D. Denis

发表

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

The Immunomodulatory Actions of Prostaglandin E2 on Allergic Airway Responses in the Rat1

D. Denis, Q. Hamid, W. Powell, 2002, The Journal of Immunology.

2,3-Diarylthiophenes as selective EP1 receptor antagonists.

D. Denis, S. Kargman, G. O'neill, 2005, Bioorganic & medicinal chemistry letters.

L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.

R. Young, D. Denis, D. Éthier, 1986, Canadian journal of physiology and pharmacology.

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

D. Denis, C. Chan, S. Charleson, 1989, Canadian journal of physiology and pharmacology.

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.

D. Riendeau, D. Denis, P. Prasit, 1992, Canadian journal of physiology and pharmacology.

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

M. Crackower, D. Denis, R. Stocco, 2011, Bioorganic & medicinal chemistry letters.

Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold.

D. Denis, Y. Leblanc, G. O'neill, 2008, Bioorganic & medicinal chemistry letters.

Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.

D. Denis, G. O'neill, Jennifer Wang, 2004, Bioorganic & medicinal chemistry letters.

Responses in the Rat on Allergic Airway 2 Prostaglandin E The Immunomodulatory Actions of

D. Denis, Q. Hamid, W. Powell, 2002 .

Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice

D. Denis, G. O'neill, R. Breyer, 2001 .

Comparison between two classes of selective EP3 antagonists and their biological activities

C. Li, D. Denis, R. Gordon, 2006 .

Comparison between two classes of selective EP(3) antagonists and their biological activities.

Chun Xing Li, D. Denis, R. Gordon, 2006, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.

D. Denis, R. Ruel, K. Metters, 2002, Bioorganic & medicinal chemistry letters.

L-648,051: an aerosol active leukotriene D4 receptor antagonist.

D. Denis, D. Éthier, A. Ford-hutchinson, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

L-649,923, Sodium (βS*, γR*)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)-γ-hydroxy-β-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist

R. Young, D. Denis, A. Ford-hutchinson, 1986 .

Pharmacological Characterization of MK-7246, a Potent and Selective CRTH2 (Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type 2 Cells) Antagonist

D. Slipetz, M. Crackower, D. Denis, 2011, Molecular Pharmacology.

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.

R. Young, D. Denis, K. Metters, 2003, Bioorganic & medicinal chemistry letters.

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

Identification of a Potent and Selective Synthetic Agonist at the CRTH2 Receptor

D. Denis, G. O'neill, C. Beaulieu, 2005, Molecular Pharmacology.

From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

C. Bayly, D. Denis, P. Prasit, 1996 .

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.

R. Young, D. Denis, K. Metters, 2003, Bioorganic & medicinal chemistry letters.

Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation

D. Denis, R. Gordon, K. Metters, 1999, British journal of pharmacology.

Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor.

D. Denis, K. Metters, Y. Gareau, 2001, Bioorganic & medicinal chemistry.

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

R. Young, D. Denis, S. Kargman, 2007, Journal of medicinal chemistry.

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.

D. Denis, K. Metters, Y. Gareau, 2001, Bioorganic & medicinal chemistry letters.

Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor.

D. Denis, R. Stocco, M. Abramovitz, 2001, Molecular pharmacology.

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.

Y. Boie, D. Denis, M. Abramovitz, 2000, Biochimica et biophysica acta.

Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore.

D. Denis, G. O'neill, R. Zamboni, 2010, Bioorganic & Medicinal Chemistry Letters.

Identification of an indole series of prostaglandin D2 receptor antagonists.

R. Young, D. Denis, C. Brideau, 2006, Bioorganic & medicinal chemistry letters.

Cellular distribution of prostanoid EP receptors mRNA in the rat gastrointestinal tract.

D. Denis, K. Metters, F. Nantel, 2000, Prostaglandins & other lipid mediators.

Structure–activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

D. Denis, R. Gordon, R. Zamboni, 2005 .

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.

P. Clark, Steve Rowland, D. Denis, 2008, Bioorganic & medicinal chemistry letters.

Mutual antagonistic relationship between prostaglandin E2 and IFN‐γ: Implications for rheumatoid arthritis

Y. Boie, P. Clark, D. Denis, 2008, European journal of immunology.

The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.

P. Clark, Steve Rowland, D. Denis, 2010, Journal of medicinal chemistry.

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

D. Denis, Y. Leblanc, G. O'neill, 2009, Bioorganic & medicinal chemistry letters.

A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.

D. Denis, K. Metters, Jean-François Truchon, 2003, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationship of Biaryl Acylsulfonamide Analogues on the Human EP3 Prostanoid Receptor

D. Denis, R. Ruel, K. Metters, 2002 .

The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.

D. Denis, A. Therien, Zhaoyin Wang, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.

Steve Rowland, D. Denis, R. Stocco, 2010, Bioorganic & medicinal chemistry letters.