Hemaka A. Rajapakse

发表

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2004, Journal of medicinal chemistry.

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).

Min Xu, Qian Huang, D. Hazuda, 2006, Journal of medicinal chemistry.

Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites.

G. McGaughey, Hemaka A. Rajapakse, M. Lai, 2007, Bioorganic & medicinal chemistry letters.

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Adam J. Simon, Georgia B. McGaughey, Philippe G. Nantermet, 2010, Bioorganic & medicinal chemistry letters.

ENANTIOSELECTIVE TOTAL SYNTHESIS OF ALTOHYRTIN C (SPONGISTATIN 2)

P. Coleman, Hemaka A. Rajapakse, A. Tyler, 1999 .

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

A. Simon, G. McGaughey, Hemaka A. Rajapakse, 2007, Bioorganic & medicinal chemistry letters.

Small molecule inhibitors of the XIAP protein-protein interaction.

Hemaka A. Rajapakse, 2007, Current topics in medicinal chemistry.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

D. Hazuda, A. Simon, G. McGaughey, 2007, Bioorganic & medicinal chemistry letters.

A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides

Hemaka A. Rajapakse, M. Young, B. Mott, 2006 .

Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines

Hemaka A. Rajapakse, M. Young, Samantha B. Charlton, 2005 .

Asymmetric syntheses of pectenotoxins-4 and -8, part I: synthesis of the C1-C19 subunit.

Hemaka A. Rajapakse, Davidr . Evans, D. Stenkamp, 2002, Angewandte Chemie.

ALKENYL-SUBSTITUTED KETALS AS EFFICIENT PRECURSORS TO CLAISEN REARRANGEMENT SUBSTRATES

Hemaka A. Rajapakse, R. Hoye, 1997 .

Enantioselective Oxidation of Secondary Alcohols Using a Chiral Nitroxyl (N-Oxoammonium salt) Catalyst

Hemaka A. Rajapakse, S. Rychnovsky, and Terri L. McLernon, 1996 .

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2009, Journal of Pharmacology and Experimental Therapeutics.

First Demonstration of Cerebrospinal Fluid and Plasma A (cid:1) Lowering with Oral Administration of a (cid:1) -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates □ S

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2008 .

Synthesis of elenic acid, an inhibitor of topoisomerase II

Hemaka A. Rajapakse, R. Hoye, Michael E. Danielson, 1999 .

Asymmetric syntheses of pectenotoxins-4 and -8, part II: synthesis of the C20-C30 and C31-C40 subunits and fragment assembly.

Hemaka A. Rajapakse, Davidr . Evans, D. Stenkamp, 2002, Angewandte Chemie.

Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors

Sujata Sharma, Hemaka A. Rajapakse, J. Vacca, 2011, Journal of neurochemistry.

Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.

Amy S. Espeseth, A. Espeseth, A. Simon, 2009, Bioorganic & medicinal chemistry letters.

Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors.

J. Renger, H. Su, Hemaka A. Rajapakse, 2016, Bioorganic & medicinal chemistry letters.

Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.

D. Hazuda, A. Simon, Hemaka A. Rajapakse, 2010, Bioorganic & medicinal chemistry letters.

Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

Alison R. Gregro, A. Simon, G. McGaughey, 2009, ChemMedChem.