C. Prives

发表

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

A. Levine, A. Børresen-Dale, S. Lowe, 2012, Cell.

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein.

J. Manfredi, C. Prives, O. Laptenko, 2016, Trends in biochemical sciences.

Blinded by the Light: The Growing Complexity of p53

C. Prives, K. Vousden, 2009, Cell.

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

P. Friedman, X. Chen, J. Bargonetti, 1993, Proceedings of the National Academy of Sciences of the United States of America.

p53: puzzle and paradigm.

C. Prives, L. Ko, 1996, Genes & development.

Covalent and noncovalent modifiers of the p53 protein

C. Prives, L. Jayaraman, 1999, Cellular and Molecular Life Sciences CMLS.

The p53 pathway

C. Prives, P. Hall, 1999, The Journal of pathology.

Mutant p53: one name, many proteins.

Carol Prives, William Freed-Pastor, C. Prives, 2012, Genes & development.

Transcriptional regulation by p53: one protein, many possibilities

C. Prives, O. Laptenko, C Prives, 2006, Cell Death and Differentiation.

Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53

M. Belvin, L. M. Young, C. Kopczynski, 2000, Cell.

High mobility group protein-1 (HMG-1) is a unique activator of p53.

C. Prives, M. Bustin, L. Jayaraman, 1998, Genes & development.

Functional dissection of p53 tumor suppressor protein.

C. Prives, L. Jayaraman, E. Freulich, 1997, Methods in enzymology.

Signalling to the C-terminus of p53

C. Prives, C. Cain, S. Shieh, 1997 .

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

C. Prives, L. Jayaraman, 1995, Cell.

How loops, β sheets, and α helices help us to understand p53

C. Prives, 1994, Cell.

Identification of p53 as a sequence-specific DNA-binding protein

K. Kinzler, B. Vogelstein, S. Kern, 1991, Science.

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

X. Chen, C. Prives, L. Ko, 1996, Genes & development.

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein.

C. Prives, P. Friedlander, J. Manley, 1996, Nucleic acids research.

Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo

C. Prives, J. Manley, G. Farmer, 1996, Molecular and cellular biology.

Regulation of p53 activity through lysine methylation

Paul Tempst, Danny Reinberg, Jon R. Wilson, 2004, Nature.

Murine p53 inhibits the function but not the formation of SV40 T antigen hexamers and stimulates T antigen RNA helicase activity

P. Friedman, N. Sonenberg, C. Prives, 2006, Chromosoma.

The transforming activity of simian virus 40 large tumor antigen.

C. Prives, J. J. Manfredi, Carol Prives, 1994, Biochimica et biophysica acta.

The p53 tumor suppressor protein: meeting review.

J. Manfredi, C. Prives, J. J. Manfredi, 1993, Genes & development.

Doing the right thing: feedback control and p53.

C. Prives, 1993, Current opinion in cell biology.

Mutational Analysis of the p 53 Core Domain L 1 Loop *

C. Prives, A. Zupnick, 2006 .

PML is induced by oncogenic ras and promotes premature senescence.

S. Lowe, E. Stanchina, C. Prives, 2000, Genes & development.

Getting p53 Out of the Nucleus

C. Prives, V. Gottifredi, 2001, Science.

P53 and PML: new partners in tumor suppression.

C. Prives, V. Gottifredi, Vanesa Gottifredi, 2001, Trends in cell biology.

p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

Vanesa Gottifredi, Carol Prives, C. Prives, 2001, Molecular and Cellular Biology.

Replication of damaged DNA in vitro is blocked by p53.

C. Prives, Jianmin Zhou, 2003, Nucleic acids research.

Down-Regulates CHK 1 through p 21 and the Retinoblastoma Protein

C. Prives, O. Karni-Schmidt, S. Shieh, 2001 .

A signaling to p 53 involves the p 19 ARF tumor suppressor

S. Lowe, F. Zindy, M. Roussel, 1998 .

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

P. Friedman, D. Beach, C. Prives, 1990, Proceedings of the National Academy of Sciences of the United States of America.

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

Yoichi Taya, Carol Prives, C. Prives, 1997, Cell.

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay

C. Prives, C. Como, 1998, Oncogene.

Signaling to p53 Breaking the MDM2–p53 Circuit

C. Prives, 1998, Cell.

Accurate and sensitive quantification of protein-DNA binding affinity

R. Mann, H. Bussemaker, William Freed-Pastor, 2018, Proceedings of the National Academy of Sciences.

p53 inhibits DNA replication in vitro in a DNA-binding-dependent manner

C. Prives, G. Farmer, S. Miller, 1995, Molecular and cellular biology.

p 53 response element-directed transactivation . protein with p 53 leads to inhibition by HBx of Direct interaction of the hepatitis B virus HBx

J. Greenblatt, C. Prives, R. Truant, 1995 .

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen.

B. Vogelstein, S. Kern, P. Friedman, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Mutant p53 proteins bind DNA abnormally in vitro.

