M. Lawrence

发表

Shape complementarity at protein/protein interfaces.

M. Lawrence, P. Colman, 1993, Journal of molecular biology.

The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.

M. Lawrence, P. Iliades, R. Fernley, 2005, Journal of molecular biology.

A method for monitoring the collapse of plastic sections as a function of electron dose.

R. Crowther, M. Lawrence, P. Luther, 1988, Ultramicroscopy.

A designed ankyrin repeat protein evolved to picomolar affinity to Her2.

Andreas Plückthun, Thomas O Joos, Frédéric Pecorari, 2007, Journal of molecular biology.

The structural biology of type I viral membrane fusion

M. Lawrence, P. Colman, Peter M. Colman, 2003, Nature Reviews Molecular Cell Biology.

Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus.

M. Lawrence, P. Colman, L. Chen, 2001, Virology.

CLIX: A search algorithm for finding novel ligands capable of binding proteins of known three‐dimensional structure

M. Lawrence, P. C. Davis, M C Lawrence, 1992, Proteins.

Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.

W. R. Jackson, M. Lawrence, E. Campi, 2000, Journal of molecular biology.

The Weissenberg method for the collection of X‐ray diffraction data from macromolecular crystals: modifications to the data‐processing program WEIS

M. Lawrence, B. A. Fields, A. Nakagawa, 1992 .

Recombinant anti-sialidase single-chain variable fragment antibody. Characterization, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex.

R. Webster, M. Lawrence, P. Colman, 1994, European journal of biochemistry.

Extending Halogen-based Medicinal Chemistry to Proteins

Brian J. Smith, J. Menting, M. Lawrence, 2016, The Journal of Biological Chemistry.

The signalling conformation of the insulin receptor ectodomain

C. Müller, J. Menting, T. Langer, 2018, Nature Communications.

The signalling conformation of the insulin receptor ectodomain

C. Müller, J. Menting, T. Langer, 2018, Nature Communications.

Estimating the proton potential in kdp from infrared and crystallographic data

G. N. Robertson, M. Lawrence, 1981 .

The interpretation of the neutron inelastic scattering and infrared absorption spectra of chromous acid using the double Morse potential model

G. N. Robertson, M. Lawrence, 1987 .

Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins.

M. Lawrence, P. Colman, T. Izard, 1994, Journal of molecular biology.

Structure and function of ecdysone receptors - interactions with ecdysteroids and synthetic agonists

D. Winkler, T. Peat, M. Lawrence, 2012 .

The X-ray Structure of a Hemipteran Ecdysone Receptor Ligand-binding Domain COMPARISON WITH A LEPIDOPTERAN ECDYSONE RECEPTOR LIGAND-BINDING DOMAIN AND IMPLICATIONS FOR INSECTICIDE DESIGN*

D. Winkler, M. Lawrence, P. Pilling, 2005 .

A Molecular Mechanism for Bacterial Susceptibility to Zinc

M. Lawrence, A. McEwan, B. Kobe, 2011, PLoS pathogens.

Understanding insulin and its receptor from their three-dimensional structures

M. Lawrence, 2021, Molecular metabolism.

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

J. Menting, M. Lawrence, B. Forbes, 2022, Structure.

Symmetric and Asymmetric Receptor Conformation Continuum induced by a Novel Insulin

Ingmar B. Schäfer, J. Menting, M. Lawrence, 2022, Nature Chemical Biology.

Aromatic Anchor at an Invariant Hormone-Receptor Interface

G. P. Cox, Brian J. Smith, J. Menting, 2014, The Journal of Biological Chemistry.

Higher-Resolution Structu re of the Human Insulin Receptor Ectodomain : Multi-Modal Inclusion of the Insert Domain Graphical

Brian J. Smith, M. Lawrence, M. Weiss, 2022 .

Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae.

M. Lawrence, P. Pilling, A. Ogunniyi, 1998, Acta crystallographica. Section D, Biological crystallography.

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

F. Ismail-Beigi, M. Lawrence, C. Roberts, 2012, Proceedings of the National Academy of Sciences.

Activation of the human insulin receptor by non-insulin-related peptides

M. Lawrence, V. Kiselyov, M. Margetts, 2022, Nature Communications.

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

M. Lawrence, R. DiMarchi, V. Jiménez, 2022, Nature Communications.

Insulin and its receptor: a grand challenge in structural biology

M. Lawrence, 2019, Biophysical Reviews.

How insulin engages its primary binding site on the insulin receptor

Andrzej M. Brzozowski, Colin W. Ward, Christopher J. Watson, 2013, Nature.

