Daniele M. Gilkes

发表

Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

G. Semenza, D. Wirtz, Daniele M. Gilkes, 2013, Molecular Cancer Research.

A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Andre Levchenko, Deok-Ho Kim, Kshitiz, 2013, Science Signaling.

Daniele M. Gilkes, 2019, Advances in Experimental Medicine and Biology.

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.

G. Semenza, Daniele M. Gilkes, Laura M. Shelton, 2016, Cancer research.

Biophysical and biomolecular determination of cellular age in humans

Jonathan J. Chen, Rong Fan, Denis Wirtz, 2017, Nature Biomedical Engineering.

MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin*

Baoli Hu, Baoli Hu, Jiandong Chen, 2006, Journal of Biological Chemistry.

Single-cell morphology encodes metastatic potential

Denis Wirtz, Pei-Hsun Wu, Rong Li, 2020, Science Advances.

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

G. Semenza, Daniele M. Gilkes, Hongxia Hu, 2014, Oncotarget.

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Denis Wirtz, G. Semenza, D. Wirtz, 2014, Nature Reviews Cancer.

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts*

Denis Wirtz, Saumendra Bajpai, G. Semenza, 2013, The Journal of Biological Chemistry.

Hypoxia-inducible Factors Sirtuin-7 Inhibits the Activity of Gene Regulation :

G. Semenza, Daniele M. Gilkes, Maimon E. Hubbi, 2013 .

Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors*

Kshitiz, G. Semenza, Daniele M. Gilkes, 2013, The Journal of Biological Chemistry.

Implications of Hypoxia in Breast Cancer Metastasis to Bone

Daniele M. Gilkes, 2016, International journal of molecular sciences.

Hypoxia-Inducible Factors and Cancer

Daniele M. Gilkes, V. Polotsky, J. Jun, 2017, Current Sleep Medicine Reports.

Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes

E. Fertig, Daniele M. Gilkes, M. Considine, 2018, Molecular Cancer Research.

A common goal to CARE: Cancer Advocates, Researchers, and Clinicians Explore current treatments and clinical trials for breast cancer brain metastases

Daniele M. Gilkes, V. Stearns, K. Redmond, 2021, NPJ breast cancer.

A software tool for the quantification of metastatic colony growth dynamics and size distributions in vitro and in vivo

Daniele M. Gilkes, Josh W DiGiacomo, I. Godet, 2018, PloS one.

Therapeutic Strategies to Block the Hypoxic Response.

Daniele M. Gilkes, Josh W DiGiacomo, 2019, Advances in experimental medicine and biology.

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

G. Semenza, Daniele M. Gilkes, Hongxia Hu, 2015, Oncotarget.

Enrichment of breast cancer stem cells following cytotoxic chemotherapy is mediated by hypoxia-inducible factors

G. Semenza, Daniele M. Gilkes, P. Chaturvedi, 2022, bioRxiv.

Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993)

Kshitiz, A. Levchenko, G. Semenza, 2013 .

Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces

Stephen R. Williams, Ludmila V. Danilova, Zachary W. Bent, 2022, bioRxiv.

Jak2/STAT3 Signaling Activation of Dendritic Cells via Inhibition of

Daniele M. Gilkes, S. Sebti, A. Beg, 2022 .

The Rate of Cisplatin Dosing Affects the Resistance and Metastatic Potential of Triple Negative Breast Cancer Cells, Independent of Hypoxia

Daniele M. Gilkes, Stavroula Sofou, I. Godet, 2022, Pharmaceutics.

The Biophysics of 3D Cell Migration

Pei-Hsun Wu, D. Wirtz, Daniele M. Gilkes, 2018 .

Extracellular fluid viscosity enhances cell migration and cancer dissemination

Sean X. Sun, A. Feinberg, K. Konstantopoulos, 2022, Nature.

Solid Stress in Brain Tumors.

D. Wirtz, Daniele M. Gilkes, 2019, Trends in cancer.

The rise of viperin: the emerging role of viperin in cancer progression

Daniele M. Gilkes, I. Godet, Alyssa G. Weinstein, 2022, The Journal of clinical investigation.

Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness

G. Riggins, Daniele M. Gilkes, I. Godet, 2022, Breast Cancer Research.

Role of hypoxia-inducible factors in breast cancer metastasis.

G. Semenza, Daniele M. Gilkes, Gregg L Semenza, 2013, Future oncology.

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

G. Semenza, Daniele M. Gilkes, P. Chaturvedi, 2014, Proceedings of the National Academy of Sciences.

Multi-compartment tumor organoids

I. Shih, Pei-Hsun Wu, D. Wirtz, 2020, bioRxiv.

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

G. Semenza, Daniele M. Gilkes, J. Bullen, 2015, Proceedings of the National Academy of Sciences.

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jonathan J. Chen, Pei-Hsun Wu, Jerry S. H. Lee, 2017, Nature Communications.

Multiple modes of Mdmx regulation affect p53 activation

Daniele M. Gilkes, 2008 .

BRCA1 and BRCA2 mutations and treatment strategies for breast cancer.

Daniele M. Gilkes, Inês Godet, Daniele M Gilkes, 2017, Integrative cancer science and therapeutics.

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Daniele M. Gilkes, Guannan Wang, I. Ye, 2019, Nature Communications.

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.

A. Levchenko, G. Semenza, Daniele M. Gilkes, 2012, The Journal of clinical investigation.

Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling1

Daniele M. Gilkes, S. Sebti, A. Beg, 2005, The Journal of Immunology.

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

G. Semenza, Daniele M. Gilkes, P. Chaturvedi, 2014, Proceedings of the National Academy of Sciences.

Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies

Daniele M. Gilkes, Josh W DiGiacomo, 2018, Targeted Oncology.

RhoB is regulated by hypoxia and modulates metastasis in breast cancer

Daniele M. Gilkes, Josh W DiGiacomo, I. Godet, 2020, Cancer reports.

Regulation of MDMX nuclear import and degradation by Chk2 and 14‐3‐3

Jiandong Chen, Daniele M. Gilkes, Lihong Chen, 2006, The EMBO journal.

The Contribution of the Immune System in Bone Metastasis Pathogenesis

Daniele M. Gilkes, Lisha Xiang, 2019, International journal of molecular sciences.

Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances

Daniele M. Gilkes, Fan Wu, I. Godet, 2022, Cells.

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

G. Semenza, Daniele M. Gilkes, P. Chaturvedi, 2014, Proceedings of the National Academy of Sciences.

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

G. Semenza, Daniele M. Gilkes, P. Chaturvedi, 2014, Journal of Molecular Medicine.

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

Denis Wirtz, G. Semenza, D. Wirtz, 2013, Proceedings of the National Academy of Sciences.

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

G. Semenza, I. Ng, D. Wirtz, 2011, Proceedings of the National Academy of Sciences.

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

G. Semenza, Daniele M. Gilkes, Hongxia Hu, 2014, Oncotarget.

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

G. Semenza, Daniele M. Gilkes, C. C. Wong, 2012, Journal of Molecular Medicine.

Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis

G. Semenza, M. Suematsu, Daniele M. Gilkes, 2014, Molecular Cancer Research.

Chromatin , Gene , and RNA Regulation Decreased Expression of Cystathionine b-Synthase Promotes Glioma Tumorigenesis

G. Semenza, M. Suematsu, Daniele M. Gilkes, 2014 .

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.

Baoli Hu, Jiandong Chen, Daniele M. Gilkes, 2007, Cancer research.

Tumour mechanopathology: Cutting the stress out

D. Wirtz, Daniele M. Gilkes, 2017, Nature Biomedical Engineering.

Collagen prolyl hydroxylases are essential for breast cancer metastasis.

G. Semenza, D. Wirtz, Daniele M. Gilkes, 2013, Cancer research.

Cell Death and Survival Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

G. Semenza, D. Wirtz, Daniele M. Gilkes, 2013 .

Molecular and Cellular Pathobiology CollagenProlyl HydroxylasesAreEssential for BreastCancer Metastasis

G. Semenza, D. Wirtz, Daniele M. Gilkes, 2013 .

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

G. Semenza, Daniele M. Gilkes, C. C. Wong, 2012, Journal of Molecular Medicine.

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression

Kshitiz, G. Semenza, Daniele M. Gilkes, 2014, Proceedings of the National Academy of Sciences.

