A. Therien

发表

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

Food Price, Food Security and Dietary Diversity: A Comparative Study of Urban Cameroon and Ghana

Evan D. G. Fraser, A. Therien, P. Antwi-Agyei, 2018 .

Mechanisms of Protection against Clostridium difficile Infection by the Monoclonal Antitoxin Antibodies Actoxumab and Bezlotoxumab

A. Therien, H. Feng, H. Yfantis, 2014, Infection and Immunity.

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012, Antimicrobial Agents and Chemotherapy.

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

A. Jackson, I. Wang, M. Peters, 2012, Respiratory Research.

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

A. Sattar, A. Therien, L. Hernandez, 2016, Antimicrobial Agents and Chemotherapy.

Toxin-Mediated Paracellular Transport of Antitoxin Antibodies Facilitates Protection against Clostridium difficile Infection

A. Therien, L. Hernandez, X. Chen, 2014, Infection and Immunity.

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.

Christopher M. Tan, D. Slipetz, H. Houshyar, 2008, American journal of respiratory cell and molecular biology.

Chapter 11 Production of Tissue-Engineered Human 3 D Bronchi In Vitro

A. Therien, É. Rousseau, J. Lavoie, 2017 .

Production of Tissue-Engineered Human 3D Bronchi In Vitro

A. Therien, J. Lavoie, V. Moulin, 2014 .

Tissue-specific Versus Isoform-specific Differences in Cation Activation Kinetics of the Na,K-ATPase (*)

N. B. Nestor, A. Therien, R. Blostein, 1996, The Journal of Biological Chemistry.

P. Clark, Steve Rowland, D. Denis, 2008, Journal of Pharmacology and Experimental Therapeutics.

The C3a receptor antagonist SB 290157 has agonist activity.

A. Therien, S. Kargman, G. O'neill, 2005, Immunology letters.

Non-native interhelical hydrogen bonds in the cystic fibrosis transmembrane conductance regulator domain modulated by polar mutations.

C. Deber, A. Therien, Lia Cardarelli, 2004, Biochemistry.

Assays for Measuring C. difficile Toxin Activity and Inhibition in Mammalian Cells

A. Therien, L. Hernandez, Zuo Zhang, 2017 .

Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro Neutralization and Epitope Modeling

A. Therien, L. Hernandez, N. Murgolo, 2014, Antimicrobial Agents and Chemotherapy.

Effect of Detergents on Intramolecular Helix-Helix Packing in a Membrane-Based Peptide Derived from CFTR

C. Deber, A. Therien, 2001 .

Agonist Activity of the Small Molecule C3aR Ligand SB 290157

A. Therien, 2005, The Journal of Immunology.

Broadening the Spectrum of (cid:1) -Lactam Antibiotics through Inhibition of Signal Peptidase Type I

J. Phillips, A. Therien, P. Beaulieu, 2012 .

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

Eric Langlois, Alexandre Caron, Mihai Petcu, 2012, Science Translational Medicine.

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

Interhelical Packing in Detergent Micelles

C. Deber, A. Therien, 2002, The Journal of Biological Chemistry.

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

D. Hazuda, D. Klein, A. Therien, 2021, PLoS pathogens.

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

D. Wyss, A. Therien, T. Fischmann, 2022, Journal of Medicinal Chemistry.

Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination

D. Hazuda, A. Therien, Abigail L Reens, 2021, Frontiers in Immunology.

Mechanisms of sodium pump regulation.

A. Therien, R. Blostein, R Blostein, 2000, American journal of physiology. Cell physiology.

K+/Na+antagonism at cytoplasmic sites of Na+-K+-ATPase: a tissue-specific mechanism of sodium pump regulation.

A. Therien, R. Blostein, 1999, American journal of physiology. Cell physiology.

The impact of DAMP-mediated inflammation in severe COVID-19 and related disorders

A. Therien, K. Best, R. Martinelli, 2021, Biochemical Pharmacology.

Missense mutations in transmembrane domains of proteins: Phenotypic propensity of polar residues for human disease

C. Deber, A. Therien, A. Partridge, 2004, Proteins.

Structure-Function Relationships in the Neuropeptide S Receptor

Christopher M. Tan, D. Slipetz, M. Crackower, 2006, Journal of Biological Chemistry.

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.

P. Clark, Steve Rowland, D. Denis, 2008, Bioorganic & medicinal chemistry letters.

K(+)/Na(+) antagonism at cytoplasmic sites of Na(+)-K(+)-ATPase: a tissue-specific mechanism of sodium pump regulation.

