S. Haan

发表

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

P. Heinrich, I. Behrmann, S. Haan, 2003, The Biochemical journal.

Nucleocytoplasmic shuttling of persistently activated STAT3

M. Mönnigmann, P. Heinrich, S. Haan, 2007, Journal of Cell Science.

Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells.

Maria Pires Pacheco, P. Wilmes, I. Thiele, 2019, Cell Reports.

Resource Integrated In Vitro and In S ilico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells Graphical

Maria Pires Pacheco, P. Wilmes, I. Thiele, 2019 .

In search of definitions: Cancer‐associated fibroblasts and their markers

Serge Haan, S. Haan, P. Ullmann, 2019, International journal of cancer.

Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

Paul Wilmes, Serge Haan, P. Wilmes, 2020, Trends in microbiology.

A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.

P. Heinrich, S. Haan, L. Mayr, 2002, European journal of biochemistry.

Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics

V. Satagopam, T. Sauter, S. Haan, 2015, Cell Communication and Signaling.

Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.

G. Gores, S. Haan, H. Isomoto, 2007, Gastroenterology.

The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

V. Satagopam, T. Sauter, S. Haan, 2015, JAK-STAT.

Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

S. Haan, P. Ullmann, E. Letellier, 2019, Cells.

SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling

I. Behrmann, S. Haan, S. Wüller, 2009, Oncogene.

An Unusual Insertion in Jak2 Is Crucial for Kinase Activity and Differentially Affects Cytokine Responses

P. Heinrich, I. Behrmann, S. Haan, 2009, The Journal of Immunology.

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

S. Haan, B. Janji, P. Nazarov, 2019, Autophagy.

Identifying and targeting cancer-specific metabolism with network-based drug target prediction

Maria Pires Pacheco, T. Sauter, S. Haan, 2019, EBioMedicine.

A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST

T. Sauter, S. Haan, C. Bahlawane, 2016, PloS one.

SOCS2: physiological and pathological functions.

S. Haan, E. Letellier, 2016, Frontiers in bioscience.

Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells.

Maria Pires Pacheco, P. Wilmes, I. Thiele, 2019, Cell reports.

Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.

Serge Haan, P. Heinrich, I. Behrmann, 2005, Cellular signalling.

The Jak1 SH2 Domain Does Not Fulfill a Classical SH2 Function in Jak/STAT Signaling but Plays a Structural Role for Receptor Interaction and Up-regulation of Receptor Surface Expression*

P. Heinrich, I. Behrmann, S. Haan, 2005, Journal of Biological Chemistry.

Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production

A. Ginolhac, S. Haan, K. Hiller, 2016, Oncotarget.

Interleukin‐27 displays interferon‐γ–like functions in human hepatoma cells and hepatocytes

P. Heinrich, S. Haan, N. Kato, 2009, Hepatology.

Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

S. Haan, P. Ullmann, E. Letellier, 2017, Molecular Cancer.

What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue

S. Haan, P. Nazarov, P. Ullmann, 2016, PloS one.

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.

J. Johnston, A. Yoshimura, P. Heinrich, 2004, The Biochemical journal.

Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer

S. Haan, P. Nazarov, L. Vallar, 2014, British Journal of Cancer.

A Fusion Protein of the gp130 and Interleukin-6Rα Ligand-binding Domains Acts as a Potent Interleukin-6 Inhibitor*

P. Heinrich, S. Haan, G. Müller-Newen, 2003, The Journal of Biological Chemistry.

REVIEW ARTICLE Principles of interleukin (IL)-6-type cytokine signalling and its regulation 1

P. Heinrich, S. Haan, H. Hermanns, 2003 .

The gut microbial metabolite formate exacerbates colorectal cancer progression

Maria Pires Pacheco, P. Wilmes, T. Sauter, 2022, Nature Metabolism.

Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges

S. Haan, E. Koncina, E. Letellier, 2020, Cancers.

Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence

A. Ginolhac, S. Haan, P. Ullmann, 2017, British Journal of Cancer.

The PD-L 1-and IL 6-mediated dampening of the IL 27 / STAT 1 anticancer responses are prevented by α-PD-L 1 or α-IL 6 antibodies

A. Ginolhac, I. Behrmann, S. Haan, 2018 .

Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3 1

Rolf Rossaint, Fred Schaper, Serge Haan, 2003, The Journal of Immunology.

The miR-371∼373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis.

A. Ginolhac, S. Haan, R. Weiskirchen, 2018, Cancer research.

Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity.

S. Haan, P. Nazarov, N. Nicot, 2019, Cancer letters.

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

I. Behrmann, S. Haan, C. Haan, 2010, Journal of cellular and molecular medicine.

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells

I. Behrmann, S. Haan, F. Schaper, 2013, JAK-STAT.

Cytokine Responses Kinase Activity and Differentially Affects An Unusual Insertion in Jak 2 Is Crucial for

P. Heinrich, I. Behrmann, S. Haan, 2009 .

Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.

