thyrotropin activity in culture.

J. Schlessinger, A. Avivi, D. Tramontano, 1981, Science.

Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

J. Schlessinger, J. Ravetch, M. Okigaki, 2000, Nature Immunology.

Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates

J. Schlessinger, A. Ullrich, K. Seedorf, 1992, Molecular and cellular biology.

Neuronal differentiation in response to epidermal growth factor of transfected murine P19 embryonal carcinoma cells expressing human epidermal growth factor receptors.

J. Schlessinger, J. den Hertog, S. D. de Laat, 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Intermolecular transphosphorylation between insulin receptors and EGF‐insulin receptor chimerae.

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1989, The EMBO journal.

Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells

B. Margolis, J. Schlessinger, G. G. Deanin, 1992, Molecular and cellular biology.

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

A. Ullrich, J. Schlessinger, H. Riedel, 1988, Proceedings of the National Academy of Sciences of the United States of America.

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

A. Ullrich, I. Lax, J. Schlessinger, 1989, The EMBO journal.

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain (*)

A. Ullrich, B. Margolis, J. Schlessinger, 1995, The Journal of Biological Chemistry.

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

C. Heldin, J. Downward, J. Schlessinger, 1994, Molecular and cellular biology.

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

A. Ullrich, J. Schlessinger, E. Skolnik, 1992, Molecular and cellular biology.

Regulation of cell growth and transformation by the epidermal growth factor receptor.

J. Schlessinger, 1988, Advances in experimental medicine and biology.

Subcellular distribution of the external and internal domains of the EGF receptor in A-431 cells.

L. Orci, A. Rees, J. Schlessinger, 1986, Experimental cell research.

The interaction of cultured thyroid cells of early bovine embryos with thyrotropin and thyroglobulin.

B. Geiger, J. Schlessinger, A. Avivi, 1982, Endocrinology.

Direct visualization of membrane clustering and endocytosis of thyrotropin into cultured thyroid cells

J. Schlessinger, A. Avivi, D. Tramontano, 1982, Molecular and Cellular Endocrinology.

Data publication with the structural biology data grid supports live analysis

Oleg V. Tsodikov, Stephen C. Blacklow, Amedeo Caflisch, 2016, Nature Communications.

Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta

J. Schlessinger, P. Hu, 1994, Molecular and cellular biology.

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

J. Schlessinger, A. Mondino, E. Skolnik, 1993 .

Measurement of lateral transport on cell surfaces.

W. Webb, E. Elson, J. Schlessinger, 1976, Progress in clinical and biological research.

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.

I. Wistuba, S. Swisher, R. Herbst, 2017, Annals of oncology : official journal of the European Society for Medical Oncology.

Quantitative determination of the lateral diffusion coefficients of the hormone-receptor complexes of insulin and epidermal growth factor on the plasma membrane of cultured fibroblasts.

I. Pastan, M. Willingham, P. Cuatrecasas, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C.

A. Ullrich, L. Coussens, Y. Yarden, 1986, Cold Spring Harbor symposia on quantitative biology.

Regulation of Cell Growth by the EGF Receptor

J. Schlessinger, 1986 .

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.

J. Schlessinger, H. Kanety, M. Hortsch, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity.

J. Zheng, D. Cowburn, J. Schlessinger, 1996, Journal of molecular biology.

The C-jun N-terminal Kinase Signaling Pathway. Epidermal Growth Factor-induced Activation of Phosphatidylinositol 3-kinase Mediates

J. Schlessinger, S. Logan, M. Falasca, 1997 .

Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway

J. Schlessinger, S. Logan, M. Falasca, 1997, Molecular and cellular biology.

EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

A. Ullrich, I. Lax, J. Schlessinger, 1991, The Journal of biological chemistry.

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.

A. Ullrich, R. Stroud, I. Lax, 1991, The Journal of biological chemistry.

Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells

J. Schlessinger, M. Edidin, A. Schreiber, 1984, The Journal of cell biology.

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB‐2 protein in the mammary tumor cell line SK‐BR‐3.

J. Schlessinger, P. Comoglio, I. Borrello, 1988, The EMBO journal.

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1990, The Journal of biological chemistry.

Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src

M. Moran, J. Schlessinger, N. Lydon, 1999, Oncogene.

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

A. Ullrich, A. M. van der Bliek, J. Schlessinger, 1994, The Journal of biological chemistry.

The ins and outs of protein phosphorylation

J. Schlessinger, J. Moscat, G. Thomas, 2000, EMBO reports.

The mechanism and role of hormone-induced clustering of membrane receptors

J. Schlessinger, 1980 .

Tyrosine 785 is a major determinant of Trk‐‐substrate interaction.

A. Ullrich, J. Schlessinger, K. Wiesmüller, 1993, The EMBO journal.

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

B. Nelson, T. Boggon, I. Lax, 2013, Proceedings of the National Academy of Sciences.

Scratching the surface with the PH domain

P. Sigler, J. Schlessinger, M. Lemmon, 1995, Nature Structural Biology.

The carbohydrate specificities of the monoclonal antibodies 29.1, 445 and 3C1B12 to the epidermal growth factor receptor of A431 cells

T. Libermann, I. Lax, J. Schlessinger, 1985, Bioscience reports.

The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis

J. Blenis, M. White, J. Schlessinger, 1996, Molecular and cellular biology.

Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-Induced Conformational Changes in the Dimer Interface

J. Schlessinger, M. Lemmon, Jessica P. Dawson, 2005, Molecular and Cellular Biology.

Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.

O. Hobert, A. Ullrich, J. Schlessinger, 1994, The Journal of biological chemistry.

J. Schlessinger, E. Peles, G. Plowman, 1997, Cell.

Β in Receptor Protein Tyrosine Phosphatase No Obvious Abnormality in Mice Deficient

J. Buxbaum, J. Schlessinger, M. Okigaki, 2000 .

Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor

A. Ullrich, J. Schlessinger, T. Dull, 1988, Molecular and cellular biology.

Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice.

T. Yoneda, J. Schlessinger, G. Mundy, 1991, Cancer research.

Differential activities of protein tyrosine phosphatases in intact cells.

A. Ullrich, J. Schlessinger, N. Tonks, 1993, The Journal of biological chemistry.

Differential signalling potential of insulin‐ and IGF‐1‐receptor cytoplasmic domains.

A. Ullrich, J. Schlessinger, R. Lammers, 1989, The EMBO journal.

Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells.

E. Elson, J. Schlessinger, S. D. de Laat, 1979, Biochimica et biophysica acta.

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

J. Schlessinger, A. Weiss, A. Batzer, 1994, Molecular and cellular biology.

Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic intervention

I. Lax, J. Schlessinger, Sangwon Lee, 2022, bioRxiv.

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.

M. Shibuya, I. Lax, J. Schlessinger, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Receptor tyrosine kinases: legacy of the first two decades.

J. Schlessinger, Joseph Schlessinger, J. Schlessinger, 2014, Cold Spring Harbor perspectives in biology.

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

D. Toomre, J. Schlessinger, Zhiqun Xi, 2022, bioRxiv.

Expression of receptor protein tyrosine phosphatase‐σ (RPTP‐σ) in the nervous system of the developing and adult rat

P. Canoll, J. Schlessinger, O. Silvennoinen, 1995, Journal of neuroscience research.

Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

M. Sheetz, J. Schlessinger, M. Falasca, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester.

J. Schlessinger, J. den Hertog, J. Sap, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors.

A. Ullrich, J. Schlessinger, L. Mosthaf, 1991, The Journal of biological chemistry.

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

G. Shulman, J. Schlessinger, Sangwon Lee, 2015, Nature Communications.

ActivationofInsulin-EpidermalGrowth Factor(EGF) Receptor Chimerae RegulatesEGF ReceptorBinding Affinity

A. Ullrich, J. Schlessinger, C. Filloux, 1992 .

Primary amines do not prevent the endocytosis of epidermal growth factor into 3T3 fibroblasts.

