Z. Hong

发表

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

C. Varaprasad, D. Barawkar, Hassan El Abdellaoui, 2006, Bioorganic & medicinal chemistry letters.

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.

Shunqi Yan, C. Varaprasad, D. Barawkar, 2006, Bioorganic & medicinal chemistry letters.

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.

Gary Larson, Shunqi Yan, J. Wu, 2006, Bioorganic & medicinal chemistry letters.

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure.

Gary Larson, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.

Gary Larson, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Isothiazoles as active-site inhibitors of HCV NS5B polymerase.

Shunqi Yan, J. Wu, R. Hamatake, 2006, Bioorganic & medicinal chemistry letters.

Hepatitis C Virus RNA-dependent RNA Polymerase (NS5B) as a Mediator of the Antiviral Activity of Ribavirin*

C. Cameron, Z. Hong, David Maag, 2001, The Journal of Biological Chemistry.

Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase.

M. Allan, Huanming Chen, Weijiang Zhang, 2006, Bioorganic & medicinal chemistry letters.

Agents in clinical development for the treatment of chronic hepatitis B

R. Hamatake, Z. Hong, A. Raney, 2003, Expert opinion on investigational drugs.

ARF 1 and GBF 1 Generate a PI 4 P-Enriched Environment Supportive of Hepatitis C Virus Replication

Leiliang Zhang, Z. Hong, Wenyu Lin, 2012 .

Novel Nonnucleoside Inhibitors That Select Nucleoside Inhibitor Resistance Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase

R. Hamatake, Z. Hong, J. Shim, 2006, Antimicrobial Agents and Chemotherapy.

A Double‐blind, randomized, placebo‐controlled study to assess the safety, antiviral activity and pharmacokinetics of GSK2336805 when given as monotherapy and in combination with peginterferon alfa‐2a and ribavirin in hepatitis C virus genotype 1‐infected treatment‐naive subjects

R. Hamatake, Z. Hong, M. Rodríguez-Torres, 2014, Liver international : official journal of the International Association for the Study of the Liver.

Conversion of Viramidine to Ribavirin in Vivo by Adenosine Deaminase and its Inhibition by 2′-Deoxycoformycin

J. Wu, Z. Hong, Jim Z Wu, 2006, Antiviral chemistry & chemotherapy.

Application of structural biology tools in the study of viral hepatitis and the design of antiviral therapy.

Z. Hong, N. Yao, J. Lau, 2002, Gastroenterology.

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase.

C. Cameron, Z. Hong, W. Zhong, 2001, Virology.

Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase.

Z. Hong, W. Zhong, B. Sodowich, 2001, Virus research.

In Vitro RNA Replication Directed by Replicase Complexes Isolated from the Subgenomic Replicon Cells of Hepatitis C Virus

Z. Hong, W. Zhong, J. Lau, 2003, Journal of Virology.

Mechanisms of Action of Ribavirin in Antiviral Therapies

Z. Hong, J. Lau, J. Y. Lau, 2001, Antiviral chemistry & chemotherapy.

TT virus infection in patients with chronic hepatitis C virus infection--effect of primers, prevalence, and clinical significance. Hepatitis Interventional Therapy Group.

Z. Hong, Z. Goodman, M. Mizokami, 2000, Journal of hepatology.

In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides.

R. Kruse, R. Hamatake, Z. Hong, 2016, Journal of hepatology.

Synthesis of 9-(2-β-C-methyl-β-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication

Z. Hong, W. Zhong, Yili Ding, 2005 .

Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

I. W. Cheney, Z. Hong, W. Zhong, 2002, Journal of Virology.

Generation and Characterization of a Hepatitis C Virus NS3 Protease-Dependent Bovine Viral Diarrhea Virus

Z. Hong, W. Zhong, R. Donis, 2000, Journal of Virology.

Dual-Action Mechanism of Viramidine Functioning as a Prodrug and as a Catabolic Inhibitor for Ribavirin

J. Wu, Z. Hong, G. Larson, 2004, Antimicrobial Agents and Chemotherapy.

Promising candidates for the treatment of chronic hepatitis C

Z. Hong, N. Yao, M. Walker, 2003, Expert opinion on investigational drugs.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.

