N. Chirgadze

发表

The crystal structures of human α‐thrombin complexed with active site‐directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors

M. Zhang, N. Chirgadze, D. Sall, 2008, Protein science : a publication of the Protein Society.

X-CHIP: An Integrated Platform for High-Throughput Protein Crystallography

E. Pai, N. Chirgadze, R. Lam, 2012 .

The crystal structure of human α‐thrombin complexed with LY178550, a nonpeptidyl, active site‐directed inhibitor

N. Chirgadze, D. Sall, S. Briggs, 1997, Protein science : a publication of the Protein Society.

D-Phe-Pro-p-Amidinobenzylamine: A potent and highly selective thrombin inhibitor

N. Chirgadze, D. Clawson, N. D. Jones, 1996 .

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.

Narendra Kumar Patel, Y. Liu, T. Mak, 2016, ACS medicinal chemistry letters.

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Narendra Kumar Patel, T. Mak, N. Chirgadze, 2014, Bioorganic & medicinal chemistry.

A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.

N. Chirgadze, S. Briggs, Sohaib A. Khan, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, T. Mak, N. Chirgadze, 2015 .

Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)

E. Pai, B. Neel, N. Chirgadze, 2014, BMC Structural Biology.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.

D. R. Berry, N. Chirgadze, D. Clawson, 1996, Journal of medicinal chemistry.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.

D. R. Berry, N. Chirgadze, D. Clawson, 1996 .

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality.

D. R. Berry, N. Chirgadze, D. Clawson, 1996, Journal of medicinal chemistry.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides.

D. R. Berry, N. Chirgadze, D. Clawson, 1996, Journal of medicinal chemistry.

Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis

N. Chirgadze, S. Briggs, K. A. McAllister, 2000, The EMBO journal.

Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: Homology of the AhpD-like structural family

E. Pai, N. Chirgadze, G. Kisselman, 2011, BMC Structural Biology.

Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)

N. Chirgadze, J. Ohren, Cindy Spessard, 2007, Protein science : a publication of the Protein Society.

The crystal structure of bacteriophage HK97 gp6: defining a large family of head-tail connector proteins.

J. Rubinstein, N. Chirgadze, A. Davidson, 2010, Journal of molecular biology.

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.

N. Chirgadze, D. Clawson, K. Appelt, 1997, Journal of medicinal chemistry.

Crystal structure of the CN-hydrolase SA0302 from the pathogenic bacterium Staphylococcus aureus belonging to the Nit and NitFhit Branch of the nitrilase superfamily

E. Pai, N. Chirgadze, W. Qiu, 2013, Journal of biomolecular structure & dynamics.

The structure of SAV1646 from Staphylococcus aureus belonging to a new `ribosome-associated' subfamily of bacterial proteins.

E. Pai, N. Chirgadze, G. Kisselman, 2015, Acta crystallographica. Section D, Biological crystallography.

Purification, characterization and preliminary X-ray study of fumarase from Saccharomyces cerevisiae.

N. Chirgadze, V. Zaitsev, J. Keruchenko, 1992, Biochimica et biophysica acta.

Structure of Francisella tularensis peptidyl-tRNA hydrolase.

S. Gothe, N. Chirgadze, R. Lam, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

SERINE PROTEASE SELECTIVITY OF THE THROMBIN INHIBITOR D-PHE-PRO-AGMATINE AND ITS HOMOLOGS

A. Schacht, N. Chirgadze, D. Clawson, 1995 .

Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.

J. A. Kyle, N. Chirgadze, S. Briggs, 2000, Journal of Medicinal Chemistry.

A family of arginal thrombin inhibitors related to efegatran.

N. Chirgadze, G. Sandusky, R. Hermann, 1996, Seminars in thrombosis and hemostasis.

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives.

R. W. Harper, N. Chirgadze, M. J. Fisher, 2000, Journal of medicinal chemistry.

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.

R. W. Harper, N. Chirgadze, S. Briggs, 1997, Journal of medicinal chemistry.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.

J. Wikel, N. Chirgadze, S. Briggs, 1998, Bioorganic & medicinal chemistry letters.

Structure and Protein-Protein Interaction Studies on Chlamydia trachomatis Protein CT670 (YscO Homolog)

N. Chirgadze, Radhey S. Gupta, T. Skarina, 2010, Journal of bacteriology.

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element.

A. Schacht, N. Chirgadze, S. Briggs, 1999, Bioorganic & medicinal chemistry letters.

N-substituted glycines as replacements for proline in tripeptide aldehyde thrombin inhibitors

A. Schacht, N. Chirgadze, D. Clawson, 1995 .

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2

E. Pai, N. Chirgadze, R. Rottapel, 2014, Acta crystallographica. Section D, Biological crystallography.

Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058

E. Pai, B. Neel, N. Chirgadze, 2021, Journal of Biomolecular Structure and Dynamics.

Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.

Ruslan Sanishvili, N. Chirgadze, T. Skarina, 2007, Journal of molecular biology.

Crystal structure of the passenger domain of the Escherichia coli autotransporter EspP.

E. Pai, N. Chirgadze, L. E. Sandercock, 2011, Journal of Molecular Biology.

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.

Yun-Xing Wang, C. Arrowsmith, N. Chirgadze, 2011, Structure.

A conserved spiral structure for highly diverged phage tail assembly chaperones.

N. Chirgadze, A. Davidson, A. Tuite, 2013, Journal of molecular biology.

Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.

N. Chirgadze, S. Briggs, D. Clawson, 2000, The Journal of biological chemistry.

A single sequence change destabilizes the influenza virus neuraminidase tetramer.

N. Chirgadze, E. Garman, W. G. Laver, 1997, Virology.

Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. Part 3. Indole-3-glyoxamides.

D. R. Berry, N. Chirgadze, D. Clawson, 1997 .

Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation

N. Chirgadze, G. Kisselman, W. Qiu, 2013 .

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

M. Tyers, A. Joachimiak, P. Sansonetti, 2008, Nature Structural &Molecular Biology.

X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection

E. Pai, N. Chirgadze, R. Lam, 2011, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of Staphylococcus aureus Zn-glyoxalase I: new subfamily of glyoxalase I family

E. Pai, N. Chirgadze, R. Lam, 2018, Journal of biomolecular structure & dynamics.

Functional identification of ‘hypothetical protein’ structures with unknown function

N. Chirgadze, A. M. Kargatov, Y. Chirgadze, 2022, Journal of biomolecular structure & dynamics.

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain.

J. Wikel, N. Chirgadze, D. Gifford-Moore, 1999, Bioorganic & medicinal chemistry letters.

X-CHIP: an integrated platform for high-throughput protein crystallization and on-the-chip X-ray diffraction data collection

E. Pai, N. Chirgadze, G. Kisselman, 2011, Acta crystallographica. Section D, Biological crystallography.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.

R. W. Harper, A. Smith, N. Chirgadze, 1999, Bioorganic & medicinal chemistry letters.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.

J. A. Kyle, Michael Robert Wiley, N. Chirgadze, 2000, Journal of Medicinal Chemistry.