J. Naismith

Gunter Schneider, James H. Naismith, Stephen A. McMahon, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis

Lester G. Carter, M. F. White, L. Carter, 2009, Nature chemical biology.

Structure of the DNA Repair Helicase Hel308 Reveals DNA Binding and Autoinhibitory Domains*

Lester G. Carter, M. F. White, L. Carter, 2008, Journal of Biological Chemistry.

Crystal structure and mechanism of a bacterial fluorinating enzyme

J. Naismith, C. Dong, D. O'Hagan, 2004, Nature.

The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

M. Page, J. Naismith, M. Ceccarelli, 2019, Nature Communications.

Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters.

J. Naismith, D. Campopiano, Andrew Piper, 2017, Nature chemical biology.

Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics.

A. Slawin, J. Naismith, N. Westwood, 2018, Organic & biomolecular chemistry.

Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations

Yuquan Wei, J. Naismith, Ting Yang, 2019, Nature Communications.

Molecular engineering of a backwards-moving myosin motor

J. Naismith, D. O'Hagan, H. Deng, 2022 .

Catalytic flexibility of rice glycosyltransferase OsUGT91C1 for the production of palatable steviol glycosides

Jie Zhou, Yuquan Wei, Wei Cheng, 2021, Nature Communications.

Purification, crystallization and preliminary crystallographic analysis of WsaF, an essential rhamnosyltransferase from Geobacillus stearothermophilus.

J. Naismith, K. Steiner, C. Schäffer, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Production and Crystallization of Nanobodies in Complex with the Receptor Binding Domain of the SARS-CoV-2 Spike Protein.

R. Owens, J. Naismith, H. Mikolajek, 2022, Bio-protocol.

Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2

R. Owens, J. Naismith, Qi Tang, 2021, Viruses.

Structure–function studies of the C3/C5 epimerases and C4 reductases of the Campylobacter jejuni capsular heptose modification pathways

J. Naismith, C. Creuzenet, L. Woodward, 2021, The Journal of biological chemistry.

Uncovering the chemistry of C–C bond formation in C-nucleoside biosynthesis: crystal structure of a C-glycoside synthase/PRPP complex

V. de Crécy-Lagard, J. Naismith, N. Richards, 2020, Chemical communications.

Corrigendum: Pac13 is a Small Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

J. Naismith, C. Chung, W. Leavens, 2020, Angewandte Chemie.

The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility

Z. Deng, J. Naismith, Yi-Zun Yu, 2020, Angewandte Chemie.

Berichtigung: Pac13 is a Small Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins

J. Naismith, C. Chung, W. Leavens, 2020, Angewandte Chemie.

Structure of the ForT/PRPP complex uncovers the mechanism of C-C bond formation in C-nucleotide antibiotic biosynthesis

V. de Crécy-Lagard, J. Naismith, N. Richards, 2020, bioRxiv.

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments

J. Naismith, R. Elliott, D. Bhella, 2017, eLife.

Structure of the archaeal Cascade subunit Csa5

M. F. White, J. Naismith, Huanting Liu, 2013, RNA biology.

A Dimeric Rep Protein Initiates Replication of a Linear Archaeal Virus Genome: Implications for the Rep Mechanism and Viral Replication

M. F. White, R. Garrett, J. Naismith, 2010, Journal of Virology.

Enzymatic Macrocyclization of 1,2,3‐Triazole Peptide Mimetics

J. Naismith, N. Westwood, M. Jaspars, 2016, Angewandte Chemie.

Tumor necrosis factor receptor superfamily.

S. Sprang, J. Naismith, 1995, Journal of inflammation.

On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A

E. Toone, J. Naismith, S. McMahon, 1999 .

Initiating a structural study of 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.

S. Niranjanakumari, E. Toone, J. Naismith, 1999, Acta crystallographica. Section D, Biological crystallography.

Initiating a crystallographic study of a class II fructose-1,6-bisphosphate aldolase.

W. Hunter, Z. Dauter, J. Naismith, 1992, Journal of molecular biology.

Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.

J. Errey, C. Whitfield, J. Naismith, 2009, Organic & biomolecular chemistry.

Pivotal Roles of the Outer Membrane Polysaccharide Export and Polysaccharide Copolymerase Protein Families in Export of Extracellular Polysaccharides in Gram-Negative Bacteria

C. Whitfield, J. Naismith, Iain L Mainprize, 2009, Microbiology and Molecular Biology Reviews.

The open structure of MscS

J. Naismith, K. Johnson, W. Wang, 2008 .

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries† †Electronic supplementary information (ESI) available: Details of the ketone and amine components of the thiogalactoside library. See DOI: 10.1039/c0ob008

J. Naismith, R. Field, T. Lowary, 2011, Organic & biomolecular chemistry.

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes

R. Owens, M. Vendruscolo, D. Clare, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Cryptic SARS-CoV2-spike-with-sugar interactions revealed by 'universal' saturation transfer analysis — Source link

Panagiotis I. Koukos, R. Owens, Q. Sattentau, 2022 .

Structure and function of the PiuA and PirA siderophore-drug 2 receptors from 3 Pseudomonas aeruginosa and Acinetobacter baumannii

M. Page, J. Naismith, D. Rolo, 2016 .

The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli

C. Whitfield, J. Naismith, C. Botting, 2007, Proceedings of the National Academy of Sciences.

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase.

