D. Xie

发表

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

W. Metzler, J. Yanchunas, C. Weigelt, 2008, Protein science : a publication of the Protein Society.

X‐Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase

D. Xie, J. Sack, Chiehying Y Chang, 2011, Chemical biology & drug design.

The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor

M. Doyle, D. Xie, P. Morin, 2014, Journal of The American Society for Mass Spectrometry.

Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders.

M. Witmer, S. Gupta, D. Xie, 2016, Analytical biochemistry.

Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).

S. Spergel, K. McIntyre, J. Tokarski, 2019, Journal of medicinal chemistry.

Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.

J. Barrish, D. Xie, N. Murugesan, 2020, ACS medicinal chemistry letters.

The Crystal Structure of Abl Kinase with BMS-354825, a Dual SRC/ABL Kinase Inhibitor.

J. Tokarski, K. Kish, H. Klei, 2004 .

Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.

J. Tokarski, D. Xie, N. Araníbar, 2017, MedChemComm.

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

S. Spergel, K. McIntyre, D. Shuster, 2019, Journal of medicinal chemistry.

Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.

J. Fargnoli, J. Tokarski, D. Xie, 2008, Journal of medicinal chemistry.

Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.

Vijay T. Ahuja, J. Tokarski, D. Xie, 2019, ACS medicinal chemistry letters.

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.

James Lin, K. McIntyre, J. Tokarski, 2019, ACS medicinal chemistry letters.

Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.

C. Weigelt, K. Kish, H. Klei, 2010, Journal of medicinal chemistry.

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain*

Stephen R. Johnson, M. Witmer, J. Tokarski, 2015, The Journal of Biological Chemistry.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

Structural basis for the high-affinity binding of pyrrolotriazine inhibitors of p38 MAP kinase.

K. Kish, D. Xie, J. Sack, 2008, Acta Crystallographica Section D: Biological Crystallography.

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors.

K. Kish, H. Klei, D. Xie, 2011, The Biochemical journal.

The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants.

M. Wittekind, J. Tokarski, K. Kish, 2006, Cancer research.

An improved protocol for amino acid type-selective isotope labeling in insect cells

L. Mueller, M. Witmer, D. Hedin, 2017, Journal of Biomolecular NMR.

Correlation of High-Throughput Pregnane X Receptor (PXR) Transactivation and Binding Assays

Zhengrong Zhu, R. Stoffel, Taosheng Chen, 2004, Journal of biomolecular screening.

Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity.

D. Xie, S. Sheriff, Chunhong Yan, 2016, Acta crystallographica. Section D, Structural biology.

Time-resolved limited proteolysis of mitogen-activated protein kinase-activated protein kinase-2 determined by LC/MS only

M. Doyle, D. Xie, J. Bryson, 2008, Journal of the American Society for Mass Spectrometry.

Structural and functional characterization of CFE88: Evidence that a conserved and essential bacterial protein is a methyltransferase

B. Dougherty, M. Doyle, K. Constantine, 2005, Protein science : a publication of the Protein Society.

Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).

D. Xie, S. Sheriff, D. Lipovšek, 2020, Acta crystallographica. Section F, Structural biology communications.

An improved protocol for amino acid type-selective isotope labeling in insect cells

M. Witmer, D. Hedin, W. Metzler, 2017, Journal of Biomolecular NMR.

The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.

A. Cacace, D. Xie, Yaqun Zhang, 2014, Acta crystallographica. Section F, Structural biology communications.

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

W. Metzler, J. Yanchunas, C. Weigelt, 2008, Protein science : a publication of the Protein Society.

Structural basis for CARM1 inhibition by indole and pyrazole inhibitors.

K. Kish, H. Klei, D. Xie, 2011, The Biochemical journal.