W. Metzler

发表

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

W. Metzler, J. Yanchunas, C. Weigelt, 2008, Protein science : a publication of the Protein Society.

J. Novotný, W. Metzler, S. Krystek, 1995, Current protocols in protein science.

Simulated annealing with restrained molecular dynamics using a flexible restraint potential: Theory and evaluation with simulated NMR constraints

Roberto Tejero, G. Montelione, R. Bruccoleri, 1996, Protein science : a publication of the Protein Society.

Refined solution structure of human profilin I

K. Constantine, M. Friedrichs, L. Mueller, 1995, Protein science : a publication of the Protein Society.

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.

M. Witmer, W. Metzler, J. Marcinkeviciene, 2003, The Journal of biological chemistry.

Use of 1HN-1HN NOEs to Determine Protein Global Folds in Perdeuterated Proteins

Bennett T. Farmer, Leonard D. Spicer, Luciano Mueller, 1995 .

Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.

L. Mueller, D. Cheney, W. Metzler, 2015, Journal of medicinal chemistry.

Identification of the poly-L-proline-binding site on human profilin.

L. Mueller, W. Metzler, T. Lavoie, 1994, The Journal of biological chemistry.

Assessing compound binding to the Eg5 motor domain using a thermal shift assay.

M. Doyle, V. Goldfarb, W. Metzler, 2009, Analytical biochemistry.

Building homogeneous time-resolved fluorescence resonance energy transfer assays for characterization of bivalent inhibitors of an inhibitor of apoptosis protein target.

Shana L. Posy, W. Metzler, R. Talbott, 2016, Analytical biochemistry.

Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern.

K. Constantine, M. Friedrichs, L. Mueller, 1993, Biochemistry.

Characterization of NADP+ binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes.

K. Constantine, M. Friedrichs, M. Wittekind, 1997, Journal of molecular biology.

NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein.

Stephen R. Johnson, David S. Taylor, K. Constantine, 2006, Journal of medicinal chemistry.

1D NMR Methods for Hit Identification

L. Mueller, W. Metzler, Caroline Fanslau, 2017 .

Solution structure of the calcium channel antagonist omega-conotoxin GVIA.

A. Pardi, W. Metzler, J. Skalicky, 1993, Protein science : a publication of the Protein Society.

Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.

V. Goldfarb, W. Metzler, K. Kish, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

HTRF assays for characterization of bivalent inhibitors of an Inhibitor of Apoptosis Protein target

Shana L. Posy, W. Metzler, R. Talbott, 2015 .

Immunologic and molecular characterization of Amb p V allergens from Ambrosia psilostachya (western Ragweed) pollen.

T. Rafnar, W. Metzler, D. Bassolino-Klimas, 1994, Journal of immunology.

Determination of the three-dimensional solution structure of ragweed allergen Amb t V by nuclear magnetic resonance spectroscopy.

M. Friedrichs, L. Mueller, W. Metzler, 1992, Biochemistry.

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

W. Metzler, Soong-Hoon Kim, Kenneth J. Leavitt, 2005, Bioorganic & medicinal chemistry letters.

λ cro Represser complex with OR3 operator DNA: 19F nuclear magnetic resonance observations

W. Metzler, P. Lu, 1989 .

Determining local conformational variations in DNA. Nuclear magnetic resonance structures of the DNA duplexes d(CGCCTAATCG) and d(CGTCACGCGC) generated using back-calculation of the nuclear Overhauser effect spectra, a distance geometry algorithm and constrained molecular dynamics.

R. Levy, A. Pardi, D. Kitchen, 1990, Journal of molecular biology.

Two-dimensional heteronuclear NOE spectroscopy; Application to 19F-labeled oligodeoxyribonucleotides

W. Metzler, P. Lu, P. Leighton, 1988 .

Relaxation study of the backbone dynamics of human profilin by two‐dimensional 1H‐15N NMR

K. Constantine, M. Friedrichs, L. Mueller, 1993, FEBS letters.

Multiple and single binding modes of fragment-like kinase inhibitors revealed by molecular modeling, residue type-selective protonation, and nuclear overhauser effects.

