M. Pikal

发表

Heat and Mass Transfer in Low Pressure Gases: Applications to Freeze Drying

M. Pikal, 1999 .

Investigations on polyplex stability during the freezing step of lyophilization using controlled ice nucleation--the importance of residence time in the low-viscosity fluid state.

M. Pikal, J. Kasper, W. Friess, 2013, Journal of pharmaceutical sciences.

Drying-induced variations in physico-chemical properties of amorphous pharmaceuticals and their impact on stability (I): stability of a monoclonal antibody.

M. Pikal, D. Kalonia, V. Truong-Le, 2007, Journal of pharmaceutical sciences.

Post-thaw aging affects activity of lactate dehydrogenase.

Sarah J. Nehm, M. Pikal, B. Bhatnagar, 2005, Journal of pharmaceutical sciences.

Prediction of the onset of crystallization of amorphous sucrose below the calorimetric glass transition temperature from correlations with mobility.

M. Pikal, D. Lechuga‐Ballesteros, C. Bhugra, 2007, Journal of pharmaceutical sciences.

Aqueous solubility of crystalline and amorphous drugs: Challenges in measurement

Ravi M Shanker, Michael J Pikal, M. Pikal, 2011, Pharmaceutical development and technology.

Solubility advantage of amorphous pharmaceuticals, part 3: Is maximum solubility advantage experimentally attainable and sustainable?

M. Pikal, R. Shanker, R. Bogner, 2011, Journal of pharmaceutical sciences.

A computational model for finite element analysis of the freeze-drying process

Hasan U. Akay, H. Akay, M. Pikal, 1997 .

Evaluation of manometric temperature measurement as a method of monitoring product temperature during lyophilization.

S L Nail, M. Pikal, M J Pikal, 1997, PDA journal of pharmaceutical science and technology.

Stabilization of Lyophilized Pharmaceuticals by Control of Molecular Mobility: Impact of Thermal History

M. Pikal, S. Luthra, 2010 .

Dynamics of pharmaceutical amorphous solids: the study of enthalpy relaxation by isothermal microcalorimetry.

Michael J. Pikal, Daniel R. Rigsbee, M. Pikal, 2002, Journal of pharmaceutical sciences.

Addition of Monovalent Electrolytes to Improve Storage Stability of Freeze-Dried Protein Formulations.

M. Pikal, M. Tyagi, M. Cicerone, 2016, Journal of pharmaceutical sciences.

Is the pre-Tg DSC endotherm observed with solid state proteins associated with the protein internal dynamics? Investigation of bovine serum albumin by solid state hydrogen/deuterium exchange.

M. Pikal, M. Mizuno, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Characterization of dynamics in complex lyophilized formulations: I. Comparison of relaxation times measured by isothermal calorimetry with data estimated from the width of the glass transition temperature region.

M. Pikal, N. Chieng, M. Mizuno, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Chemical stability of amorphous materials: specific and general media effects in the role of water in the degradation of freeze-dried zoniporide.

M. Pikal, A. Medek, E. Shalaev, 2012, Journal of pharmaceutical sciences.

Effect of Sugars on the Molecular Motion of Freeze-Dried Protein Formulations Reflected by NMR Relaxation Times

M. Pikal, S. Yoshioka, Y. Aso, 2011, Pharmaceutical Research.

Correlation of annealing with chemical stability in lyophilized pharmaceutical glasses.

M. Pikal, I. Hodge, M. Utz, 2008, Journal of pharmaceutical sciences.

Different measures of molecular mobility: comparison between calorimetric and thermally stimulated current relaxation times below Tg and correlation with dielectric relaxation times above Tg.

M. Pikal, C. Bhugra, Rama A. Shmeis, 2008, Journal of pharmaceutical sciences.

Role of mechanical stress in crystallization and relaxation behavior of amorphous indomethacin.

M. Pikal, C. Bhugra, Rama A. Shmeis, 2008, Journal of pharmaceutical sciences.

Prediction of onset of crystallization from experimental relaxation times. II. Comparison between predicted and experimental onset times.

M. Pikal, C. Bhugra, Rama A. Shmeis, 2008, Journal of pharmaceutical sciences.

The challenge of drying method selection for protein pharmaceuticals: product quality implications.

