Y. Gwack

发表

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

Y. Gwack, Sonia Sharma, J. Nardone, 2006, Nature.

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Bogdan Tanasa, Patrick G. Hogan, Mark Daly, 2006, Nature.

Poly(ADP-Ribose) Polymerase 1 and Ste20-Like Kinase hKFC Act as Transcriptional Repressors for Gamma-2 Herpesvirus Lytic Replication

S. Gygi, H. Kung, Y. Gwack, 2003, Molecular and Cellular Biology.

ORAI 1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4

Y. Gwack, S. Srikanth, J. Peti-Peterdi, 2017 .

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4

Y. Gwack, S. Srikanth, J. Peti-Peterdi, 2017, Circulation research.

CREB-Binding Protein and Histone Deacetylase Regulate the Transcriptional Activity of Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50

C. Lim, J. Choe, Y. Gwack, 2001, Journal of Virology.

Principal Role of TRAP/Mediator and SWI/SNF Complexes in Kaposi's Sarcoma-Associated Herpesvirus RTA-Mediated Lytic Reactivation

R. Roeder, Y. Gwack, M. Meisterernst, 2003, Molecular and Cellular Biology.

The Transcriptional Activity of cAMP Response Element-binding Protein-binding Protein Is Modulated by the Latency Associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus*

C. Lim, J. Choe, Y. Gwack, 2001, The Journal of Biological Chemistry.

Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma

Y. Gwack, S. Srikanth, N. Park, 2016, Oncotarget.

Deletion of Orai1 leads to bone loss aggravated with aging and impairs function of osteoblast lineage cells

Y. Gwack, S. Srikanth, S. Tetradis, 2018, Bone Reports.

Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.

Y. Gwack, S. Srikanth, N. Park, 2016, Biochemical and biophysical research communications.

The Role of ORAI1 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells

Y. Gwack, S. Srikanth, N. Park, 2015, Journal of dental research.

Pathway To Drive Th17 Differentiation Induction of the Nuclear Orphan Receptor Calcium Signaling via Orai1 Is Essential for

R. Damoiseaux, Y. Gwack, S. Srikanth, 2014 .

Death and Enhances T Cell Survival ORAI1 Deficiency Impairs Activated T Cell

Y. Gwack, S. Srikanth, D. Mock, 2011 .

Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.

Y. Gwack, S. Srikanth, S. Feske, 2007, Cell calcium.

Kaposi's Sarcoma-associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3*

C. Lim, J. Choe, Y. Gwack, 2002, The Journal of Biological Chemistry.

Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via up-regulating Nr4a2

Y. Gwack, Mingye Feng, Hongmin Wu, 2022, Science advances.

Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria

Y. Gwack, L. Birnbaumer, S. Cha, 2021, Nature Communications.

Protein Kinase D Orchestrates the Activation of DRAK2 in Response to TCR-Induced Ca2+ Influx and Mitochondrial Reactive Oxygen Generation

Y. Gwack, S. Srikanth, M. Cahalan, 2011, The Journal of Immunology.

Oxygen Generation Influx and Mitochondrial Reactive 2+of DRAK2 in Response to TCR-Induced Ca Protein Kinase D Orchestrates the Activation

Y. Gwack, S. Srikanth, M. Cahalan, 2010 .

The Third Transmembrane Segment of Orai1 Protein Modulates Ca2+ Release-activated Ca2+ (CRAC) Channel Gating and Permeation Properties*

Y. Gwack, S. Srikanth, B. Ribalet, 2011, The Journal of Biological Chemistry.

Decoupling the role of RORγt in the differentiation and effector function of TH17 cells

Y. Gwack, Zhiheng He, Hongmin Wu, 2022, Science advances.

Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity.

C. Lim, J. Choe, Y. Gwack, 2000, The Journal of general virology.

Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein.

J. Choe, Y. Gwack, J. Han, 1997, Virus research.

RNA-Stimulated ATPase and RNA Helicase Activities and RNA Binding Domain of Hepatitis G Virus Nonstructural Protein 3

J. Choe, Y. Gwack, Hyouna Yoo, 1999, Journal of Virology.

Modulation of Orai1 and STIM1 by Cellular Factors

Y. Gwack, S. Srikanth, Jin Seok Woo, 2017 .

Functional Dissection of Latency-Associated Nuclear Antigen 1 of Kaposi's Sarcoma-Associated Herpesvirus Involved in Latent DNA Replication and Transcription of Terminal Repeats of the Viral Genome

C. Lim, J. Choe, Y. Gwack, 2002, Journal of Virology.

The K-bZIP Protein from Kaposi's Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional Activity

J. Choe, Y. Gwack, Seungmin Hwang, 2000, Journal of Virology.

Long‐Term Ligature‐Induced Periodontitis Exacerbates Development of Bisphosphonate‐Related Osteonecrosis of the Jaw in Mice

Y. Gwack, R. Kim, Sol Kim, 2022, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Dental enamel cells express functional SOCE channels

Y. Gwack, S. Srikanth, S. Feske, 2015, Scientific Reports.

Methods to measure cytoplasmic and mitochondrial Ca(2+) concentration using Ca(2+)-sensitive dyes.