Vale Colin Ward—A Leader in Receptor Structural Biology

M. Lawrence, P. Colman, 2017, Front. Endocrinol..

Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.

J. Menting, M. Lawrence, C. Ward, 2015, Structure.

A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

J. Menting, M. Lawrence, C. Ward, 2009, Biochemistry.

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Brian J. Smith, J. Menting, J. Trewhella, 2009, Journal of molecular biology.

Insulin receptor structure and its implications for the IGF-1 receptor.

M. Lawrence, N. Mckern, C. Ward, 2007, Current opinion in structural biology.

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

J. Menting, M. Lawrence, B. Forbes, 2017, Scientific Reports.

Estimating the barrier to proton or deuteron tunnelling in hydrogen-bonded crystals

G. N. Robertson, M. Lawrence, 1980 .

Analysis of proton tunnelling in KDP using a realistic proton potential

G. N. Robertson, M. Lawrence, 1981 .

The temperature and pressure dependence of the proton tunnelling frequency in KPD

G. N. Robertson, M. Lawrence, 1980 .

Do protons tunnel in the formic acid dimer and in the crystal

G. N. Robertson, M. Lawrence, 1981 .

Proton tunnelling in chromous acid

G. N. Robertson, M. Lawrence, 1981 .

How ligand binds to the type 1 insulin-like growth factor receptor

J. Menting, M. Lawrence, V. Kiselyov, 2018, Nature Communications.

The signalling conformation of the insulin receptor ectodomain

C. Müller, J. Menting, T. Langer, 2018, Nature Communications.

How ligand binds to the type 1 insulin-like growth factor receptor

J. Menting, M. Lawrence, V. Kiselyov, 2018, Nature Communications.

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.

Brian J. Smith, M. Lawrence, M. Weiss, 2016, Structure.

Protective hinge in insulin opens to enable its receptor engagement

Brian J. Smith, Virander S. Chauhan, J. Menting, 2014, Proceedings of the National Academy of Sciences.

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

Brian J. Smith, J. Menting, D. Steiner, 2010, Proceedings of the National Academy of Sciences.

N‐linked glycans of the human insulin receptor and their distribution over the crystal structure

M. Lawrence, N. Mckern, C. Ward, 2008, Proteins.

Structure of the insulin receptor ectodomain reveals a folded-over conformation

M. Lawrence, R. Fernley, P. Pilling, 2006, Nature.

Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase

M. Lawrence, P. Colman, P. Hoyne, 1993, Journal of virology.

Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase.

M. Lawrence, P. Pilling, N. E. Hall, 1997, Journal of molecular biology.

Ecdysone receptors: from the Ashburner model to structural biology.

F. Bonneton, M. Lawrence, I. Billas, 2013, Annual review of entomology.

Landmarks in Insulin Research

M. Lawrence, C. Ward, 2011, Front. Endocrin..

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

Brian J. Smith, J. Menting, R. Norton, 2020, Nature Structural & Molecular Biology.

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Brian J. Smith, F. Ismail-Beigi, M. Lawrence, 2017, The Journal of Biological Chemistry.

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Brian J. Smith, J. Menting, R. Norton, 2016, Nature Structural &Molecular Biology.

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor*

Brian J. Smith, J. Menting, M. Lawrence, 2016, The Journal of Biological Chemistry.

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

M. Lawrence, N. Mckern, C. Ward, 2007, Trends in biochemical sciences.

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

M. Lawrence, A. Belfiore, F. Frasca, 2017, Endocrine reviews.

Ligand‐induced activation of the insulin receptor: a multi‐step process involving structural changes in both the ligand and the receptor

M. Lawrence, C. Ward, 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.

Structural insights into ligand‐induced activation of the insulin receptor

M. Lawrence, N. Mckern, C. Ward, 2007, Acta physiologica.

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

F. Ismail-Beigi, M. Lawrence, M. Weiss, 2017, The Journal of Biological Chemistry.

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.

M. Lawrence, P. Colman, P. Pilling, 2004, Journal of molecular biology.

Least-Squares Method of Alignment Using Markers

Michael C. Lawrence, M. Lawrence, 1992 .