Y. Yarden, J. Schlessinger, M. Gabbay, 1981, Biochimica et biophysica acta.

Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.

C. Croce, K. Huebner, M. Jaye, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Bacterial Infection to Degranulation and Host Defense Responses Pyk2 Is Required for Neutrophil

J. Schlessinger, C. Lowell, Lynn Kamen, 2022 .

Identiﬁcation of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction

M. Jaye, J. Schlessinger, M. Mohammadi, 1996 .

Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein

D. Baker, J. Schlessinger, Sangwon Lee, 2022, Cell reports.

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

I. Lax, J. Schlessinger, F. Tomé, 2014, Proceedings of the National Academy of Sciences.

Specific role for the PH domain of dynamin‐1 in the regulation of rapid endocytosis in adrenal chromaffin cells

J. Schlessinger, M. Lemmon, H. Palfrey, 1997, The EMBO journal.

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

A. Ullrich, J. Schlessinger, T. Dull, 1986, Nature.

Differential Effects ofcAMPontheMAP Kinase Cascade: Evidence foracAMP-insensitive Stepthat CanBypassRaf-I

J. Schlessinger, Accepted June, Submitted March, 1995 .

Gi2-mediated Activation oftheMAP KinaseCascade AnnM.Pace,* MichelFaure,t andHenryR.Bournet

J. Schlessinger, 1995 .

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2022, Journal of medicinal chemistry.

Novel fluorescent approaches for studying cell signaling in single cells

J. Schlessinger, 2000, Nature Biotechnology.

Epidermal Growth Factor Receptor Autophosphorylation Is Not Required for Normal Mitogenic or Transforming Signal Generation

A. Ullrich, J. Schlessinger, A. Gray, 1991 .

A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.

H. Kawasaki, K. Suzuki, A. Ullrich, 1993, The Journal of biological chemistry.

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

A. Ullrich, J. Schlessinger, R. Hudziak, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation

A. Ullrich, J. Schlessinger, D. Givol, 1987, Molecular and cellular biology.

Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.

J. Schlessinger, K. Ogura, V. Mandiyan, 1999, Journal of molecular biology.

Epidermal growth factor-induced phosphoinositide hydrolysis in permeabilized 3T3 cells: lack of guanosine triphosphate dependence and inhibition by tyrosine-containing peptides.

J. Schlessinger, I. Verlaan, W. Moolenaar, 1990, Cell regulation.

Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.

A. Ullrich, B. Margolis, K. Skorecki, 1991, Cell regulation.

TGFI3-induced GrowthInhibition inPrimary Fibroblasts Requires theRetinoblastoma Protein

J. Schlessinger, 1996 .

Induction of cell attachment and morphological differentiation in a pheochromocytoma cell line and embryonal sensory cells by the extracellular matrix.

I. Lax, J. Schlessinger, Z. Fuks, 1982, Developmental biology.

Identification of a Novel 135-kDa Grb2-binding Protein in Osteoclasts*

R. Baron, J. Schlessinger, L. Bakiri, 1996, The Journal of Biological Chemistry.

Covalent Modification of the JH2 Domain of Janus Kinase 2.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2022, ACS medicinal chemistry letters.

Tyrosine Phosphorylation of the c-cbl Proto-oncogene Protein Product and Association with Epidermal Growth Factor (EGF) Receptor upon EGF Stimulation (*)

J. Schlessinger, I. Dikic, W. Langdon, 1995, The Journal of Biological Chemistry.

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

A. Ullrich, D. Bar-Sagi, B. Margolis, 1992, Cell.

Use of tyrosine-phosphorylated proteins to screen bacterial expression libraries for SH2 domains.

B. Margolis, J. Schlessinger, E. Skolnik, 1995, Methods in enzymology.

Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin

S. Spiegel, J. Schlessinger, P. Fishman, 1984, The Journal of cell biology.

Receptor Protein Tyrosine Phosphatase γ Is a Marker for Pyramidal Cells and Sensory Neurons in the Nervous System and Is Not Necessary for Normal Development

J. Buxbaum, H. Meziane, J. Schlessinger, 2006, Molecular and Cellular Biology.

Monoclonal Antibodies against the Membrane Receptor for Epidermal Growth Factor: A Versatile Tool for Structural and Mechanistic Studies

T. Libermann, Y. Yarden, I. Lax, 1984 .

Purification and characterization of a 90 kDa protein released from human tumors and tumor cell lines

N. Tinari, S. Iacobelli, J. Schlessinger, 1993, FEBS letters.

‘ In vitro and in vivo studies of a VEGF 121 / rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

I. Lax, J. Schlessinger, A. Wong, 2002 .

Cloning and expression of a widely expressed receptor tyrosine phosphatase.

P. D’Eustachio, J. Schlessinger, D. Givol, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells

J. Schlessinger, W. Li, J. Schlessinger, 1991, Molecular and cellular biology.

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

P. Seeburg, T. Libermann, A. Ullrich, 1985, Science.

10 – The EGF Receptor Protooncogene: Structure, Evolution of Properties of Receptor Mutants

J. Schlessinger, 1991 .

Solubilization of the receptor for the neuropeptide gastrin-releasing peptide (bombesin) with functional ligand binding properties.

T. Moody, J. Schlessinger, L. Naldini, 1990, Biochemistry.

Differential effects of W mutations on p145c-kit tyrosine kinase activity and substrate interaction.

A. Ullrich, J. Schlessinger, R. Herbst, 1992, The Journal of biological chemistry.

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.

K. Manova, M. Shibuya, I. Lax, 2005, Molecular and Cellular Biology.

THE DYNAMIC PROPERTIES OF CYTOSKELETAL STRUCTURE ASSOCIATED WITH ADHAERENS JUNCTIONS IN LIVING CELLS : MICROINJECTION COMBINED WITH FLUORESCENCE PHOTOBLEACHING RECOVERY MEASUREMENTS

B. Geiger, J. Schlessinger, 2004 .

The dynamic interrelationships of actin and vinculin in cultured cells.

B. Geiger, J. Schlessinger, 1983, Cell motility.

J. Schlessinger, G. Barnea, R. U. Margolis, 1994, Cell.

Separation ofv-Src-induced Mitogenesis and Morphological Transformation byInhibition ofAP-1

J. Schlessinger, 1994 .

Large deletions in the cytoplasmic kinase domain of the epidermal growth factor receptor do not affect its laternal mobility

Z. Kam, J. Schlessinger, M. Benveniste, 1986, The Journal of cell biology.

Expression of functional epidermal growth factor receptors in a human hematopoietic cell line.

E. Gilboa, J. Schlessinger, R. Hershberg, 1991, Cancer research.

Growth factor signaling by receptor tyrosine kinases

A. Ullrich, J. Schlessinger, A. Ullrich, 1992, Neuron.

Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.

A. Zilberstein, J. Schlessinger, A. Levitzki, 1989, The Journal of biological chemistry.

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies.

Y. Yarden, J. Schlessinger, Y Yarden, 1985, The Journal of biological chemistry.

Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling.

J. Schlessinger, E. Peles, J Schlessinger, 1998, Trends in biochemical sciences.

The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin

J. Schlessinger, G. Barnea, E. Peles, 1995, Cell.

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

P. Seeburg, T. Libermann, A. Ullrich, 1984, Nature.

Condorcet Optimal Clustering with Delaunay Triangulation: Climate Zones and World Happiness Insights

William R. Pulleyblank, Jacob Schmidt, Travis Russell, 2019, SBP-BRiMS.