Y. Gwack, S. Srikanth, Kyun-Do Kim, 2014, Methods in enzymology.

Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes.

Y. Gwack, S. Srikanth, Sonal Srikanth, 2013, Methods in molecular biology.

Global Changes in Kaposi's Sarcoma-Associated Virus Gene Expression Patterns following Expression of a Tetracycline-Inducible Rta Transactivator

Y. Gwack, Jae U. Jung, S. Zeichner, 2003, Journal of Virology.

Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

Y. Gwack, S. Srikanth, Sonal Srikanth, 2013, Molecules and cells.

Regulation of CRAC channels by protein interactions and post-translational modification

Y. Gwack, S. Srikanth, B. Ribalet, 2013, Channels.

Molecular regulation of the pore component of CRAC channels, Orai1.

Y. Gwack, S. Srikanth, Sonal Srikanth, 2013, Current topics in membranes.

Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx

Y. Gwack, S. Srikanth, Brij B. Singh, 2007, Journal of Biological Chemistry.

Orai1 is an essential pore subunit of the CRAC channel

Y. Gwack, S. Srikanth, S. Feske, 2006, Nature.

Biochemical and Functional Characterization of Orai Proteins*

Y. Gwack, S. Srikanth, S. Feske, 2007, Journal of Biological Chemistry.

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

Y. Gwack, S. Srikanth, J. Whitelegge, 2010, Nature Cell Biology.

Mutational analysis of the hepatitis C virus RNA helicase

J. Choe, Y. Gwack, J. Han, 1997, Journal of virology.

Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA

E. Cesarman, R. Means, Y. Gwack, 2005, Journal of Virology.

Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50 Represses p53-Induced Transcriptional Activity and Apoptosis

C. Lim, J. Choe, Y. Gwack, 2001, Journal of Virology.

Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis

Lukasz Kurgan, D. H. Kim, C. Hetz, 2014, Science Signaling.

Laminar flow downregulates Notch activity to promote lymphatic sprouting

H. Vogel, Y. Gwack, S. Srikanth, 2017, The Journal of clinical investigation.

Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes.

Y. Gwack, S. Srikanth, Jin Seok Woo, 2017, Advances in experimental medicine and biology.

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

W. Jefferies, Y. Gwack, S. Srikanth, 2014, Nature Immunology.

Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation

R. Damoiseaux, Y. Gwack, S. Srikanth, 2014, The Journal of Immunology.

ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival

Y. Gwack, S. Srikanth, D. Mock, 2011, The Journal of Immunology.

Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5.

J. Choe, Y. Gwack, Seungmin Hwang, 2003, The Journal of general virology.

Kaposi ’ s sarcoma-associated herpesvirus K 8 protein interacts with hSNF 5

J. Choe, Y. Gwack, Seungmin Hwang, 2003 .

The Kaposi ’ s Sarcoma-Associated Herpesvirus K 8 Protein Interacts with CREB-Binding Protein ( CBP ) and Represses CBP-Mediated Transcription

C. Lim, J. Choe, Y. Gwack, 2001 .

CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses

M. Pellegrini, Y. Gwack, S. Srikanth, 2018, The Journal of Immunology.

SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development

Y. Gwack, Jianming Xu, Zhiheng He, 2019, The Journal of Immunology.

SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner

Y. Gwack, Jianming Xu, Zhiheng He, 2017, Proceedings of the National Academy of Sciences.

Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein.

J. Choe, Y. Gwack, J. Han, 1996, Biochemical and biophysical research communications.

Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68

R. Sun, Y. Gwack, T. Kowalik, 2009, PLoS pathogens.

Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

Y. Gwack, S. Srikanth, S. Savic, 2021, eLife.

A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals

Y. Gwack, S. Srikanth, M. Jiang, 2016, Science Signaling.

Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements.

J. Choe, Y. Gwack, Seungmin Hwang, 2002, Molecules and cells.

Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity

Y. Gwack, M. Kang, I. Nishimura, 2021, Journal of dentistry research.

A Report of Novel STIM1 Deficiency and 6-Year Follow-Up of Two Previous Cases Associated with Mild Immunological Phenotype

Y. Gwack, S. Srikanth, S. O'Riordan, 2018, Journal of Clinical Immunology.

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

K. Rajewsky, E. Lamperti, Y. Gwack, 2008, Molecular and Cellular Biology.

The Ca2+ sensor STIM1 regulates type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

R. Sun, Y. Gwack, S. Srikanth, 2018, Nature Immunology.

The Ca2+ sensor STIM1 regulates type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

R. Sun, Y. Gwack, S. Srikanth, 2018, Nature Immunology.

NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells

Y. Gwack, S. Srikanth, Jin Seok Woo, 2021, Cell reports.

DNA helicase activity of the hepatitis C virus nonstructural protein 3.