M. Pikal, D. Kalonia, A. Abdul-Fattah, 2007, Journal of pharmaceutical sciences.

Solid state chemistry of proteins: I. glass transition behavior in freeze dried disaccharide formulations of human growth hormone (hGH).

M. Pikal, D. Rigsbee, M. L. Roy, 2007, Journal of pharmaceutical sciences.

Coupling Between Chemical Reactivity and Structural Relaxation in Pharmaceutical Glasses

Bruno C. Hancock, M. Pikal, S. Shamblin, 2006, Pharmaceutical Research.

Calorimetric investigation of the structural relaxation of amorphous materials: evaluating validity of the methodologies.

M. Pikal, K. Kawakami, 2005, Journal of pharmaceutical sciences.

Evaluation of glassy-state dynamics from the width of the glass transition: results from theoretical simulation of differential scanning calorimetry and comparisons with experiment.

M. Pikal, L. Chang, X. Tang, 2004, Journal of pharmaceutical sciences.

Stability testing of pharmaceuticals by high-sensitivity isothermal calorimetry at 25°C: cephalosporins in the solid and aqueous solution states☆

M. Pikal, K. Dellerman, 1989 .

Optical coherence tomography-based freeze-drying microscopy

R. D. Ferguson, W. Kessler, M. Pikal, 2011, Biomedical optics express.

Transport Mechanisms in Iontophoresis. II. Electroosmotic Flow and Transference Number Measurements for Hairless Mouse Skin

Michael J. Pikal, M. Pikal, Saroj Shah, 1990, Pharmaceutical Research.

Determination and comparison of Hittorf and cell transference numbers for aqueous silver nitrate solutions at 25.deg.

Donald G. Miller, M. Pikal, 1970 .

Tracer diffusion of HTO and simple ions in aqueous solutions of sodium p-ethylbenzene sulfonate. Comparisons with polyelectrolyte solutions and gels

M. Pikal, G. Boyd, 1973 .

The Effect of Stabilizers and Denaturants on the Cold Denaturation Temperatures of Proteins and Implications for Freeze-Drying

M. Pikal, X. Tang, 2005, Pharmaceutical Research.

Process control in freeze drying: determination of the end point of sublimation drying by an electronic moisture sensor.

M. Pikal, M J Pikal, M L Roy, 1989, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

Stability of Freeze-Dried Protein Formulations: Contributions of Ice Nucleation Temperature and Residence Time in the Freeze-Concentrate.

M. Pikal, R. Bogner, S. Nail, 2020, Journal of pharmaceutical sciences.

Applications of the Tunable Diode Laser Absorption Spectroscopy: In-Process Estimation of Primary Drying Heterogeneity and Product Temperature During Lyophilization.

W. Kessler, M. Pikal, R. Bogner, 2019, Journal of pharmaceutical sciences.

THE FREEZE DRYING PROCESS

M. Pikal, V. Koganti, S. Luthra, 2019, Chemical Engineering in the Pharmaceutical Industry.

Impact of Natural Variations in Freeze-Drying Parameters on Product Temperature History: Application of Quasi Steady-State Heat and Mass Transfer and Simple Statistics

M. Pikal, R. Bogner, Paritosh Pande, 2018, AAPS PharmSciTech.

Effect of Controlled Ice Nucleation on Stability of Lactate Dehydrogenase During Freeze-Drying.

M. Pikal, R. Bogner, Rui Fang, 2017, Journal of pharmaceutical sciences.

Development of a Mini-Freeze Dryer for Material-Sparing Laboratory Processing with Representative Product Temperature History

W. Kessler, M. Pikal, W. Obeidat, 2017, AAPS PharmSciTech.

Spatial Variation of Pressure in the Lyophilization Product Chamber Part 2: Experimental Measurements and Implications for Scale-up and Batch Uniformity

Alina A. Alexeenko, M. Pikal, A. Ganguly, 2017, AAPS PharmSciTech.

Investigation of drying stresses on proteins during lyophilization: differentiation between primary and secondary-drying stresses on lactate dehydrogenase using a humidity controlled mini freeze-dryer.

M. Pikal, D. Kalonia, S. Luthra, 2007, Journal of pharmaceutical sciences.

Freeze Drying Properties of Some Oligonucleotides

M. Pikal, F. Jameel, K. Amsberry, 2001, Pharmaceutical development and technology.

Rubber closures as a source of haze in freeze dried parenterals: test methodology for closure evaluation.

