Mark D. McBriar

发表

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

W. Greenlee, Mark D. McBriar, H. Guzik, 2006, Journal of medicinal chemistry.

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Ruo Xu, Zhiqiang Zhao, Murali Rajagopalan, 2007 .

Melanin-Concentrating Hormone as a Therapeutic Target

Mark D. McBriar, T. Kowalski, Timothy J. Kowalski, 2005 .

Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity

Mark D. McBriar, T. Kowalski, Timothy J Kowalski, 2004, Expert opinion on investigational drugs.

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2008, Bioorganic & medicinal chemistry letters.

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2013, Bioorganic & medicinal chemistry letters.

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Ruo Xu, William J Greenlee, Daniel J Weston, 2006, Bioorganic & medicinal chemistry.

Spongistatin synthetic studies. 3. Construction of the C(1–17) spiroketal

Mark D. McBriar, A. M. Boldi, Amos B. Smith, 1997 .

Spongistatin synthetic studies. 1. Construction of a C(29–48) subtarget

Mark D. McBriar, P. Verhoest, A. M. Boldi, 1997 .

Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2.

Clay S. Bennett, Mark D. McBriar, A. M. Boldi, 2009, Tetrahedron.

The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment.

Mark D. McBriar, A. M. Boldi, K. Nakayama, 2001, Angewandte Chemie.

SAR of tricyclic sulfones as γ-secretase inhibitors

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2011 .

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.

W. Greenlee, Mark D. McBriar, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.

Mark D. McBriar, H. Guzik, J. Clader, 2006, European journal of pharmacology.

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

William J Greenlee, Anandan Palani, Brian Hawes, 2005, Journal of medicinal chemistry.

Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.

William J Greenlee, Anandan Palani, Brian Hawes, 2005, Bioorganic & medicinal chemistry letters.

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

Ruo Xu, William J Greenlee, Anandan Palani, 2005, Journal of medicinal chemistry.

The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2.

Mark D. McBriar, K. Nakayama, L. Zhuang, 2001, Angewandte Chemie.

Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: impacting hERG liability via aryl modifications.

Mark D. McBriar, H. Guzik, S. Shapiro, 2006, Bioorganic & medicinal chemistry letters.