K. Gable, T. Dunn, J. Naismith, 2019, Journal of lipid research.

Crystallization and preliminary crystallographic analysis of the bacterial capsule assembly-regulating tyrosine phosphatases Wzb of Escherichia coli and Cps4B of Streptococcus pneumoniae

C. Whitfield, J. Naismith, G. Hagelueken, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Cryo-plasma FIB/SEM volume imaging of biological specimens

D. Clare, J. Naismith, J. Plitzko, 2022, bioRxiv.

A flavin-dependent tryptophan 6-halogenase and its use in modification of pyrrolnitrin biosynthesis

J. Naismith, C. Dong, K. van Pée, 2006 .

Bypassing the proline/thiazoline requirement of the macrocyclase PatG† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc06550g

J. Naismith, N. Westwood, M. Jaspars, 2017, Chemical communications.

Identification of Conserved Residues Contributing to the Activities of Adenovirus DNA Polymerase

J. Naismith, R. Hay, H. Liu, 2000, Journal of Virology.

Adenovirus DNA replication.

J. Naismith, R. Hay, H. Liu, 2003, Current topics in microbiology and immunology.

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates.

J. Naismith, D. Robinson, D. O'Hagan, 2006, Organic & biomolecular chemistry.

MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca2 + Ion Bound at the Constriction Zone

J. Naismith, M. Winterhalter, J. Pagés, 2016, Journal of molecular biology.

The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory

Chris Morris, Bill Lin, Kim Henrick, 2011, Acta crystallographica. Section D, Biological crystallography.

Plasma FIB milling for the determination of structures in situ

J. Naismith, J. Mitchels, M. Grange, 2022, bioRxiv.

The purification, crystallization and preliminary structural characterization of glucose-1-phosphate thymidylyltransferase (RmlA), the first enzyme of the dTDP-L-rhamnose synthesis pathway from Pseudomonas aeruginosa.

J. Naismith, G. Leonard, W. Blankenfeldt, 2000, Acta crystallographica. Section D, Biological crystallography.

Two-step purification of outer membrane proteins.

C. Whitfield, J. Naismith, I. Booth, 2006, International journal of biological macromolecules.

Concanavalin A distorts the b -GlcNAc-(1 (cid:1) 2)-Man linkage of b -GlcNAc-(1 (cid:1) 2)- a -Man-(1 (cid:1) 3)-[ b -GlcNAc-(1 (cid:1) 2)- a -Man-(1 (cid:1) 6)]-Man upon binding

J. Naismith, D. N. Moothoo, 1998 .

Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway.

C. Walsh, A. B. Merkel, J. Naismith, 2002, Acta crystallographica. Section D, Biological crystallography.

The purification, crystallization and structural elucidation of dTDP-D-glucose 4,6-dehydratase (RmlB), the second enzyme of the dTDP-L-rhamnose synthesis pathway from Salmonella enterica serovar typhimurium.

C. Whitfield, J. Naismith, M. Giraud, 2000, Acta crystallographica. Section D, Biological crystallography.

Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium.

C. Whitfield, J. Naismith, G. Leonard, 1999, Acta crystallographica. Section D, Biological crystallography.

Purification, crystallization and preliminary structural studies of dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC), the third enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar typhimurium.

C. Whitfield, J. Naismith, M. Giraud, 1999, Acta crystallographica. Section D, Biological crystallography.

A general method for co-crystallization of concanavalin A with carbohydrates.

J. Naismith, D. N. Moothoo, 1999, Acta crystallographica. Section D, Biological crystallography.

A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose.

L. Major, C. Whitfield, J. Naismith, 2003, Biochemical Society transactions.

Mechanism of enzymatic fluorination in Streptomyces cattleya.

Xiaofeng Zhu, J. Naismith, D. Robinson, 2007, Journal of the American Chemical Society.

The fluorinase from Streptomyces cattleya is also a chlorinase.

J. Naismith, D. Robinson, D. O'Hagan, 2005, Angewandte Chemie.

Chemical synthesis of UDP-Glc-2,3-diNAcA, a key intermediate in cell surface polysaccharide biosynthesis in the human respiratory pathogens B. pertussis and P. aeruginosa.

D. Maskell, J. Naismith, M. Rejžek, 2009, Organic & biomolecular chemistry.

Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme.

J. Naismith, D. O'Hagan, S. McMahon, 2016, Bioorganic chemistry.

Structural and mechanistic basis of bacterial sugar nucleotide-modifying enzymes.

J. Naismith, R. Field, 2003, Biochemistry.

Bacterial polysaccharide synthesis and export.

J. Naismith, L. Woodward, 2016, Current opinion in structural biology.

Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30.

C. Whitfield, J. Naismith, K. Beis, 2004, Acta crystallographica. Section D, Biological crystallography.

Epimerases: structure, function and mechanism

J. Naismith, M. Giraud, S. Allard, 2001, Cellular and Molecular Life Sciences CMLS.

Trapped translocation intermediates establish the route for export of capsular polysaccharides across Escherichia coli outer membranes

C. Whitfield, J. Naismith, Iain L Mainprize, 2014, Proceedings of the National Academy of Sciences.

Chemical insights from structural studies of enzymes.

