C. Fierke

发表

E. Toone, Stephen W B Fullerton, Jennifer S Griffiths, 2005, Bioorganic & medicinal chemistry.

Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase.

S. Niranjanakumari, E. Toone, Jennifer S Griffiths, 2002, Bioorganic & medicinal chemistry.

Determinants of catalytic activity and stability of carbonic anhydrase II as revealed by random mutagenesis.

C. Fierke, J. Krebs, 1993, The Journal of biological chemistry.

Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.

C. Fierke, S. Gantt, Samuel G. Gattis, 2006, Biochemistry.

Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations*

C. Fierke, S. Gantt, Caleb G. Joseph, 2009, The Journal of Biological Chemistry.

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis.

C. Fierke, S. Neidle, S. Haider, 2011, Bioorganic & medicinal chemistry letters.

Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity.

C. Fierke, K. Hicks, Heather L Hartman, 2005, Biochemistry.

Context-dependent substrate recognition by protein farnesyltransferase.

Corissa L. Lamphear, James L. Hougland, Richard A Gibbs, 2009, Biochemistry.

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates.

James L. Hougland, Richard A Gibbs, R. Gibbs, 2010, Bioorganic & medicinal chemistry letters.

Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities.

James L. Hougland, C. Fierke, K. Hicks, 2010, Journal of molecular biology.

Expansion of Protein Farnesyltransferase Specificity Using “Tunable” Active Site Interactions

James L. Hougland, C. Fierke, Soumyashree A. Gangopadhyay, 2012, The Journal of Biological Chemistry.

Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase.

Amy M. Danowitz, R. Gibbs, M. Distefano, 2016, Bioorganic & medicinal chemistry letters.

UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.

C. Fierke, C. Raetz, J. Jackman, 1999, Biochemistry.

Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design

Carol A. Fierke, David W. Christianson, C. Fierke, 1996 .

Contribution of Fluorine to Protein−Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II

Chu-Young Kim, Carol A. Fierke, David W. Christianson, 2000 .

Mobile trap algorithm for zinc detection using protein sensors.

M. V. Inamdar, A. Sastry, C. Fierke, 2007, The Journal of chemical physics.

Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor.

Andrea K. Stoddard, J. Lakowicz, C. Fierke, 2014, Metallomics : integrated biometal science.

Cu+- and Cu2+-sensitive PEBBLE fluorescent nanosensors using DsRed as the recognition element

Carol A. Fierke, Raoul Kopelman, Andrea K. Stoddard, 2006 .

The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond

D. Herschlag, C. Fierke, 2007 .

A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors

Hamed S. Hayatshahi, B. Sankaran, C. Fierke, 2020, bioRxiv.

A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors **

Hamed S. Hayatshahi, B. Sankaran, C. Fierke, 2020, ChemMedChem.

Performance enhancement of fluorescence energy transfer-based biosensors by site-directed mutagenesis of the transducer.

Z. Ge, C. Fierke, R. Thompson, 1996, Journal of biomedical optics.

Interplay between substrate recognition, 5′ end tRNA processing and methylation activity of human mitochondrial RNase P

C. Fierke, A. Karasik, M. Koutmos, 2018, bioRxiv.

Interplay between substrate recognition, 5’ end tRNA processing and methylation activity of human mitochondrial RNase P

C. Fierke, A. Karasik, M. Koutmos, 2018 .

Binding and cleavage of unstructured RNA by nuclear RNase P.

D. Engelke, C. Fierke, Michael C. Marvin, 2011, RNA.

Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release

Seth M. Cohen, P. Jennings, C. Fierke, 2015, Journal of medicinal chemistry.

Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions.

Corissa L. Lamphear, C. Fierke, Elaina A. Zverina, 2012, Current opinion in chemical biology.

Global Identification of Protein Prenyltransferase Substrates: Defining the Prenylated Proteome

Corissa L. Lamphear, James L. Hougland, C. Fierke, 2011 .

Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.

P. Casey, C. Fierke, K. Bowers, 2003, Biochemistry.

Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.

C. Fierke, Yuta Suzuki, D. Andres, 2012, Biochemistry.

Lysine β311 of Protein Geranylgeranyltransferase Type I Partially Replaces Magnesium*

C. Fierke, K. Bowers, Heather L Hartman, 2004, Journal of Biological Chemistry.

Mutagenesis Studies of Protein Farnesyltransferase Implicate Aspartate β352 as a Magnesium Ligand*

C. Fierke, K. Bowers, J. Pickett, 2003, Journal of Biological Chemistry.

An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity.