A thing of beauty: Structure and function of insulin's “aromatic triplet”

M. Lawrence, M. Weiss, 2018, Diabetes, obesity & metabolism.

Contribution of TyrB26 to the Function and Stability of Insulin

M. Lawrence, M. Weiss, N. Rege, 2016, The Journal of Biological Chemistry.

Structural Relationships of 7S and 11S Globulins

M. Lawrence, 1999 .

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor

M. Lawrence, J. Sandow, B. Forbes, 2020, Structure.

Insertion of a Synthetic Switch Into Insulin Provides Metabolite-Dependent Regulation of Hormone-Receptor Activation

M. Lawrence, Yule Liu, T. Hattier, 2021, Proceedings of the National Academy of Sciences.

Inhibition of Parainfluenza Virus Type 3 and Newcastle Disease Virus Hemagglutinin-Neuraminidase Receptor Binding: Effect of Receptor Avidity and Steric Hindrance at the Inhibitor Binding Sites

M. Lawrence, M. Porotto, J. McKimm-Breschkin, 2004, Journal of Virology.

The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.

M. Lawrence, P. Colman, J. McKimm-Breschkin, 2001, Structure.

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Brian J Smith, Yibin Xu, Brian J. Smith, 2014, eLife.

The application of the maximum entropy method to electron microscopic tomography.

B. Sewell, M. Lawrence, B T Sewell, 1989, Ultramicroscopy.

A generalized transformation to correct for image-plate and camera-geometry distortion in large-radius Weissenberg cameras

M. Lawrence, 1994 .

Structural Features of the Receptor Tyrosine Kinase Ectodomains

M. Lawrence, C. Ward, 2015 .

Crystallographic structure of allosterically inhibited phosphofructokinase at 7 A resolution.

P. Evans, M. Lawrence, G. Farrants, 1986, Journal of molecular biology.

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

A. Cowman, M. Lawrence, W. Wong, 2016, eLife.

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

J. Menting, M. Lawrence, C. Ward, 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

The application of the molecular replacement method to the de novo determination of protein structure

M. Lawrence, 1991, Quarterly Reviews of Biophysics.

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

J. Menting, M. Lawrence, B. Forbes, 2017, Scientific Reports.

The Structure and Function of Ecdysone Receptors

D. Moras, M. Lawrence, I. Billas, 2009 .

The X-ray Structure of a Hemipteran Ecdysone Receptor Ligand-binding Domain

D. Winkler, M. Lawrence, P. Pilling, 2005, Journal of Biological Chemistry.

Visualization of Insulin Receptor Activation by a Novel Insulin Analog with Elongated A Chain and Truncated B Chain

J. Menting, M. Lawrence, C. Hill, 2021 .

M. Lawrence, C. Ward, 2012, Current opinion in structural biology.

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

C. Kahn, M. Lawrence, R. DiMarchi, 2022, Nature Communications.

The νs infrared absorption band profile of isotopically diluted oh groups in crystals

G. N. Robertson, M. Lawrence, 1979 .

The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein.

M. Lawrence, P. Pilling, A. Ogunniyi, 1998, Structure.

CONSCRIPT: a program for generating electron density isosurfaces for presentation in protein crystallography

M. Lawrence, P. Bourke, Michael C. Lawrence, 2000 .

Modelling the structure of the fusion protein from human respiratory syncytial virus.

Brian J. Smith, M. Lawrence, P. Colman, 2002, Protein engineering.

Isolation, characterization, cDNA cloning and gene expression of an avian transthyretin. Implications for the evolution of structure and function of transthyretin in vertebrates.

M. Lawrence, R. Wettenhall, A. Jaworowski, 1991, European journal of biochemistry.

Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells.

M. Lawrence, R. A. Easom, M. Lawrence, 2001, Molecular endocrinology.

Leucine-zippered human insulin receptor ectodomain with single bound insulin - ""lower"" membrane-proximal part

C. Müller, J. Menting, T. Langer, 2018 .

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor*

Brian J. Smith, J. Menting, M. Lawrence, 2016, The Journal of Biological Chemistry.

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

F. Ismail-Beigi, M. Lawrence, C. Roberts, 2012, Proceedings of the National Academy of Sciences.

Semiclassical approximations in problems involving double‐minimum potentials: A reply

G. N. Robertson, M. Lawrence, 1988 .

Ecdysone receptors: from the Ashburner model to structural biology.

F. Bonneton, M. Lawrence, I. Billas, 2013, Annual review of entomology.

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

F. Ismail-Beigi, M. Lawrence, M. Weiss, 2017, The Journal of Biological Chemistry.

Ligand‐induced activation of the insulin receptor: a multi‐step process involving structural changes in both the ligand and the receptor

M. Lawrence, C. Ward, 2009, BioEssays : news and reviews in molecular, cellular and developmental biology.

Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells.

M. Lawrence, R. A. Easom, H. Bhatt, 2001, Molecular endocrinology.