Yongxin Han

发表

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.

M. Rudd, P. Coleman, J. Vacca, 2014, ACS medicinal chemistry letters.

The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.

R. Young, Yongxin Han, J. Regan, 2007, Experimental cell research.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Rebecca T. Ruck, Yongxin Han, J. Howe, 2016, ACS medicinal chemistry letters.

Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons

J. Bilsland, Yongxin Han, S. Harper, 2002, The Journal of Neuroscience.

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Yongxin Han, S. Gagné, Y. Ducharme, 2011, Bioorganic & medicinal chemistry letters.

3,4-Diarylpiperidines as potent renin inhibitors.

J. Falgueyret, Yongxin Han, E. Cauchon, 2012, Bioorganic & medicinal chemistry letters.

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors.

Yongxin Han, Jinbo Hu, Lingchun Li, 2015, Journal of the American Chemical Society.

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.

Theodore A. Martinot, Yongxin Han, N. Solban, 2022, Journal of medicinal chemistry.

A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation*

N. Méthot, Yongxin Han, R. Zamboni, 2004, Journal of Biological Chemistry.

Side-chain anchoring strategy for solid-phase synthesis of peptide acids with C-terminal cysteine.

Yongxin Han, G. Bárány, B. Hargittai, 2003, Biopolymers.

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Bioorganic & medicinal chemistry letters.

Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y(14).

Yongxin Han, J. Gauthier, S. Kargman, 2011, Bioorganic & medicinal chemistry letters.

Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury*

D. Holtzman, G. Robertson, Yongxin Han, 2002, The Journal of Biological Chemistry.

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2005, Bioorganic & medicinal chemistry letters.

One pot biaryl synthesis via in situ boronate formation

Yongxin Han, P. Prasit, A. Giroux, 1997 .

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Yongxin Han, R. Zamboni, P. Tawa, 2007, Bioorganic & medicinal chemistry letters.

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2005, Bioorganic & medicinal chemistry letters.

Repurposing a Histamine Detection Platform for High-Throughput Screening of Histidine Decarboxylase

Yongxin Han, X. Fradera, Y. Juang, 2018, SLAS discovery : advancing life sciences R & D.

Design and synthesis of potent, isoxazole-containing renin inhibitors.

J. Falgueyret, M. Percival, Yongxin Han, 2012, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.

J. Falgueyret, Yongxin Han, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.

Yongxin Han, P. Tawa, D. Nicholson, 2006, Analytical biochemistry.

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.

David A. Scott, Bin Wang, Yongxin Han, 2008, Journal of medicinal chemistry.

Copper-mediated trifluoromethylthiolation of α-diazoesters.

Yongxin Han, Jinbo Hu, W. Miao, 2014, Organic letters.

Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).

Patrick J. Curran, Mee Ra Heo, M. Augustin, 2020, ACS medicinal chemistry letters.

Synthesis of phenylacetic acids under rhodium-catalyzed carbonylation conditions

Yongxin Han, A. Giroux, C. Nadeau, 2000 .

Silicon directed ipso-substitution of polymer bound arylsilanes: Preparation of biaryls via the Suzuki cross-coupling reaction☆

R. Young, Yongxin Han, S. Walker, 1996 .

Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis(1)(,)(2).

Yongxin Han, F. Albericio, G. Bárány, 1997, The Journal of organic chemistry.

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.

Theodore A. Martinot, Michael J. Ardolino, Xiao Wang, 2019, ACS medicinal chemistry letters.

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.

Claude Dufresne, Yves Leblanc, Michel Therien, 2008, Bioorganic & medicinal chemistry letters.

Total synthesis of cis-clerodane diterpenoids: (–)-agelasine A and (+)-(3R,4S,5R,8S,9R,10S)-3,4-epoxyclerod-13-en-15,16-olide

Yongxin Han, E. Piers, G. Plourde, 1995 .

Large-Scale Synthesis of Oligonucleotide Phosphorothioates Using 3-Amino-1,2,4-dithiazole-5-thione as an Efficient Sulfur-Transfer Reagent

Yongxin Han, J. Tang, Zhaoda Zhang, 2000 .

Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.

Yongxin Han, S. Kargman, R. Lobell, 2009, Bioorganic & medicinal chemistry letters.