V. Rotter, K. Kinzler, B. Vogelstein, 1991, Oncogene.

p53: more research and more questions

C. Prives, A. W. Braithwaite, 2006, Cell Death and Differentiation.

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Y Taya, C. Prives, Y. Taya, 2000, Genes & development.

p53 represses Sp1 DNA binding and HIV-LTR directed transcription.

A. Chicas, J. Bargonetti, C. Prives, 1997, Cellular and molecular biology.

Enhanced phosphorylation of p53 by ATM in response to DNA damage.

Y Taya, Y. Shiloh, C. Prives, 1998, Science.

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

A. Levine, J. Bargonetti, C. Prives, 1992, Genes & development.

The Chk2 protein kinase.

C. Prives, Jinwoo Ahn, Marshall Urist, 2004, DNA repair.

Identification of redox/repair protein Ref-1 as a potent activator of p53.

T. Curran, C. Prives, L. Jayaraman, 1997, Genes & development.

Replication Inhibits Polyomavirus Origin DNA Large T Antigen in Murine Cell Extracts and Phosphorylation State of Polyomavirus The Retinoblastoma Protein Alters the

I. Reynisdottir, C. Prives, D. Zhang, 2013 .

Poly(A) Polymerase Phosphorylation Is Dependent on Novel Interactions with Cyclins

C. Prives, J. Manley, G. Bond, 2000, Molecular and Cellular Biology.

The Retinoblastoma Protein Alters the Phosphorylation State of Polyomavirus Large T Antigen in Murine Cell Extracts and Inhibits Polyomavirus Origin DNA Replication

I. Reynisdottir, C. Prives, D. Zhang, 1999, Journal of Virology.

Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non‐consensus sites

C. Prives, K. Murthy, J. Manley, 1998, The EMBO journal.

Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen

C. Prives, S. Bhattacharyya, H. Li, 1997, Journal of virology.

A role for ATR in the DNA damage-induced phosphorylation of p53.

Y Taya, J. Sarkaria, C. Prives, 1999, Genes & development.

Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation*

C. Prives, Jinwoo Ahn, 2002, The Journal of Biological Chemistry.

C. Prives, K. Murthy, J. Manley, 1996, Nature.

Regulation of p53 after different forms of stress and at different cell cycle stages.

C. Prives, S. Shieh, V. Gottifredi, 2000, Cold Spring Harbor symposia on quantitative biology.

The replication functions of SV40 T antigen are regulated by phosphorylation

C. Prives, 1990, Cell.

William Freed-Pastor, C. Prives, 2011, Cell cycle.

p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

X. Chen, J. Bargonetti, C. Prives, 1995, Cancer research.

P53 and aging: A fresh look at an old paradigm

C. Prives, M. Poyurovsky, 2010, Aging.

Inhibition of TFII-I-Dependent Cell Cycle Regulation by p53

N. Rosenberg, C. Prives, A. Roy, 2005, Molecular and Cellular Biology.

A subclass of polyomavirus middle tumor antigen binds to DNA cellulose

M. Israel, C. Prives, J. Bolen, 1986, Journal of virology.

Expression of polyomavirus large T antigen by using a baculovirus vector

W. C. Rice, C. Prives, L. Miller, 1987, Journal of virology.

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

A. Barsotti, C. Prives, N. Baptiste-Okoh, 2008, Cell cycle.

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

C. Cordon-Cardo, C. Prives, O. Karni-Schmidt, 2008, Journal of Cell Science.

Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus

A. Fersht, M. Sheetz, C. Prives, 2007, Oncogene.

DECOD: fast and accurate discriminative DNA motif finding

Ziv Bar-Joseph, Marcel H. Schulz, Shan Zhong, 2011, Bioinform..

Use of oligonucleotides for antisense experiments in Xenopus laevis oocytes.

C. Prives, D. Foukai, 1991, Methods in cell biology.

E1A signaling to p53 involves the p19 tumor suppressor

S. Lowe, F. Zindy, M. Roussel, 1998 .

Advances in Brief p 53 , through p 21 ( WAF 1 / CIP 1 ) , Induces Cyclin Dl Synthesis 1

J. Bargonetti, C. Prives, Xinbin Chen, 2006 .

Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response*

C. Prives, Jinwoo Ahn, Marshall Urist, 2003, Journal of Biological Chemistry.

Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neurons.

M. van Lookeren Campagne, C. Prives, K. Okamoto, 1999, Brain research. Molecular brain research.

p53 accumulates but is functionally impaired when DNA synthesis is blocked.