M. Pikal, J. Lang, M J Pikal, 1978, Journal of the Parenteral Drug Association.

Intravial distribution of moisture during the secondary drying stage of freeze drying.

M. Pikal, S. Shah, 1997, PDA journal of pharmaceutical science and technology.

Optimization of the Secondary Drying Step in Freeze Drying Using TDLAS Technology

W. Kessler, M. Pikal, H. Gieseler, 2011, AAPS PharmSciTech.

The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

M. Pikal, R. Riggin, M. L. Roy, 1991, Pharmaceutical Research.

Ion-pair formation and the theory of mutual diffusion in a binary electrolyte

M. Pikal, 1971 .

Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis.

J. Rantanen, J. Boetker, M. Pikal, 2013, International journal of pharmaceutics.

Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples.

M. Pikal, J. Carpenter, T. Randolph, 2014, Journal of pharmaceutical sciences.

Effect of Initial Buffer Composition on pH Changes During Far-From-Equilibrium Freezing of Sodium Phosphate Buffer Solutions

M. Pikal, N. Rodríguez-Hornedo, Gerardo Gómez, 2004, Pharmaceutical Research.

Alina A. Alexeenko, W. Kessler, M. Pikal, 2017, AAPS PharmSciTech.

Correction to: Evaluation of Predictors of Protein Relative Stability Obtained by \Solid-State Hydrogen/Deuterium Exchange Monitored by FTIR

M. Pikal, R. Bogner, W. Obeidat, 2020, Pharmaceutical Research.

Aqueous solubility of crystalline and amorphous drugs: Challenges in measurement

M. Pikal, R. Shanker, R. Bogner, 2011, Pharmaceutical development and technology.

Transport Mechanisms in Iontophoresis. I. A Theoretical Model for the Effect of Electroosmotic Flow on Flux Enhancement in Transdermal Iontophoresis

M. Pikal, 1990, Pharmaceutical Research.

Vapor pressure of nitroglycerin in sublingual molded tablets: implications for stability.

M. Pikal, A. L. Lukes, L. Ellis, 1976, Journal of pharmaceutical sciences.

The glass transition and sub-T(g)-relaxation in pharmaceutical powders and dried proteins by thermally stimulated current.

M. Pikal, G. Collins, L. Chang, 2009, Journal of pharmaceutical sciences.

Evaluation of a Raman Chemometric Method for Detecting Protein Structural Conformational Changes in Solution.

M. Pikal, R. Bogner, L. Fontana, 2022, Journal of pharmaceutical sciences.

Design of a Formulation for Freeze Drying

M. Pikal, F. Jameel, 2010 .

Protein Internal Dynamics Associated With Pre-System Glass Transition Temperature Endothermic Events: Investigation of Insulin and Human Growth Hormone by Solid State Hydrogen/Deuterium Exchange.

M. Pikal, R. Bogner, P. Grobelny, 2016, Journal of pharmaceutical sciences.

Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. Correlation of protein-sugar interaction with native structure preservation.

N. Warne, M. Pikal, S. Tchessalov, 2009, Journal of pharmaceutical sciences.

Rational Design of Solid Protein Formulations

M. Pikal, Bingquan Wang, 2012 .

Solid state chemistry of proteins: II. The correlation of storage stability of freeze-dried human growth hormone (hGH) with structure and dynamics in the glassy solid.

M. Pikal, J. Carpenter, M. Cicerone, 2008, Journal of pharmaceutical sciences.

Solid state stability of proteins III: calorimetric (DSC) and spectroscopic (FTIR) characterization of thermal denaturation in freeze dried human growth hormone (hGH).

M. Pikal, D. Rigsbee, M. L. Roy, 2008, Journal of pharmaceutical sciences.

Effect of hydration on the secondary structure of lyophilized proteins as measured by fourier transform infrared (FTIR) spectroscopy.

M. Pikal, D. Kalonia, S. Luthra, 2007, Journal of pharmaceutical sciences.

Study of the individual contributions of ice formation and freeze-concentration on isothermal stability of lactate dehydrogenase during freezing.

M. Pikal, B. Bhatnagar, R. Bogner, 2008, Journal of Pharmacy and Science.

Characterization of dynamics in complex lyophilized formulations: II. Analysis of density variations in terms of glass dynamics and comparisons with global mobility, fast dynamics, and Positron Annihilation Lifetime Spectroscopy (PALS).