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand–receptor interactions

I. Lax, J. Schlessinger, M. Gunel, 2015, Proceedings of the National Academy of Sciences.

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK

I. Lax, J. Schlessinger, M. Gunel, 2015, Science Signaling.

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2020, Journal of medicinal chemistry.

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.

Kam Y. J. Zhang, Chao Zhang, Gideon Bollag, 2004, Molecular cell.

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

Cherrington, R A Blake, S. Hubbard, 2000, Cancer research.

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1987, Molecular and cellular biology.

A point mutation at the ATP‐binding site of the EGF‐receptor abolishes signal transduction.

A. Ullrich, J. Schlessinger, A. Honegger, 1988, The EMBO journal.

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

Joseph Schlessinger, J. Schlessinger, 2002, Cell.

FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors

I. Lax, J. Schlessinger, N. Gotoh, 2000, Molecular and Cellular Biology.

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

I. Lax, J. Schlessinger, J. Schlessinger, 1998, Molecular and Cellular Biology.

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

D. Bar-Sagi, I. Lax, J. Schlessinger, 1997, Cell.

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

A. Ullrich, J. Schlessinger, R. Bradshaw, 1994, The EMBO journal.

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

M. Wigler, D. Bar-Sagi, J. Schlessinger, 1993, Science.

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

D. Bar-Sagi, J. Schlessinger, N. Gale, 1993, Nature.

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

Nanxin Li, D. Bar-Sagi, B. Margolis, 1993, Nature.

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Sheila M. Thomas, T. Pawson, P. Pelicci, 1992, Nature.

A comparative study of NAD+ binding sites in dehydrogenases by circular polarization of fluorescence.

I. Z. Steinberg, J. Schlessinger, A. Levitzki, 1975, Journal of molecular biology.

Optical Rotatory Power in the Ground State and Electronically Excited State of Diketopiperazines Containing Aromatic Side Chains

I. Z. Steinberg, J. Schlessinger, A. Gafni, 1974 .

Fluorescence and Optical Activity of Acridine Dyes Bound to Poly-A and DNA

I. Z. Steinberg, J. Schlessinger, A. Gafni, 1973 .

Circular polarization of fluorescence of probes bound to chymotrypsin. Change in asymmetric environment upon electronic excitation.

I. Z. Steinberg, J. Schlessinger, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Spatial control of EGF receptor activation by reversible dimerization on living cells

Derek Toomre, Ira Mellman, Joseph Schlessinger, 2010, Nature.

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells.

I. Pastan, M. Willingham, J. Schlessinger, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor

Joseph Schlessinger, I. Lax, J. Schlessinger, 2007, Cell.

Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.

A. Joachimiak, J. Schlessinger, X. Kong, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Scanning electron microscopy of cells and tissues under fully hydrated conditions.

D. Sprinzak, S. Thiberge, E. Moses, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha

A. Ullrich, B. Vennstrom, I. Lax, 1988, Molecular and cellular biology.

Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide

M. Jaye, J. Schlessinger, K. Nagata, 1999, Journal of biomolecular NMR.

Activation of c‐erbB in avian leukosis virus‐induced erythroblastosis leads to the expression of a truncated EGF receptor kinase.

A. Ullrich, I. Lax, J. Schlessinger, 1985, The EMBO journal.

Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation

A. Ullrich, J. Schlessinger, T. Dull, 1990, Molecular and cellular biology.

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

A. Ullrich, M. Waterfield, I. Lax, 1985, Cell.

Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk

J. Schlessinger, S. Nicoli, Q. Cheng, 2017, Proceedings of the National Academy of Sciences.

Collection of insulin, EGF and α 2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

I. Pastan, M. Willingham, J. Schlessinger, 1978, Cell.

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high‐affinity binding site for SH2 domains of phospholipase C gamma.

A. Ullrich, Nanxin Li, B. Margolis, 1992, The EMBO journal.

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

A. Ullrich, A. Ullrich, U. Francke, 1987, The EMBO journal.

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

Charis Eng, Zhou Songyang, Kermit L. Carraway, 1995, Nature.

Two EGF molecules contribute additively to stabilization of the EGFR dimer

D. Engelman, I. Lax, J. Schlessinger, 1997, The EMBO journal.

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

A. Zilberstein, B. Margolis, J. Schlessinger, 1989, Cell.

Signal transduction by allosteric receptor oligomerization.

J. Schlessinger, J Schlessinger, 1988, Trends in biochemical sciences.

Rotational diffusion of epidermal growth factor complexed to cell surface receptors reflects rapid microaggregation and endocytosis of occupied receptors.

T M Jovin, Y. Yarden, J. Schlessinger, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Lateral diffusion of surface immunoglobulin, Thy-1 antigen, and a lipid probe in lymphocyte plasma membranes.

J. Schlessinger, R. Blumenthal, P. Henkart, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Receptor diffusion on cell surfaces modulated by locally bound concanavalin A.

G. Edelman, W. Webb, E. Elson, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin.

P. Cuatrecasas, J. Schlessinger, Y. Shechter, 1978, Proceedings of the National Academy of Sciences of the United States of America.

5. Fluorescence Methods for Studying Membrane Dynamics

E. Elson, J. Schlessinger, 1982 .

The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site

I. Lax, J. Schlessinger, S. Yuzawa, 2009, Cell.

High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses

A. Ullrich, J. Schlessinger, S. Felder, 1990, The Journal of cell biology.

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor.

Y. Yarden, J. Schlessinger, Y Yarden, 1987, Biochemistry.

Structural Basis for FGF Receptor Dimerization and Activation

S. Hubbard, J. Schlessinger, M. Mohammadi, 1999, Cell.

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

P. Sigler, J. Schlessinger, M. Lemmon, 1995, Cell.

Phosphatidylinositol 3′‐kinase associates with p145c‐kit as part of a cell type characteristic multimeric signalling complex.

A. Ullrich, J. Schlessinger, R. Herbst, 1993, The EMBO journal.

DYNAMICS OF HORMONE RECEPTORS ON CELL MEMBRANE *

J. Schlessinger, 1981, Annals of the New York Academy of Sciences.

Conformational changes induced in a homogeneous anti-type III pneumococcal antibody by oligosaccharides of increasing size.

J. Schlessinger, D. Givol, I. Pecht, 1975, Biochemistry.

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

Nanxin Li, C. Der, C. Bassing, 1993, Cell.

Identification of a novel contactin‐associated transmembrane receptor with multiple domains implicated in protein–protein interactions

J. Schlessinger, E. Peles, G. Plowman, 1997, The EMBO journal.

Mechanism for the activation of the anaplastic lymphoma kinase receptor

I. Lax, J. Schlessinger, C. Kalodimos, 2021, Nature.

Allosteric regulation of the epidermal growth factor receptor kinase

J. Schlessinger, J Schlessinger, 1986, The Journal of cell biology.

Mutations in different components of FGF signaling in LADD syndrome

C. Cremers, H. Brunner, H. Kayserili, 2006, Nature Genetics.

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

A. Ullrich, J. Schlessinger, T. Fleming, 1987, Cell.

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

S. Mane, T. Boggon, Kaya Bilgüvar, 2016, Proceedings of the National Academy of Sciences.

Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.

