C. Gregorio

发表

G.O.2 Mutations in LMOD3 cause severe nemaline myopathy by disrupting thin filament organisation in skeletal muscle

E. Bertini, K. Pelin, M. Lek, 2014, Neuromuscular Disorders.

To the heart of myofibril assembly.

C. Gregorio, P. Antin, 2000, Trends in cell biology.

Striated muscle cytoarchitecture: an intricate web of form and function.

M. Beckerle, C. Gregorio, K. A. Clark, 2002, Annual review of cell and developmental biology.

Desmoplakin and Talin2 Are Novel mRNA Targets of Fragile X–Related Protein-1 in Cardiac Muscle

Daniela C. Zarnescu, D. Zarnescu, D. Nelson, 2011, Circulation research.

Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy

Jason R. Myers, C. Gregorio, K. L. de Mesy Bentley, 2018, Circulation.

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

S. Gabriel, M. Daly, D. MacArthur, 2014, The Journal of clinical investigation.

Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy

I. Krantz, C. T. Pappas, L. Medne, 2019, Science Advances.

Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality

P. R. Cox, H. Zoghbi, C. Gregorio, 2003, The Journal of cell biology.

Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta

C. Gregorio, V. Fowler, J. Black, 1994, The Journal of cell biology.

Effects of denervation on spectrin concentration in avian skeletal muscle

C. Gregorio, E. Repasky, M. S. Hudecki, 1988, Muscle and Nerve.

Mutations in the sensitive giant titin result in a broken heart.

L. Leinwand, C. Gregorio, J. Tardiff, 2012, Circulation research.

The desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments

C. Gregorio, Gloria M Conover, Gloria M. Conover, 2011, Journal of Cell Science.

The N-terminal End of Nebulin Interacts with Tropomodulin at the Pointed Ends of the Thin Filaments*

C. Gregorio, V. Fowler, A. McElhinny, 2001, The Journal of Biological Chemistry.

Molecular dissection of the interaction of desmin with the C-terminal region of nebulin.

M. Bang, C. Gregorio, S. Labeit, 2002, Journal of structural biology.

Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development

C. Gregorio, A. McElhinny, S. Labeit, 2004, Journal of Cell Science.

Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc.

J. Cooper, C. T. Pappas, C. Gregorio, 2008, Molecular biology of the cell.

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.

Wolfgang Rottbauer, Christian Andresen, Laura T Donlin, 2012, Genes & development.

Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes

S. Preibisch, C. Gregorio, S. Lehnart, 2019, Proceedings of the National Academy of Sciences.

A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics*

A. McCulloch, Leonard K. Lee, J. Omens, 2012, The Journal of Biological Chemistry.

EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability

S. Novak, C. Gregorio, J. Garcia, 2021, Pulmonary circulation.

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

S. Novak, C. Gregorio, H. Sorimachi, 2013, Journal of molecular biology.

Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle.

C. Gregorio, P. Krieg, R. Heimark, 2008, Cell motility and the cytoskeleton.

Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function

J. Seidman, J. Rossant, B. Bruneau, 2017, Biology Open.

Cellular self-organization by autocatalytic alignment feedback

Siu Ling Leung, Pak Kin Wong, Michael Junkin, 2011, Journal of Cell Science.

Nebulin regulates actin filament lengths by a stabilization mechanism

C. T. Pappas, C. Gregorio, P. Krieg, 2010, Journal of Cell Biology.

A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture.

C. Gregorio, Gloria M Conover, S. N. Henderson, 2008, Molecular biology of the cell.

Expression and regulation of mouse SERDIN1, a highly conserved cardiac‐specific leucine‐rich repeat protein

C. Gregorio, S. Tevosian, N. R. Houston-Cummings, 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle

C. Gregorio, Mert Colpan, Jessika Iwanski, 2021, Communications biology.

HSPB7 is indispensable for heart development by modulating actin filament assembly

Roberta B. Nowak, C. T. Pappas, C. Gregorio, 2017, Proceedings of the National Academy of Sciences.

Models of thin filament assembly in cardiac and skeletal muscle.

C. Gregorio, 1997, Cell structure and function.

Probing the functional roles of titin ligands in cardiac myofibril assembly and maintenance.

C. Gregorio, A. McElhinny, S. Labeit, 2000, Advances in experimental medicine and biology.

Tropomodulin: An Important Player in Cardiac Myofibrillogenesis

C. Gregorio, C. McLellan, 2002 .

Molecular tools for the study of titin's differential expression.

C. Gregorio, H. Granzier, F. Fougerousse, 2000, Advances in experimental medicine and biology.

Tropomodulin function and thin filament assembly in cardiac myocytes.

C. Gregorio, V. Fowler, 1996, Trends in cardiovascular medicine.

The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes

C. Gregorio, V. Fowler, M. Richards, 2003, The Journal of cell biology.

Interferon-a Alters Spectrin Organization in Normal and Leukemic Human B Lymphocytes

C. Gregorio, E. Repasky, S. Evans, 2003 .

Interferon-alpha alters spectrin organization in normal and leukemic human B lymphocytes.