I. W. Cheney, J. Wu, Z. Hong, 2005, Acta crystallographica. Section D, Biological crystallography.

Clinical Utility of Current NNRTIs and Perspectives of New Agents in This Class under Development

R. Hamatake, Z. Hong, Zhijun Zhang, 2004, Antiviral chemistry & chemotherapy.

In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor

R. Hamatake, Z. Hong, J. Vamathevan, 2013, Antimicrobial Agents and Chemotherapy.

Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.

R. Hamatake, Z. Hong, Suetying Chow, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of new 2'-β-C-methyl related triciribine analogues as anti-HCV agents

S. Lang, Z. Hong, W. Zhong, 2004 .

Dinucleotide Analogues as Novel Inhibitors of RNA-Dependent RNA Polymerase of Hepatitis C Virus

D. Barawkar, Z. Hong, W. Zhong, 2003, Antimicrobial Agents and Chemotherapy.

Viramidine, a Prodrug of Ribavirin, Shows Better Liver-Targeting Properties and Safety Profiles Than Ribavirin in Animals

Z. Hong, D. Vitarella, L. Yeh, 2003, Antiviral chemistry & chemotherapy.

A Novel Nonnucleoside Analogue That Inhibits Human Immunodeficiency Virus Type 1 Isolates Resistant to Current Nonnucleoside Reverse Transcriptase Inhibitors

R. Hamatake, Z. Hong, J. Shim, 2006, Antimicrobial Agents and Chemotherapy.

HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.

M. Erion, Z. Hong, Chin-chung Lin, 2006, Current opinion in investigational drugs.

Hepatitis C replication inhibitors that target the viral NS4B protein.

D. J. Price, R. Hamatake, Z. Hong, 2014, Journal of medicinal chemistry.

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

I. W. Cheney, Shunqi Yan, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Antiviral Agents for Hepatitis Viruses

R. Hamatake, Z. Hong, W. Zhong, 2002 .

Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.

C. Varaprasad, Z. Hong, W. Zhong, 2007, Bioorganic chemistry.

Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design

J. Wu, Z. Hong, Jim Z Wu, 2003, The Journal of antimicrobial chemotherapy.

Mechanism of action of ribavirin in the combination treatment of chronic HCV infection

Z. Hong, J. Lau, R. Tam, 2002, Hepatology.

6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors.

R. Hamatake, Z. Hong, F. Rong, 2007, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antiviral activity of adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus.

J. Wu, Z. Hong, W. Zhong, 2005, Journal of medicinal chemistry.

SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication.

Leiliang Zhang, Z. Hong, R. Chung, 2013, Antiviral research.

Virus-Specific Cofactor Requirement and Chimeric Hepatitis C Virus/GB Virus B Nonstructural Protein 3

S. Lemon, Z. Hong, W. Zhong, 2000, Journal of Virology.

Nucleoside triphosphatase and RNA helicase activities associated with GB virus B nonstructural protein 3.

Z. Hong, W. Zhong, N. Yao, 1999, Virology.

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

J. Arnold, C. Cameron, R. Andino, 2000, Nature Network Boston.

Effects of genotypic variations on hepatitis C virus nonstructural protein 5B structure and activity

Z. Hong, W. Zhong, C. Lesburg, 2003 .

HCV RNA-dependent RNA polymerase as a target for antiviral development.

Z. Hong, M. Walker, 2002, Current opinion in pharmacology.

Pleiotropic mechanisms of ribavirin antiviral activities.