C. Fierke, Caleb G. Joseph, Noah A. Wolfson, 2014, Analytical biochemistry.

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.

C. Fierke, A. Ramamoorthy, A. Bhunia, 2016, Chemical communications.

Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase.

C. Fierke, K. Hightower, 1999, Current opinion in chemical biology.

Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain.

C. Fierke, M. Philbert, R. Richardson, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Combining Active Carbonic Anhydrase with Nanogels: Enzyme Protection and Zinc Sensing

C. Fierke, R. Kopelman, Guochao Nie, 2021, International journal of nanomedicine.

Understanding protein palmitoylation: Biological significance and enzymology

C. Fierke, X. Guan, 2011, Science China. Chemistry.

Zinc and Health : Current Status and Future Directions Function and Mechanism of Zinc Metalloenzymes 1

C. Fierke, K. McCall, Chih‐chin Huang, 2000 .

Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.

R. Gibbs, C. Fierke, E. Wright, 2016, Bioorganic & medicinal chemistry letters.

Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites.

C. Fierke, L. Kiefer, 1994, Biochemistry.

Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase.

E. Toone, C. Fierke, T. Christensen, 2001, Biochemistry.

Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.

Carol Ann Castañeda, M. Scholle, C. Fierke, 2017, Biochemistry.

A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease

B. Sankaran, C. Fierke, D. Russell, 2022, bioRxiv.

Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family.

C. Fierke, E. Roush, C. Decastro, 1997, Biochemistry.

Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand

C. Fierke, A. Mapp, Ningkun Wang, 2014, Proceedings of the National Academy of Sciences.

Active Site Metal Ion in UDP-3-O-((R)-3-Hydroxymyristoyl)-N-acetylglucosamine Deacetylase (LpxC) Switches between Fe(II) and Zn(II) Depending on Cellular Conditions*

C. Fierke, Samuel G. Gattis, M. Hernick, 2010, The Journal of Biological Chemistry.

Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II.

C. Fierke, J. Krebs, S. A. Paterno, 1993, Biochemistry.

Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.

C. Fierke, D. Christianson, C. Lesburg, 1997, Biochemistry.

Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants.

E. Toone, C. Fierke, T. Christensen, 2001, Biochemistry.

Evidence for a Catalytic Role of Zinc in Protein Farnesyltransferase

P. Casey, C. Fierke, Chih‐chin Huang, 1997, The Journal of Biological Chemistry.

Colorimetric and fluorimetric assays to quantitate micromolar concentrations of transition metals.

C. Fierke, K. McCall, 2000, Analytical biochemistry.

Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.

C. Fierke, D. Whittington, D. Christianson, 2006, Biochemistry.

Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency

C. Fierke, S. A. Paterno, L. Kiefer, 1995 .

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

Ted Natoli, Aravind Subramanian, Carol A. Fierke, 2014, ACS chemical biology.

HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking.

Sarah E. Haynes, Brent R. Martin, C. Fierke, 2017, Journal of the American Chemical Society.

Probing determinants of the metal ion selectivity in carbonic anhydrase using mutagenesis.

C. Fierke, K. McCall, 2004, Biochemistry.

Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface.

Corissa L. Lamphear, T. Pan, M. Wilde, 2013, Cell reports.

Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy.

A. Lipton, C. Fierke, P. D. Ellis, 2008, Journal of the American Chemical Society.

Getting a handle on protein prenylation.

James L. Hougland, C. Fierke, 2009, Nature chemical biology.

Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs.

Bikash R. Sahoo, Andrea K. Stoddard, M. Ivanova, 2018, Chemical communications.

Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

Bikash R. Sahoo, Andrea K. Stoddard, M. Ivanova, 2018, bioRxiv.

Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P

C. Fierke, A. Karasik, M. Koutmos, 2020, RNA.

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase P

C. Fierke, A. Karasik, M. Koutmos, 2020, bioRxiv.

Differential substrate recognition by isozymes of plant protein-only Ribonuclease P

C. Fierke, A. Karasik, M. Koutmos, 2016, RNA.

Mode of inhibition of RNase P by gambogic acid and juglone

C. Fierke, A. Karasik, M. Koutmos, 2022, bioRxiv.

Role of metals in the reaction catalyzed by protein farnesyltransferase.