B. Margolis, M. White, J. Schlessinger, 1992, The EMBO journal.

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

S. Harrison, J. Schlessinger, S. Shoelson, 1996, Nature Structural Biology.

Role of IRS-1-GRB-2 complexes in insulin signaling

M. White, J. Schlessinger, L. Yenush, 1994, Molecular and cellular biology.

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

Jonathan A. Cooper, J. Schlessinger, A. Batzer, 1994, Molecular and cellular biology.

The function of GRB2 in linking the insulin receptor to Ras signaling pathways.

Nanxin Li, B. Margolis, J. Schlessinger, 1993, Science.

Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding.

J. Schlessinger, S. Shoelson, M. Chaudhuri, 1993, Biochemistry.

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange

J Ureña, A. Ullrich, M. White, 1993, Molecular and cellular biology.

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

M. White, J. Schlessinger, S. Shoelson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Activation of phospholipase Cγ by PI 3‐kinase‐induced PH domain‐mediated membrane targeting

J. Schlessinger, S. Logan, M. Falasca, 1998 .

Integrated mutational landscape analysis of uterine leiomyosarcomas

Gloria S. Huang, M. Imieliński, L. Alexandrov, 2021, Proceedings of the National Academy of Sciences.

A putative molecular-activation switch in the transmembrane domain of erbB2

Sarel J. Fleishman, Nir Ben-Tal, Joseph Schlessinger, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up

I. Wistuba, S. Swisher, R. Herbst, 2017, Annals of oncology : official journal of the European Society for Medical Oncology.

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

I. Lax, J. Schlessinger, P. Través, 2014, eLife.

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.

Robert J Linhardt, Shaun K Olsen, Fuming Zhang, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG).

M. Jaye, J. Schlessinger, D. Givol, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components.

I. Pastan, W. Webb, E. Elson, 1977, Proceedings of the National Academy of Sciences of the United States of America.

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

R. Herbst, D. Zelterman, D. Rimm, 2018, Nature Communications.

Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors

Gloria S. Huang, R. Lifton, J. Schlessinger, 2018, Proceedings of the National Academy of Sciences.

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction.

M. Jaye, J. Schlessinger, C. Dionne, 1992, Biochimica et biophysica acta.

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

A. Ullrich, J. Schlessinger, S. Felder, 1990, Cell.

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

A. Ullrich, B. Margolis, J. Schlessinger, 1992, Molecular and cellular biology.

The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.

T Pawson, T. Pawson, J. Schlessinger, 1993, Molecular biology of the cell.

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

E. Hafen, T. Pawson, B. Margolis, 1993, Cell.

The docking protein FRS2α is a critical regulator of VEGF receptors signaling

I. Lax, J. Schlessinger, G. Tellides, 2014, Proceedings of the National Academy of Sciences.

FRS2α Regulates Erk Levels to Control a Self-Renewal Target Hes1 and Proliferation of FGF-Responsive Neural Stem/Progenitor Cells

T. Shimazaki, H. Okano, Y. Satoh, 2010, Stem cells.

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.

I. Lax, J. Schlessinger, A. Wong, 2002, Molecular cell.

FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl

I. Lax, J. Schlessinger, A. Wong, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways

I. Lax, J. Schlessinger, N. Gotoh, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade

M. Santoro, A. Fusco, I. Lax, 2001, Molecular and Cellular Biology.

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

I. Lax, J. Schlessinger, N. Gotoh, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

M. Jaye, J. Schlessinger, M. Mohammadi, 1991, Molecular and cellular biology.

Signal transduction by the α6β4 integrin: distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes

J. Schlessinger, M. Mohammadi, F. Giancotti, 1995 .

The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations

K. Anderson, J. Schlessinger, C. Furdui, 2009, Science Signaling.

Whole-exome sequencing characterizes the landscape of somatic mutations and copy number alterations in adrenocortical carcinoma.

Annabelle L. Fonseca, S. Mane, C. Larsson, 2015, The Journal of clinical endocrinology and metabolism.

Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.

J. Kuriyan, B. Margolis, D. Kominos, 1994, Structure.

Characterization of the submicroscopic deletion in the small‐cell lung carcinoma (SCLC) cell line U2020

J. Bergh, J. Schlessinger, R. Gemmill, 1992, Genes, chromosomes & cancer.

Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues.

Y. Shiloh, J. Schlessinger, D. Givol, 1988, Cancer research.

The EGFR family: not so prototypical receptor tyrosine kinases.

J. Schlessinger, M. Lemmon, K. Ferguson, 2014, Cold Spring Harbor perspectives in biology.

The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development

Fiona M. Watt, Alexander Fleischmann, Axel Behrens, 2000, Cell.

SH2 and PTB Domains in Tyrosine Kinase Signaling

Joseph Schlessinger, J. Schlessinger, M. Lemmon, 2003, Science's STKE.

Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

M. Jaye, J. Schlessinger, M. Mohammadi, 1996, Molecular and cellular biology.

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

S. Lev, J. Schlessinger, G. Tokiwa, 1996, Science.

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

M. Jaye, I. Lax, J. Schlessinger, 1994, Cell.

Functional analysis of the ligand binding site of EGF‐receptor utilizing chimeric chicken/human receptor molecules.

A. Ullrich, I. Lax, J. Schlessinger, 1989, The EMBO journal.

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants

E. Wagner, A. Ullrich, J. Schlessinger, 1992, Molecular and cellular biology.

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization

A. Ullrich, Y. Yarden, J. Schlessinger, 1991, Molecular and cellular biology.

Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains.

J. Schlessinger, H. Yokote, K. Sakaguchi, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog

P. Sternberg, D. Yannoukakos, J. Schlessinger, 1996, Molecular and cellular biology.

Synthetic peptide approach to the analysis of kinase activities of avian EGF receptor and v-erbB protein.

A. Ullrich, M. Waterfield, I. Lax, 1985, Biochimie.

The Membrane Receptor for Epidermal Growth Factor

T. Libermann, Y. Yarden, I. Lax, 1985 .

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

A. Schlessinger, E. Pardon, J. Steyaert, 2019, Proceedings of the National Academy of Sciences.

Lacrimo-Auriculo-Dento-Digital Syndrome Is Caused by Reduced Activity of the Fibroblast Growth Factor 10 (FGF10)-FGF Receptor 2 Signaling Pathway

V. P. Eswarakumar, I. Lax, J. Schlessinger, 2007, Molecular and Cellular Biology.

Robust de novo design of protein binding proteins from target structural information alone

D. Baker, K. Garcia, I. Wilson, 2021, bioRxiv.

The Docking Protein Gab1 Is an Essential Component of an Indirect Mechanism for Fibroblast Growth Factor Stimulation of the Phosphatidylinositol 3-Kinase/Akt Antiapoptotic Pathway

Walter Birchmeier, Joseph Schlessinger, W. Birchmeier, 2004, Molecular and Cellular Biology.

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

J. Schlessinger, D. Rotin, E. Skolnik, 1994, Molecular and cellular biology.

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

I. Lax, J. Schlessinger, B. Lamothe, 2004, BMC Biology.

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

J. Schlessinger, M. Falasca, M. Lemmon, 1997 .

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

J. Schlessinger, M. Lemmon, K. Ferguson, 1996, Cell.

SH2/SH3 signaling proteins.

J. Schlessinger, 1994, Current opinion in genetics & development.

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC‐gamma.

T. Pawson, A. Ullrich, Nanxin Li, 1990, The EMBO journal.

Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.