C. Cameron, Z. Hong, 2002, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Remofovir Mesylate: A Prodrug of PMEA with Improved Liver-Targeting and Safety in Rats and Monkeys

M. Erion, Z. Hong, D. Vitarella, 2004, Antiviral chemistry & chemotherapy.

Hepatitis C Virus Therapies: Current Treatments, Targets and Future Perspectives

Todd C Appleby, Z. Hong, W. Zhong, 2003, Antiviral chemistry & chemotherapy.

Phosphorylation of Ribavirin and Viramidine by Adenosine Kinase and Cytosolic 5′-Nucleotidase II: Implications for Ribavirin Metabolism in Erythrocytes

J. Wu, Z. Hong, G. Larson, 2005, Antimicrobial Agents and Chemotherapy.

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

Charles A. Lesburg, P. Weber, Z. Hong, 1999, Nature Structural Biology.

Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus

J. Wu, Z. Hong, W. Zhong, 2005, Antiviral chemistry & chemotherapy.

Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase

C. Cameron, Z. Hong, W. Zhong, 2000, Journal of Virology.

Therapeutic Strategies Targeting the Innate Antiviral Immune Response

Z. Hong, A. Varnavski, Sung-kwon Kim, 2008 .

Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.

Z. Hong, Yili Ding, J. Girardet, 2005, Bioorganic & medicinal chemistry letters.

Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli

Z. Hong, B. Baroudy, E. Ferrari, 1999, Journal of Virology.

Amantadine and rimantadine have no direct inhibitory effects against hepatitis C viral protease, helicase, ATPase, polymerase, and internal ribosomal entry site-mediated translation.

Z. Hong, R. Jubin, M. Murray, 2000, The Journal of infectious diseases.

Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions

J. Wu, Z. Hong, Jim Z Wu, 2003, Antimicrobial Agents and Chemotherapy.

Design and evaluation of a potential mutagen for Hepatitis C virus.

Z. Hong, J. Shim, J. Girardet, 2007, Bioorganic & medicinal chemistry letters.

The Amino-Terminal Domain of Bovine Viral Diarrhea Virus Npro Protein Is Necessary for Alpha/Beta Interferon Antagonism

Z. Hong, W. Zhong, R. Donis, 2006, Journal of Virology.

Structure of the hepatitis C virus RNA helicase domain

A. Kwong, P. Weber, Z. Hong, 1997, Nature Structural Biology.

Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system

G. Seelig, A. Kwong, Z. Hong, 1996, Journal of virology.

Generation of recombinant herpes simplex virus ampiicons.

A. Kwong, Z. Hong, 1999, Methods in molecular medicine.

Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors.

Z. Hong, N. Yao, B. Baroudy, 2000, Journal of hepatology.

Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.

Zhuyan Guo, Frank Bennett, Rong-Sheng Yang, 2007, Journal of medicinal chemistry.

Development of novel anti-HCV therapies: HCV protease, helicase, and polymerase as therapeutic targets.

Z. Hong, D. Standring, B. Baroudy, 2000, Acta gastro-enterologica Belgica.

De Novo Initiation of RNA Synthesis by Hepatitis C Virus Nonstructural Protein 5B Polymerase

Z. Hong, W. Zhong, J. Lau, 2000, Journal of Virology.

Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees.

G. Reyes, Z. Hong, R. Lanford, 1999, Virology.

Establishment of a Subgenomic Replicon for Bovine Viral Diarrhea Virus in Huh-7 Cells and Modulation of Interferon-Regulated Factor 3-Mediated Antiviral Response

Z. Hong, W. Zhong, R. Donis, 2005, Journal of Virology.

Functional Properties of a Monoclonal Antibody Inhibiting the Hepatitis C Virus RNA-dependent RNA Polymerase*

T. Hügle, R. Bartenschlager, J. Wu, 2002, The Journal of Biological Chemistry.

Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner.

Leiliang Zhang, Z. Hong, Xiaojie Yang, 2014, Antiviral research.