C. Fierke, K. Hightower, M. J. Saderholm, 2000, Biochemistry.

Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state.

C. Fierke, C. Huang, K. Hightower, 2000, Biochemistry.

Determination of zinc using carbonic anhydrase-based fluorescence biosensors.

Rebecca A. Bozym, Andrea K. Stoddard, C. Fierke, 2008, Methods in enzymology.

Combinatorial modulation of protein prenylation.

Sarah A. Scott, R. Gibbs, C. Fierke, 2007, ACS chemical biology.

Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers.

Bikash R. Sahoo, Andrea K. Stoddard, J. Nowick, 2019, Journal of molecular biology.

Gambogic acid and juglone inhibit RNase P through distinct mechanisms

C. Fierke, A. Karasik, M. Koutmos, 2022, The Journal of biological chemistry.

Apolipoprotein A-I Mimetic 4F Peptide Generates Amyloid Cytotoxins by Forming Hetero-oligomers with β-amyloid

Bikash R. Sahoo, Andrea K. Stoddard, J. Nowick, 2019, bioRxiv.

Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma.

C. Fierke, E. Roush, 1992, Biochemistry.

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

C. Fierke, Kai S Yang, W. Liu, 2022, bioRxiv.

Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.

M. Pirrung, C. Fierke, C. Raetz, 2002, Journal of medicinal chemistry.

Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.

C. Fierke, C. Raetz, J. Jackman, 2001, Biochemistry.

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

C. Fierke, J. Brender, A. Ramamoorthy, 2014, The journal of physical chemistry letters.

REDESIGNING THE ZINC-BINDING SITE OF HUMAN CARBONIC ANHYDRASE-II - STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON.

C. Fierke, J. Ippolito, D. Christianson, 1993 .

The affinity of magnesium binding sites in the Bacillus subtilis RNase P x pre-tRNA complex is enhanced by the protein subunit.

C. Fierke, J. Kurz, 2002, Biochemistry.

Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives

C. Fierke, J. Brender, A. Ramamoorthy, 2015, Journal of diabetes research.

A Novel Y-Shaped, S-O-N-O-S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease.

C. Fierke, D. Russell, Kai S Yang, 2023, ACS chemical biology.

Mechanisms of metal-dependent hydrolases in metabolism

C. Fierke, M. Hernick, 2010 .

Function and mechanism of zinc metalloenzymes.

C. Fierke, C A Fierke, K A McCall, 2000, The Journal of nutrition.

Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.

E. Toone, N. Wymer, C. Fierke, 2001, Structure.

Long Wavelength Fluorescence Ratiometric Zinc Biosensor

Andrea K. Stoddard, C. Fierke, E. Matveeva, 2013, Journal of Fluorescence.

Role of binding energy with coenzyme A in catalysis by 3-oxoacid coenzyme A transferase.

A Whitty, A. Whitty, W. Jencks, 1995, Biochemistry.

The BaeSR regulon is involved in defense against zinc toxicity in E. coli.

C. Fierke, Da Wang, 2013, Metallomics : integrated biometal science.

Ratiometric Zinc Biosensor Based on Bioluminescence Resonance Energy Transfer: Trace Metal Ion Determination with Tunable Response

Andrea K. Stoddard, C. Fierke, E. Matveeva, 2022, International journal of molecular sciences.

Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives.

C. Fierke, R. Thompson, T. Hurst, 2010, Biochimica et biophysica acta.

Practical Aspects of Fluorescence Analysis of Free Zinc Ion in Biological Systems: pZn for the Biologist

Rebecca A. Bozym, C. Fierke, M. Hershfinkel, 2005 .

Fluorescence-based biosensing of zinc using carbonic anhydrase

C. Fierke, R. Thompson, 2001, Biometals.

Fluorescent zinc indicators for neurobiology

B. Maliwal, C. Fierke, P. Heřman, 2002, Journal of Neuroscience Methods.

Fiber optic biosensor for Co(II) and Cu(II) based on fluorescence energy transfer with an enzyme transducer

C. Fierke, R. Thompson, M. Patchan, 1996 .

Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor.

Rebecca A. Bozym, Andrea K. Stoddard, C. Fierke, 2006, ACS chemical biology.