C. Prives, Y. Taya, S. Shieh, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Baculovirus p33 Binds Human p53 and Enhances p53-Mediated Apoptosis

C. Prives, E. Freulich, Yan Wang, 1999, Journal of Virology.

Baculovirus p 33 Binds Human p 53 and Enhances p 53-Mediated Apoptosis

C. Prives, E. Freulich, Yan Wang, 1998 .

Deconstruction of p53 functions and regulation

V. Rotter, C. Prives, A. Robles, 2002, Oncogene.

Cancer: DNA damage enables p73

E. White, C. Prives, 1999, Nature.

p53: master of life, death, and the epigenome

C. Prives, O. Laptenko, 2017, Genes & Development.

Study of the Functional Activities Concomitantly Retained by the 115,000 Mr Super T Antigen, an Evolutionary Variant of Simian Virus 40 Large T Antigen Expressed in Transformed Rat Cells

C. Prives, P. May, E. May, 1983, Journal of virology.

O-GlcNAc transferase regulates p21 protein levels and cell proliferation through the FoxM1–Skp2 axis in a p53-independent manner

C. Prives, Rafaela Muniz de Queiroz, S. Moon, 2022, The Journal of biological chemistry.

p73α Regulation by Chk1 in Response to DNA Damage

C. Cordon-Cardo, C. Prives, Susana González, 2003, Molecular and Cellular Biology.

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity

J. Bargonetti, C. Prives, Devon Lundine, 2021, Oncotarget.

The p53-HAT connection

C. Prives, O. Laptenko, 2012, Cell cycle.

p53 and Metabolism: The GAMT Connection.

C. Prives, Yan Zhu, 2009, Molecular cell.

Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA

C. Prives, S. Bhattacharyya, H. E. Lorimer, 1995, Journal of virology.

The replication functions of polyomavirus large tumor antigen are regulated by phosphorylation

C. Prives, E. Wang, S. Bhattacharyya, 1993, Journal of virology.

ATP induces the assembly of polyoma large tumor antigen into hexamers.

C. Prives, E. Wang, 1991, Virology.

DNA helicase and duplex DNA fragment unwinding activities of polyoma and simian virus 40 large T antigen display similarities and differences.

C. Prives, E. Wang, 1991, The Journal of biological chemistry.

The DNA-binding properties of polyomavirus large T antigen are altered by ATP and other nucleotides

C. Prives, E. Wang, H. E. Lorimer, 1991, Journal of virology.

DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitro

J. Hurwitz, C. Prives, Y. Murakami, 1987, Molecular and cellular biology.

Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication.

J. Hurwitz, C. Prives, Y. Murakami, 1986, Proceedings of the National Academy of Sciences of the United States of America.

DNA-Binding Properties of Simian Virus 40 T-Antigen

C. Prives, Y. Gluzman, L. Covey, 2003 .

DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication

C. Prives, Y. Gluzman, L. Covey, 1983, Molecular and cellular biology.

DNA-Binding Properties ofSimian Virus 40T-Antigen Mutants Defective inViral DNA Replication

C. Prives, Y. Gluzman, ColdSpring Harbor, 1983 .

Discrete regions of simian virus 40 large T antigen are required for nonspecific and viral origin-specific DNA binding

C. Prives, G. Khoury, G. Jay, 1982, Journal of virology.

A small subclass of SV40 T antigen binds to the viral origin of replication

C. Prives, L. Covey, A. Scheller, 1982, Cell.

Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA

C. Prives, M. Oren, D. Gidoni, 1982, Journal of virology.

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network

X. Jacq, C. Prives, Yan Zhu, 2013, PloS one.

Ribosomal protein L 37 and the p 53 network

C. Prives, Yan Zhu, Lilyn Daftuar, 2011 .

Ribosomal protein L37 and the p53 network

C. Prives, Yan Zhu, Lilyn Daftuar, 2010, Cell cycle.

Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen

C. Prives, J. J. Manfredi, 1990, Journal of virology.

Association of simian virus 40 T antigen with the nuclear matrix of infected and transformed monkey cells

C. Prives, L. Covey, Y. Choi, 1984, Molecular and cellular biology.

Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigen.

E. Gilboa, C. Prives, E. Winocour, 1977, Proceedings of the National Academy of Sciences of the United States of America.

p21 can be a barrier to ferroptosis independent of p53

B. Stockwell, C. Prives, D. Venkatesh, 2020, Aging.

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

O. Podhajcer, C. Prives, V. Gottifredi, 2006, Oncogene.

p53, DNA damage, and NAD+ homeostasis

C. Prives, Kathryn E Yoh, N. Pfister, 2014, Cell cycle.

GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma.

B. Stockwell, C. Prives, K. Yokote, 2022, Cancer research.

Relevance of the p53-MDM2 axis to aging.

C. Prives, Danyi Wu, 2018 .

Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation.

P. Friedman, I. Reynisdottir, C. Prives, 1993, The Journal of biological chemistry.

Purification of SV-40 messenger RNA by hybridization to SV-40 DNA covalently bound to Sepharose.

E. Gilboa, C. Prives, H. Aviv, 1975, Biochemistry.

In vitro splicing of simian virus 40 early pre mRNA.