Synthetic Studies of 2,2-Difluorobicyclo[1.1.1]pentanes (BCP-F2 ): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists

Yongxin Han, Xiaoshen Ma, L. N. Pham, 2020 .

A novel polymer-supported sulfur-transfer reagent for the synthesis of phosphorothioates

Yongxin Han, J. Tang, Zhaoda Zhang, 2002 .

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Journal of medicinal chemistry.

Small Molecular Immune Modulators as Anticancer Agents.

Yongxin Han, Wei Hu, Wei Wu, 2020, Advances in experimental medicine and biology.

Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics

N. Méthot, Yongxin Han, R. Zamboni, 2004, The Journal of experimental medicine.

A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F2".

Yongxin Han, D. J. Bennett, Xiaoshen Ma, 2019, Organic letters.

Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors.

Patrick J. Curran, Theodore A. Martinot, Yongxin Han, 2021, ACS medicinal chemistry letters.

Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

Andrew M Haidle, Chunsheng Zhang, Yongxin Han, 2021, Oncoimmunology.

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.

P. Clark, Steve Rowland, D. Denis, 2008, Bioorganic & medicinal chemistry letters.

Mutual antagonistic relationship between prostaglandin E2 and IFN‐γ: Implications for rheumatoid arthritis

Y. Boie, P. Clark, D. Denis, 2008, European journal of immunology.

The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.

P. Clark, Steve Rowland, D. Denis, 2010, Journal of medicinal chemistry.

Neuroprotective effects of M826, a reversible caspase‐3 inhibitor, in the rat malonate model of Huntington's disease

G. Robertson, Yongxin Han, M. Rigby, 2004, British journal of pharmacology.

Neuroprotective effects of M 826 , a reversible caspase-3 inhibitor , in the rat malonate model of Huntington ’ s disease

G. Robertson, Yongxin Han, M. Rigby, 2004 .

Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors.

Yongxin Han, N. Solban, X. Fradera, 2020, ACS medicinal chemistry letters.

A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

Selective Synthesis of 1-Dialkylamino-2-alkylbicyclo-[1.1.1]pentanes.

Yongxin Han, D. J. Bennett, Xiaoshen Ma, 2020, Organic letters.

Preparation and Applications of Xanthenylamide (XAL) Handles for Solid-Phase Synthesis of C-Terminal Peptide Amides under Particularly Mild Conditions(1-3).

Yongxin Han, F. Albericio, S. Kates, 1996, The Journal of organic chemistry.

S-Xanthenyl side-chain anchoring for solid-phase synthesis of cysteine-containing peptides

Yongxin Han, S. Kates, B. Hargittai, 2002 .

Novel S-Xanthenyl Protecting Groups for Cysteine and Their Applications for the Nα-9-Fluorenylmethyloxycarbonyl (Fmoc) Strategy of Peptide Synthesis1-3

Yongxin Han, G. Barany, 1997 .

Synthesis of Phenylacetic Acids under Rhodium‐Catalyzed Carbonylation Conditions.

Yongxin Han, A. Giroux, C. Nadeau, 2000 .

Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.

Bin Wang, Yongxin Han, P. Lyne, 2012, ACS medicinal chemistry letters.

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

R. Hotchkiss, Yongxin Han, P. Swanson, 2000, Nature Immunology.

Conformational difference between PDE4 apoenzyme and holoenzyme.

A. Govindarajan, Yongxin Han, M. Gresser, 2000, Biochemistry.

Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.

M. Rudd, J. Uslaner, Yongxin Han, 2023, ACS Medicinal Chemistry Letters.

Remote electronic control in the regioselective reduction of succinimides: a practical, scalable synthesis of Ep4 antagonist MF-310.

Yongxin Han, C. Raab, M. Palucki, 2009, The Journal of organic chemistry.

Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.

Steve Rowland, D. Denis, R. Stocco, 2010, Bioorganic & medicinal chemistry letters.

A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives

Yongxin Han, A. Giroux, A. Roy, 2000 .

Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors

C. Bayly, R. Young, Yongxin Han, 1999 .

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.

David A. Scott, Bin Wang, Yongxin Han, 2008, Journal of medicinal chemistry.