Ming-Chih Crouthamel

发表

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2004, Journal of medicinal chemistry.

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).

Min Xu, Qian Huang, D. Hazuda, 2006, Journal of medicinal chemistry.

Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities*

Min Xu, Qian Huang, D. Hazuda, 2003, Journal of Biological Chemistry.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

A. Simon, S. Stachel, C. Coburn, 2008, The Journal of pharmacology and experimental therapeutics.

Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2007 .

Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2007, Journal of medicinal chemistry.

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Amy S. Espeseth, Min Xu, Qian Huang, 2005, The Journal of biological chemistry.

Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Ming-Chih Crouthamel, Rakesh Kumar, S. Rabindran, 2014, PloS one.

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Min Xu, Qian Huang, D. Hazuda, 2003, The Journal of biological chemistry.

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.

D. Hazuda, A. Simon, G. McGaughey, 2007, Bioorganic & medicinal chemistry letters.

Conformationally biased P3 amide replacements of beta-secretase inhibitors.

M Katharine Holloway, S. Stachel, C. Coburn, 2006, Bioorganic & medicinal chemistry letters.

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

Ming-Chih Crouthamel, D. Rominger, P. Tummino, 2009, British Journal of Cancer.

Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia

G. Sundaresan, Ming-Chih Crouthamel, Rakesh Kumar, 2009, Clinical Cancer Research.

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

R. Vessella, Ming-Chih Crouthamel, Baochau Le, 2013, Oncotarget.

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2009, Journal of Pharmacology and Experimental Therapeutics.

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

A. Simon, S. Stachel, C. Coburn, 2008, Journal of Pharmacology and Experimental Therapeutics.

First Demonstration of Cerebrospinal Fluid and Plasma A (cid:1) Lowering with Oral Administration of a (cid:1) -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates □ S

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2008 .

Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

Ming-Chih Crouthamel, L. Harrington, T. Gilmer, 2007, Molecular Cancer Therapeutics.

A presenilin‐independent aspartyl protease prefers the γ‐42 site cleavage

D. Hazuda, M. Lai, Ming-Chih Crouthamel, 2006 .

Rational design and synthesis of selective BACE-1 inhibitors.

D. Hazuda, S. Singh, V. Garsky, 2004, Bioorganic & medicinal chemistry letters.

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.

Adam J. Simon, Georgia B. McGaughey, Philippe G. Nantermet, 2010, Bioorganic & medicinal chemistry letters.

with oral administration of a BACE1 inhibitor in nonhuman primates

Amy S. Espeseth, Adam T. Gates, D. Hazuda, 2008 .

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the production of amyloid β peptide by BACE1 in vitro and in cells

Amy S. Espeseth, Min Xu, Qian Huang, 2005 .

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the productio no famyloi d βpeptid eb yBACE 1in vitr oan di ncells

Amy S. Espeseth, Min Xu, Qian Huang, 2005 .

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Xiao-Ping Shi, Amy S Espeseth, Min Xu, 2005, Analytical biochemistry.

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

M Katharine Holloway, Gergely M Makara, Zhongguo Chen, 2004, Journal of medicinal chemistry.

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

D. Hazuda, M. Lai, Ming-Chih Crouthamel, 2006, Journal of neurochemistry.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Min Xu, Qian Huang, D. Hazuda, 2005, Journal of Alzheimer's disease : JAD.

Evaluating scoring functions for docking and designing β-secretase inhibitors

Alison R. Gregro, M. Katharine Holloway, Georgia B. McGaughey, 2007 .