D. Hilton

D. Hilton, M. Layton, C. Owczarek, 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Distinct Roles for Leukemia Inhibitory Factor Receptor α-Chain and gp130 in Cell Type-specific Signal Transduction*

W. Alexander, D. Hilton, U. Novak, 1997, The Journal of Biological Chemistry.

IL-4 Signal Transduction Cutting Edge: SOCS-1 Is a Potent Inhibitor of

D. Hilton, P. Rothman, J. Losman, 1999 .

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

J. G. Zhang, W. Alexander, D. Hilton, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures

T. Martin, D. Hilton, N. Udagawa, 1996, The Journal of experimental medicine.

SOCS5 Is Expressed in Primary B and T Lymphoid Cells but Is Dispensable for Lymphocyte Production and Function

W. Alexander, D. Hilton, D. Tarlinton, 2004, Molecular and Cellular Biology.

Development of hydrocephalus in mice lacking SOCS7.

W. Alexander, D. Hilton, M. O’Bryan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.

D. Hilton, N. Nicola, D. Metcalf, 1991, Blood.

The SOCS proteins: a new family of negative regulators of signal transduction

D. Hilton, S. Nicholson, 1998, Journal of leukocyte biology.

Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.

D. Hilton, N. Nicola, D. Metcalf, 1988, Leukemia.

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome.

W. Alexander, D. Hilton, H. Scott, 2009, Blood.

Proximal genomic localization of STAT1 binding and regulated transcriptional activity

Terence P Speed, Gordon K Smyth, Douglas J Hilton, 2006, BMC Genomics.

Anti-Inflammatory Response General Nature of the STAT3-Activated

D. Hilton, M. Myers, D. Kaushal, 2013 .

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.

W. Alexander, D. Hilton, F. Walker, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Identification, Purification, and Characterization of a Soluble Interleukin (IL)-13-binding Protein

R. Moritz, W. Alexander, D. Hilton, 1997, The Journal of Biological Chemistry.

c-Myb is required for progenitor cell homeostasis in colonic crypts

H. Clevers, M. Cooke, J. Malaterre, 2007, Proceedings of the National Academy of Sciences.

Molecules d'interet therapeutique

D. Hilton, R. Simpson, Jian‐guo Zhang, 1997 .

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

W. Alexander, D. Hilton, N. Nicola, 2005, Blood.

The Box-1 Region of the Leukemia Inhibitory Factor Receptor α-Chain Cytoplasmic Domain Is Sufficient for Hemopoietic Cell Proliferation and Differentiation*

D. Hilton, T. Willson, N. Nicola, 1998, The Journal of Biological Chemistry.

LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells.

R. Williams, D. Hilton, T. Willson, 1989, Reproduction, fertility, and development.

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane‐Associated Ring‐CH (MARCH) proteins MARCH2, 3, 4 and 9

W. Alexander, D. Hilton, J. Sandow, 2021, Proteomics.

Cellular processing of murine colony-stimulating factor (Multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell lines.

D. Hilton, N. Nicola, D. Metcalf, 1988, Growth factors.

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2

W. Alexander, D. Hilton, A. Roberts, 2009, Growth factors.

Structural characterization of a murine myeloid leukaemia inhibitory factor.

D. Hilton, R. Simpson, E. Nice, 1988, European journal of biochemistry.

Leukemia inhibitory factor binds with high affinity to preosteoblastic RCT-1 cells and potentiates the retinoic acid induction of alkaline phosphatase.

D. Hilton, G. Wesolowski, G. Rodan, 1990, Endocrinology.

The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.

W. Alexander, D. Hilton, A. Roberts, 2007, Blood.

Identification, Purification, and Characterization of a Soluble Interleukin (IL)-13-binding Protein EVIDENCE THAT IT IS DISTINCT FROM THE CLONED IL-13 RECEPTOR AND IL-4 RECEPTOR a-CHAINS*

R. Moritz, W. Alexander, D. Hilton, 1997 .

Generation of sensory neurons is stimulated by leukemia inhibitory factor.

D. Hilton, P. Bartlett, M. Murphy, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Leukemia inhibitory factor: a novel bone-active cytokine.

T. Martin, D. Hilton, J. Cornish, 1990, Endocrinology.

Purification of a murine leukemia inhibitory factor from Krebs ascites cells.

D. Hilton, N. Nicola, D. Metcalf, 1988, Analytical biochemistry.

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Matthew E. Ritchie, Linden J. Gearing, A. Keniry, 2022, Nature Communications.

Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest.

C. Begley, D. Hilton, S. Jane, 2000, Experimental hematology.

Twenty proteins containing a C-terminal SOCS box form five structural classes.

W. Alexander, D. Hilton, T. Willson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A family of cytokine-inducible inhibitors of signalling

Warren S. Alexander, Donald Metcalf, Douglas J. Hilton, 1997, Nature.

Molecular cloning of two novel transmembrane ligands for Eph-related kinases (LERKS) that are related to LERK-2.

D. Hilton, T. Willson, N. Nicola, 1996, Growth factors.

A familyof cytokine-inducible inhibitorsof signalling

W. Alexander, D. Hilton, B. Jenkins, 2022 .

Gigantism in mice lacking suppressor of cytokine signalling-2

W. Alexander, D. Hilton, T. Willson, 2000, Nature.

Crystal Structure of the Entire Ectodomain of gp130

M. Pocock, D. Hilton, P. Czabotar, 2010, The Journal of Biological Chemistry.

SOCS Proteins: Negative Regulators of Cytokine Signaling

D. Hilton, D. Krebs, Douglas J. Hilton, 2001, Stem cells.

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

Paul J Hertzog, Douglas J Hilton, D. Hilton, 2006, Nature Immunology.

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

Paul J Hertzog, Donald Metcalf, Warren S Alexander, 1999, Cell.

Cytokines: From the laboratory to the clinic

D. Hilton, A. Nash, J. Kurek, 1999 .

Leukemia inhibitory factor and its receptor

D. Hilton, N. Nicola, 1997 .

Inhibition of differentiation in a murine F9 embryonal carcinoma cell subline by leukemia inhibitory factor (LIF).

D. Hilton, M. Brown, N. Gough, 1992, Growth factors.

Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors.

W. Alexander, D. Hilton, C. Hyland, 2004, Blood.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Toru Okamoto, Renwick C J Dobson, Donald Metcalf, 2013, Immunity.

Ankyrin Repeat and Suppressors of Cytokine Signaling Box Protein Asb-9 Targets Creatine Kinase B for Degradation*

W. Alexander, D. Hilton, R. Simpson, 2007, Journal of Biological Chemistry.

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage

Elizabeth A. Kruse, P. Nurden, W. Alexander, 2009, Proceedings of the National Academy of Sciences.

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

Elizabeth A. Kruse, K. J. Henley, W. Alexander, 2008, Nature Immunology.

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

Donald Metcalf, Shirley Pease, Erwin F. Wagner, 1988, Nature.

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

Paul J Hertzog, Donald Metcalf, Warren S Alexander, 2006, Nature Immunology.

SOCS2 negatively regulates growth hormone action in vitro and in vivo.

Claes Ohlsson, Mattias Lorentzon, Donald Metcalf, 2005, The Journal of clinical investigation.

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Wei Shi, Michael J. Wilson, Nick Wilson, 2018, Nucleic Acids Res..

scPipe: A flexible R/Bioconductor preprocessing pipeline for single-cell RNA-sequencing data

Luyi Tian, Matthew E Ritchie, Matthew E. Ritchie, 2018, PLoS Comput. Biol..

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.

K. J. Henley, D. Kastner, W. Alexander, 2012, Immunity.

Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.

D. Hilton, T. Willson, D. Gearing, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).

A. Kelso, D. Hilton, E. Nice, 1987, The EMBO journal.

Transcriptional profiling of eosinophil subsets in interleukin‐5 transgenic mice

Jessica E. Bolden, Erin C. Lucas, D. Hilton, 2018, Journal of leukocyte biology.

Identification of a Siglec-F+ granulocyte-macrophage progenitor

Warren S. Alexander, Matthew E. Ritchie, Geyu Zhou, 2018, Journal of leukocyte biology.

Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein

D. Hilton, C. Bernard, A. Hilton, 1995, Journal of neurochemistry.

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

Belinda Phipson, Ian J. Majewski, Warren S. Alexander, 2010, Blood.

Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity

G. Smyth, M. Bahlo, W. Alexander, 2008, PLoS biology.

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation

G. Kay, N. Brockdorff, S. Dunwoodie, 2008, Nature Genetics.

The art and design of genetic screens: mouse

D. Hilton, B. Kile, 2005, Nature Reviews Genetics.

SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice*

E. Van Obberghen, B. Emanuelli, D. Hilton, 2001, The Journal of Biological Chemistry.

In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis

M. Dawson, D. Hilton, C. D. de Graaf, 2023, Nature Communications.

The Immunoglobulin-like Module of gp130 Is Required for Signaling by Interleukin-6, but Not by Leukemia Inhibitory Factor*

D. Hilton, J. Wijdenes, J. Layton, 1998, The Journal of Biological Chemistry.

Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist.