J. Naismith, 2004, Biochemical Society transactions.

Potentiometric analysis of UDP-galactopyranose mutase: stabilization of the flavosemiquinone by substrate.

C. Whitfield, Stephen W B Fullerton, J. Naismith, 2003, Biochemistry.

Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis.

J. Naismith, K. van Pée, E. P. Patallo, 2011, Angewandte Chemie.

Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-α-2,3-Gal-β-O-PNP☆

J. Naismith, R. Field, S. Schenkman, 2001 .

Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation

D. Clare, J. Naismith, E. Brignole, 2022, Frontiers in Molecular Biosciences.

Crystallization and X-ray diffraction of 5'-fluoro-5'-deoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya.

J. Naismith, C. Dong, D. O'Hagan, 2003, Acta crystallographica. Section D, Biological crystallography.

Review Epimerases: structure, function and mechanism

J. Naismith, S. Allard, 2001 .

Halogenation and Dehalogenation

J. Naismith, E. P. Patallo, K. Pée, 2016 .

Overexpression, purification, crystallization and data collection of 3-methylaspartase from Clostridium tetanomorphum.

J. Naismith, W. Blankenfeldt, J. Pollard, 2001, Acta crystallographica. Section D, Biological crystallography.

The rhamnose pathway.

J. Naismith, M. Giraud, 2000, Current opinion in structural biology.

The structure of NADH in the enzyme dTDP-d-glucose dehydratase (RmlB).

D. Philp, J. Naismith, G. Murshudov, 2003, Journal of the American Chemical Society.

Biological Fluorination in Streptomyces cattleya : The Fluorinase

Xiaofeng Zhu, J. Naismith, D. O'Hagan, 2008 .

Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides

C. Whitfield, J. Naismith, S. McMahon, 2018, Proceedings of the National Academy of Sciences.

An Enzymatic Route to Selenazolines

J. Naismith, S. Shirran, C. Botting, 2013, Chembiochem : a European journal of chemical biology.

The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily.

Kenneth A Johnson, James H Naismith, Robert S Phillips, 2007, Biochemistry.

Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.

J. Naismith, C. Dong, M. McNeil, 2003, Bioorganic & medicinal chemistry letters.

Mechanisms of cyanobactin biosynthesis.

J. Naismith, Y. Ge, C. Czekster, 2016, Current opinion in chemical biology.

RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.

J. Errey, L. Major, C. Whitfield, 2007, Journal of molecular biology.

The chemical nature of amavadin

J. Naismith, J. Charnock, D. Collison, 1993 .

Unusual chromophore and cross-links in ranasmurfin: a blue protein from the foam nests of a tropical frog.

Lester G. Carter, M. F. White, L. Carter, 2008, Angewandte Chemie.

Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.

E. Toone, N. Wymer, C. Fierke, 2001, Structure.

Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa

M. Page, J. Naismith, M. Ceccarelli, 2019, BioMetals.

Structural Basis of Trimannoside Recognition by Concanavalin A (*)

J. Naismith, R. Field, J H Naismith, 1996, The Journal of Biological Chemistry.

The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway.

C. Whitfield, J. Naismith, M. Giraud, 2001, Journal of molecular biology.

The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.

Geoffrey J Barton, Kenneth A Johnson, Lester G. Carter, 2007, Journal of molecular biology.

The Respiratory Arsenite Oxidase: Structure and the Role of Residues Surrounding the Rieske Cluster

Joanne M. Santini, James H. Naismith, Konstantinos Thalassinos, 2013, PloS one.

Accurate quantification of modified cyclic peptides without the need for authentic standards.

J. Naismith, M. Jaspars, A. Raab, 2016, Tetrahedron.

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Spectator no more, the role of the membrane in regulating ion channel function.

J. Naismith, C. Pliotas, 2017, Current opinion in structural biology.

Halomethane biosynthesis: structure of a SAM-dependent halide methyltransferase from Arabidopsis thaliana.

J. Naismith, R. Edwards, D. O'Hagan, 2010, Angewandte Chemie.

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway.

J. Naismith, A. Bent, E. Rizzi, 2016, Angewandte Chemie.

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.

Lester G. Carter, L. Carter, J. Naismith, 2010, Molecular bioSystems.

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

J. Naismith, M. Winterhalter, J. Pagés, 2019, Nature Reviews Microbiology.

NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond.

J. Naismith, R. Hagan, M. Bühl, 2010, Angewandte Chemie.

A Novel Outer Membrane Protein, Wzi, Is Involved in Surface Assembly of the Escherichia coli K30 Group 1 Capsule

C. Whitfield, J. Naismith, Andrea Rahn, 2003, Journal of bacteriology.

A simple and efficient expression and purification system using two newly constructed vectors.

J. Naismith, Huanting Liu, 2009, Protein expression and purification.

The structural basis of the catalytic mechanism and regulation of glucose‐1‐phosphate thymidylyltransferase (RmlA)

J. Naismith, W. Blankenfeldt, J. Lam, 2000, The EMBO journal.

Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a

C. Whitfield, J. Naismith, B. R. Clarke, 2012, Molecular microbiology.

TNFα and the TNF receptor superfamily: Structure‐function relationship(s)

J. Naismith, H. Idriss, 2000, Microscopy research and technique.

Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD

Wael E Houssen, J. Naismith, A. Bent, 2016, Acta crystallographica. Section D, Structural biology.

