S. Hagen

发表

A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs.

C. Humblet, E. Lunney, S. Hagen, 1994, Journal of medicinal chemistry.

5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease.

G. Zeikus, E. Lunney, S. Gulnik, 2000, Journal of medicinal chemistry.

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids.

S. Hagen, J. Domagala, J. Sánchez, 1988, Journal of medicinal chemistry.

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry.

P. Andrews, S. Hagen, H. Showalter, 2018, Organic & biomolecular chemistry.

Impact of compliance to oral hypoglycemic agents on short-term disability costs in an employer population.

S. Hagen, W. Talamonti, D. Edington, 2014, Population health management.

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.

G. Zeikus, C. Humblet, E. Lunney, 1999, Bioorganic & medicinal chemistry.

Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-carboxylic acids.

S. Hagen, J. Domagala, J. Johnson, 1991, Journal of medicinal chemistry.

Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.

S. Hagen, J. Domagala, M. Schroeder, 1993, Journal of medicinal chemistry.

Effect of Health Risk Appraisal Frequency on Change in Health Status

C. Pai, S. Hagen, D. Edington, 2009, Journal of occupational and environmental medicine.

Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not

S. Hagen, J. Domagala, 2003 .

The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.

W. Denny, S. Hagen, J. Smaill, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.

E. Lunney, S. Hagen, J. Domagala, 1997, Journal of medicinal chemistry.

Synthesis and Antibacterial Activity of New Quinolones Containing a 7‐( 3‐(1‐Amino‐1‐methylethyl)‐1‐pyrrolidinyl) Moiety. Gram‐Positive Agents with Excellent Oral Activity and Low Side‐Effect Potential.

S. Hagen, J. Domagala, S. Gracheck, 1994 .

6-Phenyl-6-alkylamido-5,6-dihydro-2H-pyran-2-ones: novel HIV protease inhibitors

E. Lunney, S. Hagen, B. Tait, 1996 .

Synthesis of 5-methyl-4-oxo-quinolinecarboxylic acids

S. Hagen, J. Domagala, 1990 .

Synthesis and antibacterial activity of new quinolones containing a 7-[3-(1-amino-1-methylethyl)-1-pyrrolidinyl] moiety. Gram-positive agents with excellent oral activity and low side-effect potential.

S. Hagen, J. Domagala, S. Gracheck, 1994, Journal of medicinal chemistry.

Nonpeptide inhibitors of HIV protease

S. Hagen, B. Tait, J. Prasad, 2000 .

New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk.

S. Hagen, J. Domagala, M. Shapiro, 1992, Journal of medicinal chemistry.

Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.

S. Hagen, J. Domagala, S E Hagen, 1991, Journal of medicinal chemistry.

Agents anti-bacteriens

S. Hagen, J. Domagala, J. Kiely, 1989 .

Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses

Karla D. Passalacqua, S. Hagen, H. Showalter, 2018, Scientific Reports.

Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema.

S. Hagen, D. Antonetti, H. Showalter, 2020, Bioorganic & medicinal chemistry.

4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.

G. Zeikus, E. Lunney, S. Hagen, 1999, Bioorganic & medicinal chemistry letters.

Presenteeism: Critical Issues

S. Hagen, D. Edington, A. Schultz, 2010, Journal of occupational and environmental medicine.

Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses

Karla D. Passalacqua, S. Hagen, H. Showalter, 2018, bioRxiv.

Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents.

S. Hagen, M. Huband, Xiujuan Wu, 2006, Bioorganic & medicinal chemistry letters.

Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.

E. Lunney, S. Hagen, J. Domagala, 1999, Bioorganic & medicinal chemistry letters.

Multilevel Analysis of the Physical Health Perception of Employees: Community and Individual Factors

S. Hagen, D. Edington, S. Sathyanarayanan, 2012, American journal of health promotion : AJHP.

7-substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials.

S. Hagen, J. Domagala, J. Sánchez, 1988, Journal of medicinal chemistry.

Presenteeism: Critical Issues

S. Hagen, D. Edington, A. Schultz, 2010, Journal of occupational and environmental medicine.

Discovery and optimization of nonpeptide HIV-1 protease inhibitors.

E. Lunney, S. Hagen, J. Domagala, 1996, Bioorganic & medicinal chemistry.