K. Briner

发表

Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.

T. I. Richardson, P. Ornstein, K. Briner, 2004, Journal of medicinal chemistry.

Water-compatible Cycloadditions of Oligonucleotide-conjugated Strained Allenes for DNA-encoded Library Synthesis.

S. Schreiber, K. Briner, Matthias V Westphal, 2020, Journal of the American Chemical Society.

Systematic Chemogenetic Library Assembly

Stephen M. Canham, Daniel S. Palacios, John A. Tallarico, 2020, bioRxiv.

Studies on the Synthesis of Aureolic Acid Antibiotics: Acyloin Glycosidation Studies.

K. Briner, W. Roush, Darin J. Gustin, 1996, The Journal of organic chemistry.

DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules

Connor W. Coley, P. Clemons, S. Schreiber, 2022, bioRxiv.

New approaches to rapid onset antidepressants.

K. Briner, R. Dodel, 1998, Current pharmaceutical design.

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Connor W. Coley, John M. Knapp, Christoph E. Dumelin, 2023, Nature communications.

From Ergolines to Indoles: Improved Inhibitors of the Human H3 Receptor for the Treatment of Narcolepsy

M. Bock, Y. Auberson, Charles R. Yang, 2015, ChemMedChem.

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

D. Curtis, M. Hild, Yiping Shen, 2018, Journal of medicinal chemistry.

A laser flash photolysis derived study of a glycosylidene carbene

K. Briner, A. Vasella, M. Platz, 1991 .

Highly stereoselective synthesis of α-L-olivomycosides via trimethylsilyl triflate mediated glycosidations of 1-O-acetyl-4-O-isobutyryl-2,6-dideoxy-2-iodo-3-C-methyl-α-L-mannopyranose

K. Briner, W. Roush, D. Sebesta, 1993 .

Studies on the Synthesis of Aureolic Acid Antibiotics: Acyloin Glycosidation Studies.

K. Briner, W. Roush, Darin J. Gustin, 1996, The Journal of organic chemistry.

Glycosylidene Carbenes a new approach to glycoside synthesis. Part 1. Preparation of glycosylidene-derived diaziridines and diazirines†

K. Briner, A. Vasella, 1989 .

Glycosylphosphonates of 2‐Amino‐2‐deoxy‐aldoses. Synthesis of a Phosphonate Analogue of Lipid X

K. Briner, A. Vasella, 1987 .

Glycosylidene Carbenes. Part 13. Synthesis and thermolysis of representative 1‐azi‐glycoses

K. Briner, A. Vasella, L. Panza, 1993 .

Glycosylidene Carbenes. Part 6. Synthesis of alkyl and fluoroalkyl glycosides

K. Briner, A. Vasella, 1992 .

Synthesis of constrained arylpiperidines using intramolecular Heck or radical reactions

C. Wermuth, K. Briner, A. Mann, 2001 .

Glycosylidene Carbenes. Part 2. Synthesis of O‐Aryl Glycosides

K. Briner, A. Vasella, 1990 .

Glycosylidene Carbenes. Part 19. Regioselective glycosidation of allyl 2-deoxy-2-phthalimido-D-allopyranosides

K. Briner, A. Vasella, B. Bernet, 1994 .

Water-compatible Cycloadditions of Oligonucleotide-conjugated Strained Allenes for DNA-encoded Library Synthesis.

S. Schreiber, K. Briner, L. Hudson, 2019, Journal of the American Chemical Society.

Systematic Chemogenetic Library Assembly

Yuan Wang, Florian Nigsch, Jeremy L. Jenkins, 2020, bioRxiv.

Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.

John A. Tallarico, Charles A. Wartchow, G. Dranoff, 2023, Cell chemical biology.

Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives.

P. Ornstein, K. Briner, M. J. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.

P. Ornstein, K. Briner, M. J. Fisher, 2005, Bioorganic & medicinal chemistry letters.

Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of N-Methyl-5-aryl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators.

D. Chin, L. Hamann, K. Briner, 2021, Journal of medicinal chemistry.

Modular Synthesis of Cyclopropane-Fused N-Heterocycles Enabled by Underexplored Diazo Reagents.

S. Schreiber, K. Briner, F. Zécri, 2022, Angewandte Chemie.

Diversity-oriented synthesis encoded by deoxyoligonucleotides

Connor W. Coley, John M. Knapp, Christoph E. Dumelin, 2023, bioRxiv.

Privileged structure-based ligands for melanocortin receptors-tetrahydroquinolines, indoles, and aminotetralines.

P. Ornstein, K. Briner, M. J. Fisher, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor.

P. Ornstein, K. Briner, M. J. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Privileged structure based ligands for melanocortin-4 receptors--aliphatic piperazine derivatives.

P. Ornstein, K. Briner, M. J. Fisher, 2006, Bioorganic & medicinal chemistry letters.

The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders

M. Bock, Y. Auberson, Charles R. Yang, 2019, ChemMedChem.

Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive–Compulsive Disorder

K. Briner, Xia Li, Denise Morrow, 2017, Front. Psychiatry.

Rational screening for cooperativity in small-molecule inducers of protein–protein associations

Bruce K. Hua, S. Schreiber, K. Briner, 2023, bioRxiv.