S. Haan, C. Haan, 2013, Methods in molecular biology.

Janus Kinase (Jak) Subcellular Localization Revisited

P. Heinrich, I. Behrmann, S. Haan, 2004, Journal of Biological Chemistry.

Real time analysis of oncogenic STAT3 in single cells

Martin Mönnigmann, Andreas Herrmann, Andreas Herrmann, 2006 .

Are STATS Arginine-methylated?*

P. Heinrich, I. Behrmann, S. Haan, 2005, Journal of Biological Chemistry.

Suppressor of Cytokine Signaling-3 Is Recruited to the Activated Granulocyte-Colony Stimulating Factor Receptor and Modulates its Signal Transduction1

J. Johnston, P. Heinrich, S. Haan, 2002, The Journal of Immunology.

The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine Signaling-1 Expression1

J. Johnston, P. Heinrich, S. Haan, 2004, The Journal of Immunology.

Cell Density–Dependent Increase of Constitutive Signal Transducers and Activators of Transcription 3 Activity in Melanoma Cells Is Mediated by Janus Kinases

P. Heinrich, I. Behrmann, S. Haan, 2007, Molecular Cancer Research.

STAT3 is enriched in nuclear bodies

P. Heinrich, S. Haan, G. Müller-Newen, 2004, Journal of Cell Science.

Cell Density-Dependent Increase of Constitutive Signal Transducers and Activators of Transcription 3 Activity in Melanoma Cells Is Mediated

P. Heinrich, I. Behrmann, S. Haan, 2007 .

Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses

S. Haan, R. Weiskirchen, C. Schoenherr, 2010, Cell Communication and Signaling.

Tyrosine Phosphorylation Disrupts Elongin Interaction and Accelerates SOCS3 Degradation*

J. Johnston, P. Heinrich, S. Haan, 2003, Journal of Biological Chemistry.

Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3 nuclear trafficking.

S. Haan, G. Müller-Newen, A. Herrmann, 2016, Cellular signalling.

Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain*

J. Schneider-Mergener, P. Heinrich, S. Haan, 1999, The Journal of Biological Chemistry.

Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation

J. Johnston, P. Heinrich, S. Haan, 2005, Journal of Biological Chemistry.

Regulation of JAKs: Insights gleaned from the functional protein domains

S. Haan, O. Silvennoinen, D. Ungureanu, 2012 .

The PD‐L1‐ and IL6‐mediated dampening of the IL27/STAT1 anticancer responses are prevented by α‐PD‐L1 or α‐IL6 antibodies

A. Ginolhac, I. Behrmann, S. Haan, 2018, Journal of leukocyte biology.

Structural Bases of Receptor-JAK-STAT Interactions

P. Heinrich, I. Behrmann, S. Haan, 2003 .

Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.

S. Haan, C. Haan, 2013, Methods in molecular biology.

Cytoplasmic STAT proteins associate prior to activation.

P. Heinrich, I. Behrmann, S. Haan, 2000, The Biochemical journal.

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).

P. Heinrich, S. Haan, G. Müller-Newen, 2009, Chemistry & biology.

This information is current as Cytokine Signaling 3 Differentially Modulated by Suppressor of Primary Human Macrophages Is Activation of STAT 3 by IL-6 and IL-10 in

R. Rossaint, P. Heinrich, S. Haan, 2003 .

Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.

Fred Schaper, Ulrike Sommer, Serge Haan, 2006, Cellular signalling.

Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines.

A. Ginolhac, I. Behrmann, S. Haan, 2017, Biochimica et biophysica acta. Molecular cell research.

Bow to your partner for signaling

P. Heinrich, S. Haan, H. Hermanns, 2005, Nature Structural &Molecular Biology.

Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.

S. Haan, P. Nazarov, K. Arumugam, 2017, Cellular signalling.

Dual Role of the Jak1 FERM and Kinase Domains in Cytokine Receptor Binding and in Stimulation-Dependent Jak Activation1

P. Heinrich, I. Behrmann, S. Haan, 2008, The Journal of Immunology.

SOCS2: physiological and pathological functions.

S. Haan, E. Letellier, 2016, Frontiers in bioscience.

JAK/STAT signaling in cancer

P. Heinrich, S. Haan, H. Hermanns, 2006 .

IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

S. Haan, H. Dolznig, A. Skupin, 2023, Nature communications.

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).

P. Heinrich, S. Haan, G. Müller-Newen, 2009, Chemistry & biology.

SOCS2: physiological and pathological functions.

S. Haan, E. Letellier, 2016, Frontiers in Bioscience.

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

P. Heinrich, I. Behrmann, S. Haan, 2003, The Biochemical journal.

Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines.

A. Ginolhac, I. Behrmann, S. Haan, 2017, Biochimica et biophysica acta. Molecular cell research.