J. Palmer

发表

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

J. R. Somoza, Dan Wang, J. Falgueyret, 2005, Journal of medicinal chemistry.

Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors

J T Palmer, P. Rosenthal, J. Palmer, 1996, Antimicrobial agents and chemotherapy.

Cathepsin S activity regulates antigen presentation and immunity.

R. Mitchell, H. Ploegh, J. Palmer, 1998, The Journal of clinical investigation.

Peptide ketobenzoxazole inhibitors bound to cathepsin K.

J. R. Somoza, M. Mcgrath, J. Palmer, 2003, Biochemistry.

A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.

J. Falgueyret, J. Palmer, C. Bryant, 2003, Journal of medicinal chemistry.

Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis.

J. Palmer, M. Murphey, R. Smith, 1994, Arthritis and rheumatism.

A convergent synthetic strategy for the polyene macrolide pimaricin

J. Palmer, D. W. Brooks, 1983 .

Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex

M. Mcgrath, J. Palmer, B. Katz, 1997, Protein science : a publication of the Protein Society.

Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei.

J. Palmer, J. McKerrow, R. Morty, 1999, Experimental parasitology.

Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones

J. Palmer, D. Brömme, H. Wex, 1999, Biological chemistry.

Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritis.

J. Palmer, L. Watts, L. Martín, 1992, Biochemical pharmacology.

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.

J. Palmer, D. Brömme, D. Rasnick, 1996, The Biochemical journal.

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.

J. Palmer, R. Rydzewski, Rohan V Mendonca, 2006, Bioorganic & medicinal chemistry letters.

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.

J. Palmer, D. Davies, C. Morton, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Edward M. Tyndall, J. Palmer, D. Davies, 2013, Bioorganic & medicinal chemistry letters.

Vinyl sulfones as mechanism-based cysteine protease inhibitors.

J. Palmer, D. Brömme, D. Rasnick, 1995, Journal of medicinal chemistry.

Keto-1,3,4-oxadiazoles as cathepsin K inhibitors.

J. Palmer, J. McCarter, H. Cheung, 2006, Bioorganic & medicinal chemistry letters.

Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.

J. Palmer, R. Rydzewski, Leland C. Burrill, 2006, Journal of medicinal chemistry.

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

J. Falgueyret, J. Palmer, M. Venuti, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase

L. Honigberg, J. Spoerke, D. Jeffery, 2007, ChemMedChem.

Cytochalasin support studies. 10. Nucleophilic and electrophilic mercaptanylations via 2-(trimethylsilyl)ethanethiol-derived reagents

J. Palmer, P. Fuchs, M. G. Ranasinghe, 1988 .

An Intramolecular Diels-alder Reaction of a Z-Diene. Generation Of The Chiral Isoindolone Nucleus Of Cytochalasin C.1

M. Hensel, J. Palmer, P. Fuchs, 1986 .

Synthetic studies of trichothecenes, an enantioselective synthesis of a C-ring precursor of anguidine

J. Palmer, D. W. Brooks, P. Grothaus, 1982 .

Synthesis and Alkylation of Vinylsulfinic Acids via Fluoride Cleavage of β-Trimethylsilylethyl Vinyl Sulfones

J. Palmer, P. Fuchs, 1988 .

Crystal structure of human cathepsin V.

J. R. Somoza, M. Mcgrath, J. Palmer, 2000, Biochemistry.

Novel route to the synthesis of peptides containing 2-amino-1'-hydroxymethyl ketones and their application as cathepsin K inhibitors.

Shankar Venkatraman, J. Palmer, S. Venkatraman, 2002, Bioorganic & medicinal chemistry letters.

The effects of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis.

J. Palmer, L. Watts, R. Esser, 1993, The Journal of rheumatology.

Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.

J. Palmer, J. McKerrow, D. Bainton, 1998, Journal of cell science.

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

David M. Shackleford, Christopher J Burns, Susan A Charman, 2009, Bioorganic & medicinal chemistry letters.

Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor.

J. Palmer, R. Gay, S. Gay, 2001, Arthritis and rheumatism.

Crystal structure of human cathepsin S

J T Palmer, J. R. Somoza, M. Mcgrath, 1998, Protein science : a publication of the Protein Society.

Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor.

J. R. Somoza, J. Palmer, K. Mortara, 2002, Acta crystallographica. Section D, Biological crystallography.

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

C. Bayly, J. Falgueyret, J. Palmer, 2006, Bioorganic & Medicinal Chemistry Letters.

The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.

J. R. Somoza, J. Palmer, J. Ho, 2002, Journal of molecular biology.

Sweet chestnut rutstroemias (Sclerotiniaceae) on an acorn and oak cupules, and Sclerotinia gregoriana n.sp. on deer-grass (Investigations into the Sclerotiniaceae - II)

J. Palmer, 1968 .

The rehabilitation of Sclerotinia bresadolae

J. Palmer, 1992 .

pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

J. Palmer, R. Rydzewski, C. Barrett, 2002, Bioorganic chemistry.

Torrendiella quintocentenaria: a new quercicolous species from Mexico

J. Palmer, C. Ochoa, R. Galán, 1993 .

Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.

J T Palmer, P. Rosenthal, J. Palmer, 1991, The Journal of clinical investigation.

Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.

J. R. Somoza, C. Bayly, J. Palmer, 2006, Journal of Medicinal Chemistry.

Development of a scalable synthesis of a nonbasic inhibitor of the serine protease tryptase

J. Palmer, C. O'bryan, David Sperandio, 2006 .

Observations on gasteromycetes. 1–3

J. Palmer, 1955 .

Design and Synthesis of Selective Keto‐1,2,4‐oxadiazole‐based Tryptase Inhibitors.

J. Palmer, R. Rydzewski, Rohan V Mendonca, 2006 .

Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.

J. Palmer, E. Setti, S. Venkatraman, 2006, Bioorganic & medicinal chemistry letters.