Importance of Measuring Free Zinc in Cells

Rebecca A. Bozym, C. Fierke, R. Thompson, 2006 .

H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.

P. Casey, C. Fierke, C. Huang, 1998, Biochemistry.

Structural characterization of the zinc site in protein farnesyltransferase.

C. Fierke, J. Penner‐Hahn, Heather L Hartman, 2003, Journal of the American Chemical Society.

Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes.

D. Engelke, C. Fierke, Carol A Fierke, 2002, Annual review of biochemistry.

EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC).

C. Fierke, J. Penner‐Hahn, J. Jackman, 2003, Journal of inorganic biochemistry.

The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I 2

P. Casey, C. Fierke, Chih‐chin Huang, 2019 .

SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent.

C. Fierke, Benjamin C Jennings, A. J. Lawton, 2018, Biochemistry.

Protein farnesyltransferase exhibits pH-dependent activity towards H-Ras peptide substrates

P. Casey, C. Fierke, K. Hightower, 2002 .

The Biochemistry of Farnesyltransferase and Geranylgeranyltransferase I

P. Casey, C. Fierke, Chih‐chin Huang, 2001 .

Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS.

K. Merz, C. Fierke, B. Wang, 2012, Journal of the American Chemical Society.

General Base-General Acid Catalysis in Human Histone Deacetylase 8.

C. Fierke, D. Christianson, C. Decroos, 2016, Biochemistry.

Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes.

C. Fierke, A. Karasik, M. Koutmos, 2016, Journal of molecular biology.

A continuous fluorescent assay for protein prenyltransferases measuring diphosphate release.

Andrea K. Stoddard, C. Fierke, K. Bowers, 2005, Analytical biochemistry.

The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions

C. Fierke, Yu Chen, Xin Liu, 2016, Biomolecules.

Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.

C. Fierke, R. Isaacs, D. Andres, 2002, Journal of the American Chemical Society.

A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei.

S. Benkovic, C. Fierke, J. Feeney, 1989, Biochemistry.

Transient kinetic approaches to enzyme mechanisms.

C. Fierke, G. Hammes, 1995, Methods in enzymology.

Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor.

Hui-Hui Zeng, Richard B Thompson, B. Maliwal, 2003, Analytical chemistry.

The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation.

C. Fierke, N. Walter, D. Rueda, 2005, Biochemistry.

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.

R. Gibbs, C. Fierke, E. Wright, 2016, Organic letters.

Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues.

C. Fierke, C A Fierke, J A Hunt, 1999, Biochemistry.

Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.

R. Gibbs, C. Fierke, E. Wright, 2016, Bioorganic & medicinal chemistry letters.

Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.

Sarah A. Scott, R. Gibbs, C. Fierke, 2007, Bioorganic & medicinal chemistry letters.

Inner-Sphere Coordination of Divalent Metal Ion with Nucleobase in Catalytic RNA.

C. Fierke, Yu Chen, Xin Liu, 2017, Journal of the American Chemical Society.

High-level 2H/13C/15N labeling of proteins for NMR studies

B. Farmer, C. Fierke, R. Venters, 1995, Journal of biomolecular NMR.

RNase P enzymes

D. Engelke, C. Fierke, M. Koutmos, 2013, RNA biology.

Divergent scaffolds for a conserved biological reaction

D. Engelke, C. Fierke, M. Koutmos, 2013 .

Determination of picomolar concentrations of metal ions using fluorescence anisotropy: biosensing with a "reagentless" enzyme transducer.

B. Maliwal, C. Fierke, R. Thompson, 1998, Analytical chemistry.

Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.

S. Niranjanakumari, C. Fierke, Mahiuddin Ahmed, 2007, RNA.

Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II.

C. Fierke, D. Christianson, R. Alexander, 1991, Biochemistry.

A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P

C. Fierke, Yu Chen, Xin Liu, 2014, Nucleic acids research.

Fibroblasts from long-lived rodent species exclude cadmium.

C. Fierke, Richard A. Miller, J. Penner‐Hahn, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

Inhibitor sensitivity of pulmonary vascular carbonic anhydrase.

C. Fierke, E. Roush, A. Bidani, 1993, Journal of applied physiology.

Catalysis and inhibition of human carbonic anhydrase IV.

W. Sly, C. Fierke, A. Waheed, 1997, Biochemistry.

Localization of a protein inhibitor of carbonic anhydrase in pig tissues.