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

Wael E Houssen, J. Naismith, S. Shirran, 2015, Nature chemical biology.

Bioactive Mechanism of Interaction Between Anthocyanins and Macromolecules Like DNA and Proteins

J. Naismith, N. Motohashi, Seetharamappa Jaldappagari, 2008 .

Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site.

L. Major, J. Naismith, B. Wolucka, 2005, Journal of the American Chemical Society.

Biological halogenation has moved far beyond haloperoxidases.

J. Naismith, C. Dong, K. van Pée, 2006, Advances in applied microbiology.

A multidisciplinary approach to probing enthalpy-entropy compensation and the interfacial mobility model.

E. Toone, J. Naismith, C. Hadad, 2011, Journal of the American Chemical Society.

UDP-galactopyranose mutase has a novel structure and mechanism

C. Whitfield, J. Naismith, D. Sanders, 2001, Nature Structural Biology.

The 1.2 A resolution structure of the Con A-dimannose complex.

J R Helliwell, A. Howard, J. Naismith, 2001, Journal of molecular biology.

Man α1-2 Man α-OMe-concanavalin A complex reveals a balance of forces involved in carbohydrate recognition

J. Naismith, R. Field, D. N. Moothoo, 1999 .

Erratum: Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

K. Gable, T. Dunn, J. Naismith, 2019, Journal of Lipid Research.

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

K. Gable, T. Dunn, J. Naismith, 2019 .

Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens.

James H Naismith, J. Naismith, N. Botting, 2007, Journal of molecular biology.

Structural aspects of non-ribosomal peptide biosynthesis.

James H Naismith, Gregory L Challis, G. Challis, 2004, Current opinion in structural biology.

Man alpha1-2 Man alpha-OMe-concanavalin A complex reveals a balance of forces involved in carbohydrate recognition.

J. Naismith, R. Field, D. N. Moothoo, 1999, Glycobiology.

MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL

James H. Naismith, Gregor Hagelueken, Richard Ward, 2012, Applied Magnetic Resonance.

Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode.

Gordon Leonard, James H Naismith, Iain D Kerr, 2002, Structure.

The molecular basis of regulation of bacterial capsule assembly by Wzc

C. Robinson, Peijun Zhang, C. Whitfield, 2021, Nature Communications.

PMP–diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9cc06975e

V. de Crécy-Lagard, J. Naismith, N. Richards, 2019, Chemical communications.

PELDOR spectroscopy distance fingerprinting of the octameric outer-membrane protein Wza from Escherichia coli.

Gregor Hagelueken, Olav Schiemann, James H Naismith, 2009, Angewandte Chemie.

Sparse Labeling PELDOR Spectroscopy on Multimeric Mechanosensitive Membrane Channels

J. Naismith, C. Pliotas, B. Bode, 2017, Biophysical journal.

Accurate Extraction of Nanometer Distances in Multimers by Pulse EPR

J. Naismith, C. Pliotas, B. Bode, 2016, Chemistry.

PELDOR in rotationally symmetric homo-oligomers

James H. Naismith, Richard Ward, Emma Branigan, 2013, Molecular physics.

Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR

M. F. White, J. Naismith, O. Schiemann, 2015, Nucleic acids research.

Enzymatic methylation of the amide bond.

J. Naismith, Haigang Song, 2020, Current opinion in structural biology.

Oxidation of the Cyanobactin Precursor Peptide Is Independent of the Leader Peptide and Operates in a Defined Order.

J. Naismith, A. Bent, Y. Ge, 2018, Biochemistry.

A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus

Lester G. Carter, L. Carter, Xiaofeng Zhu, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

J. Naismith, C. Botting, Lijuan Chen, 2016, Nature Communications.

The Scottish Structural Proteomics Facility: targets, methods and outputs

Geoffrey J. Barton, Xu Peng, James H. Naismith, 2010, Journal of Structural and Functional Genomics.

Mark DorwardMichal ZawadzkiChristopher CozensHelen FalconerHelen Powers • Ian M. OvertonC. A. Johannes van NiekerkXu PengPrakash PatelRoger A. Garrett • David PrangishviliCatherine H. BottingPeter J. CooteDavid T. F. DrydenGeoffrey J. Barton • Ulrich Schwarz-LinekGregory L. ChallisGarry L. TaylorMal

James H. Naismith, J. Naismith, 2010 .

The structural basis of chain length control in Rv1086.

J. Naismith, Wenjian Wang, C. Dong, 2008, Journal of molecular biology.

CRISPR interference: a structural perspective

James H. Naismith, Malcolm F. White, M. F. White, 2013, The Biochemical journal.

Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.

Jing Zhang, Kim Brugger, Shirley Graham, 2012, Molecular cell.

Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)*

M. F. White, J. Naismith, M. Young, 2011, The Journal of Biological Chemistry.

Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates

J. Naismith, A. Bent, H. Ludewig, 2018, ACS chemical biology.

Tumor Necrosis Factor (TNF)

J. Naismith, H. Idriss, 2002 .

The Position of a Key Tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) Alters the Substrate Profile for This RmlC-like Enzyme*

C. Walsh, J. Errey, L. Major, 2004, Journal of Biological Chemistry.

The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.