C. Prives, J. Manley, J. Noble, 1986, Nucleic acids research.

Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences

C. Prives, E. Wang, R. Markowitz, 1988, Journal of virology.

Simian Virus40(SV40) T Antigen BindsSpecifically to Double-Stranded DNA butNottoSingle-Stranded DNA or DNA/RNAHybrids Containing theSV40Regulatory Sequences

C. Prives, R. Markowitz, K. Auborn, 1988 .

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

X. Chen, C. Prives, L. Ko, 1997, Molecular and cellular biology.

How loops, beta sheets, and alpha helices help us to understand p53.

C. Prives, 1994, Cell.

Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block*

C. Prives, K. Mckinney, V. Gottifredi, 2004, Journal of Biological Chemistry.

Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro

D. O'reilly, I. Reynisdottir, C. Prives, 1990, Journal of virology.

Helicase, DNA-binding, and immunological properties of replication-defective simian virus 40 mutant T antigens

C. Prives, K. Auborn, M. Guo, 1989, Journal of virology.

Characterization of Measles Virus-Specific Proteins Synthesized In Vivo and In Vitro from Acutely and Persistently Infected Cells

C. Prives, S. Rozenblatt, M. Gorecki, 1979, Journal of virology.

Primary rat cells expressing a hybrid polyomavirus-simian virus 40 large T antigen have altered growth properties

C. Prives, J. J. Manfredi, 1993, Journal of Virology.

Two conditional tsA mutant simian virus 40 T antigens display marked differences in thermal inactivation

I. Reynisdottir, C. Prives, 1992, Journal of virology.

Simian virus 40 and polyomavirus large tumor antigens have different requirements for high-affinity sequence-specific DNA binding

C. Prives, A. Scheller, 1985, Journal of virology.

Cell-free translation of simian virus 40 16S and 19S L-strand-specific mRNA classes to simian virus 40 major VP-1 and minor VP-2 and VP-3 capsid proteins

C. Prives, H. Shure, 1979, Journal of virology.

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

C. Prives, J. Manley, A. Fradin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

The C terminus of p53 binds the N-terminal domain of MDM2

C. Prives, O. Laptenko, A. Friedler, 2011, Nature Structural &Molecular Biology.

p53: Guardian of the Metabolome

C. Prives, M. Poyurovsky, 2013 .

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

S. Sugano, Yutaka Suzuki, C. Prives, 2010, Proceedings of the National Academy of Sciences.

Wild-type p53 activates transcription in vitro

P. Friedman, J. Bargonetti, C. Prives, 1992, Nature.

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

Allegra T. Aron, B. Stockwell, S. Moon, 2020, Genes & development.

Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

L. Hengst, S. Reed, C. Prives, 1998, Molecular and Cellular Biology.

Erratum: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication (Molecular and Cellular Biology 18:1 (629))

L. Hengst, S. Reed, C. Prives, 1998 .

hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes

C. Prives, Tomoaki Tanaka, I. Tatsuno, 2007, Cell.

Deconstructing nucleotide binding activity of the Mdm2 RING domain

C. Prives, M. Poyurovsky, C. Priest, 2010, Nucleic acids research.

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

Darjus F. Tschaharganeh, S. Lowe, E. Stanchina, 2019, Cell.

Assembly of functional U1 and U2 human-amphibian hybrid snRNPs in Xenopus laevis oocytes.

C. Prives, Z. Pan, 1988, Science.

Inhibition of viral protein synthesis in monkey cells treated with interferon late in simian virus 40 lytic cycle

C. Prives, E. Winocour, E. Yakobson, 1977, Cell.

Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation

J. Greenblatt, C. Prives, R. Truant, 1995, Journal of virology.

p53 linear diffusion along DNA requires its C terminus.

C. Prives, K. Mckinney, V. Gottifredi, 2004, Molecular cell.

E1A signaling to p53 involves the p19(ARF) tumor suppressor.

S. Lowe, F. Zindy, M. Roussel, 1998, Genes & development.

Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

X. Chen, C. Prives, Xinbin Chen, 1993, Genes & development.

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

C. Prives, A. J. Donner, J. Espinosa, 2009, Genes & Development.

The roles and regulation of MDM2 and MDMX: it is not just about p53

C. Prives, D. Venkatesh, Alyssa M. Klein, 2021, Genes & development.

p53 responsive elements in human retrotransposons

A. Levine, C. Prives, J. Hoh, 2009, Oncogene.

Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.

C. Prives, N. Pfister, 2017, Cold Spring Harbor perspectives in medicine.

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells

A. Børresen-Dale, B. Tian, J. Bargonetti, 2015, Genes & development.

Mutant p 53 cooperates with the SWI / SNF chromatin remodeling complex to regulate VEGFR 2 in breast cancer cells

A. Børresen-Dale, B. Tian, J. Bargonetti, 2015 .

Pro-proliferative FoxM1 is a target of p53-mediated repression

A. Barsotti, C. Prives, 2009, Oncogene.

A role of cyclin G in the process of apoptosis

C. Prives, K. Okamoto, 1999, Oncogene.

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Jianmin Wu, Sean M. Grimmond, Christian Pilarsky, 2014, Cell.