C. Fierke, E. Roush, Y. Ridderstråle, 2002, Acta physiologica Scandinavica.

Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis.

A. Mason, C. Fierke, E. Roush, 2008, Biochemistry.

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer

Carol L. Williams, J. Rosenfeld, G. Getz, 2019, Nature Genetics.

HDAC8 substrates: Histones and beyond.

C. Fierke, Noah A. Wolfson, Carol Ann Pitcairn, 2013, Biopolymers.

Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates

O. Schueler‐Furman, C. Fierke, Julia K. Varga, 2021, Scientific Reports.

Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis.

C. Fierke, M. Hernick, 2006, Biochemistry.

Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli

C. Fierke, T. Tatsuta, T. Ogura, 1999, Molecular microbiology.

Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically Encoded Nε-Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent

C. Fierke, W. Liu, Shiqing Xu, 2023, bioRxiv.

Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity

Ora Schueler-Furman, Carol A. Fierke, Nir London, 2011, PLoS Comput. Biol..

Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1.

C. Fierke, B. Ruotolo, Shuai Niu, 2017, International journal of mass spectrometry.

Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion

Rebecca A. Bozym, G. Fiskum, C. Fierke, 2012, Journal of Bioenergetics and Biomembranes.

Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues.

C. Fierke, R. Thompson, 2017, Methods in enzymology.

Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.

C. Fierke, D. Christianson, D. Dowling, 2008, Biochemistry.

Roles of protein subunits in RNA-protein complexes: lessons from ribonuclease P.

C. Fierke, A. Andrews, J. Hsieh, 2004, Biopolymers.

Metal-dependent Deacetylases: Cancer and Epigenetic Regulators.

C. Fierke, Eric D. Sullivan, Carol A Fierke, 2016, ACS chemical biology.

Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis.

C. Fierke, J. Hsieh, J. K. Smith, 2007, Biopolymers.

Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.

S. Niranjanakumari, C. Fierke, D. Christianson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation.

H. Al‐Hashimi, C. Fierke, A. Andrews, 2006, RNA.

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.

S. Benkovic, C. Fierke, K. Johnson, 1987, Biochemistry.

Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarchaeon Methanosarcina thermophila.

C. Colangelo, C. Fierke, D. Silverman, 1999, Biochemistry.

Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer

K. Merz, C. Fierke, J. Jackman, 1996 .

Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.

C. Fierke, J. Ippolito, D. Christianson, 1993, The Journal of biological chemistry.

Selection of Carbonic Anhydrase Variants Displayed on Phage

Carol A. Fierke, C. Fierke, Jennifer A. Hunt, 1997, The Journal of Biological Chemistry.

Protein engineering of dihydrofolate reductase. pH dependency of Phe-31 mutants

S. Benkovic, C. Fierke, K. Taira, 1987 .

Measuring the Stoichiometry of Magnesium Ions Bound to RNA

C. Fierke, A. Andrews, 2008 .

Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P.

C. Fierke, J. Kurz, Sharon M. Crary, 2002, RNA.

Ionic interactions between PRNA and P protein in Bacillus subtilis RNase P characterized using a magnetocapture-based assay.

S. Niranjanakumari, C. Fierke, Jeremy J. Day-Storms, 2004, RNA.

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases*

Carol L. Williams, C. Fierke, Kathleen R. Noon, 2016, The Journal of Biological Chemistry.

Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation.

Bikash R. Sahoo, Andrea K. Stoddard, C. Fierke, 2018, Journal of molecular biology.

Structure-Based Identification of HDAC8 Non-histone Substrates.

O. Schueler‐Furman, C. Fierke, Nawsad Alam, 2016, Structure.

Structure-Based Identifica tion of HDAC 8 Non-histone Substrates Graphical Abstract Highlights

Ora Schueler-Furman, Carol A. Fierke, Nawsad Alam, 2016 .

The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli.

S. Benkovic, C. Fierke, J. Adams, 1991, Biochemistry.

Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding.

S. Benkovic, C. Fierke, 1989, Biochemistry.

On interpreting the inhibition of and catalysis by dihydrofolate reductase

S. Benkovic, C. Fierke, K. Taira, 1987 .

Insights into enzyme function from studies on mutants of dihydrofolate reductase.

S. Benkovic, C. Fierke, S J Benkovic, 1988, Science.

Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.

D. Engelke, C. Fierke, Shaohua Xiao, 2006, RNA.

Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing.