B. Lim, J. Settleman, J. Schlessinger, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

M. White, J. Schlessinger, M. G. Myers, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition

I. Lax, J. Schlessinger, L. P. Sousa, 2016, Proceedings of the National Academy of Sciences.

Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis

V. P. Eswarakumar, I. Lax, J. Schlessinger, 2006, Proceedings of the National Academy of Sciences.

Factor-Induced PC 12 Cell Differentiation Is Essential for Fibroblast Growth Binding of Shp 2 Tyrosine Phosphatase to FRS 2

I. Lax, J. Schlessinger, Y. Hadari, 1998 .

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

S. Lev, J. Schlessinger, G. Tokiwa, 1996, Nature.

Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

I. Lax, J. Schlessinger, M. Lemmon, 1995, Cell.

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

Nanxin Li, M. Jaye, J. Schlessinger, 1992, Nature.

On the nature of low- and high-affinity EGF receptors on living cells.

Peter Klein, Joseph Schlessinger, I. Lax, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A structure-based model for ligand binding and dimerization of EGF receptors.

Peter Klein, Joseph Schlessinger, J. Schlessinger, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts.

Y. Yarden, J. Schlessinger, S. D. de Laat, 1982, The Journal of biological chemistry.

Thyrotropin induces changes in the morphology and the organization of microfilament structures in cultured thyroid cells.

L. Barak, B. Geiger, J. Schlessinger, 1982, Experimental cell research.

SH3 domains direct cellular localization of signaling molecules

D. Bar-Sagi, J. Schlessinger, V. Mandiyan, 1993, Cell.

The Dark Side of Cell Signaling: Positive Roles for Negative Regulators

Anatoly Kiyatkin, Joseph Schlessinger, A. Kiyatkin, 2016, Cell.

Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain

J. Schlessinger, F. Inagaki, H. Morioka, 2016, Genes to cells : devoted to molecular & cellular mechanisms.

Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain

M. Inouye, J. Schlessinger, F. Inagaki, 2015, Genes to cells : devoted to molecular & cellular mechanisms.

The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.

T. Boggon, I. Lax, J. Schlessinger, 2015, Molecular cell.

Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin

Steven Gygi, Noah Dephoure, Joseph Schlessinger, 2011, Molecular biology of the cell.

Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.

William L Jorgensen, Joseph Schlessinger, W. L. Jorgensen, 2010, Journal of medicinal chemistry.

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

Joseph Schlessinger, T. Boggon, I. Lax, 2010, Proceedings of the National Academy of Sciences.

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

J. Schlessinger, S. Yuzawa, Yan Yang, 2008, Proceedings of the National Academy of Sciences.

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

M. Jaye, I. Lax, J. Schlessinger, 1994, The Journal of biological chemistry.

Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells

A. Ullrich, J. Schlessinger, A. Honegger, 1990, The Journal of cell biology.

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

A. Ullrich, J. Schlessinger, A. Honegger, 1987, Cell.

Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system.

T. Libermann, Y. Yarden, I. Lax, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Appearance of functional EGF receptor kinase during rodent embryogenesis.

J. Schlessinger, C. Webb, M. Hortsch, 1983, The EMBO journal.

Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3).

T. Libermann, Y. Yarden, I. Lax, 1983, Proceedings of the National Academy of Sciences of the United States of America.

A nonmitogenic analogue of epidermal growth factor induces early responses mediated by epidermal growth factor

Y. Yarden, J. Schlessinger, A. Schreiber, 1982, The Journal of cell biology.

A non-mitogenic analogue of epidermal growth factor enhances the phosphorylation of endogenous membrane proteins.

Y. Yarden, J. Schlessinger, A. Schreiber, 1981, Biochemical and biophysical research communications.

Activation of the JNK pathway is essential for transformation by the Met oncogene

J. Schlessinger, Morag Park, G. Rodrigues, 1997, The EMBO journal.

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

P. Sigler, J. Schlessinger, R. O'brien, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

B. Shilo, J. Schlessinger, D. Segal, 1985, Cell.

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

Joseph Schlessinger, J. Schlessinger, J. Bae, 2010, Molecules and cells.

Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.

J. Schlessinger, Yan Yang, J. Ureña, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin

P. Sigler, J. Schlessinger, M. Lemmon, 1994, Cell.

Expression of ki‐ras oncogene in tumor cell variants exhibiting different metastatic capabilities

J. Schlessinger, A. Avivi, M. Bar‐eli, 1985, International journal of cancer.

Autoregulatory Mechanisms in Protein-tyrosine Kinases*

S. Hubbard, J. Schlessinger, M. Mohammadi, 1998, The Journal of Biological Chemistry.

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.

M. Frasch, J. Schlessinger, R. Fernandez, 1995, The EMBO journal.

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

J. Schlessinger, A. Mondino, E. Skolnik, 1993, Molecular and cellular biology.

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

A. Ullrich, B. Margolis, J. Schlessinger, 1991, Cell.

The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

B. Margolis, J. Schlessinger, A. Batzer, 1995, Molecular and cellular biology.

RAC1P29S is a spontaneously activating cancer-associated GTPase

Matthew J. Davis, R. Halaban, T. Boggon, 2013, Proceedings of the National Academy of Sciences.

Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

A. Ullrich, J. Schlessinger, R. Prywes, 1986, The EMBO journal.

Mitogenic Effects of Fibroblast Growth Factors in Cultured Fibroblastsa

M. Jaye, J. Schlessinger, C. Dionne, 1991 .

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.

D. Levy, J. Schlessinger, C. Schindler, 1993, Science.

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

Matthew J. Davis, R. Halaban, M. Krauthammer, 2012, Proceedings of the National Academy of Sciences.

A solid base for assaying protein kinase activity

J. Schlessinger, 2002, Nature Biotechnology.

Regulation of signal transduction and signal diversity by receptor oligomerization.

J. Schlessinger, M. Lemmon, 1994, Trends in biochemical sciences.

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

T. Boggon, Murim Choi, Shrikant Mane, 2013, Proceedings of the National Academy of Sciences.

Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding

J. Schlessinger, D. Friedlander, J. Sap, 1994, Molecular and cellular biology.

Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region

P. D’Eustachio, J. Schlessinger, J. Sap, 1993, Molecular and cellular biology.

Anti-epidermal growth factor receptor antibodies inhibit the autocrine-stimulated growth of MDA-468 human breast cancer cells.

S. Bates, J. Schlessinger, J. Mendelsohn, 1989, Molecular endocrinology.

New Roles for Src Kinases in Control of Cell Survival and Angiogenesis

J. Schlessinger, 2000, Cell.

Disulfide Bond Structure of Human Epidermal Growth Factor Receptor*

I. Lax, J. Schlessinger, D. Kohda, 1998, The Journal of Biological Chemistry.

Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways

J. Schlessinger, N. Dulin, A. Sorokin, 1998, Oncogene.

The genesis of Zelboraf: Targeting mutant B-Raf in melanoma

Matthew J. Davis, J. Schlessinger, 2012, The Journal of cell biology.

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3

V. P. Eswarakumar, J. Schlessinger, 2007, Proceedings of the National Academy of Sciences.

Nerve growth factor acutely reduces chemical transmission by means of postsynaptic TrkA-like receptors in squid giant synapse.

R. Llinás, M. Sugimori, E. Leznik, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.

A. Ullrich, J. Schlessinger, R. Lammers, 1993, The Journal of biological chemistry.

Direct Binding and Activation of Receptor Tyrosine Kinases by Collagen

J. Schlessinger, 1997, Cell.

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

Joseph Schlessinger, S. Hubbard, J. Schlessinger, 1996, Cell.

FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma.

Joseph Schlessinger, J. Schlessinger, Yaron Hadari, 2009, The Journal of clinical investigation.

Switching Signals On or Off by Receptor Dimerization

Arthur Weiss, Joseph Schlessinger, J. Schlessinger, 1998, Cell.