Stability of Checkpoint Kinase 2 Is Regulated via Phosphorylation at Serine 456*

E. Kass, C. Prives, Tomoaki Tanaka, 2007, Journal of Biological Chemistry.

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

C. Prives, Tomoaki Tanaka, Marshall Urist, 2004, Genes & development.

Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities

E. Kass, C. Prives, Yan Zhu, 2009, Cell cycle.

p53-dependent Induction of PVT1 and miR-1204*

N. Caplen, A. Barsotti, C. Prives, 2011, The Journal of Biological Chemistry.

The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation

C. Prives, S. Rokudai, Yan Zhu, 2021, The Journal of biological chemistry.

The Roles of MDM2 and MDMX in Cancer.

C. Prives, O. Karni-Schmidt, M. Lokshin, 2016, Annual review of pathology.

Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription*

C. Prives, Y. Taya, Tomoaki Tanaka, 2006, Journal of Biological Chemistry.

Cyclin A-CDK Phosphorylation Regulates MDM2 Protein Interactions*

C. Prives, Tingting Zhang, 2001, The Journal of Biological Chemistry.

Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes.

R. Mann, H. Bussemaker, C. Prives, 2017, Cell reports.

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

C. Prives, O. Laptenko, Y. Taya, 2013, Proceedings of the National Academy of Sciences.

Erratum: Cooperative DNA binding of p53 with TFIID (TBP): A possible mechanism for transcriptional activation (Genes and Development 7 (1837- 1849))

C. Prives, Xinbin Chen, G. Farmer, 1993 .

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

J. Qin, C. Prives, M. Avantaggiati, 1998, Molecular cell.

Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs

R. Jove, C. Prives, J. Manley, 1984, Cell.

Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites

Carol Prives, C. Prives, J. Manley, 1987, Cell.

U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing.

C. Prives, Z. Pan, 1989, Genes & development.

Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs.

C. Prives, J. Manley, Z. Pan, 1989, Nucleic acids research.

Regulation of simian virus 40 gene expression in Xenopus laevis oocytes

C. Prives, T. Michaeli, 1985, Molecular and cellular biology.

The p21 and PCNA partnership: A new twist for an old plot

C. Prives, V. Gottifredi, 2008, Cell cycle.

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

O. Podhajcer, C. Prives, V. Gottifredi, 2008, Journal of Cell Science.

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

M. B. Vallerga, C. Prives, V. Gottifredi, 2013, Nucleic acids research.

Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA

C. Prives, L. Jayaraman, S. Miller, 1997, Molecular and cellular biology.

Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry

X. Jacq, C. Prives, Yan Zhu, 2013, Genes & development.

The C9ORF72 Gene, Implicated in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Encodes a Protein That Functions in Control of Endothelin and Glutamate Signaling

B. Tian, C. Prives, J. Manley, 2018, Molecular and Cellular Biology.

Cellular and cell-free synthesis of simian virus 40 T-antigens in permissive and transformed cells

C. Prives, E. Winocour, Y. Gluzman, 1978, Journal of virology.

Transcriptional regulation by p53.

C. Prives, R. Beckerman, 2010, Cold Spring Harbor perspectives in biology.

Transcriptional Regulation by p 53

C. Prives, R. Beckerman, 2010 .

Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression.

Scott Lowe, Carlos Cordon-Cardo, Carol Prives, 2011, The American journal of pathology.

Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

C. Prives, Y. Li, 2007, Oncogene.

DNA damage‐inducible phosphorylation of p53 at N‐terminal sites including a novel site, Ser20, requires tetramerization

Y Taya, C. Prives, Y. Taya, 1999, The EMBO journal.

DNA binding properties of simian virus 40 T-antigens synthesized in vivo and in vitro

C. Prives, H. Shure, Y. Beck, 1980, Journal of virology.

Cell-free translation of messenger RNA of simian virus 40: synthesis of the major capsid protein.

C. Prives, H. Aviv, B. Paterson, 1974, Proceedings of the National Academy of Sciences of the United States of America.

p53 in the Cytoplasm A Question of Overkill?

C. Prives, N. Baptiste, 2004, Cell.

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Y. Shiloh, A. Jochemsen, J. Marine, 2005, Molecular and Cellular Biology.

These include:

Y. Shiloh, A. Jochemsen, J. Marine, 2004 .

Unleashing the power of p53: lessons from mice and men.

C. Prives, M. Poyurovsky, 2006, Genes & development.

Unleashing the power of p 53 : lessons from mice and men

C. Prives, M. Poyurovsky, 2006 .

P53 and Prognosis New Insights and Further Complexity

C. Prives, K. Vousden, 2005, Cell.

p53 Frameshift Mutations Couple Loss-of-Function with Unique Neomorphic Activities

J. Manfredi, C. Prives, O. Laptenko, 2021, Molecular Cancer Research.

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

K. Mimori, T. Mak, C. Prives, 2011, Nature Medicine.

Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.