D. Engelke, C. Fierke, C. Srisawat, 2005, RNA.

Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant.

C. Fierke, S. Nair, D. Christianson, 1993, Biochemistry.

Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.

C. Fierke, D. Christianson, R. Alexander, 1993, Biochemistry.

UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine Deacetylase Functions through a General Acid-Base Catalyst Pair Mechanism*

C. Fierke, D. Whittington, D. Christianson, 2005, Journal of Biological Chemistry.

Zinc hydrolases: the mechanisms of zinc-dependent deacetylases.

C. Fierke, M. Hernick, 2005, Archives of biochemistry and biophysics.

Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis

C. Fierke, D. Whittington, D. Christianson, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases

C. Fierke, Desirée García-Torres, 2019, The Journal of Biological Chemistry.

Insights into Enzymic Catalysis from Studies on Dihydrofolate Reductases

S. Benkovic, C. Fierke, J. Adams, 1989 .

Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase.

S. Benkovic, R. Mayer, C. Fierke, 1986, Proceedings of the National Academy of Sciences of the United States of America.

A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P.

C. Fierke, J. Beebe, 1994, Biochemistry.

Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II.

C. Fierke, T. Calderone, J. Krebs, 1991, Biochemistry.

Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 .

C. Fierke, D. Christianson, K. E. Cole, 2011, Biochemistry.

Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity.

C. Fierke, J. Penner‐Hahn, Samuel G. Gattis, 2010, Biochemistry.

A bacterial selection for the directed evolution of pyruvate aldolases.

E. Toone, Jennifer S Griffiths, Manoj Cheriyan, 2004, Bioorganic & medicinal chemistry.

Unexpected specificity within dynamic transcriptional protein–protein complexes

C. Fierke, T. Cierpicki, A. Mapp, 2020, Proceedings of the National Academy of Sciences.

Unexpected Specificity within Dynamic Transcriptional Protein-Protein Complexes

C. Fierke, T. Cierpicki, A. Mapp, 2020, bioRxiv.

Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant.

Carol Ann Castañeda, C. Fierke, S. Haider, 2019, Biochemistry.

ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc.

C. Fierke, Da Wang, Olijahwon Hosteen, 2012, Journal of inorganic biochemistry.

Ribonuclease P protein structure: evolutionary origins in the translational apparatus.

S. Niranjanakumari, C. Fierke, D. Christianson, 1998, Science.

High-level expression of rat farnesyl:protein transferase in Escherichia coli as a translationally coupled heterodimer.

C. Fierke, D. Hupe, K. Zimmerman, 1998, Protein expression and purification.

Mutagenesis of the phosphate‐binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates

E. Toone, Manoj Cheriyan, C. Fierke, 2007, Protein science : a publication of the Protein Society.

Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion

J. Sarvey, D. McAdoo, D. Prough, 2006, Experimental Neurology.

Transient-state Kinetic Analysis of Transcriptional Activator·DNA Complexes Interacting with a Key Coactivator*

C. Fierke, A. Mapp, Ningkun Wang, 2011, The Journal of Biological Chemistry.

Fluorescence microscopy of stimulated Zn(II) release from organotypic cultures of mammalian hippocampus using a carbonic anhydrase-based biosensor system

B. Maliwal, C. Fierke, W. Whetsell, 2000, Journal of Neuroscience Methods.

Expanded dynamic range of free zinc ion determination by fluorescence anisotropy.

B. Maliwal, C. Fierke, R. Thompson, 1998, Analytical chemistry.

Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.

C. Fierke, J. Ippolito, D. Christianson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release.

D. Engelke, C. Fierke, S. Walker, 2009, RNA.

Ribonuclease P: a ribonucleoprotein enzyme.

C. Fierke, J. Kurz, Jeffrey C. Kurz, 2000, Current opinion in chemical biology.

Effects of 5' leader and 3' trailer structures on pre-tRNA processing by nuclear RNase P.

J. J. Day, D. Engelke, C. Fierke, 2000, Biochemistry.

Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme.

S. Niranjanakumari, T. Pan, C. Fierke, 1998, Biochemistry.

Expression, purification and characterization of the recombinant ribonuclease P protein component from Bacillus subtilis

Carol A. Fierke, S. Niranjanakumari, Jeffrey C. Kurz, 1998, Nucleic Acids Res..

