R. Rydzewski

发表

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

J. R. Somoza, Dan Wang, J. Falgueyret, 2005, Journal of medicinal chemistry.

Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research

Robert M. Rydzewski, R. Rydzewski, 2008 .

Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides.

R. Rydzewski, M. J. Mcroberts, J. Verheyden, 1992, Journal of medicinal chemistry.

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

J. Falgueyret, R. Rydzewski, M. Percival, 2001, Journal of medicinal chemistry.

Free fatty acids promote hepatic lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway

G. Gores, A. Canbay, L. Burgart, 2004 .

O0040 FREE FATTY ACIDS PROMOTE HEPATIC LIPOTOXICITY BY STIMULATING TNF‐ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY

G. Gores, A. Canbay, L. Burgart, 2004, Journal of Pediatric Gastroenterology and Nutrition.

Swelling and shrinking of a polyelectrolyte gel induced by a salt solution

R. Rydzewski, 1990 .

Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors.

C. Bryant, R. Rydzewski, R. Oballa, 2002, Bioorganic & medicinal chemistry.

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.

J. Palmer, R. Rydzewski, Rohan V Mendonca, 2006, Bioorganic & medicinal chemistry letters.

An allylic azide route to 4'-azido carbocyclic nucleosides. Synthesis of (.+-.)-(1'.alpha.,2'.alpha.,3'.beta.)- and (.+-.)-(1'.alpha.,2'.beta.,3'.beta.)-1-[1-azido-2-hydroxy-1-(hydroxymethyl)-3-cyclopentyl]thymine

R. Rydzewski, H. Maag, 1992 .

Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics.

M. Erion, Q. Dang, P. D. van Poelje, 2009, Journal of medicinal chemistry.

Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and cellular properties of potent, selective proteasome inhibitors.

J. Palmer, R. Rydzewski, Leland C. Burrill, 2006, Journal of medicinal chemistry.

An unexpected cyclization discovered during the synthesis of 8-substituted purines from a 4,5-diaminopyrimidine

M. Erion, Q. Dang, R. Rydzewski, 2008 .

4-Substituted-5(3)-carbamoyl-3(5)-(2-deoxy-β-D-ribofuranosyl)pyrazoles. Application of Palladium Catalyzed Glycal Coupling Methodology to the Synthesis of Pyrazofurin Analogs

M. Erion, R. Rydzewski, 1997 .

Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration.

M. Erion, Q. Dang, P. D. van Poelje, 2007, Bioorganic & medicinal chemistry letters.

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

J. Falgueyret, R. Rydzewski, M. Percival, 2001, Journal of medicinal chemistry.

Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.

J. C. Martin, R. Rydzewski, D. McGee, 1988, Journal of medicinal chemistry.

Structure-Activity Relationships Among HIV Inhibitory 4′-Substituted Nucleosides

R. Rydzewski, J. Verheyden, H. Maag, 1993 .

Project Considerations

Robert M. Rydzewski, R. Rydzewski, 2008, Real World Drug Discovery.

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.

G. Gores, A. Canbay, R. Rydzewski, 2003, The Journal of clinical investigation.

pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

J. Palmer, R. Rydzewski, C. Barrett, 2002, Bioorganic chemistry.

Design and Synthesis of Selective Keto‐1,2,4‐oxadiazole‐based Tryptase Inhibitors.

J. Palmer, R. Rydzewski, Rohan V Mendonca, 2006 .