B. Stockwell, C. Prives, R. Skouta, 2011, Cancer discovery.

Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response*♦

C. Prives, Y. Shaul, P. Tsvetkov, 2009, The Journal of Biological Chemistry.

The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity

A. Kentsis, C. Prives, K. Borden, 2007, The EMBO journal.

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.

M. Chalfie, X. Jacq, C. Prives, 2003, Molecular cell.

Cyclin G recruits PP2A to dephosphorylate Mdm2.

S. Thorgeirsson, M. Jensen, C. Prives, 2002, Molecular cell.

The N Terminus of p53 Regulates Its Dissociation from DNA*

C. Prives, Jinwoo Ahn, Scott G. Miller, 2000, The Journal of Biological Chemistry.

Stxbp4 Regulates ΔNp63 Stability by Suppression of RACK1-Dependent Degradation

C. Prives, M. Peart, Yingchun Li, 2009, Molecular and Cellular Biology.

Why Is p53 Acetylated?

C. Prives, J. Manley, 2001, Cell.

Transcriptional regulation by p53 and p73.

C. Prives, M. Lokshin, T. Tanaka, 2005, Cold Spring Harbor symposia on quantitative biology.

Cyclin-dependent Kinases Phosphorylate p73 at Threonine 86 in a Cell Cycle-dependent Manner and Negatively Regulate p73*

Yoichi Taya, Carol Prives, C. Prives, 2003, Journal of Biological Chemistry.

A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain

C. Prives, J. Ahn, T. Zhang, 2001, Molecular and Cellular Biology.

The S phase checkpoint: when the crowd meets at the fork.

C. Prives, V. Gottifredi, 2005, Seminars in cell & developmental biology.

An excised SV40 intron accumulates and is stable in Xenopus laevis oocytes.

C. Prives, Z. Pan, T. Michaeli, 1988, Genes & development.

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

P. Friedman, I. Reynisdottir, J. Bargonetti, 1992, Genes & development.

p53-Dependent p21 mRNA Elongation Is Impaired when DNA Replication Is Stalled

C. Prives, K. Mckinney, V. Gottifredi, 2006, Molecular and Cellular Biology.

Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.

H. Bussemaker, P. Schirmacher, D. Grunwald, 2012, Molecular cell.

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

C. Prives, P. Friedlander, Xinbin Chen, 2002, Oncogene.

At the Crossroads of Inflammation and Tumorigenesis

Carlos Cordon-Cardo, Carol Prives, C. Cordon-Cardo, 1999, The Journal of experimental medicine.

Mdm2 and MdmX as Regulators of Gene Expression.

C. Prives, J. Manley, L. Biderman, 2012, Genes & cancer.

A non-canonical Hippo pathway represses the expression of ΔNp63

C. Prives, David R. Tong, C. Katz, 2023, bioRxiv.

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

C. Prives, Yan Wang, 1995, Nature.

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

P. Friedman, C. Prives, E. Wang, 1989, Cell.

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

C. Prives, O. Laptenko, E. Freulich, 2011, Proceedings of the National Academy of Sciences.

Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

L. Hengst, S. Reed, C. Prives, 1998, Molecular and Cellular Biology.

The cell-free translation of SV40 messenger RNA.

E. Gilboa, C. Prives, H. Aviv, 1975, Cold Spring Harbor symposia on quantitative biology.

A unique subpopulation of murine DNA polymerase alpha/primase specifically interacts with polyomavirus T antigen and stimulates DNA replication

C. Prives, K. Moses, 1994, Molecular and cellular biology.

TheReplication Functions ofPolyomavirus LargeTumor Antigen AreRegulated byPhosphorylation

C. Prives, S. Bhattacharyya, 1993 .

TAp63 prevents premature aging by promoting adult stem cell maintenance.

K. Tsai, C. Prives, S. Sinha, 2009, Cell stem cell.

p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells

C. Prives, C. J. Di Como, C. Gaiddon, 1999, Molecular and Cellular Biology.

Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells

C. Prives, Seung-Min Lee, R. Prywes, 2016, Proceedings of the National Academy of Sciences.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

J. Onuchic, K. Mikoshiba, N. Rothman, 2018, Cell Death & Differentiation.

Dysfunction of the MDM2/p53 axis is linked to premature aging.

C. Prives, J. Högel, David R. Tong, 2017, The Journal of clinical investigation.

A comparison of the translation of Mengo virus RNA and globin mRNA in krebs ascites cell‐free extracts

C. Prives, B. Lebleu, E. Falcoff, 1972, FEBS letters.

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

C. Prives, M. Oren, S. Volarevic, 2012, Proceedings of the National Academy of Sciences.

Ribosomal protein S7 is both a regulator and a substrate of MDM2.