The protein component of Bacillus subtilis ribonuclease P increases catalytic efficiency by enhancing interactions with the 5' leader sequence of pre-tRNAAsp.

S. Niranjanakumari, C. Fierke, S. M. Crary, 1998, Biochemistry.

Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNAAsp.

S. Niranjanakumari, C. Fierke, J. Kurz, 1998, Biochemistry.

Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNAAsp.

C. Fierke, J. Kurz, J. Beebe, 1996, Biochemistry.

Carbonic Anhydrase-Based Biosensing of Metal Ions: Issues and Future Prospects

Rebecca A. Bozym, Andrea K. Stoddard, C. Fierke, 2005 .

In situ measurement of free zinc in an ischemia model and cell culture using a ratiometric fluorescence-based biosensor

Christopher J. Frederickson, Hui-Hui Zeng, Carol A. Fierke, 2005, SPIE BiOS.

DsRed as a highly sensitive, selective, and reversible fluorescence-based biosensor for both Cu(+) and Cu(2+) ions.

Raoul Kopelman, Richard B Thompson, Michele Cramer, 2006, Biosensors & bioelectronics.

Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P.

C. Fierke, M. Harris, N. Zahler, 2010, Journal of molecular biology.

Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate.

C. Fierke, J. Hsieh, 2009, RNA.

Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase.

R. Gibbs, C. Fierke, K. Hicks, 2005, Biochemistry.

Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I.

C. Fierke, K. Hicks, Heather L Hartman, 2005, Biochemistry.

Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA.

M. Kimura, C. Fierke, T. Hall, 2020, Nucleic acids research.

Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .

C. Fierke, D. Christianson, D. Dowling, 2010, Biochemistry.

Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II.

B. Farmer, C. Fierke, R. Venters, 1996, Journal of molecular biology.

Characterization and crystal structure of Escherichia coli KDPGal aldolase.

E. Toone, C. Fierke, J. Naismith, 2008, Bioorganic & medicinal chemistry.

Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein.

T. Oas, C. Fierke, J. Kurz, 2001, Biochemistry.

Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.

C. Fierke, D. Christianson, C. Lesburg, 1996, Biochemistry.

Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates.

E. Toone, Manoj Cheriyan, C. Fierke, 2012, Biochemistry.

Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate.

E. Toone, Manoj Cheriyan, C. Fierke, 2011, Bioorganic & medicinal chemistry.

Long Wavelength Fluorescence Ratiometric Zinc Biosensor

Andrea K. Stoddard, C. Fierke, E. Matveeva, 2013, Journal of Fluorescence.

Genetically encoded ratiometric biosensors to measure intracellular exchangeable zinc in Escherichia coli.

C. Fierke, R. Thompson, T. Hurst, 2011, Journal of biomedical optics.

Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding.

C. Brooks, H. Al‐Hashimi, C. Fierke, 2015, Journal of the American Chemical Society.

In vivo and intracellular sensing and imaging of free zinc ion

Richard B. Thompson, Hui-Hui Zeng, Carol A. Fierke, 2004, SPIE BiOS.

Kinetic mechanism of bacterial RNase P

C. Fierke, Kristin S. Koutmou, J. Hsieh, 2010 .

Kinetic mechanism of human mitochondrial RNase P

C. Fierke, M. Koutmos, Xin Liu, 2019, bioRxiv.

Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP.

C. Fierke, J. Bhat, A. Ramamoorthy, 2015, Biochemistry.

Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases

J. Dixon, C. Fierke, Z. Bao, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5′ processing

C. Fierke, M. Koutmos, Michael J Howard, 2012, Proceedings of the National Academy of Sciences.

Uniform 13C isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II.

C. Fierke, T. Calderone, R. Venters, 1991, Biochemistry.

A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc05771k

Bikash R. Sahoo, Andrea K. Stoddard, T. Ando, 2019, Chemical science.

Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P*

C. Fierke, Bradley P. Klemm, Michael J Howard, 2015, The Journal of Biological Chemistry.

Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.

C. Fierke, S. Nair, D. Christianson, 1992, The Journal of biological chemistry.

Active-site engineering of carbonic anhydrase and its application to biosensors.

