Z. Pursell

发表

Urban De Souza, Suivis Vaze, Z. Pursell, 2003 .

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Z. Pursell, B. Campbell, Nicholas Light, 2018, eLife.

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.

Z. Pursell, Z. Suo, Hua Lu, 2020, Molecular cell.

DNA polymerase epsilon: a polymerase of unusual size (and complexity).

T. Kunkel, Z. Pursell, 2008, Progress in Nucleic Acid Research and Molecular Biology.

Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.

Z. Pursell, Leena Maddukuri, Amit D Ketkar, 2015, Biochemistry.

The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection

Z. Pursell, L. Morici, Kalen Hall, 2022, Frontiers in Cellular and Infection Microbiology.

Human DNA Polymerase ϵ Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides*

Z. Pursell, Z. Suo, K. Lecompte, 2012, The Journal of Biological Chemistry.

Mismatch Repair–Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase ε

T. Kunkel, I. Rogozin, Z. Pursell, 2010, PLoS genetics.

Chapter 4:Mechanisms for High Fidelity DNA Replication

T. Kunkel, Z. Pursell, S. A. N. McElhinny, 2009 .

Bright G-Quadruplex Nanostructures Functionalized with Porphyrin Lanterns.

A. Phan, Z. Pursell, B. Gibb, 2019, Journal of the American Chemical Society.

DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells.

G. Getz, K. Cole, T. Kunkel, 2020, Cancer discovery.

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity

J. Tyson McDonald, Thomas A. Kunkel, Christopher K. Mathews, 2008, Nucleic acids research.

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

T. Kunkel, Z. Pursell, C. Mathews, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

T. Kunkel, Z. Pursell, S. A. Nick McElhinny, 2012, PLoS genetics.

The high fidelity and unique error signature of human DNA polymerase ε

Z. Pursell, K. Lecompte, D. Korona, 2010, Nucleic acids research.

DNA polymerase epsilon: a polymerase of unusual size (and complexity).

T. Kunkel, Z. Pursell, 2008, Progress in nucleic acid research and molecular biology.

Identification and Cloning of Two Histone Fold Motif-containing Subunits of HeLa DNA Polymerase ε*

Z. Pursell, S. Linn, Ying Li, 2000, The Journal of Biological Chemistry.

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Roland Arnold, Richard G Grundy, Daniele Merico, 2015, Nature Genetics.

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

Chris Sander, Nikolaus Schultz, Kyle R Covington, 2014, Genome research.

Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication

T. Kunkel, Z. Pursell, E. Johansson, 2007, Science.

Comprehensive Analysis of Hypermutation in Human Cancer

K. Cole, P. Raman, C. Hawkins, 2017, Cell.

POLE proofreading defects: Contributions to mutagenesis and cancer.

Z. Pursell, Vivian S. Park, 2019, DNA repair.

Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade

C. Hawkins, Alberto Martin, Z. Pursell, 2020, Cancer Research.

Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80.

Z. Pursell, Heather L. Machado, D. Waizman, 2022, Nature cancer.

Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction.

Z. Pursell, K. Lecompte, A. Y. Göksenin, 2013, DNA repair.

Yeast DNA polymerase epsilon participates in leading-strand DNA replication.

T. Kunkel, Z. Pursell, E. Johansson, 2007, Science.

RNA-mediated double-strand break repair in human cells

N. Jonoska, Z. Pursell, F. Storici, 2022, bioRxiv.

Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase ε

T. Kunkel, Z. Pursell, E. Johansson, 2007, Nucleic acids research.

Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development

Z. Pursell, J. Jackson, K. Hodel, 2022, NAR cancer.

Mouse model and human patient data suggest critical roles for Pten and p53 in suppressing POLE mutant tumor development

Z. Pursell, J. Jackson, K. Hodel, 2021, bioRxiv.

DNA polymerase ε and its roles in genome stability

Z. Pursell, Erin E. Henninger, Zachary F. Pursell, 2014, IUBMB life.

In colonic ρ0 (rho0) cells reduced mitochondrial function mediates transcriptomic alterations associated with cancer

Z. Pursell, S. Savkovic, E. Flemington, 2017, Oncoscience.

Enriched zones of embedded ribonucleotides are associated with DNA replication and coding sequences in the human mitochondrial genome

Alli L. Gombolay, C. Vascotto, G. Tell, 2023, bioRxiv.

Replication DNA polymerases, genome instability and cancer therapies

Z. Pursell, Juliet D. Strauss, 2023, NAR cancer.

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Z. Pursell, Nicholas Light, A. Shlien, 2018, eLife.

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

S. Scherer, D. Merico, P. Nathan, 2015, Nature Genetics.