X. Jacq, C. Prives, Yan Zhu, 2009, Molecular cell.

Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers

C. Prives, O. Laptenko, David R. Tong, 2018, Genes & development.

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

B. Vogelstein, S. Kern, P. Friedman, 1991, Cell.

Regulation of p53 DNA Binding

C. Prives, K. Mckinney, 2007 .

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

X. Chen, J. Bargonetti, C. Prives, 1993, Genes & development.

The C-terminus of p53: the more you learn the less you know

C. Prives, Jinwoo Ahn, 2001, Nature Structural Biology.

Mutant p53 gain of function: the NF-Y connection.

C. Prives, M. Peart, 2006, Cancer Cell.

The continuing saga of p53--more sleepless nights ahead.

J. Manfredi, C. Prives, 2005, Molecular cell.

Lysine-Independent Turnover of Cyclin G1 Can Be Stabilized by B′α Subunits of Protein Phosphatase 2A

C. Prives, Hongyun Li, K. Okamoto, 2008, Molecular and Cellular Biology.

Cyclin G Recruits PP 2 A to Dephosphorylate Mdm 2

S. Thorgeirsson, M. Jensen, C. Prives, 2002 .

p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

M. Mumby, C. Prives, D. Beach, 1996, Molecular and cellular biology.

p53 leans on its siblings.

C. Prives, Marshall Urist, 2002, Cancer cell.

Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

C. Prives, K. Mckinney, 2002, Molecular and Cellular Biology.

Regulation of Mutant p53 Temperature-sensitive DNA Binding*

C. Prives, T. Soussi, P. Friedlander, 1996, The Journal of Biological Chemistry.

The C-terminus of p53 binds the N-terminal domain of MDM2

C. Prives, O. Laptenko, A. Friedler, 2010, Nature Structural &Molecular Biology.

The C terminus of p 53 binds the N-terminal domain of MDM 2

C. Prives, O. Laptenko, A. Friedler, 2010 .

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis

A. Barsotti, C. Prives, N. Baptiste-Okoh, 2008, Proceedings of the National Academy of Sciences.

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

C. Prives, M. Oren, P. Friedlander, 1996, Molecular and cellular biology.

Lysines in the tetramerization domain of p53 selectively modulate G1 arrest

C. Prives, O. Karni-Schmidt, O. Laptenko, 2016, Cell cycle.

Mutational Analysis of the p53 Core Domain L1 Loop*

C. Prives, A. Zupnick, 2006, Journal of Biological Chemistry.

Relevance of the p53–MDM2 axis to aging

C. Prives, Danyi Wu, 2017, Cell Death and Differentiation.

Ref‐1 regulates the transactivation and pro‐apoptotic functions of p53 in vivo

C. Prives, N. C. Moorthy, C. Gaiddon, 1999, The EMBO journal.

Alternative splicing of SV40 early pre-mRNA is determined by branch site selection.

C. Prives, J. Manley, J L Manley, 1988, Genes & development.

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

A. Levine, E. Stanchina, C. Prives, 2006, Oncogene.

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

C. Prives, K. Mckinney, A. Zupnick, 2009, Cell cycle.

p 53 Mutants in Mammalian Cells p 73 Function Is Inhibited by Tumor-Derived

C. Prives, C. Como, C. Gaiddon, 1999 .

The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain.

I. Simon, J. Manfredi, C. Prives, 2015, Molecular cell.

The p 53 C Terminus Contr ols Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain Graphical Abstract Highlights

I. Simon, J. Manfredi, C. Prives, 2015 .

p53 and p73 display common and distinct requirements for sequence specific binding to DNA

C. Prives, Yingchun Li, C. Gaiddon, 2006, Nucleic acids research.

The linchpin? Pin1 meets p73.

C. Prives, Marshall Urist, 2004, Cancer cell.

p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer.

C. Cordon-Cardo, M. Drobnjak, C. Prives, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Expression in Human Normal and Tumor Tissues : Loss of p 73 Expression Is Associated with Tumor Progression in Bladder Cancer

C. Cordon-Cardo, M. Drobnjak, C. Prives, 2003 .

apoptosis . p 53-responsive genes cannot induce A mutant p 53 that discriminates between

C. Prives, M. Oren, P. Friedlander, 1996 .

A role for p53 in base excision repair

Samuel H. Wilson, C. Prives, Jianmin Zhou, 2001, The EMBO journal.

MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

C. Prives, Yael Assia, J. Manley, 2012, Molecular and Cellular Biology.

p73alpha regulation by Chk1 in response to DNA damage.

C. Cordon-Cardo, C. Prives, Susana González, 2003, Molecular and cellular biology.

p53 tumour suppressor

David Lane, Carol Prives, A. Levine, 1998, Current Biology.