Wayne Vaccaro, Luciano Mueller, K. Constantine, 2008, Journal of medicinal chemistry.

Lambda phage cro repressor interaction with its operator DNA: 2'-deoxy-5-fluorouracil OR3 analogues.

K. Arndt, W. Metzler, P. Lu, 1985, Biochemistry.

An improved protocol for amino acid type-selective isotope labeling in insect cells

L. Mueller, M. Witmer, D. Hedin, 2017, Journal of Biomolecular NMR.

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

W. Metzler, C. Weigelt, L. Hamann, 2006, Archives of biochemistry and biophysics.

The Amb V Allergens from Ragweed

T. Rafnar, W. Metzler, D. Marsh, 1996 .

Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family.

P. Linsley, J. Bajorath, W. Metzler, 1997, Journal of molecular graphics & modelling.

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28

K. Constantine, L. Mueller, P. Linsley, 1997, Nature Structural Biology.

Analysis of the three-dimensional antigenic structure of giant ragweed allergen, Amb t 5.

T. Rafnar, W. Metzler, D. Bassolino-Klimas, 1998, Molecular immunology.

Expression and analysis of recombinant Amb a V and Amb t V allergens. Comparison with native proteins by immunological assays and NMR spectroscopy.

L. Mueller, T. Rafnar, W. Metzler, 1992, The Journal of biological chemistry.

The Ligand Binding Domain of the Human Retinoic Acid Receptor γ Is Predominantly α-Helical with a Trp Residue in the Ligand Binding Site (*)

W. Metzler, P. Reczek, J. Lupisella, 1995, The Journal of Biological Chemistry.

Solution structure of the calcium channel antagonist ω‐conotoxin GVIA

A. Pardi, W. Metzler, J. Skalicky, 1993 .

Hydrophobicity Profiles for Protein Sequence Analysis

W. Metzler, S. Krystek, J. Novotny, 1995, Current protocols in protein science.

An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.

Robert A Copeland, M. Witmer, J. Hendrick, 2005, Biochemistry.

Characterization of the three-dimensional solution structure of human profilin: proton, carbon-13, and nitrogen-15 NMR assignments and global folding pattern

K. Constantine, M. Friedrichs, L. Mueller, 1993 .

Limited sampling of conformational space by the distance geometry algorithm: implications for structures generated from NMR data.

A. Pardi, W. Metzler, W J Metzler, 1989, Biochemistry.

Proton resonance assignments and three-dimensional solution structure of the ragweed allergen Amb a V by nuclear magnetic resonance spectroscopy.

L. Mueller, W. Metzler, D. Marsh, 1992, Biochemistry.

Solution structure of an isolated antibody VL domain.

K. Constantine, M. Friedrichs, M. Wittekind, 1994, Journal of molecular biology.

An improved protocol for amino acid type-selective isotope labeling in insect cells

M. Witmer, D. Hedin, W. Metzler, 2017, Journal of Biomolecular NMR.

Removal of diagonal peaks in two-dimensional NMR spectra by means of digital filtering

Mark S. Friedrichs, Luciano Mueller, M. Friedrichs, 1991 .

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

W. Metzler, J. Yanchunas, C. Weigelt, 2008, Protein science : a publication of the Protein Society.

Incorporation of 1H/13C/15N-{Ile, Leu, Val} into a Perdeuterated, 15N-Labeled Protein: Potential in Structure Determination of Large Proteins by NMR

M. Wittekind, V. Goldfarb, L. Mueller, 1996 .

Protein-ligand NOE matching: a high-throughput method for binding pose evaluation that does not require protein NMR resonance assignments.

Brian L Claus, Brian L. Claus, Luciano Mueller, 2006, Journal of the American Chemical Society.