Crystal structure of the ARF‐GAP domain and ankyrin repeats of PYK2‐associated protein β

S. Hubbard, J. Schlessinger, V. Mandiyan, 1999, The EMBO journal.

binding and Ras activation. beta-receptor kinase insert is involved in GRB2 Tyr-716 in the platelet-derived growth factor

J. Downward, J. Schlessinger, S. Wennström, 2013 .

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy

Gloria S. Huang, L. Alexandrov, T. Boggon, 2019, Proceedings of the National Academy of Sciences.

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

W R Taylor, T. Blundell, W. Taylor, 1987, Biochimica et biophysica acta.

Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

Joseph Schlessinger, S. Hubbard, J. Schlessinger, 2000, Cell.

Mobility of microinjected rhodamine actin within living chicken gizzard cells determined by fluorescence photobleaching recovery

B. Geiger, J. Schlessinger, T. Kreis, 1982, Cell.

Identification of a New Pyk2 Target Protein with Arf-GAP Activity

J. Schlessinger, G. Plowman, D. Sabatini, 1999, Molecular and Cellular Biology.

Chimeric NGF-EGF receptors define domains responsible for neuronal differentiation.

J. Schlessinger, M. Chao, H. Yan, 1991, Science.

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos

A. Ullrich, J. Schlessinger, S. Ishii, 1994, Nature Structural Biology.

'Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages

R. Baron, J. Schlessinger, L. Ivashkiv, 2008, Nature Immunology.

Protein tyrosine kinase Pyk2 mediates the Jak‐dependent activation of MAPK and Stat1 in IFN‐γ, but not IFN‐α, signaling

T. Taniguchi, A. Takaoka, J. Schlessinger, 1999 .

Common and Distinct Elements in Cellular Signaling via EGF and FGF Receptors

Joseph Schlessinger, J. Schlessinger, 2004, Science.

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.

A. Takaoka, J. Schlessinger, T. Miyazaki, 1998, Genes & development.

Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor

D. Levy, G. Stark, I. Kerr, 1996, Molecular and cellular biology.

BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

D. Birnbaum, M. Jaye, J. Schlessinger, 1991, Oncogene.

Cellular signaling by receptor tyrosine kinases.

J. Schlessinger, 1993, Harvey lectures.

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

J. Schlessinger, A. Weiss, J. Sap, 1993, Cell.

Cloning and expression of two distinct high‐affinity receptors cross‐reacting with acidic and basic fibroblast growth factors.

M. Jaye, J. Schlessinger, G. Searfoss, 1990, The EMBO journal.

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

Ivan Dikic, Joseph Schlessinger, I. Lax, 1994, Current Biology.

Regression of Chemotherapy-Resistant Polymerase ϵ (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

R. Lifton, J. Schlessinger, P. Schwartz, 2016, Clinical Cancer Research.

An angiogenic growth factor is expressed in human glioma cells.

T. Libermann, M. Jaye, J. Schlessinger, 1987, The EMBO journal.

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase

A. Zilberstein, M. Jaye, J. Schlessinger, 1990, Molecular and cellular biology.

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

Wei Li, J. Schlessinger, J. Vilček, 1993, The Journal of biological chemistry.

Five enzymes of the glycolytic pathway serve as substrates for purified epidermal-growth-factor-receptor kinase.

J. Schlessinger, H. Kanety, J Schlessinger, 1986, The Biochemical journal.

Transmembrane signaling by receptor oligomerization.

J. Schlessinger, M. Lemmon, 1998, Methods in molecular biology.

Ligand‐induced transphosphorylation between different FGF receptors.

M. Jaye, J. Schlessinger, C. Dionne, 1991, The EMBO journal.

Surface Binding Inhibitors of the SCF–KIT Protein–Protein Interaction

D. Margulies, I. Lax, J. Schlessinger, 2009, Chembiochem : a European journal of chemical biology.

Lateral diffusion of membrane lipids and proteins during the cell cycle of neuroblastoma cells.

E. Elson, J. Schlessinger, S. D. de Laat, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Identification of autophosphorylation sites of HER2/neu.

A. Ullrich, A. Zilberstein, B. Margolis, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Restricted mobility of membrane constituents in cell-substrate focal contacts of chicken fibroblasts

B. Geiger, J. Schlessinger, Z. Avnur, 1982, The Journal of cell biology.

Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor

A. Zilberstein, J. Schlessinger, U. Rapp, 1991 .

Epidermal growth factor (EGF) stimulates association and kinase activity of Raf-1 with the EGF receptor.

A. Ullrich, A. Zilberstein, J. Schlessinger, 1991, Molecular and cellular biology.

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

J. Schlessinger, S. Logan, M. Falasca, 1998, The EMBO journal.

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond.

A. Ullrich, J. Schlessinger, M. Lemmon, 1994, The Journal of biological chemistry.

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

J. Schlessinger, A. Weiss, S. Beinke, 2010, Proceedings of the National Academy of Sciences.

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

S. Lev, J. Schlessinger, A. Weiss, 1997, The Journal of experimental medicine.

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy.

D. Cowburn, J. Schlessinger, S. Cahill, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of p145c-kit function in cells of patients with acute myeloblastic leukemia.

J. Schlessinger, B. Bossenmaier, H. Kalbacher, 1993, Cancer research.

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function.

Peter Klein, Joseph Schlessinger, I. Lax, 2004, Proceedings of the National Academy of Sciences of the United States of America.

All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.

A. Ullrich, B. Margolis, I. Lax, 1989, The Journal of biological chemistry.

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

J. Schlessinger, Yan Yang, P. Xie, 2010, Proceedings of the National Academy of Sciences.

Dynamic interactions of fluorescently labeled microtubule-associated proteins in living cells

B. Geiger, J. Schlessinger, T. Kreis, 1984, The Journal of cell biology.

Induces Regression of Established Tumors SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Updated

S. Hubbard, A. Ullrich, N. Shenoy, 2000 .

SU 6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors 1

S. Hubbard, A. Ullrich, N. Shenoy, 2000 .

Solution structure of the SH3 domain of phospholipase C-γ

J. Schlessinger, D. Kohda, V. Mandiyan, 1993, Cell.

Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β

T. Pawson, J. Schlessinger, E. Peles, 1998, Current Opinion in Neurobiology.

Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.

A. Ullrich, J. Schlessinger, D. Kohda, 1994, Structure.

Lateral diffusion of epidermal growth factor complexed to its surface receptors does not account for the thermal sensitivity of patch formation and endocytosis.

J. Schlessinger, G. M. Hillman, 1982, Biochemistry.

Characterization of the detergent solubilized receptor for gastrin-releasing peptide

T. Moody, J. Schlessinger, L. Naldini, 1990, Peptides.

Onset of endogenous synthesis of epidermal growth factor in neonatal mice.

A. Ullrich, J. Schlessinger, A. Avivi, 1987, Developmental biology.

Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor

A. Ullrich, J. Schlessinger, S. Felder, 1993, The Journal of cell biology.

Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein

S. Lev, J. Schlessinger, Alon Chen, 1999, Molecular and Cellular Biology.

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

J. Schlessinger, J. Chernoff, E. Skolnik, 1996, The Journal of Biological Chemistry.

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

B. Turk, J. Schlessinger, Xiarong Shi, 2020, Proceedings of the National Academy of Sciences.

Definition of Signals for Neuronal Differentiation

J. Schlessinger, R. Bradshaw, A. Choidas, 1995, Annals of the New York Academy of Sciences.

Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain

J. Schlessinger, K. Ogura, V. Mandiyan, 1997, Journal of biomolecular NMR.

Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line.