A. Therien, R. Blostein, 1999, The American journal of physiology.

Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

A. Therien, P. Orth, L. Hernandez, 2014, The Journal of Biological Chemistry.

Mutual antagonistic relationship between prostaglandin E2 and IFN‐γ: Implications for rheumatoid arthritis

Y. Boie, P. Clark, D. Denis, 2008, European journal of immunology.

Expression and Functional Role of the γ Subunit of the Na,K-ATPase in Mammalian Cells*

A. Therien, S. Karlish, R. Blostein, 1999, The Journal of Biological Chemistry.

Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease.

R. Stocco, A. Therien, B. Koller, 2006, American journal of physiology. Lung cellular and molecular physiology.

Interhelical hydrogen bonds in the CFTR membrane domain

C. Deber, A. Therien, Fiona E.M. Grant, 2001, Nature Structural Biology.

Discovery of Novel P2Y14 Agonist and Antagonist Using Conventional and Nonconventional Methods

C. Bayly, A. Therien, C. Brideau, 2011, Journal of biomolecular screening.

The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.

P. Clark, Steve Rowland, D. Denis, 2010, Journal of medicinal chemistry.

Peptidase Type I Antibiotics through Inhibition of Signal-Lactam β Broadening the Spectrum of

Alexandre Caron, Mihai Petcu, Kenneth E. Wilson, 2012 .

Novel neutrophil subsets associated with sepsis, vascular dysfunction and metabolic alterations identified using systems immunology

A. Therien, C. White, C. Woelk, 2022, bioRxiv.

Electrode-saddle for electrocardiogram recording in large animals.

A. Therien, L. Deroth, 1978, The Canadian veterinary journal = La revue veterinaire canadienne.

A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.

P. Clark, Steve Rowland, D. Denis, 2011, Bioorganic & medicinal chemistry letters.

A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays

A. Therien, C. Verma, S. Kannan, 2023, Bioengineering & Translational Medicine.

The Impact of the Rise of Supermarkets on Household Urban Food Security: A Case Study of Accra, Ghana

A. Therien, 2017 .

Modulation of Na,K-ATPase by the gamma subunit: studies with transfected cells and transmembrane mimetic peptides.

C. Deber, A. Therien, R. Blostein, 2003, The Journal of biological chemistry.

Tissue-specific Distribution and Modulatory Role of the γ Subunit of the Na,K-ATPase

A. Therien, S. Karlish, R. Goldshleger, 1997, The Journal of Biological Chemistry.

Interhelical Packing in Detergent Micelles FOLDING OF A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CONSTRUCT*

C. Deber, A. Therien, 2002 .

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

D. Lacy, A. Therien, Xinwei Sher, 2017, Journal of molecular biology.

Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants

D. Lacy, A. Therien, J. Julien, 2017, The Journal of Biological Chemistry.

Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage.

A. Therien, J. Tam, G. Beilhartz, 2015, Chemistry & biology.

The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.

D. Denis, A. Therien, Zhaoyin Wang, 2011, Bioorganic & medicinal chemistry letters.

Oligomerization of a peptide derived from the transmembrane region of the sodium pump gamma subunit: effect of the pathological mutation G41R.

C. Deber, A. Therien, 2002, Journal of molecular biology.

Expression and purification of two hydrophobic double-spanning membrane proteins derived from the cystic fibrosis transmembrane conductance regulator.

C. Deber, A. Therien, M. Glibowicka, 2002, Protein expression and purification.

Prevention of Clostridium difficile infections—The role of vaccines and therapeutic immunoglobulins

A. Therien, J. Heinrichs, 2014 .

Putting the β-breaks on membrane protein misfolding

C. Deber, A. Therien, 2002, Nature Structural Biology.

Polar mutations in membrane proteins as a biophysical basis for disease.

C. Deber, A. Therien, A. Partridge, 2002, Biopolymers.

K 1 / Na 1 antagonism at cytoplasmic sites of Na 1K 1-ATPase : a tissue-specific mechanism of sodium pump regulation

A. Therien, R. Blostein, 1999 .

Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.

Steve Rowland, D. Denis, R. Stocco, 2010, Bioorganic & medicinal chemistry letters.

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin

A. Sattar, A. Therien, L. Hernandez, 2016, Antimicrobial Agents and Chemotherapy.

Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage.

A. Therien, J. Tam, R. Melnyk, 2015, Chemistry & biology.

Broad Coverage of Genetically Diverse Strains of Clostridium difficile by Actoxumab and Bezlotoxumab Predicted by In Vitro Neutralization and Epitope Modeling

A. Therien, L. Hernandez, N. Murgolo, 2014, Antimicrobial Agents and Chemotherapy.

511. Treatment with Molnupiravir in the MOVe-In and MOVe-Out Clinical Trials Results in an Increase in Transition Mutations Across the SARS-CoV-2 Genome

A. Therien, N. Murgolo, J. Butterton, 2021, Open Forum Infectious Diseases.

Putting the beta-breaks on membrane protein misfolding.

C. Deber, A. Therien, 2002, Nature structural biology.