James H Naismith, J. Naismith, R. Hay, 2006, The Biochemical journal.

The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family.

J. Naismith, A. J. Bennet, M. Moore, 2017, The international journal of biochemistry & cell biology.

The role of polar interactions in the molecular recognition of CD40L with its receptor CD40

Juswinder Singh, Juswinder Singh, J. Naismith, 1998, Protein science : a publication of the Protein Society.

Adenylate-forming enzymes.

J. Naismith, S. Schmelz, 2009, Current opinion in structural biology.

The External Aldimine Form of Serine Palmitoyltransferase

Lester G. Carter, L. Carter, J. Naismith, 2009, The Journal of Biological Chemistry.

Structures of the extracellular domain of the type I tumor necrosis factor receptor.

S R Sprang, S. Sprang, T. Kohno, 1996, Structure.

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9*

M. Tatham, J. Naismith, R. Hay, 2001, The Journal of Biological Chemistry.

Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance

John H. White, Lester G. Carter, L. Carter, 2009, Nucleic acids research.

Seeing double: Crystal structures of the type I TNF receptor

S. Sprang, J. Naismith, B. Brandhuber, 1996, Journal of molecular recognition : JMR.

Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales

M. F. White, E. Koonin, K. Makarova, 2011, Proceedings of the National Academy of Sciences.

The role of lipids in mechanosensation

Terry K. Smith, Mark S. P. Sansom, Ian R. Booth, 2015, Nature Structural &Molecular Biology.

A coiled-coil domain acts as a molecular ruler in LPS chain length regulation

D. Svergun, C. Whitfield, J. Naismith, 2014, Nature Structural &Molecular Biology.

Three-dimensional Structure of Wza, the Protein Required for Translocation of Group 1 Capsular Polysaccharide across the Outer Membrane of Escherichia coli*

C. Whitfield, J. Naismith, K. Beis, 2004, Journal of Biological Chemistry.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

TarO: a target optimisation system for structural biology

Geoffrey J. Barton, Lester G. Carter, David M. A. Martin, 2008, Nucleic Acids Res..

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Jordan J. Clark, R. Owens, J. Stewart, 2021, Nature Communications.

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

E. Pardon, J. Steyaert, J. Naismith, 2021, Nature Methods.

Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins.

M. Page, J. Naismith, M. Winterhalter, 2018, ACS infectious diseases.

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1

James H Naismith, J. Naismith, D. Xirodimas, 2005, The EMBO journal.

Periplasmic Protein-Protein Contacts in the Inner Membrane Protein Wzc Form a Tetrameric Complex Required for the Assembly of Escherichia coli Group 1 Capsules*

C. Whitfield, J. Naismith, K. Beis, 2006, Journal of Biological Chemistry.

A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions.

Jan Passchier, Sharon Ashworth, David O'Hagan, 2014, Angewandte Chemie.

The crystal structure of a class II fructose-1,6-bisphosphate aldolase shows a novel binuclear metal-binding active site embedded in a familiar fold.

W. Hunter, J. Naismith, G. Leonard, 1996, Structure.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

R. Owens, D. Stuart, G. Screaton, 2020, Nature Structural & Molecular Biology.

Wzi Is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia coli

C. Whitfield, J. Naismith, M. Wear, 2013, Structure.

Crystal structure of the tyrosine phosphatase Cps4B from Steptococcus pneumoniae TIGR4 in complex with phosphate.

J. Naismith, G. Hagelueken, Hexian Huang, 2009 .

Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii

M. Page, J. Naismith, M. Ceccarelli, 2018, eLife.

TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates

D. Bumann, J. Naismith, T. Köhler, 2018, Antimicrobial Agents and Chemotherapy.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

J. Naismith, M. Winterhalter, J. Pagés, 2019, Nature Reviews Microbiology.

Structure of the archaeal Cascade subunit Csa 5 Relating the small subunits of CRISPR effector complexes

M. F. White, J. Naismith, Huanting Liu, 2013 .

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

T. Dunn, J. Naismith, P. Langridge-Smith, 2013, Journal of the American Chemical Society.

Structural, mechanistic and regulatory studies of serine palmitoyltransferase.

T. Dunn, J. Naismith, D. Campopiano, 2012, Biochemical Society transactions.

The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein.

J. Naismith, D. Campopiano, D. Clarke, 2010, Biopolymers.

The structural biology of patellamide biosynthesis.

Wael E Houssen, J. Naismith, A. Bent, 2014, Current opinion in structural biology.

Structure of PatF from Prochloron didemni

Wael E Houssen, J. Naismith, A. Bent, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Modularity in the TNF-receptor family.

S R Sprang, S. Sprang, J. Naismith, 1998, Trends in biochemical sciences.

The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 protein

R. Owens, J. Naismith, W. James, 2021, Royal Society Open Science.

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

Wael E Houssen, J. Naismith, J. Vendôme, 2012, Nature Structural &Molecular Biology.

Single Cell Cryo-Soft X-ray Tomography Shows That Each Chlamydia Trachomatis Inclusion Is a Unique Community of Bacteria

J. Naismith, I. Kounatidis, M. Harkiolaki, 2021, Life.

Inferring the chemical mechanism from structures of enzymes.