C. Gregorio, E. Repasky, W. C. Wang, 1993, Blood.

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

C. Gregorio, H. Granzier, F. Fougerousse, 2000, Circulation Research.

Effects of percutaneous electrical stimulation on functional ability, plasma creatine kinase, and pectoralis musculature of normal and genetically dystrophic chickens

C. Gregorio, M. S. Hudecki, C. Pollina, 1985, Experimental Neurology.

Preparation of developing Xenopus muscle for sarcomeric protein localization by high-resolution imaging.

C. Gregorio, P. Krieg, Chinedu U Nworu, 2014, Methods.

Ca2+ attenuates nucleation activity of leiomodin

A. Kostyukova, C. Gregorio, V. Galkin, 2022, Protein science : a publication of the Protein Society.

Leiomodin creates a leaky cap at the pointed end of actin-thin filaments

A. Kostyukova, C. Gregorio, J. Cort, 2020, PLoS biology.

Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure.

C. T. Pappas, C. Gregorio, Gerrie P. Farman, 2018, Journal of molecular and cellular cardiology.

Nebulin, a multi-functional giant

C. T. Pappas, C. Gregorio, M. Chu, 2016, Journal of Experimental Biology.

endothelial cells: role of Rac, GIT1, FAK, and paxillin S1P induces FA remodeling in human pulmonary

R. Salgia, C. Gregorio, A. Malik, 2015 .

Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

M. Bang, C. Gregorio, H. Granzier, 2001, The Journal of cell biology.

Mutation‐specific effects on thin filament length in thin filament myopathy

K. Pelin, B. Engelen, V. Lehtokari, 2016, Annals of neurology.

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

P. Wong, C. T. Pappas, C. Gregorio, 2015, Proceedings of the National Academy of Sciences.

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle

C. T. Pappas, C. Gregorio, H. Granzier, 2010, Journal of Cell Science.

The complete mouse nebulin gene sequence and the identification of cardiac nebulin.

Christian C Witt, Siegfried Labeit, C. Gregorio, 2003, Journal of molecular biology.

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

S. Gabriel, M. Daly, D. MacArthur, 2015, The Journal of clinical investigation.

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1

C. Gregorio, H. Sorimachi, A. McElhinny, 2002, The Journal of cell biology.

The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

Dietmar Labeit, Siegfried Labeit, M. Bang, 2001 .

I-Band Titin in Cardiac Muscle Is a Three-Element Molecular Spring and Is Critical for Maintaining Thin Filament Structure

Wolfgang A. Linke, Siegfried Labeit, Mathias Gautel, 1999, The Journal of cell biology.

The titin cDNA sequence and partial genomic sequences: insights into the molecular genetics, cell biology and physiology of the titin filament system.

W. Linke, C. Gregorio, G. Stier, 1999, Reviews of physiology, biochemistry and pharmacology.

The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity

Siegfried Labeit, Henk Granzier, C. Gregorio, 1998, The Journal of cell biology.

Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs.

K. Suzuki, W. Linke, C. Gregorio, 1997, Journal of molecular biology.

Tropomodulin assembles early in myofibrillogenesis in chick skeletal muscle: evidence that thin filaments rearrange to form striated myofibrils.

C. Gregorio, V. Fowler, A. Almenar-Queralt, 1999, Journal of cell science.

Overview of the Muscle Cytoskeleton.

S. Novak, C. Gregorio, C. Henderson, 2017, Comprehensive Physiology.

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system.

T Centner, M. Bang, C. Gregorio, 2001, Circulation research.

Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.

T Centner, W Hell, C. Gregorio, 2000, Circulation research.

Fragile hearts: new insights into translational control in cardiac muscle.

Daniela C. Zarnescu, D. Zarnescu, C. Gregorio, 2013, Trends in cardiovascular medicine.

Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly

C. Gregorio, V. Fowler, Carol C. Gregorio, 1995, The Journal of cell biology.

CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle

C. Gregorio, Mert Colpan, Jessika Iwanski, 2021, Communications Biology.

Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart

C. Gregorio, P. Krieg, S. Whitman, 2012, Cytoskeleton.

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

C. T. Pappas, C. Gregorio, H. Granzier, 2014, Proceedings of the National Academy of Sciences.

myofilament organization Smyd 2 controls cytoplasmic lysine methylation of Hsp 90 and Material

W. Rottbauer, B. Chait, A. Tarakhovsky, 2012 .

Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle

C. Gregorio, A. McElhinny, Carol C. Gregorio, 2006, Journal of Muscle Research & Cell Motility.

The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

Christian C Witt, Dietmar Labeit, Siegfried Labeit, 2003, Journal of molecular biology.

Myofibrillogenesis in the Heart

C. Gregorio, P. Antin, 2001 .

THE STUDY OF TITIN'S DIFFERENTIAL EXPRESSION

C. Gregorio, F. Fougerousse, H. Granzier, 2000 .

Muscle assembly: a titanic achievement?