M. Pikal, M. Cicerone, N. Chieng, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The effect of solubilization on counter ion binding to micelles

M. Pikal, J. Larsen, Walter K. Mathews, 1972 .

Addition of Amino Acids to Further Stabilize Lyophilized Sucrose-Based Protein Formulations: I. Screening of 15 Amino Acids in Two Model Proteins.

M. Pikal, R. Bogner, Kelly M Forney-Stevens, 2016, Journal of pharmaceutical sciences.

SMART TM FREEZE DRYER TECHNOLOGY : IMPACT OF WATER RE-ADSORPTION OF POLYVINYLPYRROLIDONE ( PVP ) ON MANOMETRIC TEMPERATURE MEASUREMENTS ( MTM ) DURING PRIMARY DRYING

M. Pikal, H. Gieseler, L. Mather, 2022 .

High-precision absolute (true) density measurements on hygroscopic powders by gas pycnometry: application to determining effects of formulation and process on free volume of lyophilized products.

M. Pikal, T. Kikuchi, B. Wang, 2011, Journal of pharmaceutical sciences.

Accurate prediction of collapse temperature using optical coherence tomography-based freeze-drying microscopy.

R. D. Ferguson, W. Kessler, M. Pikal, 2013, Journal of pharmaceutical sciences.

RELATIVE VISCOSITIES OF SOME AQUEOUS RARE EARTH CHLORIDE SOLUTIONS AT 25 DEG

M. Pikal, F. H. Spedding, 1966 .

Apparent Molal Volumes of Some Aqueous Rare Earth Chloride and Nitrate Solutions at 25°1

M. Pikal, F. H. Spedding, B. O. Ayers, 1966 .

Development of freeze-dried biosynthetic Factor VIII: I. A case study in the optimization of formulation

M. Pikal, F. Jameel, S. Tchessalov, 2009, Pharmaceutical development and technology.

Choked flow and importance of Mach I in freeze-drying process design

Swetaprovo Chaudhuri, Michael J. Pikal, Sajal M. Patel, 2010 .

Process Analytical Technologies (PAT) in freeze-drying of parenteral products

Sajal Manubhai Patel, Michael Pikal, M. Pikal, 2009, Pharmaceutical development and technology.

Heat and mass transfer scale-up issues during freeze-drying, III: Control and characterization of dryer differences via operational qualification tests

Michael J. Pikal, M. Pikal, S. Tchessalov, 2006, AAPS PharmSciTech.

Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect

Michael J. Pikal, M. Pikal, S. Rambhatla, 2003, AAPS PharmSciTech.

Cake Shrinkage During Freeze Drying: A Combined Experimental and Theoretical Study

Michael J Pikal, M. Pikal, S. Luthra, 2005, Pharmaceutical development and technology.

Freeze‐Drying of Proteins. Process, Formulation, and Stability.

Michael J. Pikal, M. Pikal, 1995 .

The collapse temperature in freeze drying: Dependence on measurement methodology and rate of water removal from the glassy phase

Michael J. Pikal, M. Pikal, Saroj Shah, 1990 .

The secondary drying stage of freeze drying: drying kinetics as a function of temperature and chamber pressure☆

Michael J. Pikal, M. Pikal, Saroj Shah, 1990 .

Use of laboratory data in freeze drying process design: heat and mass transfer coefficients and the computer simulation of freeze drying.

M. Pikal, M J Pikal, 1985, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

Mass and heat transfer in vial freeze-drying of pharmaceuticals: role of the vial.

M. Pikal, M J Pikal, S Shah, 1984, Journal of pharmaceutical sciences.

Freezing of Aqueous Solutions and Chemical Stability of Amorphous Pharmaceuticals: Water Clusters Hypothesis.

A. Soper, M. Pikal, C. Roberts, 2019, Journal of pharmaceutical sciences.

Effect of dimethyl sulfoxide, urea, guanidine hydrochloride, and sodium chloride on hydrophobic interactions. Heats of dilution of tetrabutylammonium bromide and lithium bromide in mixed aqueous solvent systems

M. Pikal, S. Lindenbaum, M. Mastroianni, 1972 .

Solubility Advantage of Amorphous Pharmaceuticals: II. Application of Quantitative Thermodynamic Relationships for Prediction of Solubility Enhancement in Structurally Diverse Insoluble Pharmaceuticals

Michael J. Pikal, M. Pikal, R. Shanker, 2010, Pharmaceutical Research.

Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis.

Ravi M Shanker, Michael J Pikal, M. Pikal, 2010, Journal of pharmaceutical sciences.

CHARACTERIZATION OF THE TIME SCALES OF MOLECULAR MOTION IN PHARMACEUTICALLY IMPORTANT GLASSES

Bruno C. Hancock, Michael J. Pikal, Xiaolin Tang, 1999 .

Desolvation kinetics of cefamandole sodium methanolate: the effect of water vapor

M. Pikal, J. Lang, Saroj Shah, 1983 .

Quantitative crystallinity determinations for beta-lactam antibiotics by solution calorimetry: correlations with stability.

M. Pikal, J. Lang, K. Gaines, 1978, Journal of pharmaceutical sciences.

Prediction of onset of crystallization in amorphous pharmaceutical systems: phenobarbital, nifedipine/PVP, and phenobarbital/PVP.

Chandan Bhugra, Michael J Pikal, M. Pikal, 2010, Journal of pharmaceutical sciences.

A Spectroscopic Investigation of Hydrogen Bond Patterns in Crystalline and Amorphous Phases in Dihydropyridine Calcium Channel Blockers

M. Pikal, L. S. Taylor, X. Tang, 2002, Pharmaceutical Research.

Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice

Xiaolin Tang, Michael J. Pikal, M. Pikal, 2004, Pharmaceutical Research.

Thermal Decomposition of Amorphous β-Lactam Antibacterials

M. Pikal, J. Lang, A. L. Lukes, 1977 .

Thermal decomposition of amorphous beta-lactam antibacterials.

M. Pikal, J. Lang, A. L. Lukes, 1977, Journal of pharmaceutical sciences.

Determination of End Point of Primary Drying in Freeze-Drying Process Control

Michael J. Pikal, Sajal M. Patel, M. Pikal, 2010, AAPS PharmSciTech.

A theoretical treatment of changes in energy and entropy of solids caused by additives or impurities in solid solution

M. Pikal, D. Grant, 1987 .

Predictions of Onset of Crystallization from Experimental Relaxation Times I-Correlation of Molecular Mobility from Temperatures Above the Glass Transition to Temperatures Below the Glass Transition

Michael J. Pikal, Chandan Bhugra, M. Pikal, 2006, Pharmaceutical Research.

Freeze-Drying Process Design by Manometric Temperature Measurement: Design of a Smart Freeze-Dryer

Xiaolin Tang, Michael J. Pikal, Steven L. Nail, 2005, Pharmaceutical Research.

Stabilization of proteins in solid form.

Michael J Pikal, M. Pikal, M. Cicerone, 2015, Advanced drug delivery reviews.

Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

David Ouellette, Michael J Pikal, M. Pikal, 2005, Journal of pharmaceutical sciences.

Using modulated DSC to investigate the origin of multiple thermal transitions in frozen 10% sucrose solutions

M. Pikal, D. Mishra, L. Chang, 2006 .

Emerging Freeze-Drying Process Development and Scale-up Issues

Michael J. Pikal, Sajal Manubhai Patel, M. Pikal, 2011, AAPS PharmSciTech.

Role of thermodynamic, molecular, and kinetic factors in crystallization from the amorphous state.

Chandan Bhugra, Michael J Pikal, M. Pikal, 2008, Journal of pharmaceutical sciences.

Reliable determination of freeze-concentration using DSC

M. Pikal, B. Bhatnagar, R. Bogner, 2005 .

Simultaneous measurement of water desorption isotherm and heats of water desorption of proteins using perfusion isothermal microcalorimetry.

M. Pikal, D. Kalonia, S. Luthra, 2007, Journal of pharmaceutical sciences.

Non-invasive product temperature determination during primary drying using tunable diode laser absorption spectroscopy.

Michael J Pikal, W. Kessler, M. Pikal, 2009, Journal of pharmaceutical sciences.

Mechanisms of protein stabilization in the solid state.

M. Pikal, L. Chang, 2009, Journal of pharmaceutical sciences.

PHARMACEUTICAL TECHNOLOGY Non-Invasive Product Temperature Determination during Primary Drying using Tunable Diode Laser Absorption Spectroscopy

W. Kessler, M. Pikal, H. Gieseler, 2009 .

Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state.