J. Naismith, 2006, Chemical Society reviews.

Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein

James H Naismith, M. F. White, Iain D Kerr, 2003, The EMBO journal.

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC

G. Challis, J. Naismith, S. McMahon, 2018, Philosophical Transactions of the Royal Society B: Biological Sciences.

Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase.

C. M. Thomson, J. Naismith, Y. Ge, 2017, Biochemistry.

Unraveling the Specific Regulation of the Central Pathway for Anaerobic Degradation of 3-Methylbenzoate

C. Eberlein, E. Díaz, J. Naismith, 2015, The Journal of Biological Chemistry.

Unraveling the Specific Regulation of the mbd Central Pathway for the Anaerobic Degradation of 3-methylbenzoate *

C. Eberlein, E. Díaz, J. Naismith, 2015 .

Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa.

R. Brenk, J. Naismith, S. McMahon, 2013, Journal of molecular biology.

Salt Bridges Regulate Both Dimer Formation and Monomeric Flexibility in HdeB and May Have a Role in Periplasmic Chaperone Function

J. Naismith, I. Booth, T. Rasmussen, 2012, Journal of molecular biology.

Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity.

Lester G. Carter, M. F. White, L. Carter, 2009, Journal of molecular biology.

Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase.

Lester G. Carter, M. F. White, G. Barton, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase.

Lester G. Carter, M. F. White, G. Barton, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Iain Donald Campbell. 24 April 1941—5 March 2014

J. Naismith, 2021, BIOGRAPHICAL MEMOIRS OF FELLOWS OF THE ROYAL SOCIETY.

The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

Wael E Houssen, J. Naismith, A. Bent, 2014, Acta crystallographica. Section F, Structural biology communications.

Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.

D. Maskell, J. Naismith, R. Field, 2001, Acta crystallographica. Section D, Biological crystallography.

Engineering Thermostability in Artificial Metalloenzymes to Increase Catalytic Activity

D. Janssen, J. Naismith, H. Rozeboom, 2021 .

Catalytic and Anticatalytic Snapshots of a Short-Form ATP Phosphoribosyltransferase

J. Naismith, Y. Ge, Huanting Liu, 2018 .

Structure and Function of Both Domains of ArnA, a Dual Function Decarboxylase and a Formyltransferase, Involved in 4-Amino-4-deoxy-L-arabinose Biosynthesis*

J. Naismith, C. Raetz, Gareth J. Williams, 2005, Journal of Biological Chemistry.

Trypanosoma cruzi trypanothione reductase. Crystallization, unit cell dimensions and structure solution.

A. Fairlamb, C. Bond, J. Naismith, 1993, Journal of molecular biology.

Mechanism of DNA loading by the DNA repair helicase XPD

M. F. White, J. Naismith, J. Penedo, 2016, Nucleic acids research.

New insights into the mechanism of enzymatic chlorination of tryptophan.

Xiaofeng Zhu, G. Seifert, J. Naismith, 2008, Angewandte Chemie.

Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli*

M. Page, J. Naismith, M. Winterhalter, 2015, The Journal of Biological Chemistry.

Altered Antibiotic Transport in OmpC Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. coli

H. Bayley, J. Naismith, I. Booth, 2011, PloS one.

Structural insights into regioselectivity in the enzymatic chlorination of tryptophan.

Xiaofeng Zhu, J. Naismith, K. van Pée, 2009, Journal of molecular biology.

The Ternary Complex of PrnB (the Second Enzyme in the Pyrrolnitrin Biosynthesis Pathway), Tryptophan, and Cyanide Yields New Mechanistic Insights into the Indolamine Dioxygenase Superfamily*

Xiaofeng Zhu, J. Naismith, K. van Pée, 2010, The Journal of Biological Chemistry.

The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction**

Greg Mann, Sally Shirran, Xiaofeng Zhu, 2013, Angewandte Chemie.

Mechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf‐62)

B. Moore, J. Naismith, D. O'Hagan, 2009, Chembiochem : a European journal of chemical biology.

Enhanced imaging of lipid rich nanoparticles embedded in methylcellulose films for transmission electron microscopy using mixtures of heavy metals

J. Naismith, J. Lucocq, Christian Hacker, 2017, Micron.

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA

David W. Gray, G. Schneider, J. Naismith, 2016, Journal of molecular biology.

The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides

J. Naismith, J. Vendôme, M. Jaspars, 2012, Chembiochem : a European journal of chemical biology.

Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-acyl-ACP Reductase from Pseudomonas aeruginosa

David W. Gray, G. Schneider, Y. Lindqvist, 2013, ACS chemical biology.

Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state.

C. Whitfield, Stephen W B Fullerton, J. Naismith, 2005, Journal of molecular biology.

Structure of ubiquitin-conjugating enzyme 9 displays significant differences with other ubiquitin-conjugating enzymes which may reflect its specificity for sumo rather than ubiquitin.

J. Naismith, M. Giraud, J H Naismith, 1998, Acta crystallographica. Section D, Biological crystallography.

Molecular insight into the enzymatic macrocyclization of multiply backbone N-methylated peptides

M. Künzler, J. Naismith, Emmanuel Matabaro, 2023, bioRxiv.

Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme

J. Naismith, C. Botting, Y. Ge, 2019, Biochemistry.

Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization

J. Naismith, N. Westwood, Brunello Nardone, 2016, ChemistryOpen.

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides**

Wael E Houssen, J. Naismith, A. Bent, 2014, Angewandte Chemie.

RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase

J. Naismith, G. Leonard, R. Field, 2000, Nature Structural Biology.

Mechanism of ubiquitylation by dimeric RING ligase RNF4

J. Naismith, R. Hay, I. Navratilova, 2011, Nature Structural &Molecular Biology.

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

R. Owens, Q. Sattentau, J. Naismith, 2021, bioRxiv.

Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.

James H Naismith, J. Naismith, I. Booth, 2012, Annual review of biophysics.

Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

J. Naismith, R. Hay, E. Jaffray, 2015, Nature Structural &Molecular Biology.

Crystallographic Evidence for Dimerization of Unliganded Tumor Necrosis Factor Receptor (*)

S R Sprang, S. Sprang, J. Naismith, 1995, The Journal of Biological Chemistry.

Concanavalin A distorts the -GlcNAc-(1->2)-Man linkage of -GlcNAc-(1->2)- -Man-(1->3)-[ -GlcNAc-(1->2)- -Man-(1->6)]-Man upon binding

J. Naismith, J H Naismith, D N Moothoo, 1998, Glycobiology.

Concanavalin A distorts the β-GlcNAc-(12)-Man linkage of β-GlcNAc-(12)-α-Man-(13)-(β-GlcNAc-(12)-α-Man-(16))-Man upon binding

J. Naismith, D. N. Moothoo, 1998 .

The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex

C. Whitfield, J. Naismith, D. Bhella, 2023, Open Biology.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Parakeet: a digital twin software pipeline to assess the impact of experimental parameters on tomographic reconstructions for cryo-electron tomography

A. Kirkland, D. Clare, J. Naismith, 2021, Open Biology.

The Structure of 3-Methylaspartase from Clostridium tetanomorphum Functions via the Common Enolase Chemical Step*

James H Naismith, J. Naismith, W. Blankenfeldt, 2002, The Journal of Biological Chemistry.

Membrane integrity — direct turbidity measurement of filtrate from MF membrane modules at an operating potable water treatment plant

James H. Naismith, J. Naismith, 2005 .

The Structure of an Open Form of an E. coli Mechanosensitive Channel at 3.45 Å Resolution

J. Naismith, I. Booth, Wenjian Wang, 2008, Science.

Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase

J. Stewart, J. Naismith, N. Richards, 2023, Open Biology.

A coiled-coil domain acts as a molecular ruler in LPS chain length regulation

D. Svergun, C. Whitfield, J. Naismith, 2014, Nature structural & molecular biology.

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme.

D. Maskell, L. Major, J. Naismith, 2003, Structure.

Characterization and crystal structure of Escherichia coli KDPGal aldolase.

E. Toone, C. Fierke, J. Naismith, 2008, Bioorganic & medicinal chemistry.

Tryptophan oxygenation: mechanistic considerations.

J. Naismith, 2012, Biochemical Society transactions.

Toward a structural understanding of the dehydratase mechanism.

D. Maskell, C. Whitfield, J. Naismith, 2002, Structure.

Crystal Structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly

C. Whitfield, J. Naismith, G. Hagelueken, 2009, Journal of molecular biology.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

Q. Sattentau, J. Naismith, A. Baldwin, 2023, bioRxiv.

Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′‐Deoxy Nucleoside of Pacidamycins

J. Naismith, C. Chung, A. Bent, 2017 .

Short and Sweet: Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3′- Deoxy Nucleoside of Pacidamycins.

J. Naismith, C. Chung, A. Bent, 2017 .

MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL

J. Naismith, O. Schiemann, R. Ward, 2012, Applied magnetic resonance.

Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure.

J R Helliwell, W N Hunter, W. Hunter, 1994, Acta crystallographica. Section D, Biological crystallography.

Structural Basis of Substrate Binding in WsaF, a Rhamnosyltransferase from Geobacillus stearothermophilus

J. Naismith, P. Messner, K. Steiner, 2010, Journal of molecular biology.

Translocation of Group 1 Capsular Polysaccharide in Escherichia coli Serotype K30

G. Harauz, C. Whitfield, J. Naismith, 2003, Journal of Biological Chemistry.

Quantification of free cysteines in membrane and soluble proteins using a fluorescent dye and thermal unfolding

J. Naismith, C. Pliotas, E. Branigan, 2013, Nature Protocols.

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.

Mahavir Singh, R. Brenk, J. Naismith, 2013, ACS chemical biology.

Novel Inhibitors of an Emerging Target in Mycobacterium tuberculosis; Substituted Thiazolidinones as Inhibitors of dTDP‐Rhamnose Synthesis.

J. Naismith, C. Dong, M. McNeil, 2003 .

SUMO protease SENP1 induces isomerization of the scissile peptide bond

James H Naismith, M. Tatham, J. Naismith, 2006, Nature Structural &Molecular Biology.

CCP4 NEWSLETTER ON PROTEIN CRYSTALLOGRAPHY An informal Newsletter associated with the BBSRC Collaborative Computational Project No. 4 on Protein Crystallography.

