Jordan J. N. Tang

发表

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.

Heather B. Miller, Arun K. Ghosh, N. Kumaragurubaran, 2008, Bioorganic & medicinal chemistry letters.

Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)

Arun K. Ghosh, L. Hong, G. Koelsch, 2001 .

Developing β‐secretase inhibitors for treatment of Alzheimer’s disease

Arun K. Ghosh, Jordan J. N. Tang, M. Brindisi, 2012, Journal of neurochemistry.

Cloning and Characterization of cDNA Encoding Cardosin A, an RGD-containing Plant Aspartic Proteinase*

Jordan J. N. Tang, M. Ramalho-Santos, I. Simões, 1999, The Journal of Biological Chemistry.

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).

Dongwoo Shin, Jacques Ermolieff, Arun K. Ghosh, 2000, Journal of the American Chemical Society.

The amino‐ and carboxylterminal sequences of canine apolipoprotein A‐I

Jordan J. N. Tang, T. Nakai, Thomas F. Weayne, 1976, FEBS letters.

Internalization of Exogenously Added Memapsin 2 (β-Secretase) Ectodomain by Cells Is Mediated by Amyloid Precursor Protein*

R. Turner, Wanpin Chang, G. Koelsch, 2004, Journal of Biological Chemistry.

β-Secretase as a therapeutic target for Alzheimer’s disease

Arun K. Ghosh, Sandra Gemma, Jordan J. N. Tang, 2008, Neurotherapeutics.

Cardosin A endocytosis mediated by integrin leads to lysosome leakage and apoptosis of epithelial cells

Hao Wu, Jordan J. N. Tang, C. Faro, 2019, Proteins.

Memapsin 2 (β‐secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

Wanpin Chang, G. Koelsch, Jordan J. N. Tang, 2002, FEBS letters.

Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production

Jordan J. N. Tang, Xiangyuan He, K. Cooley, 2007, The Journal of Neuroscience.

Stabilin‐1 localizes to endosomes and the trans‐Golgi network in human macrophages and interacts with GGA adaptors

S. Goerdt, Jordan J. N. Tang, S. Mamidi, 2004, Journal of leukocyte biology.

Prospects of β‐Secretase Inhibitors for the Treatment of Alzheimer’s Disease

Arun K. Ghosh, Jordan J. N. Tang, Jordan Tang, 2015, ChemMedChem.

Chapter 13 – Memapsin 1

Jordan J. N. Tang, Jordan Tang, 2013 .

Analysis of Amyloid Precursor Protein Processing Protease β‐Secretase: Tools for Memapsin 2 (β‐Secretase) Inhibition Studies

Arun K. Ghosh, Vajira Weerasena, G. Koelsch, 2005 .

Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications.

L. Hong, Wanpin Chang, Jordan J. N. Tang, 2004, Acta biochimica et biophysica Sinica.

Crystal structure of the human GGA1 GAT domain.

A. Joachimiak, Jordan J. N. Tang, Rongguang Zhang, 2003, Biochemistry.

Design, Synthesis, Protein-ligand X-ray Structures and Biological Evaluation of a Series of Novel Macrocyclic HIV-1 Protease Inhibitors to Combat Drug-resistance

David D. Anderson, Arun K. Ghosh, I. Weber, 2010 .

Crystal structure of human GGA1 GAT domain complexed with the GAT‐binding domain of Rabaptin5

Jordan J. N. Tang, Xiangyuan He, Xuejun C. Zhang, 2004, The EMBO journal.

Cloning of the glucose-6-phosphate dehydrogenase gene of Drosophila melanogaster using 17-base oligonucleotide mixtures as probes

Jordan J. N. Tang, E. Ohtsuka, Takayuki Takahashi, 1985 .

Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy

R. Schinazi, Jordan J. N. Tang, Xinli Lin, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism

Arun K. Ghosh, Hao Wu, Jordan J. N. Tang, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group

Arun K. Ghosh, R. Turner, Jordan J. N. Tang, 2012, Applied Microbiology and Biotechnology.

Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.

M. Ohno, Jordan J. N. Tang, L. Devi, 2015, Current Alzheimer research.

[31] Streptokinase and staphylokinase

Jordan J. N. Tang, K. Jackson, N. Esmon, 1981 .

THE STREPTOKINASE-PLASMINOGEN INTERACTION: A MODEL FOR BINDING ACTIVATION OF SERINE-PROTEASE ZYMOGENS1

Jordan J. N. Tang, K. Jackson, Jordan Tang, 1982 .

Chapter 3 – Pepsin A

Jordan J. N. Tang, Jordan Tang, 2013 .

Jordan J. N. Tang, Jordan Tang, 2004 .

Localization of β-Secretase Memapsin 2 in the Brain of Alzheimer's Patients and Normal Aged Controls

G. Koelsch, Jordan J. N. Tang, A. Sun, 2002, Experimental Neurology.

Design, Synthesis and X-ray Structure of Protein−Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors

Lin Hong, Hui Lei, Arun K. Ghosh, 2006 .

Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.

Arun K. Ghosh, Sarang S Kulkarni, Xiaoming Xu, 2012, Bioorganic & medicinal chemistry letters.

Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.

David D. Anderson, Simon Terzyan, Arun K. Ghosh, 2012, Journal of medicinal chemistry.

Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.

Lin Hong, Arun K. Ghosh, N. Kumaragurubaran, 2007, Journal of medicinal chemistry.