C. Fierke, D. Christianson, R. Thompson, 2000, EXS.

Antibacterial Agents That Target Lipid A Biosynthesis in Gram-negative Bacteria

M. Pirrung, C. Fierke, C. Raetz, 2000, The Journal of Biological Chemistry.

Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

C. Brooks, C. Fierke, T. Cierpicki, 2018, Proceedings of the National Academy of Sciences.

Measurement of kinetic isotope effects to probe the reaction mechanism catalyzed by mammalian protein farnesyltransferase

C. Fierke, J. E. Pais, 2007 .

Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase.

C. Fierke, K. Bowers, Carol A Fierke, 2006, Journal of the American Chemical Society.

Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.

P. Casey, C. Fierke, K. Hightower, 2001, Biochemistry.

Selectivity and sensitivity of fluorescence lifetime-based metal ion biosensing using a carbonic anhydrase transducer.

B. Maliwal, C. Fierke, R. Thompson, 1999, Analytical biochemistry.

Cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and antagonist for amylin fibrillation

Bikash R. Sahoo, Andrea K. Stoddard, C. Fierke, 2018, bioRxiv.

Site‐specific mutagenesis of dihydrofolate reductase from Escherichia coli

S. Benkovic, R. Mayer, C. Fierke, 1985, Journal of cellular biochemistry.

Kinetics and thermodynamics of metal‐binding to histone deacetylase 8

Byungchul Kim, C. Fierke, Amit S. Pithadia, 2015, Protein science : a publication of the Protein Society.

Two functional domains of coenzyme A activate catalysis by coenzyme A transferase. Pantetheine and adenosine 3'-phosphate 5'-diphosphate.

W. Jencks, C. Fierke, 1986, The Journal of biological chemistry.

Kinetic and spectroscopic studies of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.

C. Fierke, J. Krebs, R. Dluhy, 1993, Biochemistry.

Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.

C. Fierke, S. Nair, D. Christianson, 1995, Biochemistry.

Ligand concentration regulates the pathways of coupled protein folding and binding.

T. Oas, S. Schmidler, C. Fierke, 2014, Journal of the American Chemical Society.

A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P.

C. Fierke, N. Walter, D. Rueda, 2010, Journal of molecular biology.

The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits.

S. Niranjanakumari, T. Pan, T. Sosnick, 2001, RNA.

HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides

Carol Ann Castañeda, C. Fierke, A. Andrews, 2017, The Journal of Biological Chemistry.

A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation

Bikash R. Sahoo, Andrea K. Stoddard, T. Ando, 2019, Chemical science.

Cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and antagonist for amylin fibrillation

Bikash R. Sahoo, Andrea K. Stoddard, C. Fierke, 2018, bioRxiv.

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer

Carol L. Williams, J. Rosenfeld, G. Getz, 2019, Nature Genetics.

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.

C. Fierke, A. Ramamoorthy, A. Bhunia, 2016, Chemical communications.

In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy.

C. Fierke, J. Brender, A. Ramamoorthy, 2014, The journal of physical chemistry letters.

Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

Bikash R. Sahoo, Andrea K. Stoddard, M. Ivanova, 2018, bioRxiv.

Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.

C. Fierke, D. Christianson, D. Dowling, 2008, Biochemistry.

Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase.

C. Fierke, J. Doyon, D. Christianson, 2002, The Journal of organic chemistry.

Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.

C. Fierke, K. Compher, J. D. Cox, 2000, Biochemistry.

Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design

C. Fierke, D. Christianson, 1996 .

Determination of metal ions by fluorescence anisotropy exhibits a broad dynamic range

Badri P. Maliwal, Richard B. Thompson, Carol A. Fierke, 1998, Photonics West - Biomedical Optics.

Expansion of Protein Farnesyltransferase Specificity Using “Tunable” Active Site Interactions

James L. Hougland, C. Fierke, Soumyashree A. Gangopadhyay, 2012, The Journal of Biological Chemistry.

Binding and cleavage of unstructured RNA by nuclear RNase P.

D. Engelke, C. Fierke, Michael C. Marvin, 2011, RNA.

Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer.

K. Merz, C. Fierke, J. Jackman, 1996, Biochemistry.

NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P

H. Al‐Hashimi, C. Fierke, Anette Casiano-Negroni, 2010, Proceedings of the National Academy of Sciences.

Fibroblasts from long-lived rodent species exclude cadmium.

C. Fierke, Richard A. Miller, J. Penner‐Hahn, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P.

C. Fierke, M. Harris, N. Zahler, 2010, Journal of molecular biology.