Michael J Pikal, M. Pikal, Xiaolin Charlie Tang, 2005, Journal of pharmaceutical sciences.

The role of electroosmotic flow in transdermal iontophoresis

Michael J. Pikal, M. Pikal, 1992 .

Interpretation of relaxation time constants for amorphous pharmaceutical systems.

Bruno C. Hancock, B C Hancock, M. Pikal, 2000, Journal of pharmaceutical sciences.

Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: Part II measurement of dry-layer resistance

Michael J. Pikal, Steven L. Nail, M. Pikal, 2008, AAPS PharmSciTech.

Use of manometric temperature measurement (MTM) and SMART freeze dryer technology for development of an optimized freeze-drying cycle.

Michael J Pikal, M. Pikal, H. Gieseler, 2007, Journal of pharmaceutical sciences.

Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice

Michael J. Pikal, John F. Carpenter, Theodore W. Randolph, 1997, Pharmaceutical Research.

Knudsen vapor pressure measurements on pure materials and solutions dispersed in porous media: molded nitroglycerin tablets.

M. Pikal, A. L. Lukes, 1976, Journal of pharmaceutical sciences.

Solid state 13C NMR investigation of impact of annealing in lyophilized glasses.

M. Pikal, M. Utz, S. Luthra, 2008, Journal of Pharmacy and Science.

Chemistry in solid amorphous matrices: Implication for biostabilization

M. Pikal, H. Levine, 2002 .

MECHANISMS OF PROTEIN STABILIZATION DURING FREEZE-DRYING AND STORAGE : THERELATIVE IMPORTANCE OF THERMODYNAMIC STABILIZATION AND GLASSY STATE RELAXAT ION DYNAMICS

Michael J. Pikal, M. Pikal, 1999 .

Freeze‐Drying of Mannitol–Trehalose–Sodium Chloride‐Based Formulations: The Impact of Annealing on Dry Layer Resistance to Mass Transfer and Cake Structure

Xiaofeng Lu, Michael J Pikal, M. Pikal, 2004, Pharmaceutical development and technology.

Formulation and stability of freeze-dried proteins: effects of moisture and oxygen on the stability of freeze-dried formulations of human growth hormone.

M. Pikal, M J Pikal, K Dellerman, 1992, Developments in biological standardization.

Physical chemistry of freeze-drying: measurement of sublimation rates for frozen aqueous solutions by a microbalance technique.

M. Pikal, J. Lang, M J Pikal, 1983, Journal of pharmaceutical sciences.

Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations.

M. Pikal, J. Lubach, E. Munson, 2012, Journal of pharmaceutical sciences.

The Effect of Temperature on Hydrogen Bonding in Crystalline and Amorphous Phases in Dihydropyrine Calcium Channel Blockers

M. Pikal, L. S. Taylor, X. Tang, 2002, Pharmaceutical Research.

The effect of dryer load on freeze drying process design.

Feroz Jameel, Michael J Pikal, M. Pikal, 2010, Journal of pharmaceutical sciences.

Impact of sucrose level on storage stability of proteins in freeze-dried solids: II. Correlation of aggregation rate with protein structure and molecular mobility.

Serguei Tchessalov, Michael J Pikal, N. Warne, 2009, Journal of pharmaceutical sciences.

Influence of Miscibility of Protein-Sugar Lyophilizates on Their Storage Stability

W. Hinrichs, H. Frijlink, M. Pikal, 2016, The AAPS Journal.

Theory of the Onsager transport coefficients lij and Rij for electrolyte solutions

M. Pikal, 1971 .

Impact of critical process and formulation parameters affecting in-process stability of lactate dehydrogenase during the secondary drying stage of lyophilization: a mini freeze dryer study.

M. Pikal, D. Kalonia, S. Luthra, 2007, Journal of pharmaceutical sciences.

Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization

Michael J. Pikal, M. Pikal, R. Bogner, 2007, Pharmaceutical development and technology.

Drying-Induced Variations in Physico-Chemical Properties of Amorphous Pharmaceuticals and Their Impact on Stability II: Stability of a Vaccine

Michael J. Pikal, Vu Truong-Le, Yi Ao, 2007, Pharmaceutical Research.

Lyophilized Drug Product Cake Appearance: What Is Acceptable?