C. Begley, D. Hilton, D. Curtis, 1997, Blood.

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

Matthew E. Ritchie, Sarah A Kessans, G. Kay, 2015, Proceedings of the National Academy of Sciences.

Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines.

D. Hilton, N. Nicola, D. Metcalf, 1988, The Journal of biological chemistry.

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification.

W. Alexander, D. Hilton, J. Pimanda, 2011, Genes & development.

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.

W. Alexander, D. Hilton, A. Roberts, 2008, Molecular immunology.

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing

Matthew E. Ritchie, Linden J. Gearing, A. Keniry, 2016, Epigenetics & Chromatin.

Signaling by type I and II cytokine receptors: ten years after.

J. Johnston, D. Hilton, J. O’Shea, 2001, Current opinion in immunology.

Negative regulation of cytokine signaling

D. Hilton, C. Greenhalgh, Christopher J. Greenhalgh, 2001, Journal of leukocyte biology.

Negative regulation of the JAK/STAT pathway

D. Hilton, R. Starr, 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

The SOCS box: a tale of destruction and degradation.

W. Alexander, D. Hilton, B. Schulman, 2002, Trends in biochemical sciences.

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

I. Reid, T. Martin, D. Hilton, 1990 .

Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution.

D. Hilton, N. Nicola, D J Hilton, 1992, The Journal of biological chemistry.

Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

D. Hilton, O. Silvennoinen, P. Saharinen, 2002, Molecular and Cellular Biology.

Correction: A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis

P. Meikle, D. Sviridov, M. Bahlo, 2008, PLoS Genetics.

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

R. Norton, D. Hilton, S. Yao, 2006, Molecular cell.

The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling*

Terence P. Speed, Warren S. Alexander, Douglas J. Hilton, 2006, Journal of Biological Chemistry.

Reduced Lymphocyte Longevity and Homeostatic Proliferation in Lamin B Receptor-Deficient Mice Results in Profound and Progressive Lymphopenia

D. Hilton, C. D. de Graaf, T. Baldwin, 2012, The Journal of Immunology.

Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction.

D. Hilton, P. Rothman, J. Losman, 1999, Journal of immunology.

The Negative Regulation of JAK/STAT Signaling

D. Hilton, G. Tannahill, James M. Murphy, 2010 .

SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation

W. Alexander, D. Hilton, R. Simpson, 2002, Molecular and Cellular Biology.

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b).

S. Asa, W. Alexander, D. Hilton, 2002, Molecular endocrinology.

CHAPTER 75 – Negative Regulation of the JAK/STAT Signaling Pathway

D. Hilton, J. Eyles, 2003 .

Negative regulators of cytokine signal transduction

D. Hilton, D. J. Hilton, 1999, Cellular and Molecular Life Sciences CMLS.

Suppressor of Cytokine Signaling-1 Has IFN-γ-Independent Actions in T Cell Homeostasis1

W. Alexander, D. Hilton, Li Wu, 2003, The Journal of Immunology.

Phylotranscriptomics resolves phylogeny of the Heliozelidae (Adeloidea: Lepidoptera) and suggests a Late Cretaceous origin in Australia

T. Jones, D. Hilton, A. Moussalli, 2020, Systematic Entomology.

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant.

D. Hilton, S. Jane, S. Foote, 2009, Blood.

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

Aaron T. L. Lun, G. Smyth, B. Phipson, 2013, Blood.

SOCS: physiological suppressors of cytokine signaling.

D. Hilton, D. Krebs, 2000, Journal of cell science.

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

Ming Yan, D. Hilton, V. Poli, 2009, Molecular and Cellular Biology.

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

W. Alexander, D. Hilton, M. Kauppi, 2006, Proceedings of the National Academy of Sciences.

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

W. Alexander, D. Hilton, T. Willson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL‐6 signal transduction

W. Alexander, D. Hilton, T. Willson, 1999, The EMBO journal.

Growth Hormone Preferentially Induces the Rapid, Transient Expression of SOCS-3, a Novel Inhibitor of Cytokine Receptor Signaling*

D. Hilton, N. Billestrup, N. Nicola, 1998, The Journal of Biological Chemistry.

Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling*

W. Alexander, D. Hilton, L. Fabri, 2002, The Journal of Biological Chemistry.

JAK-STAT signaling in the mouse liver through induction

Ming Yan, D. Hilton, Dong-er Zhang, 2009 .

