D. Davis

发表

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

J. R. Somoza, Dan Wang, J. Falgueyret, 2005, Journal of medicinal chemistry.

3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity.

D. Davis, E. Setti, J. McCarter, 2003, Bioorganic & medicinal chemistry letters.

3,4-Disubstituted Azetidinones as Selective Inhibitors of the Cysteine Protease Cathepsin K. Exploring P3 Elements for Potency and Selectivity.

D. Davis, E. Setti, J. McCarter, 2003 .

Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.

D. Davis, A. Railkar, Amy D. Fung, 2014, Journal of medicinal chemistry.

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

D. Davis, J. Trimmer, K. Hoff, 2018, PloS one.

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.

A. Kuglstatter, D. Davis, Jaehyeon Park, 2015, Journal of medicinal chemistry.

Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.

A. Kuglstatter, D. Davis, R. Kondru, 2015, Bioorganic & medicinal chemistry letters.

Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

C. Bayly, J. Falgueyret, J. Palmer, 2006, Bioorganic & Medicinal Chemistry Letters.

Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity.

M. Wolzt, S. Moncada, P. Vallance, 1999, The Journal of biological chemistry.

Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.

J. R. Somoza, C. Bayly, J. Palmer, 2006, Journal of Medicinal Chemistry.

3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity.

D. Jeffery, D. Davis, E. Setti, 2003, Bioorganic & medicinal chemistry letters.