G. Vignaroli

发表

Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.

M. Radi, C. Tintori, F. Musumeci, 2013, Journal of medicinal chemistry.

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands.

Stephan A. Ohnmacht, G. Vignaroli, S. Neidle, 2013, Bioorganic & medicinal chemistry letters.

Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions.

G. Vignaroli, M. Botta, M. Mori, 2016, Bioorganic & medicinal chemistry letters.

Discovery of 14‐3‐3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug‐Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693

C. Ottmann, G. Vignaroli, M. Botta, 2014, ChemMedChem.

A Versatile and Practical Synthesis toward the Development of Novel HIV‐1 Integrase Inhibitors

C. Tintori, G. Vignaroli, M. Botta, 2011, ChemMedChem.

Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.

M. Radi, G. Vignaroli, E. Crespan, 2014, ACS combinatorial science.

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

G. Biamonti, M. Radi, C. Tintori, 2015, Journal of medicinal chemistry.

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

C. Supuran, G. Vignaroli, I. Laurenzana, 2015, ACS chemical biology.

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

C. Zamperini, G. Vignaroli, S. Schenone, 2016, Molecular Cancer Therapeutics.

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

F. Musumeci, C. Zamperini, E. Dreassi, 2017, Journal of medicinal chemistry.

Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery

C. Zamperini, E. Dreassi, G. Vignaroli, 2016, Scientific Reports.

Small molecules modulation of 14-3-3 protein-protein interactions.

Maurizio Botta, Mattia Mori, G. Vignaroli, 2013, Drug discovery today. Technologies.

An alternative synthetic approach for the synthesis of biologically relevant 1,4-disubstituted pyrazolo[3,4-d]pyrimidines

M. Radi, G. Vignaroli, S. Schenone, 2013 .

AuNP Pyrazolo[3,4-d]pyrimidine Nanosystem in Combination with Radiotherapy against Glioblastoma.

E. Dreassi, G. Vignaroli, S. Schenone, 2020, ACS medicinal chemistry letters.

CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction.

M. Radi, F. Musumeci, C. Zamperini, 2014, Drug metabolism and pharmacokinetics.

Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors.

M. Radi, F. Musumeci, C. Zamperini, 2013, ACS medicinal chemistry letters.

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

C. Zamperini, G. Vignaroli, S. Schenone, 2016, Molecular Cancer Therapeutics.