Kevin Cowtan, James H. Naismith, P J Briggs, 2000 .

Chapter 11 Bacterial Membrane Proteins: The New Soluble Proteins?

J. Naismith, K. Beis, Hubing Lou, 2009 .

Hydrolase and sialyltransferase activities of trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-gal-Gal-beta-O-PNP.

J. Naismith, R. Field, S. Schenkman, 2001, Bioorganic & Medicinal Chemistry Letters.

Studies on amavadin and related chemical systems.

J. Naismith, J. Charnock, D. Collison, 1991 .

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

J. Naismith, J. Benesch, I. Booth, 2017, Biochemistry.

The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac.

J. Naismith, P. Fernandes, M. Ramos, 2016, Chemistry.

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

J. Naismith, Huanting Liu, 2008, BMC biotechnology.

Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design

Karl G. Kempf, J. Naismith, N. Westwood, 2021, Bioorganic & medicinal chemistry.

Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens.

J. Naismith, A. Kotzsch, C. Dong, 2004, Acta crystallographica. Section D, Biological crystallography.

Hijacking of the Enterobactin Pathway by a Synthetic Catechol Vector Designed for Oxazolidinone Antibiotic Delivery in Pseudomonas aeruginosa.

J. Naismith, M. Ceccarelli, I. Schalk, 2022, ACS infectious diseases.

A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa.

J. Naismith, Y. Mély, J. Godet, 2018, ACS chemical biology.

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

J. Naismith, Huanting Liu, 2008, BMC biotechnology.

Structural Basis for Acyl Acceptor Specificity in the Achromobactin Biosynthetic Enzyme AcsD

G. Challis, J. Naismith, C. Botting, 2011, Journal of molecular biology.

REFINED STRUCTURE OF CONCANAVALIN A COMPLEXED WITH ALPHA-METHYL-D-MANNOPYRANOSIDE AT 2.0 ANGSTROMS RESOLUTION AND COMPARISON WITH THE SACCHARIDE-FREE STRUCTURE

W. Hunter, J. Naismith, J. Helliwell, 1994 .

The Scottish Structural Proteomics Facility: targets, methods and outputs

Lester G. Carter, Md. Arif Sheikh, M. F. White, 2010, Journal of Structural and Functional Genomics.

Non-pharmaceutical interventions for COVID-19: a systematic review on environmental control measures

J. Naismith, M. Cevik, S. Fitzgerald, 2023, Philosophical Transactions of the Royal Society A.

Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.

M. F. White, J. Naismith, Jing Zhang, 2012, Molecular cell.

High-resolution structures of single-metal-substituted concanavalin A: the Co,Ca-protein at 1.6 A and the Ni,Ca-protein at 2.0 A.

J R Helliwell, K S Wilson, Z Dauter, 1994, Acta crystallographica. Section D, Biological crystallography.

THE CRYSTAL STRUCTURE OF DTDP-D-GLUCOSE 4,6-DEHYDRATASE (RMLB)FROM SALMONELLA ENTERICA SEROVAR TYPHIMURIUM

C. Whitfield, J. Naismith, M. Giraud, 2001 .

Crystal structure of a single stranded DNA binding protein

J. Naismith, I. Kerr, 2003 .

Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria.

J. Errey, J. Naismith, S. Fairhurst, 2009, Organic and biomolecular chemistry.

Mechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf‐62)

B. Moore, J. Naismith, D. O'Hagan, 2009, Chembiochem : a European journal of chemical biology.

Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments

J. Naismith, R. Elliott, D. Bhella, 2017, eLife.

Tryptophan oxygenation: mechanistic considerations.

J. Naismith, 2012, Biochemical Society transactions.

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

T. Dunn, J. Naismith, P. Langridge-Smith, 2013, Journal of the American Chemical Society.

Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase[S]

K. Gable, T. Dunn, J. Naismith, 2019, Journal of Lipid Research.

Pathogen-sugar interactions revealed by universal saturation transfer analysis

Panagiotis I. Koukos, R. Owens, Q. Sattentau, 2022, Science.

University of Dundee Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

J. Naismith, R. Hay, E. Jaffray, 2015 .

AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system

J. Naismith, J. Benesch, I. Booth, 2017 .

Crystal structure of the tyrosine phosphatase Cps4B from Steptococcus pneumoniae TIGR4.

J. Naismith, G. Hagelueken, Hexian Huang, 2009 .

Structural Biology and Crystallization Communications the Aeropath Project Targeting Pseudomonas Aeruginosa: Crystallographic Studies for Assessment of Potential Targets in Early-stage Drug Discovery

G. Schneider, W. Hunter, J. Naismith, 2022 .

Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii

M. Page, J. Naismith, D. Rolo, 2017, Antimicrobial Agents and Chemotherapy.

Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa.

R. Brenk, J. Naismith, S. McMahon, 2013, Journal of molecular biology.

Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli*

M. Page, J. Naismith, M. Winterhalter, 2015, Journal of Biological Chemistry.

Refined structure of cadmium-substituted concanavalin A at 2.0 A resolution.

J R Helliwell, W N Hunter, W. Hunter, 1993, Acta crystallographica. Section D, Biological crystallography.

Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras.

Lester G. Carter, C. F. van der Walle, J. Naismith, 2008, Chemical communications.