Distinct Roles of MDMX in the Regulation of p53 Response to Ribosomal Stress

Jiandong Chen, Daniele M. Gilkes, 2007, Cell cycle.

Extracellular Matrix–Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer

Daniele M. Gilkes, Josh W DiGiacomo, I. Godet, 2020, Molecular Cancer Research.

ATM and Chk2‐dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

William Arbuthnot Sir Lane, Yu Pan, Jiandong Chen, 2005, The EMBO journal.

MDMX regulation of p53 response to ribosomal stress

Jiandong Chen, Daniele M. Gilkes, Lihong Chen, 2006, The EMBO journal.

Regulation of MDMX Expression by Mitogenic Signaling

T. Yeatman, D. Coppola, Yu Pan, 2008, Molecular and Cellular Biology.

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX.

Baoli Hu, Jiandong Chen, Daniele M. Gilkes, 2007, Cancer research.

Introductions 2 Small images , big picture : Artificial intelligence in microscopy

Pieterjan Vanden Boer, J. Phillip, Daniele M. Gilkes, 2020 .

Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1*

G. Semenza, Daniele M. Gilkes, Maimon E. Hubbi, 2012, The Journal of Biological Chemistry.

Abnormal MDMX degradation in tumor cells due to ARF deficiency

Jiandong Chen, Daniele M. Gilkes, Bao-zong Li, 2011, Oncogene.

Post-Hypoxic Cells Promote Metastatic Recurrence after Chemotherapy Treatment in TNBC

Daniele M. Gilkes, Mahelet Mamo, D. M. Rosen, 2021, Cancers.

The Biophysics of 3 D Cell Migration

Pei-Hsun Wu, D. Wirtz, Daniele M. Gilkes, 2018 .

Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis

G. Semenza, Pei-Hsun Wu, D. Wirtz, 2017, Molecular Cancer Research.

The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study

P. Buehler, A. Palmer, Daniele M. Gilkes, 2018, PloS one.

RhoB: Team Oncogene or Team Tumor Suppressor?

Daniele M. Gilkes, Julia A Ju, Julia A. Ju, 2018, Genes.

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions

Pei-Hsun Wu, D. Wirtz, Daniele M. Gilkes, 2015, Oncotarget.

Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation–Specific and HIF-Dependent Manner

Daniele M. Gilkes, Mahelet Mamo, B. Downs, 2020, Cancer Research.

Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis

G. Semenza, Daniele M. Gilkes, Haiquan Lu, 2021, Proceedings of the National Academy of Sciences.

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by novel fate-mapping and computational modeling

Daniele M. Gilkes, P. Macklin, I. Godet, 2021, bioRxiv.

Collective cancer cell invasion induced by coordinated contractile stresses

Denis Wirtz, Sean X. Sun, Pei-Hsun Wu, 2015, OncoTarget.

HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs

G. Semenza, B. Krishnamachary, S. Sukumar, 2011, Oncogene.

Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces.

L. Wood, Zachary W. Bent, A. Favorov, 2023, Cell systems.

Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells

G. Riggins, Daniele M. Gilkes, Yuan-Hung Wang, 2023, Cancers.

A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Kshitiz, A. Levchenko, G. Semenza, 2013, Science Signaling.

Controlling pericellular oxygen tension in cell culture reveals distinct breast cancer responses to low oxygen tensions

Zachary J. Rogers, N. Slavov, B. Woolston, 2023, bioRxiv.

Hypoxia-inducible factors enhance glutamate signaling in cancer cells

G. Semenza, Daniele M. Gilkes, Hongxia Hu, 2014, Oncotarget.

Biophysical and biomolecular determination of cellular age in humans

Jonathan J. Chen, Pei-Hsun Wu, J. Phillip, 2017, Nature Biomedical Engineering.

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

G. Semenza, D. Wirtz, Daniele M. Gilkes, 2013, Proceedings of the National Academy of Sciences.

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling

Daniele M. Gilkes, I. Godet, Soumitra Bhoyar, 2021, iScience.