Gerhard Winter, Andrea Hawe, Steven L Nail, 2017, Journal of pharmaceutical sciences.

The impact of drying method and formulation on the physical properties and stability of methionyl human growth hormone in the amorphous solid state.

Michael J Pikal, M. Pikal, D. Kalonia, 2008, Journal of pharmaceutical sciences.

The Stability of Insulin in Crystalline and Amorphous Solids: Observation of Greater Stability for the Amorphous Form

M. Pikal, D. Rigsbee, 1997, Pharmaceutical Research.

The role of electroosmotic flow in transdermal iontophoresis.

M. Pikal, M J Pikal, 1992, Advanced drug delivery reviews.

Effects of annealing on enthalpy relaxation in lyophilized disaccharide formulations: mathematical modeling of DSC curves.

M. Pikal, I. Hodge, S. Luthra, 2008, Journal of pharmaceutical sciences.

Moisture transfer from stopper to product and resulting stability implications.

M. Pikal, M J Pikal, S Shah, 1992, Developments in biological standardization.

A test of the onsager reciprocal relations and a discussion of the ionic isothermal vector transport coefficientsIIj for aqueous AgNO3 at 25°C

Donald G. Miller, M. Pikal, 1972 .

The study of phase separation in amorphous freeze-dried systems. Part I: Raman mapping and computational analysis of XRPD data in model polymer systems.

M. Pikal, Yonglai Yang, R. Bogner, 2011, Journal of pharmaceutical sciences.

Thermophysical Properties of Pharmaceutically Compatible Buffers at Sub-Zero Temperatures: Implications for Freeze-Drying

Michael J. Pikal, Evgenyi Y. Shalaev, M. Pikal, 2002, Pharmaceutical Research.

The study of phase separation in amorphous freeze-dried systems, part 2: investigation of Raman mapping as a tool for studying amorphous phase separation in freeze-dried protein formulations.

Michael J Pikal, M. Pikal, Adora M Padilla, 2011, Journal of pharmaceutical sciences.

Isotope effect in tracer diffusion. Comparison of the diffusion coefficients of 24Na+ and 22Na+ in aqueous electrolytes

M. Pikal, 1972 .

Reduced Pressure Ice Fog Technique for Controlled Ice Nucleation during Freeze-Drying

Michael J. Pikal, Sajal M. Patel, Chandan Bhugra, 2009, AAPS PharmSciTech.

Heat and mass transfer scale-up issues during freeze drying: II. Control and characterization of the degree of supercooling

Michael J. Pikal, Chandan Bhugra, M. Pikal, 2004, AAPS PharmSciTech.

A Pragmatic Test of a Simple Calorimetric Method for Determining the Fragility of Some Amorphous Pharmaceutical Materials

Bruno C. Hancock, Michael J. Pikal, M. Pikal, 1998, Pharmaceutical Research.

Dynamics in Polysaccharide Glasses and Their Impact on the Stability of Encapsulated Flavors

M. Pikal, D. Siegel, M. Thakur, 2016, Food Biophysics.

The effect of annealing on the stability of amorphous solids: chemical stability of freeze-dried moxalactam.

M. Pikal, A. Abdul-Fattah, R. Bogner, 2007, Journal of pharmaceutical sciences.

Freeze-Drying Process Development and Scale-Up: Scale-Up of Edge Vial Versus Center Vial Heat Transfer Coefficients, Kv.

M. Pikal, R. Bogner, Puneet Sharma, 2016, Journal of pharmaceutical sciences.

Spatial Variation of Pressure in the Lyophilization Product Chamber Part 1: Computational Modeling

Alina A. Alexeenko, M. Pikal, A. Ganguly, 2017, AAPS PharmSciTech.

Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study

Gregory A Sacha, Lisa M. Hardwick, Elizabeth A. Oslos, 2011, Pharmaceutical development and technology.

Evaluation of tunable diode laser absorption spectroscopy for in-process water vapor mass flux measurements during freeze drying.

Steven J Davis, Michael J Pikal, W. Kessler, 2007, Journal of pharmaceutical sciences.

Impact of Natural Variations in Freeze-Drying Parameters on Product Temperature History: Application of Quasi Steady-State Heat and Mass Transfer and Simple Statistics

M. Pikal, R. Bogner, Paritosh Pande, 2018, AAPS PharmSciTech.

Freeze-drying in novel container system: Characterization of heat and mass transfer in glass syringes.