A Novel Mutation in the Nfkb2 Gene Generates an NF-κB2 “Super Repressor”1

W. Alexander, D. Hilton, D. Tarlinton, 2007, The Journal of Immunology.

B 2 ' ' Super Repressor ' ' κ Generates an NF-Gene Nfkb 2 A Novel Mutation in the

W. Alexander, D. Hilton, D. Tarlinton, 2007 .

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.

W. Alexander, D. Hilton, B. Jenkins, 2007, Blood.

The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways

D. Hilton, Sam Wormald, 2007, Current opinion in hematology.

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

D. Hilton, C. D. de Graaf, Li Wu, 2018, Front. Immunol..

Molecular and Cellular Pathobiology Epigenetic Regulator Smchd 1 Functions as a Tumor Suppressor

G. Smyth, Yifang Hu, W. Alexander, 2013 .

stress hematopoiesis in mice is required for self-renewal of hematopoietic stem cells during Erg

G. Smyth, W. Alexander, D. Hilton, 2011 .

Receptors Competitiveness in Mice Deficient for Thrombopoietin and Steel Factor Synergystic Effects on Erythropoiesis , Thrombopoiesis and Stem Cell

W. Alexander, D. Hilton, C. Hyland, 2004 .

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

D. Hilton, T. Garrett, N. Nicola, 2007, Proceedings of the National Academy of Sciences.

Complex of the soluble IL-11 receptor and IL-11 acts as IL-6-type cytokine in hepatic and nonhepatic cells.

D. Hilton, A. Mackiewicz, H. Baumann, 1996, Journal of immunology.

Expression and function of members of the cytokine receptor superfamily on breast cancer cells

Robert L Sutherland, Douglas J Hilton, C. Begley, 1997, Oncogene.

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

W. Alexander, D. Hilton, N. Nicola, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1*

D. Hilton, J. Eyles, M. Grusby, 2002, The Journal of Biological Chemistry.

Distribution and binding properties of receptors for leukaemia inhibitory factor.

D. Hilton, N. Nicola, D. Metcalf, 1992, Ciba Foundation symposium.

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

W. Alexander, D. Hilton, A. Roberts, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins.

D. Hilton, J. Nielsen, N. Billestrup, 1999, Molecular endocrinology.

Tissue-specific induction of SOCS gene expression by PRL.

D. Hilton, M. Waters, J. Djiane, 2001, Endocrinology.

Chromosomes distribute randomly to, but not within, human neutrophil nuclear lobes

Erin C. Lucas, G. Smyth, K. Rogers, 2020, bioRxiv.

COMMENTARY SOCS: physiological suppressors of cytokine signaling

D. Hilton, D. Krebs, 2000 .

Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.

D. Hilton, P. Murray, S. Watowich, 1995, Proceedings of the National Academy of Sciences of the United States of America.

STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver

R. Wilkins, D. Hilton, T. Adams, 1999, Molecular and Cellular Endocrinology.

The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor.

C. Begley, D. Hilton, T. Willson, 1996, Oncogene.

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

W. Alexander, D. Hilton, A. Elefanty, 1999, Journal of leukocyte biology.

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells*

W. Alexander, D. Hilton, T. Kay, 2003, Journal of Biological Chemistry.

Differential regulation of SOCS genes in normal and transformed erythroid cells

W. Alexander, D. Hilton, D. Chappell, 2003, Oncogene.

Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transduction in Vitro and in Vivo *

Warren S. Alexander, Douglas J. Hilton, Jian-Guo Zhang, 2001, The Journal of Biological Chemistry.

A preliminary molecular phylogeny of shield-bearer moths (Lepidoptera: Adeloidea: Heliozelidae) highlights rich undescribed diversity.

T. Jones, D. Hilton, Stephen A. Wilcox, 2018, Molecular phylogenetics and evolution.

Tyrosine Residues in the Granulocyte Colony-stimulating Factor (G-CSF) Receptor Mediate G-CSF-induced Differentiation of Murine Myeloid Leukemic (M1) Cells*

D. Hilton, U. Novak, J. Layton, 1996, The Journal of Biological Chemistry.

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.