E. Neufeld, J. Schlessinger, Y. Shechter, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Sequence‐specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

J. Kuriyan, J. Schlessinger, J. Borg, 1997, The EMBO journal.

Specific phosphopeptide binding regulates a conformational change in the PI 3‐kinase SH2 domain associated with enzyme activation.

J. Schlessinger, S. Shoelson, M. Weiss, 1993, The EMBO journal.

Erratum: Signal transduction by the α6β4 integrin: Distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes (EMBO Journal (1995) 14 (4470-4481))

J. Schlessinger, M. Mohammadi, F. Giancotti, 2000 .

The catalytic activity of the CD45 membrane‐proximal phosphatase domain is required for TCR signaling and regulation.

J. Schlessinger, O. Silvennoinen, A. Weiss, 1994, The EMBO journal.

The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases

J. Schlessinger, S. Courtneidge, M. L. Galisteo, 1999, Oncogene.

Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites.

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1988, The EMBO journal.

Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.

J. Schlessinger, E. Ratner, G. Bollag, 2023, Gynecologic oncology.

A hypothalamic pathway for Augmentor α–controlled body weight regulation

T. Harkany, T. Horvath, M. Shanabrough, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Structural basis for ligand reception by anaplastic lymphoma kinase

I. Lax, J. Schlessinger, Y. Tsutsui, 2021, Nature.

Stoichiometry, Kinetic and Binding Analysis of the Interaction between Epidermal Growth Factor (EGF) and the Extracellular Domain of the EGF Receptor

E C Nice, R. Jorissen, A. Burgess, 2000, Growth factors.

Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor*

I. Lax, J. Schlessinger, M. Lemmon, 1997, The Journal of Biological Chemistry.

Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2021, Tetrahedron letters.

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2017, ACS medicinal chemistry letters.

The biochemical response of the heart to hypertension and exercise.

Elliot L Elson, Joseph Schlessinger, E. Elson, 2004, Trends in biochemical sciences.

Antibody-hapten interactions: circular and linear polarization of the fluorescence of dansyl bound to anti-dansyl antibodies.

I. Z. Steinberg, J. Schlessinger, I. Pecht, 1974, Journal of molecular biology.

A study of subtilisin types Novo and Carlsberg by circular polarization of fluorescence.

I. Z. Steinberg, J. Schlessinger, R. S. Roche, 1975, Biochemistry.

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation

J. Schlessinger, B. Wollnik, J. Bae, 2007, Proceedings of the National Academy of Sciences.

Tyrosine Kinase Activity IsEssential fortheAssociation of Phospholipase C-ywiththeEpidermal GrowthFactor Receptor

J. Schlessinger, andMax-Planck-Institut, 1990 .

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β–dependent mechanisms

B. Turk, J. Schlessinger, Peng Yue, 2016, Proceedings of the National Academy of Sciences.

Cooperativity in associating proteins. Monomer-dimer equilibrium coupled to ligand binding.

J. Schlessinger, A. Levitzki, 1974, Biochemistry.

Human Sos 1 : A Guanine Nucleotide Exchange Factor for Ras That Binds to GRB 2

M. Wigler, J. Schlessinger, J. Camonis, 2012 .

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

M. Jaye, J. Schlessinger, N. Sarver, 1988, The EMBO journal.

The EGF receptor kinase: evidence for allosteric activation and intramolecular self-phosphorylation.

Y. Yarden, J. Schlessinger, 2008, Ciba Foundation symposium.

The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies

A. Ullrich, J. Downward, M. Waterfield, 1985, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Circular polarization of fluorescence of chlorophyll in solution and in native structures.

I. Z. Steinberg, J. Schlessinger, A. Gafni, 1975, Biochimica et biophysica acta.

Improved survival of patients with hypermutation in uterine serous carcinoma

R. Lifton, J. Schlessinger, S. Bellone, 2015, Gynecologic oncology reports.

Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases.

A. Ullrich, B. Margolis, J. Schlessinger, 1992, Cold Spring Harbor symposia on quantitative biology.

Tyrosine phosphatase inhibition permits analysis of signal transduction complexes in p185HER2/neu-overexpressing human tumor cells.

A. Ullrich, J. Schlessinger, B. Jallal, 1992, The Journal of biological chemistry.

Comparison of EGF receptor sequences as a guide to study the ligand binding site.

A. Ullrich, I. Lax, J. Schlessinger, 1991, Oncogene.

Induction of Neurite Outgrowth through Contactin and Nr-CAM by Extracellular Regions of Glial Receptor Tyrosine Phosphatase β

J. Schlessinger, E. Peles, M. Grumet, 1997, The Journal of cell biology.

The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system.

P. Canoll, M. Ehrlich, J. Schlessinger, 1993, Brain research. Developmental brain research.

CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX

J. Schlessinger, M. Mohammadi, B. K. Yeh, 2000 .

Variations of Proline-Rich Kinase Pyk2 Expression Correlate with Prostate Cancer Progression

R. Franco, P. Chieffi, S. Staibano, 2001, Laboratory Investigation.

No Obvious Abnormality in Mice Deficient in Receptor Protein Tyrosine Phosphatase β

J. Rosenbluth, J. Buxbaum, J. Schlessinger, 2000, Molecular and Cellular Biology.

Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer

Gloria S. Huang, J. Schlessinger, E. Ratner, 2018, Clinical Cancer Research.

Quantitative Methods for Studying the Mobility and Distribution of Receptors on Viable Cells

E. Elson, J. Schlessinger, 1981 .

Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1992, The Journal of cell biology.

Autoinhibition Control

J. Schlessinger, 2003, Science.

Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies.

Ana S. Newton, W. L. Jorgensen, J. Schlessinger, 2022, ACS medicinal chemistry letters.

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection

J. Schlessinger, C. Lowell, Lynn Kamen, 2011, The Journal of Immunology.

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

R. Herbst, D. Zelterman, D. Rimm, 2018, Nature Communications.

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

J. Shendure, H. Ruohola-Baker, L. Carter, 2023, bioRxiv.

Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach.

J. Schlessinger, S. Felder, A. Ullrich, 1991, The Journal of biological chemistry.

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.

A. Ullrich, J. Schlessinger, A. Honegger, 1989, The EMBO journal.

Reduced Activation of RAF-1 and MAP Kinase by a Fibroblast Growth Factor Receptor Mutant Deficient in Stimulation of Phosphatidylinositol Hydrolysis (*)

J. Schlessinger, M. Mohammadi, G. Rodrigues, 1995, The Journal of Biological Chemistry.

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase.

A. Ullrich, J. Schlessinger, M. Mohammadi, 1993, Biochemistry.

Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring

J. Schlessinger, M. Lemmon, 2006, Cell.

Structural diversity and binding of FGF receptors.

M. Jaye, J. Schlessinger, C. Dionne, 1991, Annals of the New York Academy of Sciences.

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

I. Lax, J. Schlessinger, Yoshihisa Suzuki, 2020, Proceedings of the National Academy of Sciences.

The epidermal growth factor receptor as a substrate for a kinase-splitting membranal proteinase.

Y. Yarden, J. Schlessinger, R. Seger, 1988, The Journal of biological chemistry.

Effects of Algorithmic Trend Promotion: Evidence from Coordinated Campaigns in Twitter's Trending Topics

Venkata Rama Kiran Garimella, Dean Eckles, J. Schlessinger, 2023, ICWSM.

Identification of the bombesin-receptor on murine and human cells by cross-linking experiments

T. Moody, J. Schlessinger, R. Hazan, 1987, Regulatory Peptides.

Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.