Michael J Pikal, M. Pikal, Sajal M Patel, 2010, Journal of pharmaceutical sciences.

Polymer sorption of nitroglycerin and stability of molded nitroglycerin tablets in unit-dose packaging.

M. Pikal, B. Rutherford, D. Bibler, 1977, Journal of pharmaceutical sciences.

Alina A. Alexeenko, Lisa M. Hardwick, Frank A. Kanka, 2023, AAPS PharmSciTech.

A procedure to optimize scale-up for the primary drying phase of lyophilization.

D M Kremer, M. Pikal, D. Kremer, 2009, Journal of pharmaceutical sciences.

Lyophilization process design space.

Sajal Manubhai Patel, Michael J Pikal, M. Pikal, 2013, Journal of pharmaceutical sciences.

The Nonsteady State Modeling of Freeze Drying: In-Process Product Temperature and Moisture Content Mapping and Pharmaceutical Product Quality Applications

H. U. Akay, Chandan Bhugra, H. Akay, 2005, Pharmaceutical development and technology.

Evaluation of manometric temperature measurement (MTM), a process analytical technology tool in freeze drying, part III: Heat and mass transfer measurement

Michael J. Pikal, Steven L. Nail, M. Pikal, 2008, AAPS PharmSciTech.

A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure.

S. Yalkowsky, M. Pikal, M. Tesconi, 1997, Journal of pharmaceutical sciences.

The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: I. Dimer formation in sodium ethacrynate.

M. Pikal, B. Wang, 2010, Journal of pharmaceutical sciences.

The impact of thermal treatment on the stability of freeze-dried amorphous pharmaceuticals: II. Aggregation in an IgG1 fusion protein.

Yukio Aso, Michael J Pikal, M. Pikal, 2010, Journal of pharmaceutical sciences.

Investigation of the impact of annealing on global molecular mobility in glasses: optimization for stabilization of amorphous pharmaceuticals.

M. Pikal, I. Hodge, S. Luthra, 2008, Journal of pharmaceutical sciences.

Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline.

M. Pikal, O. Korhonen, C. Bhugra, 2008, Journal of pharmaceutical sciences.

Optimization of a Raman microscopy technique to efficiently detect amorphous-amorphous phase separation in freeze-dried protein formulations.

Michael J Pelletier, Michael J Pikal, M. Pikal, 2014, Journal of pharmaceutical sciences.

The study of amorphous phase separation in a model polymer phase-separating system using Raman microscopy and a low-temperature stage: effect of cooling rate and nucleation temperature.

Sumit Luthra, Michael J Pikal, M. Pikal, 2011, Journal of pharmaceutical sciences.

Transport Mechanisms in Iontophoresis. III. An Experimental Study of the Contributions of Electroosmotic Flow and Permeability Change in Transport of Low and High Molecular Weight Solutes

M. Pikal, Saroj Shah, 1990, Pharmaceutical Research.

The Freeze‐Drying Process: The Use of Mathematical Modeling in Process Design, Understanding, and Scale‐Up

M. Pikal, V. Koganti, S. Luthra, 2010 .

Evaluation of manometric temperature measurement, a process analytical technology tool for freeze-drying: Part I, product temperature measurement

Xiaolin Tang, Michael J. Pikal, Steven L. Nail, 2006, AAPS PharmSciTech.

Lyophilization of Therapeutic Proteins in Vials: Process Scale-Up and Advances in Quality by Design

Bingquan Wang, Timothy R. McCoy, Michael J. Pikal, 2015 .

APPLICABILITY OF MANOMETRIC TEMPERATURE MEASUREMENT (MTM) AND SMART ™ FREEZE DRYER TECHNOLOGY TO DEVELOPMENT OF AN OPTIMIZED FREEZE DRYING CYCLE: PRELIMINARY INVESTIGATION OF TWO AMORPHOUS SYSTEMS

M. Pikal, H. Gieseler, H. Lee, 2005 .

Apparent molal volumes and viscosities of some aqueous rare-earth chloride solutions at 25°C

M. Pikal, 1966 .

Measurement of the Kinetics of Protein Unfolding in Viscous Systems and Implications for Protein Stability in Freeze-Drying

M. Pikal, X. Tang, 2005, Pharmaceutical Research.