A. Woods, D. Zaller, D. Hilton, 2013, Biochemical Journal.

A Somatic Cell Genetic System for Dissecting Hemopoietic Cytokine Signal Transduction*

D. Hilton, R. Starr, R. Richardson, 2002, The Journal of Biological Chemistry.

SOCS2 deficiency induces molecular and metabolic changes that partially overlap with GH- dependent effects

W. Alexander, D. Hilton, G. Norstedt, 2004 .

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

E. Stanley, W. Alexander, D. Hilton, 2003, Immunity.

Robustness insimple biochemical networks

W. Alexander, D. Hilton, B. Jenkins, 1997 .

Estimating the proportion of microarray probes expressed in an RNA sample

Wei Shi, Hamish S. Scott, Douglas J. Hilton, 2010, Nucleic acids research.

A new extant family of primitive moths from Kangaroo Island, Australia, and its significance for understanding early Lepidoptera evolution

D. Hilton, N. Wahlberg, A. Kallies, 2015 .

Regulation of hematopoietic stem cells by their mature progeny

G. Smyth, W. Alexander, D. Hilton, 2010, Proceedings of the National Academy of Sciences.

Revision of Cossinae and small Zeuzerinae from Australia (Lepidoptera: Cossidae)

D. Hilton, A. Kallies, 2012 .

156 A Novel Mutation in the Nfkb2 Gene Generates an NFκB2 ‘Super Repressor’

D. Hilton, D. Tarlinton, N. Sims, 2007 .

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity

D. Hilton, D. Metcalf, James M. Murphy, 2010, Growth factors.

Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression.

C. Begley, D. Hilton, L. Robb, 1997, Genomics.

Robustness insimple bioc h emic al netw orks

W. Alexander, D. Hilton, B. Jenkins, 2022 .

SOCS 3 regulates CD 8 T cell proliferation by inhibition of IL-6 and IL-27

W. Alexander, D. Hilton, B. Jenkins, 2007 .

Membrane-Associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Ra).

W. Alexander, D. Hilton, S. Ishido, 2019, The Biochemical journal.

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.

Douglas J Hilton, D. Hilton, L. Fabri, 2002, Biochemistry.

Osteoblasts display receptors for and responses to leukemia‐inhibitory factor

D. Hilton, K. Ng, M. Brown, 1990, Journal of cellular physiology.

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.

E. Stanley, D. Hilton, C. Biben, 1998, Developmental biology.

DAN is a secreted glycoprotein related to Xenopus cerberus

E. Stanley, D. Hilton, C. Biben, 1998, Mechanisms of Development.

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

J. G. Zhang, R. Moritz, W. Alexander, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

A. Elefanty, W. Alexander, D. Hilton, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

W. Alexander, D. Hilton, Ashley P Ng, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization

H. Lodish, D. Hilton, S. Watowich, 1994, Molecular and cellular biology.

Cloning of a murine IL‐11 receptor alpha‐chain; requirement for gp130 for high affinity binding and signal transduction.

C. Begley, C. Begley, D. Hilton, 1994, The EMBO journal.

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.

W. Alexander, D. Hilton, B. Croker, 2000, Gene.

Homodimerization and constitutive activation of the erythropoietin receptor.

H. Lodish, A. Yoshimura, D. Hilton, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.

J. G. Zhang, D. Hilton, L. Fabri, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1

A. Elefanty, W. Alexander, D. Hilton, 1999, Leukemia.

Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays.

D. Hilton, T. Willson, D. Metcalf, 1995, Leukemia.

Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.

D. Hilton, R. Simpson, J. Wijdenes, 2000, The Biochemical journal.

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

W. Alexander, D. Hilton, N. Nicola, 2005, Blood.

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia.

W. Alexander, D. Hilton, B. Kile, 2009, Blood.

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells.

K. J. Henley, D. Kastner, W. Alexander, 2012, Immunity.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

A. Strasser, W. Alexander, D. Hilton, 2013, Immunity.

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo.

G. Smyth, K. Rogers, W. Alexander, 2014, Blood.

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2

W. Alexander, D. Hilton, A. Roberts, 2009, Growth Factors.

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

Aaron T. L. Lun, G. Smyth, B. Phipson, 2013, Blood.

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

W. Alexander, D. Hilton, T. Sargeant, 2015, Blood.

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

J. Malaterre, W. Alexander, D. Hilton, 2013, Cell Death and Disease.

Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1.

D. Hilton, R. Starr, 2003, Immunity.

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.

W. Alexander, D. Hilton, N. Nicola, 2005, Blood.