T. Steele

发表

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2004, Journal of medicinal chemistry.

Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

Paul Zuck, Georgia McGaughey, Amy S. Espeseth, 2009, Bioorganic & medicinal chemistry letters.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

A. Simon, S. Stachel, C. Coburn, 2008, The Journal of pharmacology and experimental therapeutics.

Expedient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones

M. Bock, C. Coburn, T. Steele, 1998 .

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

J. Barrow, K. Rittle, R. Freidinger, 2000 .

Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.

G. McGaughey, S. Stachel, T. Steele, 2012, Bioorganic & medicinal chemistry letters.

Expedient Synthesis of 5-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones.

M. Bock, C. Coburn, T. Steele, 1999 .

Conformationally biased P3 amide replacements of beta-secretase inhibitors.

M Katharine Holloway, S. Stachel, C. Coburn, 2006, Bioorganic & medicinal chemistry letters.

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

A. Simon, S. Stachel, C. Coburn, 2008, Journal of Pharmacology and Experimental Therapeutics.

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

John D. Schreier, Min Xu, D. Hazuda, 2015, Journal of medicinal chemistry.

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

J. Barrow, K. Rittle, R. Freidinger, 2000, Journal of medicinal chemistry.

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Xiao-Ping Shi, Amy S Espeseth, Min Xu, 2005, Analytical biochemistry.

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

M Katharine Holloway, Gergely M Makara, Zhongguo Chen, 2004, Journal of medicinal chemistry.

Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.

John D. Schreier, Min Xu, D. Hazuda, 2017, Bioorganic & medicinal chemistry letters.

Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

John D. Schreier, Min Xu, D. Hazuda, 2016, Journal of Medicinal Chemistry.

BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres

M. Katharine Holloway, Adam J. Simon, Lixia Jin, 2006 .

Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.

Amy S. Espeseth, G. McGaughey, S. Stachel, 2009, Bioorganic & medicinal chemistry letters.