Gain-of-function mutant p53: history and speculation

J. Bargonetti, C. Prives, 2019, Journal of molecular cell biology.

APC/CCdc20 targets E2F1 for degradation in prometaphase

Carol Prives, Emmy W Verschuren, E. Kass, 2010, Cell cycle.

Discovering Transcription Factor Noncoding RNA Targets Using ChIP-Seq Analysis.

C. Prives, Vitalay Fomin, 2020, Methods in molecular biology.

p53: upstream, downstream and off stream. Review of the 8th p53 workshop (Dundee, July 5-9, 1996).

C. Prives, M. Oren, 1996, Biochimica et biophysica acta.

SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes.

C. Prives, J. Manley, E. Lund, 1991, Gene.

Differential affinities of simian virus 40 large tumor antigen for DNA.

C. Prives, M. Oren, E. Winocour, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Replication of RNA viruses: structure of a 6 s RNA synthesized by the Q RNA polymerase.

C. Prives, P. Silverman, 1972, Journal of molecular biology.

Cancer: Mutant p53 and chromatin regulation

S. Lowe, C. Prives, 2015, Nature.

STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma

C. Prives, T. Oyama, S. Yoshiyama, 2017, Clinical Cancer Research.

STXBP 4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma

C. Prives, T. Oyama, S. Yoshiyama, 2017 .

MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53

C. Prives, David R. Tong, C. Katz, 2021, Proceedings of the National Academy of Sciences.

STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis

C. Prives, A. Christiano, S. Rokudai, 2018, Proceedings of the National Academy of Sciences.

Targeting mutant p53 through the mevalonate pathway

C. Prives, William A. Freed-Pastor, 2016, Nature Cell Biology.

Does control of mutant p53 by Mdm2 complicate cancer therapy?

E. White, C. Prives, 2008, Genes & development.

Characterization of an Immunologically Distinct Population of Simian Virus 40 Large Tumor Antigen

C. Prives, L. Covey, P. Kwok, 1987 .

Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression

A. Barsotti, C. Prives, 2010, Cell.

Sprouty4 is required for Mdm2 regulation of invasion, focal adhesion formation and metastasis in cells lacking p53

A. Rustgi, C. Prives, A. Guzman, 2023, bioRxiv.

How Terri Grodzicker transformed Genes & Development

C. Prives, 2023, Genes & development.

Mutant p53 succumbs to starvation

S. Moon, C. Prives, 2013, Cell cycle.

Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.

J. Manfredi, D. Maier, M. Rosenfeld, 1993, Genes & development.

Xenopus laevis p53 protein: sequence-specific DNA binding, transcriptional regulation and oligomerization are evolutionarily conserved.

C. Prives, T. Soussi, Y. Wang, 1995, Oncogene.

A Subclass ofPolyomavirus Middle TumorAntigen Bindsto DNA Cellulose

M. Israel, C. Prives, J. Bolen, 1986 .

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

J. Onuchic, K. Mikoshiba, N. Rothman, 2018, Cell Death & Differentiation.

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.

C. Prives, A. J. Donner, J. Espinosa, 2009, Genes & development.

p53-dependent Induction of PVT1 and miR-1204*

N. Caplen, A. Barsotti, C. Prives, 2011, Journal of Biological Chemistry.

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

O. Podhajcer, C. Prives, V. Gottifredi, 2008, Journal of Cell Science.

A role for caspase 2 and PIDD in the process of p53-mediated apoptosis

A. Barsotti, C. Prives, N. Baptiste-Okoh, 2008, Proceedings of the National Academy of Sciences.

GLS2 is a tumor suppressor and a regulator of ferroptosis 1 in hepatocellular carcinoma

B. Stockwell, C. Prives, K. Yokote, 2022 .

Does control of mutant p53 by Mdm2 complicate cancer therapy?

E. White, C. Prives, 2008, Genes & development.

Effect of cerebral stimulation on biosynthesis of nucleotides and RNA in brain slices in vitro.

C. Prives, J. H. Quastel, 1969, Biochimica et biophysica acta.

Effects of Cerebral Stimulation on the Biosynthesis in vitro of Nucleotides and RNA in Brain

C. Prives, J. H. Quastel, 1969, Nature.

DNA-binding properties of the p53 tumor suppressor protein.

J. Bargonetti, C. Prives, P. Friedlander, 1994, Cold Spring Harbor symposia on quantitative biology.

STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis

C. Prives, A. Christiano, S. Rokudai, 2018, Proceedings of the National Academy of Sciences.

Functional consequences of the interactions of the p53 tumor suppressor protein and SV40 large tumor antigen.

P. Friedman, J. Bargonetti, C. Prives, 1991, Cold Spring Harbor symposia on quantitative biology.

Inaugural Article: p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

C. Prives, O. Laptenko, R. Beckerman, 2011 .

Anything but simple: a phosphorylation-driven toggle within Brd4 triggers gene-specific transcriptional activation.

C. Prives, O. Laptenko, 2013, Molecular cell.