C. Tintori

发表

Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.

M. Radi, C. Tintori, F. Musumeci, 2013, Journal of medicinal chemistry.

Computational studies of the interaction between the HIV‐1 integrase tetramer and the cofactor LEDGF/p75: Insights from molecular dynamics simulations and the Informational spectrum method

Cristina Tintori, Nevena Veljkovic, Veljko Veljkovic, 2010, Proteins.

Antiproliferative and proapoptotic activities of new pyrazolo[3,4‐d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

C. Tintori, S. Schenone, A. Angelucci, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family.

C. Tintori, C. Zamperini, E. Dreassi, 2016, Journal of medicinal chemistry.

Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors.

M. Trincavelli, C. Martini, P. Fossa, 2005, Journal of medicinal chemistry.

Structure–Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase

L. Altucci, A. Mai, C. Tintori, 2017, ChemMedChem.

A Combination Strategy to Inhibit Pim‐1: Synergism between Noncompetitive and ATP‐Competitive Inhibitors

M. Radi, C. Tintori, F. Musumeci, 2013, ChemMedChem.

Substituted Pyrazolo[3,4‐b]pyridines as Potent A1 Adenosine Antagonists: Synthesis, Biological Evaluation, and Development of an A1 Bovine Receptor Model

M. Trincavelli, C. Martini, C. Tintori, 2008, ChemMedChem.

A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia

C. Tintori, I. Laurenzana, S. Schenone, 2016, Oncotarget.

Computational Studies Identifying Entry Inhibitor Scaffolds Targeting the Phe 43 Cavity of HIV‐1 gp120

B. Clotet, C. Tintori, M. Botta, 2013, ChemMedChem.

Using insights into Pim1 structure to design new anticancer drugs.

C. Tintori, S. Schenone, M. Botta, 2010, Current pharmaceutical design.

Bcr-Abl tyrosine kinase inhibitors: a patent review

C. Tintori, F. Musumeci, C. Brullo, 2015, Expert opinion on therapeutic patents.

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.

C. Tintori, M. Botta, Z. Debyser, 2007, Bioorganic & medicinal chemistry letters.

Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti‐HIV Agents

C. Tintori, C. Brullo, E. Crespan, 2013, ChemMedChem.

A Versatile and Practical Synthesis toward the Development of Novel HIV‐1 Integrase Inhibitors

C. Tintori, G. Vignaroli, M. Botta, 2011, ChemMedChem.

4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling.

I. D. de Esch, C. Tintori, A. L. Fallacara, 2016, Journal of medicinal chemistry.

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2008, Journal of medicinal chemistry.

Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally “frozen” analogues of L-glutamic acid

C. Tintori, M. Botta, R. Fabio, 2014, Beilstein journal of organic chemistry.

Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling.

A. Furlan, C. Tintori, M. Botta, 2012, European journal of medicinal chemistry.

Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.

M. Modugno, P. Fossa, C. Tintori, 2006, Journal of medicinal chemistry.

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2009, Bioorganic & medicinal chemistry letters.

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

G. Biamonti, M. Radi, C. Tintori, 2015, Journal of medicinal chemistry.

Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.

M. Radi, C. Tintori, F. Musumeci, 2011, Journal of medicinal chemistry.

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

A. Furlan, C. Tintori, M. Botta, 2012, Bioorganic & medicinal chemistry letters.

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

C. Tintori, M. Botta, R. Ferrarese, 2017, Chembiochem : a European journal of chemical biology.

The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors

C. Tintori, A. L. Fallacara, I. Laurenzana, 2014, ChemMedChem.

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction.

Cristina Tintori, Maurizio Botta, Anna Lucia Fallacara, 2014, Bioorganic & medicinal chemistry letters.

Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors

C. Tintori, M. Botta, Z. Debyser, 2012, Journal of biomolecular screening.

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors

Cristina Tintori, Maurizio Botta, Giovanni Maga, 2015, J. Chem. Inf. Model..

Inhibition of HIV‐1 Reverse Transcriptase Dimerization by Small Molecules

C. Tintori, M. Botta, M. Clementi, 2016, Chembiochem : a European journal of chemical biology.

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

S. Franco, A. Meyerhans, C. Tintori, 2016, Proceedings of the National Academy of Sciences.

Insight into the Allosteric Inhibition of Abl Kinase

Cristina Tintori, Maurizio Botta, Anna Lucia Fallacara, 2014, J. Chem. Inf. Model..

Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.

M. Radi, C. Tintori, F. Musumeci, 2015, Journal of medicinal chemistry.

Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.

M. Radi, C. Tintori, F. Musumeci, 2011, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.

C. Tintori, C. Brullo, E. Crespan, 2008, European journal of medicinal chemistry.

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.

Cristina Tintori, Tiziano Tuccinardi, Pier Andrea Borea, 2013, Journal of medicinal chemistry.

Novel broad spectrum virucidal molecules against enveloped viruses

C. Tintori, M. Botta, R. Cavalli, 2018, PloS one.

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides

C. Tintori, C. Zamperini, E. Dreassi, 2018, PloS one.

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.

C. Tintori, M. Botta, F. Morreale, 2015, Bioorganic & medicinal chemistry letters.

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

C. Tintori, M. Botta, Z. Debyser, 2015, Chembiochem : a European journal of chemical biology.

2-Aminothiazolones as Anti-HIV Agents That Act as gp120-CD4 Inhibitors

C. Tintori, C. Zamperini, M. Botta, 2014, Antimicrobial Agents and Chemotherapy.

The anti-HIV activity of ADS-J1 targets the HIV-1 gp120.

B. Clotet, C. Tintori, M. Botta, 2005, Virology.

Discovery of small molecule HIV-1 integrase dimerization inhibitors.

Cristina Tintori, Silvio Massa, Zeger Debyser, 2012, Bioorganic & medicinal chemistry letters.

Targets Looking for Drugs: A Multistep Computational Protocol for the Development of Structure-Based Pharmacophores and Their Applications for Hit Discovery

Cristina Tintori, Fabrizio Manetti, Maurizio Botta, 2008, J. Chem. Inf. Model..

Protein-protein interactions and human cellular cofactors as new targets for HIV therapy.

C. Tintori, A. L. Fallacara, S. Schenone, 2014, Current opinion in pharmacology.

A Combination of Molecular Dynamics and Docking Calculations to Explore the Binding Mode of ADS-J1, a Polyanionic Compound Endowed with Anti-HIV-1 Activity

Cristina Tintori, Fabrizio Manetti, Silvio Massa, 2006, J. Chem. Inf. Model..

Hck inhibitors as potential therapeutic agents in cancer and HIV infection.

C. Tintori, F. Musumeci, C. Brullo, 2015, Current medicinal chemistry.

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

C. Tintori, A. L. Fallacara, M. Botta, 2013, ACS medicinal chemistry letters.

Substituted Pyrazolo[3,4‐b]pyridines as Potent A1 Adenosine Antagonists: Synthesis, Biological Evaluation, and Development of an A1 Bovine Receptor Model

M. Trincavelli, C. Martini, C. Tintori, 2008, ChemMedChem.

A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.

M. Radi, C. Tintori, A. L. Fallacara, 2016, Bioorganic & medicinal chemistry letters.