J. Schlessinger, P. Comoglio, I. Borrello, 1989, Oncogene.

Lateral motion and valence of Fc receptors on rat peritoneal mast cells

W. Webb, J. Schlessinger, H. Metzger, 1976, Nature.

Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions.

A. Ullrich, J. Schlessinger, A. Schmidt, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation.

B. Margolis, K. Skorecki, J. Schlessinger, 1990, The Biochemical journal.

Use of Large Combinatorial Chemical Libraries for Anticancer Drug Discovery

K. Lam, M. Lebl, A. Ullrich, 1995 .

One bead, one chemical compound: use of the selectide process for anticancer drug discovery.

K. Lam, M. Lebl, A. Ullrich, 1994, Acta oncologica.

Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity.

A. Ullrich, J. Schlessinger, M. Mohammadi, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Activation of Ras and other signaling pathways by receptor tyrosine kinases.

D. Bar-Sagi, J. Schlessinger, 1994, Cold Spring Harbor symposia on quantitative biology.

living cells. autophosphorylation of the EGF receptors in (EGF)-induced intermolecular Evidence for epidermal growth factor

A. Ullrich, J. Schlessinger, A. Honegger, 2013 .

and RecyclingofEGF ReceptorMutants

A. Ullrich, J. Schlessinger, S. Felder, 1992 .

Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

A. Ullrich, I. Lax, J. Schlessinger, 1990, Cell regulation.

Aryl Extensions of Thienopyrimidinones as Fibroblast Growth Factor Receptor 1 Kinase Inhibitors.

W. L. Jorgensen, J. Schlessinger, K. Ravindranathan, 2011, Tetrahedron letters.

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation.

I. Lax, J. Schlessinger, S. Felder, 1993, Biochemistry.

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2.

J. Schlessinger, S. Yuzawa, J. Lulo, 2009, Biochemical and biophysical research communications.

Folding, association, and interactions of domains in the antibody molecule.

M. Gavish, I. Z. Steinberg, J. Schlessinger, 1977, Cold Spring Harbor Symposia on Quantitative Biology.

Multiple forms of the human tyrosine phosphatase RPTP alpha. Isozymes and differences in glycosylation.

J. Schlessinger, E. Fischer, G. Daum, 1994, The Journal of biological chemistry.

Characterization of a human recombinant receptor-linked protein tyrosine phosphatase.

J. Schlessinger, E. Fischer, G. Daum, 1991, The Journal of biological chemistry.

Brain Tumors Expression of Epidermal Growth Factor Receptors in Human Updated Version

Y. Yarden, J. Schlessinger, H. Soreq, 2006 .

Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors.

A. Ullrich, E. Van Obberghen, J. Schlessinger, 1991, The Journal of biological chemistry.

Microaggregation of hormone‐occupied epidermal growth factor receptors on plasma membrane preparations.

Y. Yarden, J. Schlessinger, T. Jovin, 1986, The EMBO journal.

Signaling by Receptor Tyrosine Kinases

J. Schlessinger, W. Fantl, M. Lemmon, 1993 .

Characterization of the submicroscopic deletion in the small‐cell lung carcinoma (SCLC) cell line U2020

J. Bergh, J. Schlessinger, R. Gemmill, 1992, Genes, chromosomes & cancer.

Supporting Online Material Materials and Methods Som Text Figs. S1 to S8 Table S1 Movies S1 to S3 a " Silent " Polymorphism in the Mdr1 Gene Changes Substrate Specificity Corrected 30 November 2007; See Last Page

Lippincott-Schwartz, M. Gottesman, E. Elson, 2022 .

Identification of the Bombesin Receptor on Murine and Human Cells by Cross‐Linking Experiments

T. Moody, J. Schlessinger, L. Naldini, 1988 .

High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF.

M. Jaye, J. Schlessinger, J. Kaplow, 1991, Oncogene.

Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-Induced Conformational Changes in the Dimer Interface

J. Schlessinger, M. Lemmon, Jessica P. Dawson, 2005, Molecular and Cellular Biology.

NOUVELLE PHOSPHOTYROSINE PHOSPHATASE - σ à FONCTION RECEPTEUR

J. Schlessinger, Hai-dong Yan, 1994 .

The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is assigned to human chromosome 20p12-pter by in situ hybridization (ISH and FISH).

J. Schlessinger, J. Sap, V. Rao, 1992, Genomics.

Binding of phosphorylcholine to an IgM Waldenström as studied by fluorescence spectroscopy and circular dichroism.

J. Schlessinger, W. Riesen, J. Jaton, 1976, Biochemistry.

Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants

J. Schlessinger, S. Krimmer, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Role of FGFs and FGF Receptors in Human Carcinogenesis

D. Birnbaum, L. Xerri, M. Jaye, 1991, Annals of the New York Academy of Sciences.

Mobilities of cell-membrane proteins: how are they modulated by the cytoskeleton?

J. Schlessinger, 1983, Trends in Neurosciences.

RAC1P29S is a spontaneously activating cancer-associated GTPase

Matthew J. Davis, R. Halaban, T. Boggon, 2013, Proceedings of the National Academy of Sciences of the United States of America.

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

I. Lax, J. Schlessinger, Jyotidarsini Mohanty, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Restricted mobility of membrane constituents in cell-substrate focal contacts of chicken fibroblasts

B. Geiger, J. Schlessinger, Z. Avnur, 1982, The Journal of cell biology.

Receptor Activation by Antigens, Cytokines, Hormones and Growth Factors

J. Schlessinger, M. Feldmann, D. Naor, 1995 .

Supporting Online Material

Lippincott-Schwartz, S. Edelman, E. Ruppin, 2004 .

Signal transduction by epidermal growth factor receptor.

A. Ullrich, J. Schlessinger, A. Honegger, 1988, Cold Spring Harbor symposia on quantitative biology.

Interaction of Epidermal Growth Factor with Vasoactive Hormones in the Regulation of Phospholipase A2

K. Skorecki, J. Schlessinger, N. Hack, 1991, Journal of basic and clinical physiology and pharmacology.

All signaling is local?

J. Schlessinger, 2002, Molecular cell.

- FGFR3: FGF receptor-3 (vertebrates)

M. Jaye, I. Lax, J. Schlessinger, 1995 .

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

I. Lax, J. Schlessinger, Sangwon Lee, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Mutational analysis of the epidermal growth factor-receptor kinase.

J. Schlessinger, 1990, Biochemical Society symposium.

A nonmitogenic analogue of epidermal growth factor induces early responses mediated by epidermal growth factor

Y. Yarden, J. Schlessinger, A. Schreiber, 1982, The Journal of cell biology.

Characterization of receptors for bombesin/gastrin-releasing peptide in human and murine cells.

T. Moody, G. Fiskum, J. Schlessinger, 1989, Methods in enzymology.

High-affinity interleukin 2 binding by an oncogenic hybrid interleukin 2-epidermal growth factor receptor molecule.

A. Ullrich, J. Schlessinger, B. Fazekas de St. Groth, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Distinct structural specificities for functional coupling of the epidermal growth factor receptor to calcium-signalling versus phospholipase A2 responses.

A. Ullrich, B. Margolis, K. Skorecki, 1991, The Biochemical journal.

Exposing the Obscured Influence of State-Controlled Media: A Causal Estimation of Influence Between Media Outlets Via Quotation Propagation pdf

Edward K. Kao, Richard Bennet, Joseph Schlessinger, 2022, ArXiv.

The docking protein FRS2α is a critical regulator of VEGF receptors signaling

I. Lax, J. Schlessinger, G. Tellides, 2014, Proceedings of the National Academy of Sciences.