C. Gregorio, H. Granzier, H. Sorimachi, 1999, Current opinion in cell biology.

Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics

A. Kostyukova, C. T. Pappas, C. Gregorio, 2019, Molecular biology of the cell.

Neonatal-lethal dilated cardiomyopathy due to a homozygous LMOD2 donor splice-site variant

C. T. Pappas, C. Gregorio, T. Roscioli, 2021, European Journal of Human Genetics.

The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

Masahiko Hoshijima, Andrew D. McCulloch, Nicholas J. Schork, 2002, Cell.

Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system.

M. Bang, C. Gregorio, T. Furukawa, 2001, Journal of molecular biology.

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

K. Pelin, M. Bang, C. Gregorio, 2001, Journal of molecular biology.

Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates.

P. Wong, C. Gregorio, K. Nam, 2018, ACS biomaterials science & engineering.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury

R. Salgia, C. Gregorio, V. Natarajan, 2015 .

Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes

C. Gregorio, V. Fowler, A. Weber, 1995, Nature.

Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1

Daniela C. Zarnescu, D. Zarnescu, P. Wong, 2017, Circulation.

The role of leiomodin in actin dynamics: a new road or a secret gate

A. Kostyukova, C. Gregorio, D. Tolkatchev, 2021, The FEBS journal.

The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2’s function

A. Kostyukova, N. Moroz, C. T. Pappas, 2016, Molecular biology of the cell.

Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis

R. Kraft, C. Gregorio, P. Krieg, 2015, Journal of Cell Science.

Dynamics of Actin in the Heart: Defining Thin Filament Length

C. Gregorio, C. Henderson, 2015 .

Phosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle

A. Kostyukova, S. Novak, C. Gregorio, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Alteration of Tropomyosin-binding Properties of Tropomodulin-1 Affects Its Capping Ability and Localization in Skeletal Myocytes*

V. Uversky, A. Kostyukova, N. Moroz, 2012, The Journal of Biological Chemistry.

Identification of Residues within Tropomodulin-1 Responsible for Its Localization at the Pointed Ends of the Actin Filaments in Cardiac Myocytes*

A. Kostyukova, S. Novak, C. Gregorio, 2010, The Journal of Biological Chemistry.

Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle

A. Kostyukova, N. Moroz, C. T. Pappas, 2010, Journal of Cell Science.

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.

Yiming Wu, Christian C Witt, Stephanie H Witt, 2004, Journal of molecular biology.

Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle

C. Gregorio, C. Ottenheijm, Jochen Gohlke, 2020, Science Advances.

Nebulin regulates the assembly and lengths of the thin filaments in striated muscle

C. Gregorio, A. McElhinny, Carol C. Gregorio, 2005, The Journal of cell biology.

Nebulin: the nebulous, multifunctional giant of striated muscle.

C. Gregorio, A. McElhinny, S. Labeit, 2003, Trends in cardiovascular medicine.

Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells

C. Gregorio, M. Khanna, S. K. Campos, 2021, Stem Cell Reports.

Dynamic aspects of cytoskeletal protein distribution in T lymphocytes: involvement of calcium in spectrin reorganization.

C. Gregorio, J. Black, E. Repasky, 1993, Blood cells.

Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes.

C. Gregorio, Camille L. Birch, J. Tardiff, 2016, Archives of biochemistry and biophysics.

In vivo elongation of thin filaments results in heart failure

C. T. Pappas, C. Gregorio, M. Chu, 2020, PloS one.

The sensitive giant: the role of titin-based stretch sensing complexes in the heart.

Henk Granzier, C. Gregorio, H. Granzier, 2004, Trends in cell biology.

The Nebulin family: an actin support group.

C. T. Pappas, C. Gregorio, A. Zieseniss, 2011, Trends in cell biology.

Investigating lasp-2 in cell adhesion: new binding partners and roles in motility

C. Gregorio, M. Chu, Katherine T. Bliss, 2013, Molecular biology of the cell.

Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein.

C. Gregorio, A. Zieseniss, A. Terasaki, 2008, Cell motility and the cytoskeleton.

Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy

C. Gregorio, G. Satou, N. Khanlou, 2023, Cells.

The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation

C. Gregorio, H. Sorimachi, N. Doi, 2014, Proceedings of the National Academy of Sciences.

Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation.

C. Gregorio, P. Antin, Y. Ono, 2005, Developmental biology.

Translocation of spectrin and protein kinase C to a cytoplasmic aggregate upon lymphocyte activation.

C. Gregorio, E. Repasky, R. Kubo, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Nebulin regulates actin filament lengths by a stabilization mechanism

C. T. Pappas, C. Gregorio, P. Krieg, 2010, The Journal of cell biology.

Molecular dissection of the interaction of desmin with the C-terminal region of nebulin.

M. Bang, C. Gregorio, S. Labeit, 2002 .

Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein

Daniela C. Zarnescu, S. Novak, C. Gregorio, 2015, PloS one.