J. Choe, Y. Gwack, J. Han, 1997, European journal of biochemistry.

The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1

Y. Gwack, S. Srikanth, Jin Seok Woo, 2020, Scientific Reports.

Orai1, STIM1, and their associating partners

Y. Gwack, S. Srikanth, Sonal Srikanth, 2012, The Journal of physiology.

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)

Y. Gwack, S. Srikanth, J. Abramson, 2012, Proceedings of the National Academy of Sciences.

Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.

V. Barr, Y. Gwack, S. Srikanth, 2008, Molecular biology of the cell.

Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca2+ dynamics in T cells

P. Ping, Y. Gwack, S. Srikanth, 2016, Proceedings of the National Academy of Sciences.

The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca2+ Release-activated Ca2+ Channels*

Y. Gwack, S. Srikanth, B. Ribalet, 2009, The Journal of Biological Chemistry.

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity.

J. Choe, Y. Gwack, J. Han, 1995, Biochemical and biophysical research communications.

Histone Lys demethylase KDM3C demonstrates anti‐inflammatory effects by suppressing NF‐κB signaling and osteoclastogenesis

Y. Gwack, R. Lux, R. Kim, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity

Y. Gwack, M. Kang, I. Nishimura, 2021, Journal of dental research.

Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt

Y. Gwack, Zhiheng He, Qihua Pang, 2017, The Journal of Immunology.

Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment

Y. Gwack, Zhiheng He, Zuoming Sun, 2016, The Journal of Immunology.

ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling

Y. Gwack, S. Srikanth, V. Arumugaswami, 2021, bioRxiv.

Blue light opens the ORAI1 LOC(K).

Y. Gwack, S. Srikanth, 2021, Cell Calcium.

The intracellular loop of Orai1 plays a central role in fast inactivation of CRAC channels

Y. Gwack, S. Srikanth, B. Ribalet, 2010 .

THE THIRD TRANSMEMBRANE SEGMENT OF ORAI1 MODULATES Ca 2+ RELEASE-ACTIVATED Ca 2+ (CRAC) CHANNEL GATING AND PERMEATION PROPERTIES

Y. Gwack, S. Srikanth, B. Ribalet, 2011 .

A large Rab GTPase family in a small GTPase world

Y. Gwack, S. Srikanth, Jin Seok Woo, 2017, Small GTPases.

Modulation of T-Cell Receptor Signal Transduction by Herpesvirus Signaling Adaptor Protein

Y. Gwack, Y. Chung, Jae U. Jung, 2004, Molecular and Cellular Biology.

Phosphorylation of ROR-Dependent and-Independent α Regulation of Th 17 Differentiation by IKK

Y. Gwack, Zhiheng He, Qihua Pang, 2017 .

The Kaposi's Sarcoma-Associated Herpesvirus K8 Protein Interacts with CREB-Binding Protein (CBP) and Represses CBP-Mediated Transcription

C. Lim, J. Choe, Y. Gwack, 2001, Journal of Virology.

Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68

R. Sun, Y. Gwack, T. Kowalik, 2009, PLoS pathogens.

via is essential to drive

R. Damoiseaux, Y. Gwack, S. Srikanth, 2013 .

The Ca 2+ sensor STIM1 regulates type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

Y. Gwack, S. Srikanth, G. Seo, 2019 .

The Ca 2+ sensor STIM1 regulates type I interferon response by retaining 1 the signaling adaptor STING at the endoplasmic reticulum

Y. Gwack, S. Srikanth, G. Seo, 2018 .

Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity.

Y. Gwack, Chunghun Lim, Hekwang Sohn, 2000, The Journal of general virology.

Laminar flow downregulates Notch activity to promote lymphatic sprouting

H. Vogel, Y. Gwack, S. Srikanth, 2017, The Journal of clinical investigation.

SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5

Yate-Ching Yuan, Y. Gwack, Mingye Feng, 2023, Proceedings of the National Academy of Sciences of the United States of America.

This information is current as Pathway To Drive Th 17 Differentiation Induction of the Nuclear Orphan Receptor Calcium Signaling via Orai 1 Is Essential for Waschek and Yousang Gwack

R. Damoiseaux, Y. Gwack, J. Waschek, 2013 .

This information is current as Pathway To Drive Th 17 Differentiation Induction of the Nuclear Orphan Receptor Calcium Signaling via Orai 1 Is Essential for Waschek and Yousang Gwack Saki

R. Damoiseaux, Y. Gwack, J. Waschek, 2013 .

The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca2+ Release-activated Ca2+ Channels*

Y. Gwack, B. Ribalet, Hea-Jin Jung, 2009, The Journal of Biological Chemistry.

A mutation in Orai1 causes immune deﬁciency by abrogating CRAC channel function

Y. Gwack, M. Prakriya, Sven-Holger Puppel, 2022 .