P. Clark

发表

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.

P. Clark, Daigen Xu, P. Nambiar, 2008, Cancer research.

Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland Published, JLR Papers in Press, October 3, 2005. DOI 10.1194/jlr.M500213-JLR200

P. Clark, L. Audoly, S. Chandrasekharan, 2005, Journal of Lipid Research.

Simultaneous analysis of prostanoids using liquid chromatography/high-field asymmetric waveform ion mobility spectrometry/tandem mass spectrometry.

P. Clark, T. Mauriala, K. Bateman, 2006, Rapid communications in mass spectrometry : RCM.

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

Effect of luminal growth factor preservation on intestinal growth

R. Playford, P. Clark, A. Woodman, 1993, The Lancet.

Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.

I. Wang, P. Clark, L. Audoly, 2009, Prostaglandins & other lipid mediators.

Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species.

P. Clark, Steve Rowland, L. Audoly, 2007, European journal of pharmacology.

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.

P. Clark, Steve Rowland, D. Denis, 2008, Bioorganic & medicinal chemistry letters.

Mutual antagonistic relationship between prostaglandin E2 and IFN‐γ: Implications for rheumatoid arthritis

Y. Boie, P. Clark, D. Denis, 2008, European journal of immunology.

The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.

P. Clark, Steve Rowland, D. Denis, 2010, Journal of medicinal chemistry.

Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis

D. Riendeau, P. Clark, Steve Rowland, 2006, Journal of Pharmacology and Experimental Therapeutics.

Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis.

G. FitzGerald, P. Clark, L. Audoly, 2008, Arthritis and rheumatism.

A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

N. Méthot, D. Riendeau, P. Clark, 2008, Journal of Pharmacology and Experimental Therapeutics.

Isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

D. Riendeau, P. Clark, Steve Rowland, 2022 .