Viability of Poliovirus/Rhinovirus VPg Chimeric Viruses and Identification of an Amino Acid Residue in the VPg Gene Critical for Viral RNA Replication

I. W. Cheney, J. Wu, Z. Hong, 2003, Journal of Virology.

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

J. Wu, Z. Hong, D. Delia, 2007, Molecular Cancer Therapeutics.

Identification of novel, selective and potent Chk2 inhibitors.

Shunqi Yan, Huanming Chen, J. Wu, 2007, Bioorganic & medicinal chemistry letters.

Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture.

I. W. Cheney, Z. Hong, W. Zhong, 2002, Virology.

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

C. Varaprasad, D. Barawkar, Hassan El Abdellaoui, 2006, Bioorganic & medicinal chemistry letters.

Hepatitis C NS3 protease: restoration of NS4A cofactor activity by N-biotinylation of mutated NS4A using synthetic peptides.

Z. Hong, B. Dasmahapatra, N. Yao, 2000, Biochemical and biophysical research communications.

No let up in the search for novel antibiotics

Z. Hong, D. Payne, A. Portnoy, 2009, Expert review of anti-infective therapy.

Crystal Structure of Complete Rhinovirus RNA Polymerase Suggests Front Loading of Protein Primer

I. W. Cheney, J. Wu, Z. Hong, 2005, Journal of Virology.

ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication

Leiliang Zhang, Z. Hong, Wenyu Lin, 2012, PloS one.

A role for retromer in hepatitis C virus replication

Leiliang Zhang, Z. Hong, R. Chung, 2016, Cellular and Molecular Life Sciences.

Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex.

A. Kwong, P. Weber, Z. Hong, 1998, Biochemistry.

Bovine Viral Diarrhea Virus Hepatitis C Virus NS 3 Protease-Dependent Generation and Characterization of a

Z. Hong, W. Zhong, R. Donis, 2000 .

GSK2878175, a pan‐genotypic non‐nucleoside NS5B polymerase inhibitor, in healthy and treatment‐naïve chronic hepatitis C subjects

R. Hamatake, Z. Hong, E. Dumont, 2018, Journal of viral hepatitis.

P1224 GSK2878175, A POTENT NON-NUCLEOSIDE INHIBITOR OF HCV NS5B WITH PAN-GENOTYPIC ACTIVITY

R. Hamatake, Z. Hong, R. Crosby, 2014 .

Targeting NS5B RNA-dependent RNA polymerase for anti-HCV chemotherapy.

J. Wu, Z. Hong, Jim Z Wu, 2003, Current drug targets. Infectious disorders.

Virus-specific interaction between the human cytomegalovirus major capsid protein and the C terminus of the assembly protein precursor

A. Kwong, Z. Hong, W. Gibson, 1996, Journal of virology.

Identification of a minimal hydrophobic domain in the herpes simplex virus type 1 scaffolding protein which is required for interaction with the major capsid protein

A. Kwong, Z. Hong, J. Durkin, 1996, Journal of virology.

Ribavirin mutagenesis: Hidden clues in mathematical models

Z. Hong, 2005, Hepatology.

O119 IN VIVO INHIBITION OF HBV ANTIGENEMIA AND VIREMIA BY ANTISENSE OLIGONUCLEOTIDES

R. Hamatake, Z. Hong, S. Wieland, 2014 .

Hepatitis C Virus NS5A Hijacks ARFGAP1 To Maintain a Phosphatidylinositol 4-Phosphate-Enriched Microenvironment

Leiliang Zhang, Lingyi Chen, Z. Hong, 2014, Journal of Virology.

Selection of 3′-Template Bases and Initiating Nucleotides by Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase

Z. Hong, G. Larson, J. Shim, 2002, Journal of Virology.

Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.

I. W. Cheney, Shunqi Yan, R. Hamatake, 2007, Bioorganic & medicinal chemistry letters.